期刊
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
卷 2, 期 3, 页码 -出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a009407
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资金
- NINDS NIH HHS [P50 NS038370] Funding Source: Medline
There has been intense interest in leucine-rich repeat kinase 2 (LRRK2) since 2004, when mutations in the LRRK2 gene were discovered to cause dominantly inherited Parkinson's disease (PD). This article will address six basic questions about LRRK2 biology as it relates to PD, with particular emphasis on its discovery, current concepts of its physiological and pathological functions, and the strategies being used to discover how LRRK2 dysfunction causes PD.
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