Review
Immunology
Yuhe Huang, Yongdui Ruan, Yuhe Ma, Dongsheng Chen, Tangxin Zhang, Shuhao Fan, Wensen Lin, Yifan Huang, Hongmei Lu, Jun-Fa Xu, Jiang Pi, Biying Zheng
Summary: Manganese is a necessary nutrient in the animal body and plays important roles in oxidative regulation and immunological responses. Manganese dioxide nanoparticles (MnO2 NPs) are a new type of inorganic nanomaterials that have potential applications as adjuvants and immunotherapeutics due to their biological and immunological activities. MnO2 NPs have advantages such as simple preparation, low cost, low toxicity, and high bioavailability. They can also enhance the efficacy of tumor treatment through remodeling the tumor microenvironment and have immunological regulation effects in innate and adaptive immunity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Lauren Dain, Guizhi Zhu
Summary: Glioblastoma multiforme (GBM) is a deadly primary brain tumor with limited treatment options. The immunogenicity of GBM tumor cells and the immunosuppressive tumor microenvironment make it challenging to develop effective GBM immunotherapeutics. Nucleic acid therapeutics and vaccines, especially mRNA-based ones, have shown promise in GBM research.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Jia Tong Loh, Kong-Peng Lam
Summary: Invasive fungal infection poses a global health threat, and the WHO has released a list of health-threatening fungi to enhance global response. Antifungal drugs have limited success due to drug resistance, emphasizing the need for immunomodulation and new therapies. This review discusses the immune response to fungal infections and emerging immunotherapies and vaccines.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Letter
Biotechnology & Applied Microbiology
Rujittika Mungmunpuntipantip, Viroj Wiwanitkit
Summary: This correspondence discusses the impact of COVID-19 vaccination on epileptic seizures in patients with epilepsy, highlighting the potential presence of confounding factors that may influence the study outcome.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Review
Medical Laboratory Technology
H. T. Pattison, B. C. Millar, J. E. Moore
Summary: Invasive fungal disease poses a significant threat to individuals with compromised immune systems, with antifungal drug resistance emerging as a concern. Developing fungal vaccines is a strategy to address this issue, but challenges in eliciting sufficient immune response in vulnerable groups remain.
BRITISH JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Review
Immunology
Sourbh Suren Garg, Atulika Sharma, Jeena Gupta
Summary: SARS-CoV-2 virus causing COVID-19 pandemic originated from Wuhan city of China, affecting millions worldwide. Immune responses, biochemical changes, and inflammatory reactions in human body after infection play a crucial role in the occurrence of the disease.
CLINICAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Ai Lin Chin, Shan Jiang, Eungyo Jang, Liqian Niu, Liwu Li, Xiaoting Jia, Rong Tong
Summary: Immune checkpoint blockade antibodies have promising clinical applications but suffer from severe toxicities and moderate patient-response rates. The authors have developed an implantable optical fiber device with both local delivery and tumor impedance measurement capabilities, which can safely elicit durable anti-tumor immunity.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
David W. Greening, Rong Xu, Anukreity Ale, Christoph E. Hagemeyer, Weisan Chen
Summary: Extracellular vesicles (EVs) serve as a means of communication and molecular transfer between cells, impacting host immune response. They can evade recognition and transfer functional components to target cells, influencing antigen presentation, immune activation, suppression, and surveillance. This review outlines the progress of EVs in immunorecognition and therapeutic intervention in cancer, including vaccine and targeted drug delivery, highlighting the use of EVs as immuno-EVs to enhance immunogenicity and tumor-killing function. The review emphasizes the need for direct assessment to improve immune response efficacy in the translation into clinical applications.
SEMINARS IN CANCER BIOLOGY
(2023)
Review
Immunology
Leila Mohamed Khosroshahi, Mohsen Rokni, Tahmineh Mokhtari, Farshid Noorbakhsh
Summary: COVID-19 infection, caused by SARS-CoV-2, is highly contagious and involves pulmonary inflammation and systemic immune dysregulation. Immune dysregulation may be the core pathogenic element, highlighting the importance of precise immune response management for successful treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
M. Tommy Gambles, Jiyuan Yang, Jindrich Kopecek
Summary: The concept of multi-targeted immunotherapeutic systems has revolutionized cancer immunotherapy by engaging the patient's immune system in various ways. The outcomes range from recruiting and activating immune cells upon recognizing cancer cells, to implementing a multi-pronged immune checkpoint blockade strategy, or achieving direct cancer cell death through engaging multiple cell surface receptors. This review focuses on the application of multi-specific immunotherapeutics for B cell malignancies, outlining diverse strategies, summarizing B cell receptor antigen targeting approaches, and discussing the challenges and future prospects of the field.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Toxicology
Michael Chary, Alexander F. Barbuto, Sudeh Izadmehr, Marc Tarsillo, Eduardo Fleischer, Michele M. Burns
Summary: SARS-CoV-2 emerged in December 2019 and caused the COVID-19 pandemic. Efforts have been made to develop therapeutics including mRNA vaccines and oral antivirals. This review discusses the biological therapeutics used or proposed for COVID-19 in the past 3 years. Monoclonal antibodies can prevent severe disease, but their effectiveness varies among variants. Convalescent plasma has similar side effects but lower efficacy. Vaccines are effective in preventing disease progression, with DNA and mRNA vaccines being more effective than protein or inactivated virus vaccines. Some adverse reactions have been observed, but the absolute risk is low.
JOURNAL OF MEDICAL TOXICOLOGY
(2023)
Review
Oncology
Alireza Tojjari, Hassan Abushukair, Anwaar Saeed
Summary: This article discusses the association between the gut microbiota and cancer immunology and immunotherapy, including the impact on immunotherapy outcomes, regulating factors, and the role of microbial interventions.
Review
Immunology
Lorena V. N. Oliveira, Ruiying Wang, Charles A. Specht, Stuart M. Levitz
Summary: Progress has been made in the development of fungal vaccines, including vaccines that have shown protective effects in mouse studies through various preparation methods; novel adjuvants are being explored to enhance the immune response against fungal infections; while some vaccines have entered human clinical trials, significant obstacles still need to be overcome for fungal vaccines to be licensed for human use.
Review
Oncology
Tarak Chouari, Francesca Soraya La Costa, Nabeel Merali, Maria-Danae Jessel, Shivan Sivakumar, Nicola Annels, Adam E. Frampton
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a challenging cancer to treat due to late detection, lack of effective screening tests, and resistance to standard treatments. Immunotherapy has emerged as a potential solution, stimulating the immune system to fight cancer cells. This paper summarizes studies on immunotherapies in PDAC, discusses their limitations, and explores avenues for future research.
Review
Immunology
Zhen Dong, Renjian Hu, Yan Du, Li Tan, Lin Li, Juan Du, Longchang Bai, Yingkang Ma, Hongjuan Cui
Summary: HPV infection is a major cause of malignant neoplasms, and early diagnosis and therapy are crucial for the treatment of these diseases. Immunological methods offer precise strategies for accurate detection and blockade of HPV, providing promising avenues for the diagnosis and treatment of HPV-related cancers.
FRONTIERS IN IMMUNOLOGY
(2021)
