Article
Cell Biology
Wenhao Yao, Xu Qian, Sebastian Ochsenreither, Ferrone Soldano, Albert B. DeLeo, Holger Sudhoff, Felix Oppel, Andreas Kuppig, Konrad Klinghammer, Andreas M. Kaufmann, Andreas E. Albers
Summary: DSF and DSF/Cu2+ inhibited cell proliferation in HNSCC, enhanced sensitivity to cisplatin and IR, and increased radio-chemo sensitivity by inducing apoptosis and ROS activity.
Article
Cell Biology
Avital Granit Mizrahi, Ahinoam Gugenheim, Haneen Hamad, Roa'a Hamed, Nino Tetro, Ofra Maimon, Salome Khutsurauli, Hovav Nechushtan, Benjamin Nisman, Deborah Duran, Widad Samman, Liron Birimberg-Schwartz, Myriam Grunewald, Sara Eyal, Tamar Peretz
Summary: This study found that histone deacetylase inhibitor valproic acid (VPA) can alter glucose metabolism in triple-negative breast cancer (TNBC) cells and is correlated with cisplatin sensitivity. Overexpression of ALDH may be one mechanism of cellular resistance to VPA, and its inhibition can enhance the therapeutic efficacy of VPA-chemotherapeutic drug combinations.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Tatyana D. Larionova, Soniya Bastola, Tatiana E. Aksinina, Ksenia S. Anufrieva, Jia Wang, Victoria O. Shender, Dmitriy E. Andreev, Tatiana F. Kovalenko, Georgij P. Arapidi, Polina Shnaider, Anastasia N. Kazakova, Yaroslav A. Latyshev, Victor V. Tatarskiy, Alexander A. Shtil, Pascale Moreau, Francis Giraud, Chaoxi Li, Yichan Wang, Maria P. Rubtsova, Olga A. Dontsova, Michael Condro, Benjamin M. Ellingson, Mikhail Shakhparonov, Harley Kornblum, Ichiro Nakano, Marat S. Pavlyukov
Summary: Larionova et al. discover a mechanism by which acidification of the tumour microenvironment induces the generation of an alternative splice isoform of ribosomal protein RPL22L1, which regulates cell stemness and increases tumour heterogeneity. The acidic pH in the tumour core switches the RNA splicing of the ribosomal gene towards the RPL22L1b isoform, allowing cells to survive acidosis and promoting stemness. In the tumour edge region, RPL22L1a interacts with ribosomes and upregulates translation of multiple messenger RNAs including TP53. Targeting this mechanism may decrease GBM heterogeneity and facilitate therapy.
NATURE CELL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ethan Read, Jarod Milford, Jiechun Zhu, Lingyun Wu, Marc Bilodeau, Guangdong Yang
Summary: Disulfiram and hydrogen sulfide can sensitize liver cancer cells by inhibiting ALDH activity, and H2S can also inhibit the adhesion of liver cancer stem cells. The combination of DSF and H2S shows potential in inhibiting cancer cell growth and tumor development by targeting ALDH.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Miae Won, Ji Hyeon Kim, Myung Sun Ji, Jong Seung Kim
Summary: ALDH, a cancer stem cell biomarker associated with drug resistance, can be targeted using a prodrug called DE-CPT, which efficiently decreases the population of CSCs and kills cancer cells.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Xiaochun Hu, Yonglin Lu, Wenrong Zhao, Menglin Sun, Ruihao Li, Lei Feng, Tianming Yao, Chunyan Dong, Shuo Shi
Summary: A multi-functional nanoplatform (PDA-DTC/Cu-MnO2) was developed for MR imaging-guided multi-therapy (CDT, PTT, and chemotherapy) in cancer treatment. Both in vitro and in vivo results confirmed the biocompatible nanoplatform's ability to significantly induce tumor cell death and inhibit tumor growth.
