Article
Medicine, General & Internal
Junhong Liu, Xiao Song, Shuangshuang Zheng, Hui Ding, Honggang Wang, Xicai Sun, Xiangfeng Ren
Summary: Currently, there is a lack of research on muscle and functional performance in COPD patients with T2DM in China. This study highlighted that COPD patients with T2DM had worse respiratory function, muscle strength, endurance, and physical performance, emphasizing the importance of actively controlling blood sugar to reduce adverse effects.
Review
Health Care Sciences & Services
Simone Pancera, Nicola F. Lopomo, Luca N. C. Bianchi, Paolo Pedersini, Jorge H. Villafane
Summary: This systematic review found that isolated resistance training can improve maximal strength in both upper and lower limbs of outpatients with COPD, with enhancements in muscle endurance and power as well, although improvements in muscle mass and cross-sectional area are limited in the analyzed trials.
Article
Medicine, Research & Experimental
Knut Sindre Molmen, Daniel Hammarstrom, Gunnar Slettalokken Falch, Morten Grundtvig, Lise Koll, Marita Hanestadhaugen, Yusuf Khan, Rafi Ahmad, Bente Malerbakken, Tore Jorgen Rodolen, Roger Lien, Bent R. Ronnestad, Truls Raastad, Stian Ellefsen
Summary: Despite the well-known pathophysiologies associated with COPD, resistance training led to improvements in lower-limb muscle strength, muscle mass, muscle quality, and endurance performance in COPD subjects, resembling or exceeding responses seen in healthy controls. These findings highlight the largely unrecognized responsiveness of COPD patients to resistance training and suggest it as a potent measure to relieve disease-related impairments.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Medicine, General & Internal
Omar Ammous, Walid Feki, Tamara Lotfi, Assem M. Khamis, Rik Gosselink, Ahmed Rebai, Samy Kammoun
Summary: Inspiratory muscle training (IMT) may not improve dyspnea, functional exercise capacity, and life quality when combined with pulmonary rehabilitation (PR) for chronic obstructive pulmonary disease (COPD) patients. However, IMT is likely to improve these outcomes when provided alone. The effects of both interventions may be greater in participants with respiratory muscle weakness and longer training durations, but further confirmation is needed.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2023)
Article
Rehabilitation
Anouk A. Stoffels, Jana De Brandt, Roy Meys, Hieronymus W. van Hees, Anouk W. Vaes, Peter Klijn, Chris Burtin, Frits M. Franssen, Bram van den Borst, Maurice J. Sillen, Daisy J. Janssen, Martijn A. Spruit
Summary: The study evaluated the response of COPD patients to a pulmonary rehabilitation program, finding improvements in 5STS and SPPB summary score post-PR. Patients with low baseline performance also showed significant improvements in balance and gait speed.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Medicine, General & Internal
Xiaosheng Dong, Xiangyu Wang, Ningxin Jia, Xianhai Chen, Meng Ding
Summary: This study compared the rehabilitation effects of Qigong exercise and aerobic exercise using a cycle ergometer in COPD patients. The results showed that participants in the cycle ergometer exercise group had significantly improved endurance capacity, quality of life, and COPD assessment results. While participants in the Qigong exercise group also showed significant improvements in endurance capacity, the differences between the two groups were not statistically significant in terms of endurance capacity and quality of life measures.
Article
Rehabilitation
An-Chi Chung, Chun-Jung Chang, Jui-Fang Liu, Ming-Szu Hung, Tien-Pei Fang, Hui-Ling Lin
Summary: The objective of this study was to explore the short- and long-term effects of lower-limb endurance training on chronic obstructive pulmonary disease outpatients. The study found that the training group showed significant improvement in the chronic obstructive pulmonary disease assessment test scores and reduced acute exacerbations after completing the training and sustaining for a year. Lower-limb endurance training can improve perceived dyspnea in daily activity and health status, and alleviate the impact of the disease on acute exacerbations.
CLINICAL REHABILITATION
(2023)
Article
Medicine, General & Internal
Burcin Ugur Tosun, Ender Angin, Berkiye Kirmizigil, Mustafa Yolcu
Summary: The study found that blood flow restriction exercises can increase strength, muscle size, and ergometer performance in elite canoe athletes.
Article
Integrative & Complementary Medicine
Danielle A. Baxter, Meaghan E. Coyle, Catherine J. Hill, Christopher Worsnop, Johannah L. Shergis
Summary: The study aimed to investigate the feasibility of implementing a manual therapy technique (muscle energy technique, MET) in a hospital pulmonary rehabilitation program for patients with moderate to severe COPD. The results showed that it is feasible to use MET as an adjunct to PR in a hospital setting, with satisfactory recruitment rates and no adverse events related to the MET component of the intervention.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2023)
Article
Rehabilitation
Patricia M. Bamonti, Julia T. Boyle, Christina L. Goodwin, Emily S. Wan, Amy K. Silberbogen, Elizabeth B. Finer, Marilyn L. Moy
Summary: The study suggests that early psychoeducation on dyspnea management and smoking and alcohol cessation may increase completion of PR.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Review
Medicine, General & Internal
Fang Zhang, Yaping Zhong, Zheng Qin, Xiaomeng Li, Wei Wang
Summary: This study included 14 RCTs and found that respiratory muscle and upper limb training can significantly improve dyspnea in patients with COPD during exercise and in daily life.
