Review
Oncology
Fernando Gallardo, Ramon M. Pujol
Summary: The genetic landscape of cutaneous lymphoma shows heterogeneity, with somatic mutational profiles and genomic copy number variations in different subtypes. This provides opportunities for personalized therapeutic strategies. The genetic heterogeneity in cutaneous lymphoma parallels with the specific subtype.
Article
Medical Laboratory Technology
Takashi Himoto, Shuhei Yamamoto, Kaho Morimoto, Satoshi Tada, Shima Mimura, Koji Fujita, Joji Tani, Asahiro Morishita, Tsutomu Masaki
Summary: Anti-Sp100 is not a complementary serological marker for PBC in AMA-negative patients. Bacterial infection may trigger the production of anti-Sp100. Another factor is required to initiate autoantibody production.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Review
Endocrinology & Metabolism
Lucas S. Santana, Augusto G. Guimaraes, Madson Q. Almeida
Summary: Primary aldosteronism (PA) is the most common form of secondary arterial hypertension, and recent advances in understanding its pathogenesis, including genetic mutations and the activation of calcium signaling, have expanded our knowledge of familial hyperaldosteronism. Additionally, the use of CYP11B2 staining to guide genetic investigations of adrenal lesions has had a significant impact on our understanding of PA.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Samaneh Delavari, Hassan Abolhassani, Farhad Abolnezhadian, Fateme Babaha, Sara Iranparast, Hamid Ahanchian, Nasrin Moazzen, Mohammad Nabavi, Saba Arshi, Morteza Fallahpour, Mohammad Hassan Bemanian, Sima Shokri, Tooba Momen, Mahnaz Sadeghi-Shabestari, Rasol Molatefi, Afshin Shirkani, Ahmad Vosughimotlagh, Molood Safarirad, Meisam Sharifzadeh, Salar Pashangzadeh, Fereshte Salami, Paniz Shirmast, Arezou Rezaei, Tannaz Moeini Shad, Minoo Mohraz, Nima Rezaei, Lennart Hammarstrom, Reza Yazdani, Asghar Aghamohamamdi
Summary: A study on patients with primary immunodeficiency disorders showed that while their incidence of infections was only 1.23 times higher than the general population, their mortality rate was 10 times higher, particularly in patients with combined immunodeficiency and immune dysregulation. Further management strategies such as hematopoietic stem cell transplantation and immunomodulatory agents should be considered to improve the survival rate in these patients.
JOURNAL OF CLINICAL IMMUNOLOGY
(2021)
Article
Microbiology
Valentina Fainardi, Chiara Sodini, Michela Deolmi, Andrea Ciuni, Kaltra Skenderaj, Maria Bice Stabile, Cosimo Neglia, Elena Mariotti Zani, Cinzia Spaggiari, Nicola Sverzellati, Susanna Esposito, Giovanna Pisi
Summary: This study demonstrates the significant clinical impact of ABPA and Af sensitization on lung function and structural damage in CF patients, leading to more exacerbations and lower BMI.
Article
Immunology
Marieke Raffenberg, Tanja Engel, Isabella C. Schoepf, Neeltje A. Kootstra, Peter Reiss, Dominique L. Braun, Christian W. Thorball, Jacques Fellay, Roger D. Kouyos, Bruno Ledergerber, Huldrych F. Guenthard, Philip E. Tarr
Summary: Delaying the start of ART during early HIV infection is associated with significant and sustained shortening of telomere length, even with a matter of weeks delay.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Nufar Marcus, Shirly Frizinsky, David Hagin, Adi Ovadia, Suhair Hanna, Michael Farkash, Ramit Maoz-Segal, Nancy Agmon-Levin, Arnon Broides, Amit Nahum, Elli Rosenberg, Amir Asher Kuperman, Yael Dinur-Schejter, Yackov Berkun, Ori Toker, Shmuel Goldberg, Ronit Confino-Cohen, Oded Scheuerman, Basel Badarneh, Na'ama Epstein-Rigbi, Amos Etzioni, Ilan Dalal, Raz Somech
Summary: The study summarized clinical and laboratory data of PID patients with COVID-19 in Israel, most of whom had mild symptoms, possibly due to their high level of awareness, extra precautions, and even self-isolation. Defects or abnormalities in specific immune pathways, such as type I interferon signaling, might increase the risk of a more severe disease course and the development of COVID-19 sequelae.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Chayarani Kelgeri, Michael Couper, Girish L. Gupte, Alexandra Brant, Mitul Patel, Lauren Johansen, Joseph Valamparampil, Evelyn Ong, Hermien Hartog, M. T. P. R. Perera, Darius Mirza, Indra van Mourik, Khalid Sharif, Jane Hartley