CHEMICAL COMMUNICATIONS
(2021)
Article
Cell & Tissue Engineering
Hiroshi Takahashi, Taku Nakashima, Takeshi Masuda, Masashi Namba, Shinjiro Sakamoto, Kakuhiro Yamaguchi, Yasushi Horimasu, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori
Summary: The study reveals that lung-resident ALDH(br) cells play a crucial role in pulmonary fibrosis, as transferring these cells can ameliorate fibrosis and the decrease in ALDH(br) cells is more significant in aged mice.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Oncology
Fei Liao, Jing Zhang, Yangyang Hu, Alireza Hassani Najafabadi, James J. Moon, Max S. Wicha, Bashir Kaspo, Joel Whitfield, Alfred E. Chang, Qiao Li
Summary: This study demonstrates the potential of targeting ALDH(high) CSCs using antigenic peptides derived from ALDH, and the enhanced efficacy achieved by combining the vaccine with anti-PD-L1 treatment.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Medicine, General & Internal
Xiufen Zhuang, Guilan Shi, Xiao Hu, Huiru Wang, Wen Sun, Yanhong Wu
Summary: This study aimed to propose a potential strategy for breast cancer by studying the effects of T cells and interferon-gamma on breast cancer stem cells. The results showed that CD8(+) T cells and interferon-gamma can decrease the number of breast cancer stem cells.
CHINESE MEDICAL JOURNAL
(2022)
Review
Oncology
Pavan Kumar Dhanyamraju, Todd D. Schell, Shantu Amin, Gavin P. Robertson
Summary: One of the challenges in cancer treatment is the development of acquired resistance to therapy, which is responsible for a large percentage of cancer-related deaths. This review focuses on persister cells, a subpopulation of drug-tolerant cells in tumors, and discusses approaches to target them. The review highlights the characteristics of a specific persister cell subpopulation with high levels of aldehyde dehydrogenase (ALDH) activity and their role in drug resistance and cancer progression. The interactions between ALDH-high persister cells and the tumor microenvironment are also explored. Therapeutic modulation of this subpopulation is proposed as a strategy for more effective cancer management.
Article
Chemistry, Medicinal
Georg A. Rennar, Tom L. Gallinger, Patrick Maeder, Kerstin Lange-Gruenweller, Simone Haeberlein, Arnold Gruenweller, Christoph G. Grevelding, Martin Schlitzer
Summary: Schistosomiasis is a neglected tropical disease with limited treatment options. This study explores the potential of a class of compounds called dithiocarbamates as antischistosomal agents. The compounds showed promising activity against Schistosoma mansoni in vitro, reducing egg production, damaging the parasite's tegument and leading to its death. Structure-activity relationship studies helped identify derivatives with improved activity. Some derivatives were found to be active at low concentrations and non-cytotoxic to human cells. Dithiocarbamates are considered interesting candidates for further development as antischistosomal drugs.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Oncology
Jakob Pueschel, Anna Dubrovska, Ielizaveta Gorodetska
Summary: Cancer stem cells are the engine of tumor progression and a source of tumor regrowth after treatment. Targeting CSCs might be a powerful tool to overcome tumor resistance and increase the efficiency of current cancer treatment strategies, with high ALDH activity being a common marker of prostate CSCs.
Article
Oncology
Yonggang Lin, Jianjiang Dong, Wei Yu, Yufei Li, Zhixin Liu, Jiaqi Liu, Cuiju Wang, Jian Qin, Liting Zhu, Jun Liang
Summary: The study suggests that CD14 may serve as a novel surface marker for esophageal cancer stem cells (ECSCs), as it is closely associated with the characteristics of ECSCs.