Article
Orthopedics
Sarah Gephine, Erik Frykholm, Andre Nyberg, Patrick Mucci, Hieronymus W. H. Van Hees, Arthur Lemson, Peter Klijn, Francois Maltais, Didier Saey
Summary: Different functional muscle properties, including quadriceps strength, endurance, and power, are associated with functional exercise capacity in people with COPD. Among these properties, muscle power has the strongest contribution to the 6-minute walking distance and 1-minute sit-to-stand test performance in individuals with COPD.
Article
Oncology
Li Jin, Wencan An, Zhenshuang Li, Liyong Jiang, Caili Chen
Summary: The study showed that pulmonary rehabilitation training combined with drug therapy significantly improved pulmonary function, exercise tolerance, sleep quality, and quality of life in stable COPD patients, with better outcomes observed in the group that underwent training five times a week.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Health Care Sciences & Services
Margaret A. French, Eva Keatley, Junyao Li, Aparna Balasubramanian, Nadia N. Hansel, Robert Wise, Peter Searson, Anil Singh, Preeti Raghavan, Stephen Wegener, Ryan T. Roemmich, Pablo Celnik
Summary: Remote monitoring of physical, cognitive, and psychosocial function in individuals with chronic obstructive pulmonary disease or stroke is feasible and shows high adherence, although reminders are required to maintain this level of adherence.
Review
Biochemistry & Molecular Biology
Salvatore Fuschillo, Debora Paris, Annabella Tramice, Pasquale Ambrosino, Letizia Palomba, Mauro Maniscalco, Andrea Motta
Summary: COPD is a diverse lung disease that requires personalized approaches and patient-centered rehabilitation programs. Metabolomics, through the analysis of metabolites in biological samples, has the potential to identify novel biomarkers for disease outcome and treatment response in COPD. This review discusses the clinical applications of metabolomic profiling of exhaled breath condensate (EBC) and plasma/serum in COPD.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Environmental Sciences
Nutchanok Niyatiwatchanchai, Chaicharn Pothirat, Warawut Chaiwong, Chalerm Liwsrisakun, Nittaya Phetsuk, Pilaiporn Duangjit, Woranoot Choomuang
Summary: The study aimed to assess small airway dysfunction, spirometry, health-related quality of life (HR-QoL), and inflammatory biomarkers between wildland firefighters and healthy controls. The results showed that wildland firefighters had significantly higher changes in small airway function during the pollution period compared to the non-pollution period, with no significant impact on spirometry, HRQoL, and inflammatory biomarkers.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2023)
Article
Infectious Diseases
Pattraporn Tajarernmuang, Pimchanok Sanwirat, Juthamas Inchai, Phichayut Phinyo, Atikun Limsukon
Summary: This study aimed to assess the predictive performance of NEWS2 in identifying early progression to severe disease in CAP patients. Among 260 patients, 25.6% had early progression to severe CAP. The combination of NEWS2 >= 8, albumin level < 3 g/dL, and BUN >= 30 mg/dL improved the predictive accuracy.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Environmental Sciences
Chalerm Liwsrisakun, Warawut Chaiwong, Chaiwat Bumroongkit, Athavudh Deesomchok, Theerakorn Theerakittikul, Atikun Limsukon, Konlawij Trongtrakul, Pattraporn Tajarernmuang, Nutchanok Niyatiwatchanchai, Chaicharn Pothirat
Summary: This study aimed to determine the association between PM10 and asthma control. It found that during high PM10 periods, asthma control, as measured by ACT scores, was significantly lower compared to low PM10 periods. Increase in monthly average PM10 levels resulted in a significant decrease in ACT scores.
Article
Medicine, General & Internal
Chalerm Liwsrisakun, Warawut Chaiwong, Chaicharn Pothirat
Summary: This study compares spirometry and impulse oscillometry (IOS) for the detection and prevalence of small airway dysfunction (SAD) in COPD and asthma patients. The results demonstrate that IOS is more sensitive in detecting SAD in asthma patients without fixed airflow obstruction (FAO), whereas spirometry is more sensitive in COPD and asthma patients with FAO.
