Review
Immunology
Arianne C. Richard
Summary: The advent of technologies that can characterize individual cells has revealed extensive diversity between cells of the same subset, including CD8(+) T cells. This review focuses on heterogeneity in CD8(+) T cell responses, particularly the impact of TCR stimulation strength and the mechanisms underlying variation between cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Lorenzo Federico, Tor Henrik Anderson Tvedt, Murat Gainullin, Julie Rokke Osen, Viktoriia Chaban, Katrine Persgard Lund, Lisa Tietze, Trung The Tran, Fridtjof Lund-Johansen, Hassen Kared, Andreas Lind, John Torgils Vaage, Richard Stratford, Simen Tennoe, Brandon Malone, Trevor Clancy, Anders Eivind Leren Myhre, Tobias Gedde-Dahl, Ludvig Andre Munthe
Summary: This study examined the relationship between humoral and T cell response in 48 HSCT recipients who received two doses of Moderna's mRNA-1273 or Pfizer/BioNTech's BNT162b2 vaccines. The results showed that nearly all HSCT patients had robust T cell immunity regardless of protective humoral responses. The data suggests that HSCT recipients with poor serological responses were protected from severe COVID-19 by vaccine-induced T cell responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jing Peng, Xueying Yao, Chunyan Yuan, Xiaoli Liu, Renxiang Xia, Jian He, Rui Li, Yunqing Yao
Summary: This study investigated the potential mechanism and therapeutic potential of hepatitis B vaccine immunotherapy for occult hepatitis B virus infection (OBI) patients. The results showed that hepatitis B vaccine significantly increased the levels of hepatitis B surface antibodies in patients and had a significant impact on the number of peripheral blood B lymphocytes and CD8(+) T lymphocytes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Sabaria Shah, Katherine W. Cook, Peter Symonds, Juliane Weisser, Anne Skinner, Abdullah Al Omari, Samantha J. Paston, Ian Pike, Lindy G. Durrant, Victoria A. Brentville
Summary: This study discovers that homocitrullinated peptides can be processed and presented via MHC-I for tumor therapy. The modified peptides show enhanced binding to HLA-A2 and induce high avidity homocitrulline-specific CD8 T-cell responses, which can kill target cells expressing the peptide.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Rheumatology
Theresa Graalmann, Katharina Borst, Himanshu Manchanda, Lea Vaas, Matthias Bruhn, Lukas Graalmann, Mario Koster, Murielle Verboom, Michael Hallensleben, Carlos Alberto Guzman, Gerd Sutter, Reinhold E. Schmidt, Torsten Witte, Ulrich Kalinke
Summary: Rituximab-treated patients and B cell-deficient mice showed reduced expansion of virus-specific CD8(+) T cells after vaccination/infection with different vaccines/pathogens, indicating that B cells can modulate CD8(+) T cell responses. The choice of vaccines for B cell-depleted patients needs to be re-evaluated to effectively induce protective CD8(+) T cell responses.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Immunology
Huimin Zhou, Jun Yang, Jie Tian, Shengjun Wang
Summary: Primary Sjogren's syndrome (pSS) is a chronic autoimmune disease characterized by damage to multiple organs and glands, with dry eyes, dry mouth, and enlarged salivary glands being common clinical manifestations. CD8(+) T lymphocytes have been found to play a significant role in acinar injury in the exocrine glands, contributing to the pathophysiology of the disease. Targeting CD8(+) T cells in treatment strategies can offer promising new approaches for managing pSS.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jihyun Yang, Eunjin Kim, Jong-Soo Lee, Haryoung Poo
Summary: The study identified a major histocompatibility complex (MHC) class I-restricted epitope for the CD8 T cell response to SARS-CoV-2 RBD in C57BL/6 mice, providing crucial insights into vaccine development.
