Article
Medicine, General & Internal
Gerard Doherty, Matthew Manktelow, Brendan Skelly, Paddy Gillespie, Anthony J. Bjourson, Steven Watterson
Summary: Gallstones are a common health issue that has a significant impact on healthcare logistics and economics. This article discusses the various presentations of gallbladder disease, as well as the factors that affect clinical care such as diagnosis, treatment outcomes, surgical risk factors, and cost-effectiveness. The importance of standardized guidelines and objective scoring systems in improving quality and cost-effectiveness of treatment is emphasized.
MEDICINA-LITHUANIA
(2022)
Review
Medicine, General & Internal
Dan Boitor-Borza, Ioana Cristina Rotar, Adelina Staicu, Roxana Constantin, Daniel Muresan
Summary: It is uncommon to find echogenic content in the fetal gallbladder, and the cause, course, and prognosis of this condition are unclear. After reviewing 34 studies, we suggest a follow-up plan for patients with this condition. Among 226 fetuses identified, 72 had biliary sludge, 30 had a single hyperechogenic focus, and 100 had multiple foci. Other ultrasound features included distal shadowing (16 cases), comet tail and twinkling (37 cases), and no acoustic artifacts (26 cases). Spontaneous resolution before birth was documented in 9 cases, while 9 fetuses had no echogenic content at birth, and 138 cases resolved within the first year of life. In most cases, the condition resolves spontaneously in the postnatal period, and medical or surgical intervention is not necessary. Asymptomatic patients can be managed with a wait-and-see approach.
Review
Pharmacology & Pharmacy
Laura Cuzzolin, Anna Maria Oggiano, Maria Grazia Clemente, Cristian Locci, Luca Antonucci, Roberto Antonucci
Summary: Ceftriaxone is a commonly used antibiotic in pediatric hospital practice, which may lead to cholelithiasis and/or biliary sludge, especially in children. Studies have shown that ceftriaxone-associated biliary pseudolithiasis is dose-dependent, usually asymptomatic but can sometimes present with symptoms such as abdominal pain, nausea, and vomiting. Conservative treatment is recommended, along with long-term follow-up to monitor resolution of symptoms. Personalized assessment of predisposing factors before prescribing ceftriaxone can help minimize the risk of developing this condition.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2021)
Article
Physiology
Ludovica Ceci, Yuyan Han, Kelsey Krutsinger, Leonardo Baiocchi, Nan Wu, Debjyoti Kundu, Konstantina Kyritsi, Tianhao Zhou, Eugenio Gaudio, Heather Francis, Gianfranco Alpini, Lindsey Kennedy
Summary: Cholestatic liver diseases are characterized by blockage of bile flow and accumulation of bile acids in the liver. There may be associations between liver damage and gallbladder damage, as both tissues are lined by biliary epithelial cells. This comprehensive article discusses the background information of the biliary tree and gallbladder, identifies gallbladder disorders in various liver diseases, and provides clinical aspects and approaches for diagnosis and treatment.
COMPREHENSIVE PHYSIOLOGY
(2023)
Article
Oncology
Xiao Luo, Wanshui Yang, Amit D. Joshi, Kana Wu, Tracey G. Simon, Chen Yuan, Lina Jin, Lu Long, Mi Na Kim, Chun-Han Lo, Xing Liu, Thomas A. Abrams, Brian M. Wolpin, Andrew T. Chan, Edward L. Giovannucci, Xuehong Zhang
Summary: This study found an increased risk of liver cancer, biliary tract cancer, and possibly pancreatic cancer associated with gallstones.
BRITISH JOURNAL OF CANCER
(2022)
Review
Nutrition & Dietetics
Dimitri Poddighe, Kuanysh Dossybayeva, Diyora Abdukhakimova, Lyudmila Akhmaltdinova, Aigul Ibrayeva
Summary: This review analyzes the pathophysiological aspects and clinical evidence of gallbladder dysfunction in CD patients, highlighting the potential medical complications and research gaps. CD patients may develop gallbladder dysmotility, leading to impaired emptying during digestion. Although CD patients do not seem to be more susceptible to gallbladder complications, further clinical studies are needed to fully understand the clinical implications of gallbladder alterations in CD patients.
Article
Medicine, General & Internal
Shimin Chen, Ke Han, Yang Song, Shaohua Liu, Xuehang Li, Shengshu Wang, Haowei Li, Rongrong Li, Jianhua Wang, Yao He, Miao Liu
Summary: Gallbladder and biliary tract cancer (GBTC) is becoming a major health burden in China, particularly among males and older individuals. From 1990 to 2019, the incidence, prevalence, mortality, and DALYs of GBTC generally increased. Although the age-standardized incidence rate and age-standardized mortality rate are predicted to decline gradually, the number of new cases and deaths is expected to grow steadily.
