期刊
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
卷 8, 期 4, 页码 359-368出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/17474124.2014.896193
关键词
thiopurines; adalimumab; maintenance; remission; infliximab; 5-ASA; golimumab; ulcerative colitis
资金
- MSD Human Health
- Pfizer
- Salix
- Shire
- Aptalis
Ulcerative colitis (UC) is a chronic idiopathic intestinal disease that requires life-long maintenance therapy to maintain clinical remission. This article reviews the current literature on maintenance treatments in UC. It examines the natural history of the condition and the proposed benefits of treatment. These include improving quality of life parameters, decreasing corticosteroid intake, the prevention of relapse, the prevention of colorectal cancer and the avoidance of colectomy. The immunosuppressive era appears to be reducing the need for elective colectomy in UC. The article explores the classes of drug currently used for maintenance of UC, reviews the literature around adherence issues, and summarizes emerging agents in this space.
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