期刊
CURRENT OPINION IN VIROLOGY
卷 3, 期 3, 页码 285-295出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2013.05.011
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资金
- NCI NIH HHS [R01 CA134241] Funding Source: Medline
- NIDCR NIH HHS [R01 DE021445] Funding Source: Medline
gamma-Herpesviral immune evasion mechanisms are optimized to support the acute, lytic and the longterm, latent phase of infection. During acute infection, specific immune modulatory proteins limit, but also exploit, the antiviral activities of cell intrinsic innate immune responses as well as those of innate and adaptive immune cells. During latent infection, a restricted gene expression program limits immune targeting and cis-acting mechanisms to reduce the antigen presentation as well as antigenicity of latency-associated proteins. Here, we will review recent progress in our understanding of gamma-herpesviral immune evasion strategies.
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