Article
Biochemistry & Molecular Biology
Zhiping Feng, Marisa E. Hom, Thomas E. Bearrood, Zachary C. Rosenthal, Daniel Fernandez, Alison E. Ondrus, Yuchao Gu, Aaron K. McCormick, Madeline G. Tomaske, Cody R. Marshall, Toni Kline, Che-Hong Chen, Daria Mochly-Rosen, Calvin J. Kuo, James K. Chen
Summary: Aldehyde dehydrogenases (ALDHs) are potential cancer drug targets, specifically certain isoforms essential for the survival of stem-like tumor cells. Selective inhibitors of ALDH1B1 have been identified, an enzyme essential for promoting colorectal and pancreatic cancer. Bicyclic imidazoliums and guanidines that target the ALDH1B1 active site have been described, with comparable molecular interactions and potencies. These inhibitors effectively suppress ALDH1B1 function in cells, with guanidines avoiding off-target mitochondrial toxicity observed with imidazoliums. A lead isoform-selective guanidinyl antagonist of ALDHs demonstrates proteome-wide target specificity and selectively hinders the growth of colon cancer spheroids and organoids. The ALDH1B1-dependent transcriptome, involving genes regulating mitochondrial metabolism and ribosomal function, has been elucidated through genetic and chemical perturbations. The importance of ALDH1B1 in colorectal cancer is supported, offering molecular probes for ALDH1B1 studies and potential leads for targeted therapies.
NATURE CHEMICAL BIOLOGY
(2022)
Article
Oncology
Lauren MacDonagh, Rhyla Mae Santiago, Steven G. Gray, Eamon Breen, Sinead Cuffe, Stephen P. Finn, Kenneth J. O'Byrne, Martin P. Barr
Summary: Despite advances in personalized medicine and immune checkpoints in lung cancer treatment, non-small cell lung cancer remains a leading cause of cancer-related deaths worldwide. Drug resistance is a key factor in the relapse of lung cancer patients due to the unlimited renewal capacity of residual cancer stem cells during chemotherapy. This study suggests that targeting the retinoic acid signaling cascade may be a novel strategy in treating subsets of CSCs in cisplatin resistant lung tumors.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Oncology
M. Duran-Poveda, P. Jimenez-Fonseca, M. Sirvent-Ochando, P. P. Garcia-Luna, J. L. Pereira-Cunill, B. Lema-Marques, M. T. Parejo-Arrondo, C. Belda-Iniesta
CLINICAL & TRANSLATIONAL ONCOLOGY
(2018)
Article
Oncology
Marina Chiara Garassino, Byoung-Chul Cho, Joo-Hang Kim, Julien Mazieres, Johan Vansteenkiste, Herve Lena, Jesus Corral Jaime, Jhanelle E. Gray, John Powderly, Christos Chouaid, Paolo Bidoli, Paul Wheatley-Price, Keunchil Park, Ross A. Soo, Yifan Huang, Catherine Wadsworth, Phillip A. Dennis, Naiyer A. Rizvi
Review
Physiology
Gorjana Rackov, Noemi Garcia-Romero, Susana Esteban-Rubio, Josefa Carrion-Navarro, Cristobal Belda-Iniesta, Angel Ayuso-Sacido
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Medicine, Research & Experimental
N. Garcia-Romero, R. Madurga, G. Rackov, I. Palacin-Aliana, R. Nunez-Torres, A. Asensi-Puig, J. Carrion-Navarro, S. Esteban-Rubio, H. Peinado, A. Gonzalez-Neira, V. Gonzalez-Rumayor, C. Belda-Iniesta, A. Ayuso-Sacido
JOURNAL OF TRANSLATIONAL MEDICINE
(2019)
Article
Oncology
