Article
Ecology
Shuichi Kitada, Hirohisa Kishino
Summary: Genetic stock identification (GSI) is an important management tool for Pacific salmon, providing rich genetic baseline data across the Pacific Rim. Analyzing data from chum salmon populations, it was observed that Japanese/Korean populations had the greatest impact and SNP selection was based on predicted structures.
ECOLOGY AND EVOLUTION
(2021)
Article
Biochemistry & Molecular Biology
Julia Leme Pablos, Ana Kristina Silva, Noemy Seraphim, Luiza de Moraes Magaldi, Anete Pereira de Souza, Andre Victor Lucci Freitas, Karina Lucas Silva-Brandao
Summary: The study on Atlantic Forest White Morpho butterflies shows that there is no clear species diversification and population structure among the populations, suggesting that the current distinction between the two species is unreasonable. Northern samples exhibit more intragroup structure, and clustering tests indicate the existence of three genetic clusters, with turnover between the states of Paran ' a and Sa similar to o Paulo.
MOLECULAR PHYLOGENETICS AND EVOLUTION
(2021)
Article
Agriculture, Dairy & Animal Science
Marcin Kucinski, Magdalena Jakubowska-Lehrmann, Agnieszka Gora, Zuzanna Mirny, Katarzyna Nadolna-Altyn, Joanna Szlinder-Richert, Konrad Ocalewicz
Summary: The aim of this study was to investigate the genetic diversity and population structure of the European flounder and determine if the Baltic flounder is present in the southern Baltic Sea. Additionally, the study aimed to determine if the decline in body condition indices of the species in the Baltic Sea is due to adaptive changes in its gene pool caused by increased fishing pressure. The results showed that the European flounder had a high level of genetic diversity and represented a single genetic cluster. No presence of the Baltic flounder was detected, and there were no signs of directional selection or density-dependent adaptive changes in the gene pool.
Review
Genetics & Heredity
Mohammed Piro
Summary: The development of molecular genetics has provided insights into the genetic diversity and domestication processes of dromedary camels, utilizing techniques such as microsatellites and nuclear SNPs. Studies have revealed a distinct global genetic structure in dromedaries, with differentiation between various regions.
FRONTIERS IN GENETICS
(2021)
Article
Agriculture, Dairy & Animal Science
Vera Mukhina, Gulnara Svishcheva, Valery Voronkova, Yurii Stolpovsky, Aleksei Piskunov
Summary: This study performed SNP genotyping of indigenous goats of Mongolia, revealing their genetic history and risks. The research discovered close genetic relations among Mongolian, Russian, Chinese, and West Asian breeds, as well as genetic features highlighting the distinct origin and breeding history of Mongolian goat breeds. Mongolian goats are of great importance in studying ancient migration routes and adaptability to harsh environments. Recent climatic disasters and uncontrolled breeding pose a threat to the genetic resources of Mongolian goats.
Article
Microbiology
Adrian Forsythe, Karen J. Vanderwolf, Jianping Xu
Summary: The ongoing White-Nose Syndrome caused by P. destructans affects hibernating bat species in North America. Research found evidence of genetic isolation in P. destructans populations in the region, but also identified gene flow among different geographic areas. Recombination was observed in the North American P. destructans population, with anthropogenic impacts significantly influencing the pathogen's population structure.
Article
Parasitology
Antoine Mignotte, Claire Garros, Simon Dellicour, Maude Jacquot, Marius Gilbert, Laetitia Gardes, Thomas Balenghien, Maxime Duhayon, Ignace Rakotoarivony, Maia de Wavrechin, Karine Huber
Summary: The study on Culicoides obsoletus in Europe found that cattle density is the main factor limiting gene flow, while low genetic differentiation and weak population structure indicate the high dispersal capacity of this species over land.
PARASITES & VECTORS
(2021)
Article
Entomology
Marija Tanaskovic, Pavle Eric, Aleksandra Patenkovic, Katarina Eric, Milica Mihajlovic, Vanja Tanasic, Szilvia Kusza, Andrzej Oleksa, Ljubisa Stanisavljevic, Slobodan Davidovic
Summary: The western honey bee is an ecologically and economically important pollinator species, but it faces challenges due to human interference. To protect genetic diversity, we studied honey bee populations in Serbia and found a relatively homogenous population. However, there are still local differences and the predominance of admixture populations in human-dominated areas.
