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Medicine, Research & Experimental
Grace Huang, Zhongjian Cheng, Alycia Hildebrand, Chunlin Wang, Maria Cimini, Rakija Roy, Anna Maria Lucchese, Cindy Benedict, Vandana Mallaredy, Ajit Magadum, Darukeshwara Joladarashi, Charan Thej, Carolina Gonzalez, May Trungcao, Venkata Naga Srikanth Garikipati, John W. Elrod, Walter J. Koch, Raj Kishore
Summary: This study suggests that diabetes impairs the function of EPC-EVs in repairing ischemic heart damage through changes in histone modification and acetylation. The use of histone deacetylase (HDAC) inhibitors may potentially restore the function of EPC and other stem cells for autologous cell therapy applications.
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Biochemistry & Molecular Biology
Graca S. Marques, Jose Teles-Reis, Nikolaos Konstantinides, Patricia H. Brito, Catarina C. F. Homem
Summary: Neuron maturation in the Drosophila larval brain involves three consecutive phases, with sequential activation of transcription and translation of neurotransmitter-related genes. This temporal regulation is important for coordinating neuron maturation with brain development and is independent of ecdysone.
Article
Cell & Tissue Engineering
Houjian Zhang, Yuli Guo, Yaqiong Yang, Yuqian Wang, Youwen Zhang, Jingbin Zhuang, Yuting Zhang, Mei Shen, Jiankai Zhao, Rongrong Zhang, Yan Qiu, Shiying Li, Jiaoyue Hu, Wei Li, Jianfeng Wu, Haiwei Xu, Steven J. Fliesler, Yi Liao, Zuguo Liu
Summary: This study found that three MAP4K proteins restrict the transdifferentiation ability of mammalian Muller glia by repressing YAP activity. However, inhibition of these proteins with a small molecule allows mouse Muller glia to regain their proliferative ability and enter a retinal progenitor cell-like state. This finding provides important insights for stimulating retinal regeneration.
NPJ REGENERATIVE MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Melania Giorgetti, Nikolai Klymiuk, Andrea Baehr, Martin Hemmerling, Lisa Jinton, Robert Tarran, Anna Malmgren, Annika Astrand, Gunnar C. Hansson, Anna Ermund
Summary: Cystic fibrosis is a recessive genetic disease characterized by mucus accumulation in the airways and intestines. Research suggests that ENaC inhibitors can alleviate mucus in CF patients, indicating that drug design should focus on NHE rather than ENaC inhibition.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Genetics & Heredity
Alejo Torres-Cano, Rosa Portella-Fortuny, Claudia Mueller-Sanchez, Sonia Porras-Marfil, Marina Ramiro-Pareta, You-Ying Chau, Manuel Reina, Francesc X. Soriano, Ofelia M. Martinez-Estrada
Summary: The study describes a new genetically engineered mouse model in which Wt1 expression is deleted from an early stage in gonad formation. The findings show the importance of Wt1 for early gonad differentiation and its impact on the formation of the adult reproductive system.
Article
Biochemistry & Molecular Biology
Chihiro Kimura, Seong-Wook Oh, Takashi Fujita, Takashi Watanabe
Summary: Antiviral lignin produced by acidic microwave glycerolysis of sugarcane bagasse exhibits antiviral activity against both nonenveloped and enveloped viruses. The lignin prepared at 200°C showed the strongest antiviral activity and inhibited viral entry to host cells through interactions with the capsid surface.
Article
Chemistry, Medicinal
Anneliese S. Ashhurst, Arthur H. Tang, Pavla Fajtova, Michael C. Yoon, Anupriya Aggarwal, Max J. Bedding, Alexander Stoye, Laura Beretta, Dustin Pwee, Aleksandra Drelich, Danielle Skinner, Linfeng Li, Thomas D. Meek, James H. McKerrow, Vivian Hook, Chien-Te Tseng, Mark Larance, Stuart Turville, William H. Gerwick, Anthony J. O'Donoghue, Richard J. Payne
Summary: The study identifies cathepsin L as a key protease used by coronaviruses for cell entry and a potential drug target for antiviral treatment against SARS-CoV-2. The researchers discovered that gallinamide A and synthetic analogues are potent inhibitors of cathepsin L, showing promising antiviral activity against SARS-CoV-2. The combination with a TMPRSS2 inhibitor further enhances the antiviral effect.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Tian Wei, Xiaowen Ji, Jinsong Xue, Yan Gao, Xiaomei Zhu, Guiran Xiao
Summary: BBSCE and its active component C3G demonstrated antitumor effects in a Drosophila model of malignant tumor by inhibiting both autonomous and non-autonomous autophagy pathways, leading to extended survival. The combination of C3G with the autophagy inhibitor chloroquine showed greater efficacy in inhibiting tumor growth, suggesting potential for cancer treatment and natural medicine development.