CHINESE MEDICAL JOURNAL
(2022)
Article
Oncology
Syed Ahsan Raza, Wilson L. da Costa, Aaron P. Thrift
Summary: This study reveals a consistent increase in gallbladder cancer incidence rates among non-Hispanic Blacks in the United States, with evidence of birth cohort effects in different regions. These findings suggest that gallbladder cancer rates will continue to rise in the near future.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Medicine, General & Internal
I. G. Bakulin, E. B. Avalueva, M. U. Serkova, T. E. Skvortsova, P. Seliverstov, M. A. Shevyakov, S. Sitkin
Summary: The study found that Ursofalk is highly effective in the treatment of biliary sludge disease, especially within the first 3 months of therapy. Additionally, compared to generic drugs from other manufacturers, the therapeutic effectiveness of the German substance Ursofalk is superior.
TERAPEVTICHESKII ARKHIV
(2021)
Review
Medicine, General & Internal
Robert Lam, Alan Zakko, Jessica C. Petrov, Priyanka Kumar, Andrew J. Duffy, Thiruvengadam Muniraj
Summary: Gallbladder disorders cover a wide range of diseases with varying severity, and it is essential to understand the clinical presentation, pathophysiology, diagnostic evaluation, and management for each specific condition mentioned.
DM DISEASE-A-MONTH
(2021)
Article
Gastroenterology & Hepatology
Aynur Unalp-Arida, Constance E. Ruhl
Summary: We analyzed data from the US National Health and Nutrition Examination Survey (NHANES) and found that mortality from gallbladder and biliary tract diseases is associated with factors such as age, sex, diabetes, and physical inactivity. Additionally, the prevalence of gallstone disease has doubled over the past 30 years, possibly due to worsening metabolic risk factors and the increasing popularity of laparoscopic cholecystectomy.
Article
Medicine, General & Internal
Emre Bozdag, Suleyman Sonmez, Erkan Somuncu, Serhan Yilmaz, Ceren Basaran, Mehmet Abdussamet Bozkurt
Summary: In this study, the anatomy and variations of the extrahepatic bile duct were evaluated to determine their importance in the formation of acute calculous cholecystitis (ACC). The results showed that the length and variations of the cystic duct and common bile duct were significantly associated with ACC. Longer cystic duct and common bile duct were found to be associated with a higher likelihood of ACC. Further studies with larger samples are needed to confirm these findings.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2022)
Article
Oncology
Sharayu Mhatre, Rebecca C. Richmond, Nilanjan Chatterjee, Preetha Rajaraman, Zhaoming Wang, Haoyu Zhang, Rajendra Badwe, Mahesh Goel, Shraddha Patkar, Shailesh Shrikhande, Prachi S. Patil, George Davey Smith, Caroline L. Relton, Rajesh P. Dikshit
Summary: The study found a causal relationship between history of gallstones and increased risk of gallbladder cancer in an Indian population. Prevention of gallstones through treatment is emphasized for preventing gallbladder cancer in high-risk individuals.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Oncology
Kazuma Kishi, Masaki Kuwatani, Yuki Ohnishi, Yasuhiro Kumaki, Hiroyuki Kumeta, Hajime Hirata, Yunosuke Takishin, Ryutaro Furukawa, Kosuke Nagai, Hiroki Yonemura, Shunichiro Nozawa, Ryo Sugiura, Kazumichi Kawakubo, Tomoyasu Aizawa, Naoya Sakamoto
Summary: A metabolomic analysis of duodenal juice was performed to identify differences between malignant and benign biliary diseases, demonstrating the potential of duodenal juice metabolomics as a diagnostic biomarker for biliary diseases.
Article
Veterinary Sciences
Irene Vonfeld, Xavier Ferreira, Aline Gay, Laurence Cornu, Alain Gravet, Julie Brunet, Brice Lefaux, Benoit Quintard
Summary: This case report describes a successfully treated case of obstructive cholelithiasis in a primate, treated by cholecystoduodenostomy and surgical removal of hepatic granuloma and gallstone.