Article
Forestry
Tomas Byrne, Niall Farrelly, Colin Kelleher, Trevor R. Hodkinson, Stephen L. Byrne, Susanne Barth
Summary: Picea sitchensis, or Sitka spruce, is a forestry species of interest both for conservation and as a productive crop. This study analyzed the genetic diversity and differentiation of this species across its native range using genotyping-by-sequencing. The results showed low levels of genetic differentiation across the broader environmental gradient, but island effects were observed on geographically distant populations. The findings provide valuable information for breeders and researchers in terms of breeding programs, scientific studies, and climate change adaptation.
Article
Ecology
Luciano Atzeni, Jun Wang, Philip Riordan, Kun Shi, Samuel A. A. Cushman
Summary: Genetic data of snow leopards from China were used to evaluate landscape genetics resistance models. The genetically optimized models outperformed habitat-based and isolation-by-distance hypotheses. The study also revealed that intermediate ruggedness and elevation in mountainous regions played a crucial role in facilitating gene flow in snow leopards.
Article
Biodiversity Conservation
Jasmin Kleissen, Niko Balkenhol, Heike Proehl
Summary: Human activities are causing continuous loss in biodiversity, especially affecting species like the yellow-bellied toad. Landscape changes impact genetic connectivity and gene flow in populations, with anthropogenic structures posing the greatest barriers. Specific landscape elements, such as underpasses, can have a positive impact on genetic distance between populations.
Article
Genetics & Heredity
Hsing-Fang Lu, Ting-Yuan Liu, Yu-Pao Chou, Shih-Sheng Chang, Yow-Wen Hsieh, Jan-Gowth Chang, Fuu-Jen Tsai
Summary: Pharmacogenetic testing has not been widely used in clinical practice, and the distribution of clinically relevant pharmacogenes in large population cohorts, particularly in East Asians, has not been fully characterized. In this study, the authors comprehensively analyzed 14 actionable pharmacogene diplotypes and phenotypes in a large sample of Taiwanese Han individuals. Their findings showed comparable pharmacogenetic phenotype frequencies between their cohort and the East Asian population. Nearly all individuals (99.9%) had at least one actionable pharmacogenetic phenotype, and a significant proportion of them (29%) had been prescribed drugs that may cause atypical responses. These findings have implications for the clinical application of pharmacogenetic testing and individualized treatment optimization.
FRONTIERS IN GENETICS
(2022)
Article
Biodiversity Conservation
E. Brunton, A. Brunton, K. Hohwieler, S. Ogbourne, G. Conroy
Summary: Urban landscapes pose barriers to wildlife movement and gene flow, impacting genetic diversity and structure of large terrestrial mammals such as the eastern grey kangaroo. This study examined the genetic profile of kangaroo populations in a rapidly urbanising region of Southeast Queensland, Australia and found regional genetic differentiation and declines in effective population size. The findings highlight the need for localized management and improved landscape connectivity to preserve genetic diversity and structure in the face of ongoing urbanization.
GLOBAL ECOLOGY AND CONSERVATION
(2022)
Article
Biology
Clement Car, Andre Gilles, Elen Goujon, Marie-Laure Delignette Muller, Luc Camoin, Sandrine Frelon, Pablo Burraco, Samuel Granjeaud, Emilie Baudelet, Stephane Audebert, German Orizaola, Jean Armengaud, Arthur Tenenhaus, Imene Garali, Jean-Marc Bonzom, Olivier Armant
Summary: By analyzing the radar observation data from the Urumqi Satellite Receiving Station, researchers have found that the mass balance of the Yabulangsha Glacier has undergone significant changes over time. The results of the study indicate a trend of increasing mass balance of the glacier, which may be attributed to factors such as increased precipitation and decreased temperature.
Article
Ecology
Scott A. Martin, William E. Peterman, Gregory J. J. Lipps Jr, H. Lisle Gibbs
Summary: Assessing environmental factors for species movement is crucial for identifying conservation actions that connect isolated populations. However, direct observations are limited, so alternate approaches like landscape genetic analyses are necessary. This study uses such analysis to assess the impact of landscape features on the movement of the eastern massasauga rattlesnake. The findings highlight the importance of land-cover and inherent landscape features on current connectivity, and provide valuable information for guiding future habitat modification and land acquisition actions to connect isolated populations.
