Review
Biochemistry & Molecular Biology
Federica Del Chierico, Novella Rapini, Annalisa Deodati, Maria Cristina Matteoli, Stefano Cianfarani, Lorenza Putignani
Summary: This review summarizes the associations between gut microbiota and Type 1 Diabetes (T1D), suggesting that dysbiosis in the gut microbiota may influence the onset and progression of T1D, and microbiota-based therapies show promise in slowing down disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Teresa Salvatore, Raffaele Galiero, Alfredo Caturano, Luca Rinaldi, Livio Criscuolo, Anna Di Martino, Gaetana Albanese, Erica Vetrano, Christian Catalini, Celestino Sardu, Giovanni Docimo, Raffaele Marfella, Ferdinando Carlo Sasso
Summary: Being overweight and obesity have long been associated with impaired glucose metabolism and type 2 diabetes (T2D), but there is also a less frequent form of T2D in non-obese individuals, especially in developing countries and non-white ethnic minorities in high-income Western countries. The mechanisms linking obesity to T2D have been extensively studied, but the pathophysiology and risk factors of T2D in non-obese people are still under debate. Understanding these factors and developing individualized clinical management may help reduce the global burden of diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Trisha Singh, Hilal Khan, David T. Gamble, Caroline Scally, David E. Newby, Dana Dawson
Summary: “Takotsubo syndrome is an acute condition with transient dysfunction of the left ventricle, which is challenging to differentiate from acute myocardial infarction. Recent studies have shown that patients with this syndrome have persistent cardiac dysfunction and limiting symptoms. They also have a substantial burden of morbidity and mortality, similar to patients with acute coronary syndrome. The underlying pathophysiology of this condition remains unclear, and further research is needed to inform evidence-based management strategies.”
Article
Endocrinology & Metabolism
Ashby F. Walker, Korey K. Hood, Matthew J. Gurka, Stephanie L. Filipp, Claudia Anez-Zabala, Nicolas Cuttriss, Michael J. Haller, Xanadu Roque, Diana Naranjo, Gina Aulisio, Ananta Addala, Jason Konopack, Sarah Westen, Katarina Yabut, Elvira Mercado, Sydney Look, Brian Fitzgerald, Jennifer Maizel, David M. Maahs
Summary: Disparities in type 1 diabetes care and technology use were found based on socioeconomic status, race, and ethnicity, with barriers identified at provider, system, and individual levels. Novel insights into the experiences of vulnerable communities highlight the need for multilevel interventions to offset disparities in diabetes care.
Review
Endocrinology & Metabolism
Plator Memaj, Francois R. Jornayvaz
Summary: Non-alcoholic fatty liver disease is increasingly prevalent in T1D patients, and may be influenced by genetic factors, oxidative stress, poor glucose control, and exogenous insulin use. Accurate differential diagnosis is crucial.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Rose Gubitosi-Klug, Xiaoyu Gao, Rodica Pop-Busui, Ian H. de Boer, Neill White, Lloyd P. Aiello, Ryan Miller, Jerry Palmer, William Tamborlane, Amisha Wallia, Mikhail Kosiborod, John M. Lachin, Ionut Bebu
Summary: The study found that the presence of microvascular disease in type 1 diabetes patients was associated with an increased risk of subsequent cardiovascular disease and major adverse cardiovascular events (MACE) in the DCCT/EDIC cohort. These associations remained significant even after adjusting for age and HbA(1c).
Review
Endocrinology & Metabolism
Shun Kohsaka, Naru Morita, Suguru Okami, Yoko Kidani, Toshitaka Yajima
Summary: The use of real-world data in healthcare decision-making, especially in understanding diabetes, has become increasingly important. Japan currently has large-scale databases that provide valuable information for diabetes management.
DIABETES OBESITY & METABOLISM
(2021)
Review
Dermatology
Piyush Kumar, Ismat Ara Khan, Anupam Das, Hiral Shah
Summary: Chronic venous disease (CVD), a common condition in dermatology outpatient department, can progress to chronic leg ulcer if left untreated. It affects patients' quality of life and work productivity. The clinical manifestations range from asymptomatic varicose veins to ulceration and scarring. Increased venous hypertension and chronic inflammation play key roles in the development of CVD.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Review
Endocrinology & Metabolism
Bernt Johan von Scholten, Frederik F. Kreiner, Stephen C. L. Gough, Matthias von Herrath
Summary: Insulin remains the key treatment for type 1 diabetes, but efforts are now shifting towards protecting beta cells to prevent dysfunction and destruction, with research focusing on antigen vaccination and agents that can reduce stress on the beta cells.