VETERINARY RECORD CASE REPORTS
(2022)
Letter
Cardiac & Cardiovascular Systems
Fabian Eichelmann, Matthias B. Schulze, Clemens Wittenbecher, Juliane Menzel, Cornelia Weikert, Romina di Giuseppe, Ronald Biemann, Berend Isermann, Andreas Fritsche, Heiner Boeing, Krasimira Aleksandrova
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Article
Endocrinology & Metabolism
Yeli Wang, Manja Koch, Romina di Giuseppe, Kirsten Evans, Jan Borggrefe, Ute Nothlings, Aase Handberg, Majken K. Jensen, Wolfgang Lieb
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2019)
Article
Oncology
Fabrizia Noro, Francesco Gianfagna, Alessandro Gialluisi, Amalia De Curtis, Augusto Di Castelnuovo, Emanuela Napoleone, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Marc F. Hoylaerts, Licia Iacoviello, Benedetta Izzi, Branislav Vohnout, Marcello Arca, Roberto Lorenzet, Augusto di Castelnuovo, Simona Costanzo, Romina di Giuseppe, Antonella Cutrone, Sara Magnacca, Marilena Crescente, Agnieszka Pampuch, Chiara Tamburrelli, Filomena Zurlo, Luisa Nanni
CLINICAL EPIGENETICS
(2019)
Article
Medicine, Research & Experimental
Matthew Schenk, Fabian Eichelmann, Matthias B. Schulze, Natalia Rudovich, Andreas F. Pfeiffer, Romina di Giuseppe, Heiner Boeing, Krasimira Aleksandrova
BIOMARKERS IN MEDICINE
(2019)
Article
Oncology
Benedetta Izzi, Francesco Gianfagna, Wen-Yi Yang, Katrien Cludts, Amalia De Curtis, Peter Verhamme, Augusto Di Castelnuovo, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Jan A. Staessen, Marc F. Hoylaerts, Licia Iacoviello, Branislav Vohnout, Marcello Arca, Chiara Cerletti, Roberto Lorenzet, Simona Costanzo, Romina di Giuseppe, Antonella Cutrone, Amalia De Curtis, Sara Magnacca, Marilena Crescente, Agnieszka Pampuch, Chiara Tamburrelli, Antonella Cutrone, Emanuela Napoleone, Filomena Zurlo, Luisa Nanni
CLINICAL EPIGENETICS
(2019)
Article
Medical Laboratory Technology
Arne Gessner, Romina di Giuseppe, Manja Koch, Martin F. Fromm, Wolfgang Lieb, Renke Maas
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2020)
Article
Nutrition & Dietetics
Iris Trefflich, Hanns-Ulrich Marschall, Romina di Giuseppe, Marcus Stahlman, Andreas Michalsen, Alfonso Lampen, Klaus Abraham, Cornelia Weikert
Review
Nutrition & Dietetics
Janine Wirth, Elaine Hillesheim, Lorraine Brennan
JOURNAL OF NUTRITION
(2020)
Article
Nutrition & Dietetics
Janine Wirth, Amit D. Joshi, Mingyang Song, Dong Hoon Lee, Fred K. Tabung, Teresa T. Fung, Andrew T. Chan, Cornelia Weikert, Michael Leitzmann, Walter C. Willett, Edward Giovannucci, Kana Wu
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2020)
Review
Pharmacology & Pharmacy
Maribel Salas, Mackenzie Henderson, Angelika Wientzek-Fleischmann, Zahidul Islam, Nora Tu, Aikaterini Bilitou, Maggie Elsharkawy, Ulf Stellmacher
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Endocrinology & Metabolism
Anna Birukov, Fabian Eichelmann, Olga Kuxhaus, Elli Polemiti, Andreas Fritsche, Janine Wirth, Heiner Boeing, Cornelia Weikert, Matthias B. Schulze
Article
Nutrition & Dietetics
Janna Enderle, Urte Klink, Romina di Giuseppe, Manja Koch, Ulrike Seidel, Katharina Weber, Marc Birringer, Ilka Ratjen, Gerald Rimbach, Wolfgang Lieb
Article
Biochemistry & Molecular Biology
Julia Langenau, Kolade Oluwagbemigun, Christian Brachem, Wolfgang Lieb, Romina di Giuseppe, Anna Artati, Gabi Kastenmueller, Leonie Weinhold, Matthias Schmid, Ute Noethlings
Article
Gastroenterology & Hepatology
Junghyun Lim, Janine Wirth, Kana Wu, Edward Giovannucci, Peter Kraft, Constance Turman, Mingyang Song, Manol Jovani, Andrew T. Chan, Amit D. Joshi
Summary: This study aimed to investigate the associations between anthropometric measures and symptomatic gallstone disease, stratified by gallstone disease polygenic risk score (PRS). The findings suggest that while adiposity is consistently associated with gallstone disease risk, individuals with higher genetic susceptibility to gallstone disease can benefit more from maintaining a healthy body weight in terms of risk reduction.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Nutrition & Dietetics
Janine Wirth, Elaine Hillesheim, Lorraine Brennan
Summary: This systematic review and meta-analysis found no clear relationship between increased protein intake and sleep outcomes, although the evidence strength was low. More randomized controlled trials focusing on this specific research question are needed.