Noemi Garcia-Romero, Josefa Carrion-Navarro, Pilar Areal-Hidalgo, Ana Ortiz de Mendivil, Adria Asensi-Puig, Rodrigo Madurga, Rocio Nunez-Torres, Anna Gonzalez-Neira, Cristobal Belda-Iniesta, Victor Gonzalez-Rumayor, Blanca Lopez-Ibor, Angel Ayuso-Sacido
Article
Microbiology
Alejandra Arguelles, Ruth Sanchez-Fresneda, Jose P. Guirao-Abad, Cristobal Belda, Jose Antonio Lozano, Francisco Solano, Juan-Carlos Arguelles
Article
Medicine, General & Internal
N. Garcia-Romero, I Palacin-Aliana, R. Madurga, J. Carrion-Nayarro, S. Esteban-Rubio, B. Jimenez, A. Collazo, F. Perez-Rodriguez, A. Ortiz de Mendivil, C. Fernandez-Carballal, S. Garcia-Duque, J. Diamantopoulos-Fernandez, C. Belda-Iniesta, R. Prat-Acin, P. Sanchez-Gomez, E. Calvo, A. Ayuso-Sacido
Article
Oncology
Gorjana Rackov, Giorgia Iegiani, Daniel Uribe, Claudia Quezada, Cristobal Belda-Iniesta, Carmen Escobedo-Lucea, Augusto Silva, Pere Puig, Victor Gonzalez-Rumayor, Angel Ayuso-Sacido
FRONTIERS IN ONCOLOGY
(2020)
Article
Clinical Neurology
Sara Garcia-Duque, Roberto Garcia-Leal, Begona Iza-Vallejo, Enrique Castro-Reyes, Fernando Fortea, Francisco Villoria, David J. Langer, Jorge Diamantopoulos, Cristobal Belda-Iniesta, Angel Ayuso-Sacido
Summary: This study found that poor neurologic status at diagnosis, AVM rupture, and conservative treatment were associated with worse outcome in AVM patients. The Lawton-Young Supplementary scale (LYSS) was the most effective method in predicting outcome.
JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
(2021)
Editorial Material
Medicine, General & Internal
Cristobal Belda-Iniesta
Article
Medicine, General & Internal
Alberto M. Borobia, Antonio J. Carcas, Mayte Perez-Olmeda, Luis Castano, Maria Jesus Bertran, Javier Garcia-Perez, Magdalena Campins, Antonio Portoles, Maria Gonzalez-Perez, Maria Teresa Garcia Morales, Eunate Arana-Arri, Marta Aldea, Francisco Diez-Fuertes, Inmaculada Fuentes, Ana Ascaso, David Lora, Natale Imaz-Ayo, Lourdes E. Baron-Mira, Antonia Agusti, Carla Perez-Ingidua, Agustin Gomez de la Camara, Jose Ramon Arribas, Jordi Ochando, Jose Alcami, Cristobal Belda-Iniesta, Jesus Frias
Summary: To date, there are no immunological data on COVID-19 heterologous vaccination schedules in humans. This study evaluated the immunogenicity and reactogenicity of administering BNT162b2 as a second dose in individuals primed with ChAdOx1-S. The results showed that BNT162b2 induced a robust immune response in individuals prime vaccinated with ChAdOx1-S, with an acceptable and manageable reactogenicity profile.
Article
Oncology
Andrew B. Lassman, Juan Manuel Sepulveda-Sanchez, Timothy F. Cloughesy, Miguel J. Gil-Gil, Vinay K. Puduvalli, Jeffrey J. Raizer, Filip Y. F. De Vos, Patrick Y. Wen, Nicholas A. Butowski, Paul M. J. Clement, Morris D. Groves, Cristobal Belda-Iniesta, Pierre Giglio, Harris S. Soifer, Steven Rowsey, Cindy Xu, Francesca Avogadri, Ge Wei, Susan Moran, Patrick Roth
Summary: The selective FGFR1-3 inhibitor infigratinib showed limited efficacy in patients with FGFR-altered recurrent gliomas, but it may provide durable disease control in patients with tumors harboring FGFR1 or FGFR3 point mutations or FGFR3-TACC3 fusions.