FRONTIERS IN MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Chaiwat Bumroongkit, Pattraporn Tajarernmuang, Konlawij Trongtrakul, Chalerm Liwsrisakun, Athavudh Deesomchok, Chaicharn Pothirat, Theerakorn Theerakittikul, Atikun Limsukon, Nutchanok Niyatiwatchanchai, Juthamas Inchai, Warawut Chaiwong
Summary: This study evaluated the performance of the National Early Warning Scores (NEWS) in predicting mortality in patients with acute pulmonary embolism (APE). The results showed that NEWS was significantly higher in non-survivors compared to survivors, and a NEWS value of >= 9 was identified as the best cutoff point for predicting 30-day mortality in APE patients, with a sensitivity of 66.9% and specificity of 66.3%. Therefore, NEWS can be used as a predictive indicator for mortality in APE patients, and those with a NEWS value >= 9 should be closely monitored.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Multidisciplinary Sciences
Nuchjira Takheaw, Chalerm Liwsrisakun, Witida Laopajon, Supansa Pata, Warawut Chaiwong, Juthamas Inchai, Pilaiporn Duangjit, Chaicharn Pothirat, Chaiwat Bumroongkit, Athavudh Deesomchok, Theerakorn Theerakittikul, Atikun Limsukon, Pattraporn Tajarernmuang, Nutchanok Niyatiwatchanchai, Konlawij Trongtrakul, Watchara Kasinrerk
Summary: The efficiency and durability of ChAdOx-1 or BNT162b2 booster vaccines in elderly individuals previously vaccinated with CoronaVac were evaluated against Omicron and other variants. After 2-dose CoronaVac, only 2.2% had NAbs against Omicron above the cut-off value. Four weeks after boosting, the percentages increased to 41.7% and 54.5% for ChAdOx-1 and BNT162b2, respectively. However, NAb levels waned significantly after 12 and 24 weeks, with only 2% having high levels of NAbs against Omicron 24 weeks after boosting. The Omicron variant showed less responsiveness to booster vaccines compared to other variants.
Article
Peripheral Vascular Disease
Chaiwat Bumroongkit, Atikun Limsukon, Chalerm Liwsrisakun, Athavudh Deesomchok, Chaicharn Pothirat, Theerakorn Theerakittikul, Konlawij Trongtrakul, Pattraporn Tajarernmuang, Nutchanok Niyatiwatchanchai, Juthamas Inchai, Warawut Chaiwong
Summary: This study aimed to validate the PESI score and 2019 ESC risk stratification in Southeast Asian patients with APE. The results showed that both PESI and ESC risk stratification can effectively predict 30-day mortality in this population.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Immunology
Warawut Chaiwong, Nuchjira Takheaw, Supansa Pata, Witida Laopajon, Pilaiporn Duangjit, Juthamas Inchai, Chaicharn Pothirat, Chaiwat Bumroongkit, Athavudh Deesomchok, Theerakorn Theerakittikul, Atikun Limsukon, Pattraporn Tajarernmuang, Nutchanok Niyatiwatchanchai, Konlawij Trongtrakul, Kantinan Chuensirikulchai, Passaworn Cheyasawan, Chalerm Liwsrisakun, Watchara Kasinrerk
Summary: This study provides data on humoral and cellular immune responses against SARS-CoV-2 in chronic obstructive pulmonary disease (COPD) patients after receiving heterologous CoVac/ChAd vaccine. The results show that the vaccine induces the production of neutralizing antibodies, with higher responses against the Alpha, Beta, and Delta variants compared to the Omicron variant. Additionally, the vaccine slightly increases the CD4 T-cell responses.
Article
Respiratory System
Nantaporn Tiyapun, Kanokkarn Sunkonkit, Warawut Chaiwong, Ratirat Worasuthaneewan, Theerakorn Theerakittikul
Summary: This study explored the factors influencing CPAP adherence in elderly OSA patients. It was found that elderly patients with adverse attitudes towards CPAP use and female patients had lower adherence rates. Therefore, individualized indications and treatment of CPAP should be considered in the elderly, with regular monitoring to address compliance and tolerance issues.
JOURNAL OF THORACIC DISEASE
(2023)
Article
Health Care Sciences & Services
Athavudh Deesomchok, Chalerm Liwsrisakun, Warawut Chaiwong, Chaicharn Pothirat, Pilaiporn Duangjit, Chaiwat Bumroongkit, Theerakorn Theerakittikul, Atikun Limsukon, Pattraporn Tajarernmuang, Konlawij Trongtrakul, Nutchanok Niyatiwatchanchai
Summary: Many studies have shown that the quality of life (QoL) is poor in COVID-19 patients at various time points. However, these studies have limitations due to their design and lack of control groups. Therefore, this prospective study aimed to assess the impact of COVID-19 pneumonia on QoL in both physical and mental health. The results showed that adult patients who recovered from COVID-19 pneumonia had lower QoL initially, but it improved over the one-year follow-up period.