期刊
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
卷 4, 期 11, 页码 -出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a015164
关键词
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资金
- National Institutes of Health [R01AR059947, P30 AR057212]
- U.S. Department of Defense [PR110793]
- Foundation for Ichthyosis and Related Skin Types (FIRST)
- Dystrophic Epidermolysis Bullosa Research Association (DEBRA) International
The discovery of methods for reprogramming adult somatic cells into induced pluripotent stem cells (iPSCs) has raised the possibility of producing truly personalized treatment options for numerous diseases. Similar to embryonic stem cells (ESCs), iPSCs can give rise to any cell type in the body and are amenable to genetic correction by homologous recombination. These ESC properties of iPSCs allow for the development of permanent corrective therapies for many currently incurable disorders, including inherited skin diseases, without using embryonic tissues or oocytes. Here, we review recent progress and limitations of iPSC research with a focus on clinical applications of iPSCs and using iPSCs to model human diseases for drug discovery in the field of dermatology.
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