ECOLOGICAL APPLICATIONS
(2023)
Article
Ecology
Michael R. Garvin, William D. Templin, Anthony J. Gharrett, Nick DeCovich, Christine M. Kondzela, Jeffrey R. Guyon, Megan V. McPhee
METHODS IN ECOLOGY AND EVOLUTION
(2017)
Article
Multidisciplinary Sciences
Wen C. Aw, Michael R. Garvin, Richard G. Melvin, J. William O. Ballard
Article
Fisheries
M. R. Garvin, A. J. Gharrett
JOURNAL OF FISH BIOLOGY
(2010)
Editorial Material
Evolutionary Biology
Michael R. Garvin, Joseph P. Bielawski, Leonid A. Sazanov, Anthony J. Gharrett
JOURNAL OF ZOOLOGICAL SYSTEMATICS AND EVOLUTIONARY RESEARCH
(2015)
Review
Biochemistry & Molecular Biology
M. R. Garvin, K. Saitoh, A. J. Gharrett
MOLECULAR ECOLOGY RESOURCES
(2010)
Article
Multidisciplinary Sciences
Michael R. Garvin, Joseph P. Bielawski, Anthony J. Gharrett
Article
Fisheries
Michael R. Garvin, Robert W. Marcotte, Katie J. Palof, Rachel J. Riley, Lisa M. Kamin, Anthony J. Gharrett
TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY
(2011)
Article
Multidisciplinary Sciences
Michael R. Garvin, Anthony J. Gharrett
ROYAL SOCIETY OPEN SCIENCE
(2014)
Article
Genetics & Heredity
Wen C. Aw, Samuel G. Towarnicki, Richard G. Melvin, Neil A. Youngson, Michael R. Garvin, Yifang Hu, Shaun Nielsen, Torsten Thomas, Russell Pickford, Sonia Bustamante, Anton Vila-Sanjurjo, Gordon K. Smyth, J. William O. Ballard
Article
Biology
Michael R. Garvin, Christiane Alvarez, J. Izaak Miller, Erica T. Prates, Angelica M. Walker, B. Kirtley Amos, Alan E. Mast, Amy Justice, Bruce Aronow, Daniel Jacobson
Article
Biochemistry & Molecular Biology
Erica T. Prates, Michael R. Garvin, Mirko Pavicic, Piet Jones, Manesh Shah, Omar Demerdash, B. Kirtley Amos, Armin Geiger, Daniel Jacobson
Summary: Although SARS-CoV and SARS-CoV-2 possess highly similar protein arsenals, they have spread among humans at extremely different rates. Through proteome-wide comparative structural analysis, unique molecular elements in the SARS-CoV-2 proteome which may explain the differing consequences have been identified, including nonconservative substitutions in key functional regions such as the spike glycoprotein, nsp1, and nsp3. The conservation of functional protein regions within the two taxa is also notable.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Biology
Alan E. Mast, Alisa S. Wolberg, David Gailani, Michael R. Garvin, Christiane Alvarez, J. Izaak Miller, Bruce Aronow, Daniel Jacobson
Summary: In COVID-19 patients, extensive fibrin deposition in the lungs and altered levels of circulating blood coagulation proteins suggest impaired local pathways that limit fibrin formation and promote clearance. Analysis of bronchoalveolar lavage fluid samples revealed decreased transcriptional levels related to fibrinolysis and increased levels related to coagulation, indicating enhanced coagulation propagation and reduced fibrinolysis as drivers of lung coagulopathy in COVID-19 patients.
Article
Multidisciplinary Sciences
Mikhail Ali Hameedi, Erica T. Prates, Michael R. Garvin, Irimpan Mathews, B. Kirtley Amos, Omar Demerdash, Mark Bechthold, Mamta Iyer, Simin Rahighi, Daniel W. Kneller, Andrey Kovalevsky, Stephan Irle, Van-Quan Vuong, Julie C. Mitchell, Audrey Labbe, Stephanie Galanie, Soichi Wakatsuki, Daniel Jacobson
Summary: The authors report on the crystallographic and computational studies that explain how SARS-CoV-2 3CLpro cleaves NF-kappa B Essential Modulator, a host protein, in addition to its viral substrates. They discuss the association between this cleavage and the high adaptability of SARS-CoV-2 in humans. The study provides insights into the binding mechanism between 3CLpro and NEMO, as well as the role of key binding residues in the fitness of SARS-CoV-2.
NATURE COMMUNICATIONS
(2022)
Article
Genetics & Heredity
David Kainer, Alan R. Templeton, Erica T. Prates, Daniel Jacboson, Euan R. O. Allan, Sharlee Climer, Michael R. Garvin
Summary: This study identifies structural variations in non-Mendelian inheritance patterns that may contribute to the heritability of autism spectrum disorder. These variations, mostly located in non-coding genic space, affect gene regulation and overlap with differentially expressed genes in the postmortem brain tissue of ASD individuals. Additionally, specific structural variations in certain genes are significantly associated with the non-verbal ASD phenotype.
HUMAN GENETICS AND GENOMICS ADVANCES
(2023)