Summary: Between January and April 2022, a liver-transplantation center in the U.K. received a total of 44 children with acute hepatitis, with 6 of them undergoing liver transplantation. Most of the children presented with symptoms such as jaundice, vomiting, and diarrhea. Human adenovirus was detected in a majority of the children, although its role in the pathogenesis of the illness is still unknown.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Orthopedics
Benjamin Zmistowski, Thema A. Nicholson, William L. Wang, Joseph A. Abboud, Surena Namdari
Summary: In patients undergoing primary shoulder arthroplasty, the presence of nonvirulent organisms in cultures taken at the time of surgery does not seem to have a clinically significant impact on short-term functional outcomes or the need for repeat surgery.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2021)
Article
Immunology
Wenjing Tang, Yu Zhang, Chong Luo, Lina Zhou, Zhiyong Zhang, Xuemei Tang, Xiaodong Zhao, Yunfei An
Summary: This study evaluated the utility of mNGS for detecting pathogens in patients with PID, demonstrating its superiority over conventional methods in pathogen identification, especially in detecting rare opportunistic pathogens. Compared to traditional methods, mNGS can provide faster pathogen diagnosis, enabling clinicians to make more timely and targeted therapeutic decisions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Orthopedics
Michael Sybert, Christian T. Oakley, Thomas Christensen, Joseph Bosco, Ran Schwarzkopf, James Slover
Summary: COVID-19 pandemic led to longer operative times and decreased likelihood of discharge to skilled nursing facilities for both primary and revision total hip arthroplasty (THA) patients. Though intensified hygiene standards may lower surgical site infection (SSI) rates, our study found no significant difference in infection rates after implementing personal protective guidelines and a mask mandate in our hospital.
JOURNAL OF ARTHROPLASTY
(2022)
Review
Medicine, General & Internal
Soren Hess
Summary: Bacteremia is a complex and potentially dangerous medical condition characterized by viable bacteria in the bloodstream. Treatment differs between simple and complex cases, with complex cases requiring more advanced treatment including long-term antibiotics or invasive drainage. This review highlights the potential role of [F-18]FDG-PET/CT in detecting metastatic infections in patients with bacteremia, which can have a significant impact on patient management, treatment strategy, and patient outcome.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Malgorzata Gajdzis, Kornelia Figula, Joanna Kaminska, Radoslaw Kaczmarek
Summary: Endogenous endophthalmitis is a severe form of ocular inflammation, where the pathogens are located inside the body and spread through the bloodstream. The prognosis is poor due to the destructive nature of the inflammation. Prompt and accurate diagnosis and treatment are crucial for prognosis, as it is closely related to the primary source of infection.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Infectious Diseases
P. Naucler, A. Huttner, C. H. Van Werkhoven, M. Singer, P. Tattevin, S. Einav, T. Tangden
Summary: The study explored the impact of time to antibiotic treatment on clinical outcomes in patients presenting to the emergency department with bacterial infections of different severity of illness and source of infection. Most articles supported prompt administration of effective antibiotics for septic shock and bacterial meningitis, but there is no clear evidence showing that a delayed start of therapy is associated with worse outcome for less severe infectious syndromes.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Immunology
Rick van der Geest, Hongye Fan, Hernan F. Penaloza, William G. Bain, Zeyu Xiong, Naina Kohli, Emily Larson, Mara L. G. Sullivan, Jonathan M. Franks, Donna B. Stolz, Ryota Ito, Kong Chen, Yohei Doi, Melanie J. Harriff, Janet S. Lee
Summary: This study found heterogeneity in the sensitivity of clinical Kp isolates to macrophage phagocytic uptake, and demonstrated that phagocytosis is a significant determinant of the pathogenicity of Kp in the lungs.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Clinical Neurology
William B. Gallentine, Shlomo Shinnar, Dale C. Hesdorffer, Leon Epstein, Douglas R. Nordli, Darrell V. Lewis, L. Matthew Frank, Syndi Seinfeld, Ruth C. Shinnar, Karen Cornett, Binyi Liu, Solomon L. Moshe, Shumei Sun
Letter
Clinical Neurology
William D. Graf, Geoffrey Miller, Leon G. Epstein, Isabelle Rapin
Article
Clinical Neurology
James A. Russell, Leon G. Epstein, Richard J. Bonnie, Robin Conwit, William D. Graf, Matthew Kirschen, Julie A. Kurek, Daniel G. Larriviere, Robert M. Pascuzzi, Matthew Rizzo, Justin A. Sattin, Zachary Simmons, Lynne Taylor, Amy Tsou, Michael A. Williams