Article
Endocrinology & Metabolism
R. David Leslie, Carmella Evans-Molina, Jacquelyn Freund-Brown, Raffaella Buzzetti, Dana Dabelea, Kathleen M. Gillespie, Robin Goland, Angus G. Jones, Mark Kacher, Lawrence S. Phillips, Olov Rolandsson, Jana L. Wardian, Jessica L. Dunne
Summary: Recent epidemiological data indicates that over half of new cases of type 1 diabetes occur in adults. Key genetic, immune, and metabolic differences are present between adult-onset and childhood-onset type 1 diabetes, many of which remain poorly understood.
Review
Clinical Neurology
Patrick W. Cullinane, Eduardo de Pablo Fernandez, Annekatrin Konig, Tiago Fleming Outeiro, Zane Jaunmuktane, Thomas T. Warner
Summary: Highly reproducible epidemiological evidence suggests that type 2 diabetes (T2D) increases the risk and progression of Parkinson's disease (PD) and repurposing certain antidiabetic medications for PD treatment shows promise. The high prevalence of T2D highlights the need for personalized antidiabetic treatment in PD patients. However, understanding the mechanistic relation and molecular pathways affected by T2D in the brain is essential. The review focuses on the evidence of T2D-associated dysregulation in peripheral and brain pathways, its impact on neurodegeneration in PD, and the challenges in unraveling the complex relationship between T2D, insulin resistance, and PD.
MOVEMENT DISORDERS
(2023)
Article
Medicine, General & Internal
Mark A. Sperling, Lori M. Laffel
Summary: A 12.5-year-old pubertal girl is referred to a tertiary medical center for management of new-onset diabetes mellitus. The initial evaluation reveals glucosuria but no ketonuria. She has no family history of type 1 diabetes mellitus and her physical examination is normal except for Tanner stage 3 breast and pubic hair development.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Araz Rawshani, Naveed Sattar, Darren K. McGuire, Oskar Wallstrom, Ulf Smith, Jan Boren, Goran Bergstrom, Elmir Omerovic, Annika Rosengren, Bjorn Eliasson, Deepak L. Bhatt, Aidin Rawshani
Summary: The study found that the incidence of valvular disease is increasing among patients with diabetes. In type 2 diabetes, systolic blood pressure, body mass index, and renal function were found to be associated with valvular lesions.
Article
Medicine, General & Internal
Teresa Quattrin, Lucy D. Mastrandrea, Lucy S. K. Walker
Summary: Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic beta cells, and individuals with this disease rely on insulin for survival. Despite advancements, the burden of this disease remains high. Research shows that blocking the immune attack on beta cells holds promise in preserving endogenous insulin production.
Article
Endocrinology & Metabolism
Sonia Butalia, Susan G. Crawford, K. Ashlee McGuire, David K. Dyjur, Julia R. Mercer, Daniele Pacaud
Summary: Youth with type 1 diabetes are at high risk for loss to follow-up during the transition from paediatric to adult diabetes care. An intervention using communication technology enhanced transition coordinator has been shown to improve clinic attendance among transitioning youth with type 1 diabetes, with no differences in glycaemic control or diabetic ketoacidosis post transfer.