Article
Immunology
Laura Padula, Eva Fisher, Wathsala Wijayalath, Noelle B. Patterson, Jun Huang, Harini Ganeshan, Tanisha Robinson, Francois A. Bates, Margaret A. Hanson, Monica L. Martin, Katelyn Rivas, Denisse Garcia, Kimberly A. Edgel, Martha Sedegah, Eileen Villasante, Natasa Strbo
Summary: The study describes a novel malaria vaccine platform based on gp96-Ig, which successfully induces liver-infiltrating, antigen-specific memory CD8+ T cell responses in mice and rhesus monkeys. The vaccine strategy can protect against malaria caused by parasites in the liver by activating antigen-presenting cells and delivering peptides/antigens to CD8+ T cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Antonella Vardeu, Charlotte Davis, Ian McDonald, Guilherme Stahlberg, Barsha Thapa, Kinga Piotrowska, Margaret A. Marshall, Thomas Evans, Vicky Wheeler, Sarah Sebastian, Katie Anderson
Summary: The use of immunotherapeutic vaccination in prostate cancer is a promising approach. The experimental approach described here uses a well-studied adenovirus-poxvirus heterologous prime-boost regimen, which can induce functional cytotoxic T cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Chemistry, Multidisciplinary
Xuedan He, Shiqi Zhou, Wei-Chiao Huang, Amal Seffouh, Moustafa T. Mabrouk, M. Thomas Morgan, Joaquin Ortega, Scott Abrams, Jonathan F. Lovell
Summary: A new vaccine adjuvant system was developed to induce strong cellular immune responses against multiple tumor cell lines, demonstrating durable immunity. The system showed the importance of stable particle formation for effective immune response induction and could control local and metastatic disease in a therapeutic setting.
Article
Immunology
Sandra Dimonte, Silvia Gimeno-Brias, Morgan Marsden, Lucy Chapman, Pragati Sabberwal, Mathew Clement, Ian R. Humphreys
Summary: CMV induction of highly functional memory T cells is of interest for vaccine vectors, but concerns remain about the pathogenesis of human CMV. Attenuated CMV vectors offer an alternative to fully replicating vectors, but their impact on immunogenicity and memory T-cell formation is not well understood, especially via relevant routes of immunization like the skin.
Article
Multidisciplinary Sciences
Takayuki Chikata, Hiroyuki Gatanaga, Hung The Nguyen, Daisuke Mizushima, Yu Zhang, Nozomi Kuse, Shinichi Oka, Masafumi Takiguchi
Summary: This study investigated HIV-1-specific CD8(+) T cell responses in 200 Japanese HIV-1-exposed seronegative (HESN) men who have sex with men (MSM). The results showed the presence of HLA-B*51:01-restricted Pol TI8- specific and HLA-A*02:06-restricted Pol SV9-specific CD8+ T cells in two and one individuals, respectively. These HIV-1-specific T cells may contribute to suppressing HIV-1 replication in HESN-MSM individuals.
Article
Multidisciplinary Sciences
David O. 'Sullivan, Michal A. Stanczak, Matteo Villa, Franziska M. Uhl, Mauro Corrado, Ramon I. Klein Geltink, David E. Sanin, Petya Apostolova, Nisha Rana, Joy Edwards-Hicks, Katarzyna M. Grzes, Agnieszka M. Kabat, Ryan L. Kyle, Mario Fabri, Jonathan D. Curtis, Michael D. Buck, Annette E. Patterson, Annamaria Regina, Cameron S. Field, Francesc Baixauli, Daniel J. Puleston, Edward J. Pearce, Robert Zeiser, Erika L. Pearce
Summary: Fever can enhance metabolic activity and effector functions of activated CD8* T cells, with limited effects on proliferation or activation marker expression. Exposure to 39 degrees Celsius increases mass and metabolism in T cells, with mitochondrial translation playing a crucial role in the enhanced metabolic activity and function observed.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Physical
Jiexin Li, He Ren, Yaping Sun, Gengqi Liu, Xingyue Yang, Qian Qiu, Yuanmeng Ding, Jonathan F. Lovell, Yumiao Zhang
Summary: A self-assembled magnetic micelle delivery system was developed for targeted delivery of CD8(+) T-cell epitopes, producing strong cellular immune responses. Metal ions enhanced vaccine immunogenicity, while a self-immolative linker allowed for rapid antigen release. The system eradicated tumors in a mouse model, demonstrating potential for developing a new generation of cancer vaccines with multiple functionalities.
CHEMISTRY OF MATERIALS
(2021)
Article
Rheumatology
Ann Cavers, Matthias Christian Kugler, Yesim Ozguler, Arshed Fahad Al-Obeidi, Gulen Hatemi, Beatrix M. Ueberheide, Didar Ucar, Olivier Manches, Johannes Nowatzky
Summary: The study revealed that the ERAP1-Hap10 haplotype is significantly associated with Behcet's disease risk in individuals with HLA-B*51, leading to changes in immunogenicity of CD8 T cells and alterations in T cell populations in affected carriers.
ANNALS OF THE RHEUMATIC DISEASES
(2022)