Article
Clinical Neurology
Ariane Lewis, James L. Bernat, Sandralee Blosser, Richard J. Bonnie, Leon G. Epstein, John Hutchins, Matthew P. Kirschen, Michael Rubin, James A. Russell, Justin A. Sattin, Eelco F. M. Wijdicks, David M. Greer
Editorial Material
Clinical Neurology
Ariane Lewis, James L. Bernat, Sandralee Blosser, Richard J. Bonnie, Leon G. Epstein, John Hutchins, Matthew P. Kirschen, Michael Rubin, James A. Russell, Justin A. Sattin, Eelco F. M. Wijdicks, David M. Greer
Article
Clinical Neurology
James A. Russell, Leon G. Epstein, David M. Greer, Matthew Kirschen, Michael A. Rubin, Ariane Lewis
Article
Genetics & Heredity
Bobby G. Ng, Paulina Sosicka, Satish Agadi, Mohammed Almannai, Carlos A. Bacino, Rita Barone, Lorenzo D. Botto, Jennifer E. Burton, Colleen Carlston, Brian Hon-Yin Chung, Julie S. Cohen, David Coman, Katrina M. Dipple, Naghmeh Dorrani, William B. Dobyns, Abdallah F. Elias, Leon Epstein, William A. Gahl, Domenico Garozzo, Trine Bjorg Hammer, Jaclyn Haven, Delphine Heron, Matthew Herzog, George E. Hoganson, Jesse M. Hunter, Mahim Jain, Jane Juusola, Shenela Lakhani, Hane Lee, Joy Lee, Katherine Lewis, Nicola Longo, Charles Marques Lourenco, Christopher C. Y. Mak, Dianalee McKnight, Bryce A. Mendelsohn, Cyril Mignot, Ghayda Mirzaa, Wendy Mitchell, Hiltrud Muhle, Stanley F. Nelson, Mariusz Olczak, Christina G. S. Palmer, Arthur Partikian, Marc C. Patterson, Tyler M. Pierson, Shane C. Quinonez, Brigid M. Regan, M. Elizabeth Ross, Maria J. Guillen Sacoto, Fernando Scaglia, Ingrid E. Scheffer, Devorah Segal, Nilika Shah Singhal, Pasquale Striano, Luisa Sturiale, Joseph D. Symonds, Sha Tang, Eric Vilain, Mary Willis, Lynne A. Wolfe, Hui Yang, Shoji Yano, Zoee Powis, Sharon F. Suchy, Jill A. Rosenfeld, Andrew C. Edmondson, Stephanie Grunewald, Hudson H. Freeze
Article
Ethics
Ariane Lewis, Richard J. Bonnie, Thaddeus Pope, Leon G. Epstein, David M. Greer, Matthew P. Kirschen, Michael Rubin, James A. Russell
JOURNAL OF LAW MEDICINE & ETHICS
(2019)
Article
Clinical Neurology
Benjamin Tolchin, Robin Conwit, Leon G. Epstein, James A. Russell
Editorial Material
Clinical Neurology
William D. Graf, Leon G. Epstein, Phillip L. Pearl
PEDIATRIC NEUROLOGY
(2020)
Article
Clinical Neurology
Winston Chiong, Benjamin David Tolchin, Richard J. Bonnie, Katharina M. Busl, Salvador Cruz-Flores, Leon G. Epstein, Ericka P. Greene, Judy Illes, Matthew Kirschen, Daniel G. Larriviere, Sneha Mantri, Michael A. Rubin, Barney J. Stern, Lynne P. Taylor
Summary: Alzheimer's disease is a feared and stigmatized condition that has a significant impact on patients, families, and society as a whole. There is an urgent need for further research in effective treatments for AD, and patients require more support from clinicians and communities, with trust being a fundamental aspect of this support.
Article
Clinical Neurology
Lynne P. Taylor, Jessica M. Besbris, William D. Graf, Michael A. Rubin, Salvador Cruz-Flores, Leon G. Epstein
Summary: Palliative care, introduced in 1974 by Dr. Balfour Mount, focuses on improving patients' quality of life through symptom control, rather than solely on the end-of-life care like hospice. However, many still confuse palliative care with hospice, leading to missed opportunities for early provision of palliative services.
Review
Clinical Neurology
William D. D. Graf, Bruce H. H. Cohen, Louisa Kalsner, Phillip L. L. Pearl, Harvey B. B. Sarnat, Leon G. G. Epstein, Ethics Comm Child Neurology Soc
Summary: The aim of this review is to discuss the bioethics of prenatal diagnosis and healthcare in light of recent legislative and judicial changes affecting reproductive rights. It recognizes that abortion involves diverse moral perspectives and examines historical aspects, ethical issues, and parental options for prenatal diagnostic testing. The article emphasizes the importance of informed consent, reproductive autonomy, and the responsibilities of physicians in the care of pregnant mothers and their unborn children. It also highlights the need for perinatal palliative care for mothers carrying anomalous fetus to term.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Letter
Clinical Neurology
William D. Graf, Leon G. Epstein, Phillip L. Pearl
PEDIATRIC NEUROLOGY
(2020)
Article
Clinical Neurology
Ana B. Chelse, Jonathan E. Kurz, Kathleen M. Gorman, Leon G. Epstein, Lauren C. Balmert, Jody D. Ciolino, Mark S. Wainwright
NEUROLOGY-CLINICAL PRACTICE
(2019)