Review
Endocrinology & Metabolism
Madison B. Smith, Anastasia Albanese-O'Neill, Tamara G. R. Macieira, Yingwei Yao, Joseph M. Abbatematteo, Debra Lyon, Diana J. Wilkie, Michael J. Haller, Gail M. Keenan
DIABETES TECHNOLOGY & THERAPEUTICS
(2019)
Article
Endocrinology & Metabolism
Diana Isaacs, Carla Cox, Kathy Schwab, Tamara K. Oser, Joanne Rinker, Mary Jo Mason, Deborah A. Greenwood, Anastasia Albanese-O'Neill
Editorial Material
Endocrinology & Metabolism
Linda A. DiMeglio, Anastasia Albanese-O'Neill, Cynthia E. Munoz, David M. Maahs
Article
Endocrinology & Metabolism
Linda A. DiMeglio, Lauren G. Kanapka, Daniel J. DeSalvo, Marisa E. Hilliard, Lori M. Laffel, William V. Tamborlane, Michelle A. Van Name, Stephanie Woerner, Saleh Adi, Anastasia Albanese-O'Neill, G. Todd Alonso, Barbara J. Anderson, Sarah D. Corathers, Kelly Fegan-Bohm, Greg P. Forlenza, Rachelle G. Gandica, Robin S. Goland, Michael J. Haller, Anat Hanono, Kara R. Harrington, Heba M. Ismail, HeatherA. Jolivette, Jennifer C. Kelley, Suzanne Kingery, Sarah A. MacLeish, Shideh Majidi, Kellee M. Miller, Pantea P. Minnock, BrandonM. Nathan, Nicole M. Sheanon, Jill H. Simmons, Muna Sunni, R. Paul Wadwa, Sara E. Watson, Kate Weyman, Kristen M. Williams, StevenM. Willi, Kupper A. Wintergerst, Jamie Wood
Summary: The study found that continuous glucose monitoring over a 6-month period in children with type 1 diabetes did not improve time in range, but significantly reduced time spent in hypoglycemia. Family behavioral intervention benefited parental well-being.
Article
Endocrinology & Metabolism
Joyce M. Lee, Emily Carlson, Anastasia Albanese-O'Neill, Carla Demeterco-Berggren, Sarah D. Corathers, Francesco Vendrame, Ruth S. Weinstock, Priya Prahalad, Guy Todd Alonso, Manmohan Kamboj, Daniel J. DeSalvo, Faisal S. Malik, Roberto Izquierdo, Osagie Ebekozien
Summary: During the COVID-19 pandemic, there was rapid adoption of telemedicine in the T1D Exchange Quality Improvement Collaborative (T1DX-QI), with a significant increase in telemedicine visits proportion that later slightly decreased. Most clinics utilized both video and telephone visits, with Zoom being the most popular video platform.
DIABETES TECHNOLOGY & THERAPEUTICS
(2021)
Article
Endocrinology & Metabolism
Christine A. March, Rebecca Oyetoro, Janey Adams, Henry Rodriguez, Anastasia Albanese-O'Neill
Summary: The study found that while the majority of school nurses believe it is reasonable to allow children to use DIY APS in school, there are still differing opinions on the responsibilities when dealing with these devices. Future development of more school guidelines for DIY APS is needed, incorporating stakeholder perspectives.
DIABETES TECHNOLOGY & THERAPEUTICS
(2021)
Article
Endocrinology & Metabolism
Guy Todd Alonso, Osagie Ebekozien, Mary Pat Gallagher, Saketh Rompicherla, Sarah K. Lyons, Abha Choudhary, Shideh Majidi, Catherina T. Pinnaro, Sadana Balachandar, Mariam Gangat, Alissa Jeanne Curda Roberts, Brynn E. Marks, Ana Creo, Janine Sanchez, Tossaporn Seeherunvong, Jose Jimenez-Vega, Neha S. Patel, Jamie R. Wood, Liana Gabriel, Kathryn M. Sumpter, Meredith Wilkes, Robert Rapaport, Anna Cymbaluk, Jenise C. Wong, Srinath Sanda, Anastasia Albanese-O'neill
Summary: Analysis of data from pediatric patients under 19 years old with type 1 diabetes and COVID-19 found that higher A1c levels were the only predictor for hospitalization, with diabetic ketoacidosis being the primary concern in this group.
JOURNAL OF DIABETES
(2021)
Article
Endocrinology & Metabolism
Anastasia Albanese-O'Neill, Julia M. Grimsmann, Ann-Marie Svensson, Kellee M. Miller, Klemens Raile, Karin Akesson, Peter Calhoun, Beate Biesenbach, Katarina Eeg-Olofsson, Reinhard W. Holl, David M. Maahs, Ragnar Hanas
Summary: The study found that HbA1c levels increased in the United States, decreased in Sweden, and remained stable in Germany/Austria between 2011 and 2017. In Sweden, there was a significant decrease in mean HbA1c across all age groups during this period, while in the United States, HbA1c levels remained stable for certain age groups and increased for others.