CLINICAL CANCER RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Megan Schwarz, Denis Torre, Daniel Lozano-Ojalvo, Anthony T. Tan, Tommaso Tabaglio, Slim Mzoughi, Rodrigo Sanchez-Tarjuelo, Nina Le Bert, Joey Ming Er Lim, Sandra Hatem, Kevin Tuballes, Carmen Camara, Eduardo Lopez-Granados, Estela Paz-Artal, Rafael Correa-Rocha, Alberto Ortiz, Marcos Lopez-Hoyos, Jose Portoles, Isabel Cervera, Maria Gonzalez-Perez, Irene Bodega-Mayor, Patricia Conde, Jesus Oteo-Iglesias, Alberto M. Borobia, Antonio J. Carcas, Jesus Frias, Cristobal Belda-Iniesta, Jessica S. Y. Ho, Kemuel Nunez, Saboor Hekmaty, Kevin Mohammed, William M. Marsiglia, Juan Manuel Carreno, Arvin C. Dar, Cecilia Berin, Giuseppe Nicoletti, Isabella Della Noce, Lorenzo Colombo, Cristina Lapucci, Graziano Santoro, Maurizio Ferrari, Kai Nie, Manishkumar Patel, Vanessa Barcessat, Sacha Gnjatic, Jocelyn Harris, Robert Sebra, Miriam Merad, Florian Krammer, Seunghee Kim-schulze, Ivan Marazzi, Antonio Bertoletti, Jordi Ochando, Ernesto Guccione
Summary: This study reports the development of two quantitative PCR assays for detecting SARS-CoV-2-specific T cell activation. These assays are rapid, internally normalized, and can quantify the magnitude and duration of cellular immune responses, helping to determine revaccination strategies in vulnerable populations.
NATURE BIOTECHNOLOGY
(2022)
Article
Medicine, General & Internal
Javier Garcia-Perez, Maria Gonzalez-Perez, Maria Castillo de la Osa, Alberto M. Borobia, Luis Castano, Maria Jesus Bertran, Magdalena Campins, Antonio Portoles, Davis Lara, Mercedes Bermejo, Patricia Conde, Lourdes Hernandez-Gutierrez, Antonio Carcas, Eunate Arana-Arri, Marta Tortajada, Inmaculada Fuentes, Ana Ascaso, Maria Teresa Garcia-Morales, Humberto Erick de la Torre-Tarazona, Jose-Ramon Arribas, Natale Imaz-Ayo, Eugenia Mellado-Pau, Antonia Agusti, Carla Perez-Ingidua, Agustin Gomez de la Camara, Jordi Ochando, Cristobal Belda-Iniesta, Jesus Frias, Jose Alcami, Mayte Perez-Olmeda
Summary: This study analyzed the evolution of humoral and cellular immune response to the ChAdOx1-S/BNT162b2 heterologous vaccination up to day 180. The results showed a decrease in antibody titers and neutralizing response against Omicron and Beta variants at day 180.
Article
Oncology
Luis Augusto Aguirre, Karla Montalban-Hernandez, Jose Avendano-Ortiz, Elvira Marin, Roberto Lozano, Victor Toledano, Laura Sanchez-Maroto, Veronica Terron, Jaime Valentin, Elisa Pulido, Jose Carlos Casalvilla, Carolina Rubio, Luke Diekhorst, Fernando Laso-Garcia, Carlos del Fresno, Ana Collazo-Lorduy, Beatriz Jimenez-Munarriz, Paloma Gomez-Campelo, Emilio Llanos-Gonzalez, Maria Fernandez-Velasco, Carlos Rodriguez-Antolin, Rebeca Perez de Diego, Ramon Cantero-Cid, Enrique Hernadez-Jimenez, Enrique Alvarez, Rocio Rosas, Blanca Dies Lopez-Ayllon, Javier de Castro, Stefanie K. Wculek, Carolina Cubillos-Zapata, Inmaculada Ibanez de Caceres, Prudencio Diaz-Agero, Maria Gutierrez Fernandez, Maria Paz de Miguel, David Sancho, Leon Schulte, Rosario Perona, Cristobal Belda-Iniesta, Lisardo Bosca, Eduardo Lopez-Collazo