Article
Chemistry, Multidisciplinary
Mi Shao, Xinyi Teng, Xin Guo, Hao Zhang, Yue Huang, Jiazhen Cui, Xiaohui Si, Lijuan Ding, Xiujian Wang, Xia Li, Jimin Shi, Mingming Zhang, Delin Kong, Tianning Gu, Yongxian Hu, Pengxu Qian, He Huang
Summary: The study reveals that sustained tonic signaling leads to hyperactivation of calcium signaling in CAR-T cells. The SOCE inhibitor BTP-2 reduces CAR-T cell exhaustion and terminal differentiation, resulting in improved antitumor potency and prolonged survival in vivo. Modulating the SOCE-calcineurin-NFAT pathway can make CAR-T cells resistant to exhaustion.
Article
Medicine, Research & Experimental
Shuzhen Han, Minghui Xiu, Shuang Li, Yan Shi, Xiaoqian Wang, Xingyao Lin, Hui Cai, Yongqi Liu, Jianzheng He
Summary: Cytarabine (Ara-C) is commonly used for the treatment of acute myeloid leukemia (AML), but it faces challenges due to severe side effects. The mechanism of Ara-C-induced damage is unclear. This study used fruit flies as an in vivo model and found that Ara-C supplementation caused developmental delays, reduced lifespan, impaired locomotor capacity, and increased stress response. Ara-C also led to intestinal morphological damage and accumulation of reactive oxygen species (ROS). Furthermore, Ara-C administration promoted gene expressions related to Toll pathway, IMD pathway, and apoptotic pathway in the gut. These findings suggest that fruit flies can be a useful in vivo model for assessing chemotherapy toxicity and screening protective drugs efficiently.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Jia-Nan Yan, Hai-Ying Zhang, Jun-Rui Li, Ying Chen, Yong-Cheng Jiang, Jia-Bing Shen, Kai-Fu Ke, Xiao-Su Gu
Summary: This study confirms that skin-derived precursor cells exhibit neuroprotective effects in Parkinson's disease by modulating the PI3K/AKT/mTOR pathway to inhibit autophagy.
NEURAL REGENERATION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Elaheh Abdollahi, Fariborz Keyhanfar, Ali-Akbar Delbandi, Reza Falak, Seyed Javad Hajimiresmaiel, Massoumeh Shafiei
Summary: Evidence suggests that the new class of anti-diabetic drugs, SGLT2 inhibitors, can have beneficial effects on atherosclerotic complications of diabetes. This study aimed to evaluate the direct anti-inflammatory effects of the SGLT2 inhibitor dapagliflozin (DAPA). The results showed that DAPA could attenuate inflammation by inhibiting the expression of TLR-4 and activation of NF-kappa B, as well as shifting macrophage polarization from an inflammatory state to an anti-inflammatory state.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Jianzheng He, Shuzhen Han, Yixuan Wang, Qian Kang, Xiaoqian Wang, Yun Su, Yaling Li, Yongqi Liu, Hui Cai, Minghui Xiu
Summary: Chemotherapy drug CPT-11 leads to various side effects in patients, including delayed development, imbalance in offspring gender ratio, shortened lifespan, impaired locomotor ability, changed metabolic capacity, ovarian atrophy, and increased excretion. It also causes intestinal damages, such as decreased intestinal length, disrupted gastrointestinal acid-based homeostasis, epithelial cell death, and damaged ultrastructure and mitochondria of epithelial cells. CPT-11 induces intestinal damage mainly through regulating several signaling pathways and increasing ROS accumulation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Erkan Kahraman, Erdem Goker
Summary: This study demonstrates that boric acid has anticancer effects on hepatocellular carcinoma by inhibiting the AKT signaling pathway.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shengying Lin, Xiaoyang Wang, Roy Wai-Lun Tang, Hung Chun Lee, Ho Hin Chan, Sheyne S. A. Choi, Tina Ting-Xia Dong, Ka Wing Leung, Sarah E. Webb, Andrew L. Miller, Karl Wah-Keung Tsim
Summary: The extracts of Polygonum cuspidatum root and rhizome were found to effectively block the entry of wild-type and omicron variant SARS-CoV-2 into cells, showing significant antiviral activity. Gallic acid, a compound in Polygonum cuspidatum, was identified as having a significant antiviral effect, potentially contributing to the overall antiviral efficacy of the herbal extract.