DIABETES TECHNOLOGY & THERAPEUTICS
(2022)
Article
Endocrinology & Metabolism
Michelle A. Van Name, Lauren G. Kanapka, Linda A. DiMeglio, Kellee M. Miller, Anastasia Albanese-O'Neill, Persis Commissariat, Sarah D. Corathers, Kara R. Harrington, Marisa E. Hilliard, Barbara J. Anderson, Jennifer C. Kelley, Lori M. Laffel, Sarah A. MacLeish, Brandon M. Nathan, William V. Tamborlane, R. Paul Wadwa, Steven M. Willi, Kristen M. Williams, Kupper A. Wintergerst, Stephanie Woerner, Jenise C. Wong, Daniel J. DeSalvo
Summary: This study examined the durability of continuous glucose monitoring (CGM) coupled with a family behavioral intervention (FBI) to improve glycemia in young children with type 1 diabetes (T1D). The results showed that CGM technology could reduce the incidence of hypoglycemia, but had limited effect on hyperglycemia.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Anastasia Albanese-O'Neill, Jann MacInnes, Michael J. Haller, Janey Adams, Nicole Thomas, Angelina Bernier
Summary: This study developed and validated a pediatric type 1 diabetes knowledge assessment tool (KAT-1) for children, adolescents, young adults, and their parents/guardians. The results showed that KAT-1 had strong internal consistency and correlated positively with established diabetes knowledge tests and negatively with HbA1c levels. The short topical subscales of KAT-1 can be used to objectively assess specific knowledge and customize diabetes education.
PEDIATRIC DIABETES
(2022)
Article
Endocrinology & Metabolism
Sarah E. Lawrence, Anastasia Albanese-O'Neill, Stephane Besancon, Taryn Black, Natasa Bratina, David Chaney, Fran R. Cogen, Elizabeth A. Cummings, Elizabeth Moreau, Jessica S. Pierce, Erick Richmond, Farid H. Mahmud
PEDIATRIC DIABETES
(2022)
Article
Endocrinology & Metabolism
Shivajirao P. Patil, Anastasia Albanese-O'Neill, Kirsten Yehl, Jane Jeffrie Seley, Allyson S. Hughes
Summary: The integration of diabetes technology into diabetes care and self-management is evolving rapidly, requiring healthcare professionals to stay current with treatment goals and practice guidelines. Diabetes care and education specialists are well positioned to contribute to a technology-enabled practice environment. This article introduces a comprehensive set of role-based competencies for healthcare professionals, diabetes care and education specialists, and support staff in the selection, implementation, and sustainability of diabetes technology.
SCIENCE OF DIABETES SELF-MANAGEMENT AND CARE
(2022)
Article
Endocrinology & Metabolism
Allyson S. Hughes, Anastasia Albanese-O'Neill, Jane Jeffrie Seley, Kirsten Yehl, Patty Scalzo, Joanne Rinker, Shivajirao P. Patil
Summary: By convening a core team of diabetes technology experts and utilizing a modified Delphi methodology, a final set of 94 competencies across 7 domains related to diabetes technology use in various care settings were determined.
SCIENCE OF DIABETES SELF-MANAGEMENT AND CARE
(2022)
Article
Medicine, General & Internal
Richard M. Bergenstal, Revital Nimri, Roy W. Beck, Amy Criego, Lori Laffel, Desmond Schatz, Tadej Battelino, Thomas Danne, Stuart A. Weinzimer, Judy Sibayan, Mary L. Johnson, Ryan J. Bailey, Peter Calhoun, Anders Carlson, Elvira Isganaitis, Rachel Bello, Anastasia Albanese-O'Neill, Klemen Dovc, Torben Biester, Kate Weyman, Korey Hood, Moshe Phillip
Summary: In adolescents and young adults with type 1 diabetes, the use of an investigational advanced hybrid closed-loop system was found to reduce hyperglycemia without increasing the occurrence of hypoglycemia compared to a commercially available MiniMed 670G system. Further testing of this technology in underserved populations and in individuals with impaired awareness of hypoglycemia could advance its effective use.
Article
Psychology, Developmental
Sarah C. Westen, Jennifer L. Warnick, Anastasia Albanese-O'Neill, Desmond A. Schatz, Michael J. Haller, Mina Entessari, David M. Janicke
JOURNAL OF PEDIATRIC PSYCHOLOGY
(2019)