Article
Genetics & Heredity
Alessandro Mineo, Esther Fuentes, Marc Furriols, Jordi Casanova
Review
Biochemistry & Molecular Biology
Alessandro Mineo, Marc Furriols, Jordi Casanova
Article
Cell Biology
Silvia Chafino, Enric Urena, Jordi Casanova, Elena Casacuberta, Xavier Franch-Marro, David Martin
Article
Multidisciplinary Sciences
Kyra Campbell, Fabrizio Rossi, Jamie Adams, Ioanna Pitsidianaki, Francisco M. Barriga, Laura Garcia-Gerique, Eduard Batlle, Jordi Casanova, Andreu Casali
NATURE COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Josefa Cruz, David Martin, Xavier Franch-Marro
Review
Cell Biology
Jing Yang, Parker Antin, Geert Berx, Cedric Blanpain, Thomas Brabletz, Marianne Bronner, Kyra Campbell, Amparo Cano, Jordi Casanova, Gerhard Christofori, Shoukat Dedhar, Rik Derynck, Heide L. Ford, Jonas Fuxe, Antonio Garcia de Herreros, Gregory J. Goodall, Anna-Katerina Hadjantonakis, Ruby J. Y. Huang, Chaya Kalcheim, Raghu Kalluri, Yibin Kang, Yeesim Khew-Goodall, Herbert Levine, Jinsong Liu, Gregory D. Longmore, Sendurai A. Mani, Joan Massague, Roberto Mayor, David McClay, Keith E. Mostov, Donald F. Newgreen, M. Angela Nieto, Alain Puisieux, Raymond Runyan, Pierre Savagner, Ben Stanger, Marc P. Stemmler, Yoshiko Takahashi, Masatoshi Takeichi, Eric Theveneau, Jean Paul Thiery, Erik W. Thompson, Robert A. Weinberg, Elizabeth D. Williams, Jianhua Xing, Binhua P. Zhou, Guojun Sheng
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2020)
Article
Genetics & Heredity
Panagiotis Giannios, Jordi Casanova
Summary: During the development of holometabolous insects like Drosophila, specific larval cells known as Adult Progenitor Cells (APCs) survive metamorphosis and differentiate into adult structures with the help of the headcase (hdc) gene. Hdc plays a dual role in systemic hormone control and local tissue growth suppression in APC clusters, contributing to their survival and response to stress. The evolutionary conserved nature of hdc suggests potential implications for human cancers.
Article
Biochemistry & Molecular Biology
Juan J. Fraire-Zamora, Sebastien Tosi, Jerome Solon, Jordi Casanova
Summary: This study investigates how hormone-driven extracellular matrix remodeling controls tissue shortening and apoptotic cell removal through the transcriptional activity of Yki, leading to organ disassembly during animal development.
Correction
Cell Biology
Jing Yang, Parker Antin, Geert Berx, Cedric Blanpain, Thomas Brabletz, Marianne Bronner, Kyra Campbell, Amparo Cano, Jordi Casanova, Gerhard Christofori, Shoukat Dedhar, Rik Derynck, Heide L. Ford, Jonas Fuxe, Antonio Garcia de Herreros, Gregory J. Goodall, Anna-Katerina Hadjantonakis, Ruby Y. J. Huang, Chaya Kalcheim, Raghu Kalluri, Yibin Kang, Yeesim Khew-Goodall, Herbert Levine, Jinsong Liu, Gregory D. Longmore, Sendurai A. Mani, Joan Massague, Roberto Mayor, David McClay, Keith E. Mostov, Donald F. Newgreen, M. Angela Nieto, Alain Puisieux, Raymond Runyan, Pierre Savagner, Ben Stanger, Marc P. Stemmler, Yoshiko Takahashi, Masatoshi Takeichi, Eric Theveneau, Jean Paul Thiery, Erik W. Thompson, Robert A. Weinberg, Elizabeth D. Williams, Jianhua Xing, Binhua P. Zhou, Guojun Sheng
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2021)
Article
Biology
Silvia Chafino, Panagiotis Giannios, Jordi Casanova, David Martin, Xavier Franch-Marro
Summary: During development, organisms go through different morphological stages, such as larva, pupa, and adult, and the sequential expression of transcription factors chinmo, Br-C, and E93 play a crucial role in determining the identity of these stages. Chinmo promotes growth in larval and imaginal tissues, while Br-C and E93 act as tumor suppressors. The role of chinmo as a juvenile specifier is conserved in hemimetabolous insects.
Article
Biochemistry & Molecular Biology
Sandra Casani, Jordi Casanova, Marta Llimargas
Article
Cell Biology
Cristina de Miguel, Josefa Cruz, David Martin, Xavier Franch-Marro
JOURNAL OF MOLECULAR CELL BIOLOGY
(2020)
Article
Genetics & Heredity
Arzu Ozturk-Colak, Camille Stephan-Otto Attolini, Jordi Casanova, Sofia J. Araujo