Article
Multidisciplinary Sciences
Klaske M. Schukken, Yinan Zhu, Petra L. Bakker, Mirjam H. Koster, Liesbeth Harkema, Sameh A. Youssef, Alain de Bruin, Floris Foijer
Summary: This study induced systemic high-grade CIN in adult mice and found that it is most toxic to the high cell turnover intestinal epithelia, causing rapid villous atrophy, atypia, and apoptosis. Despite severe intestinal phenotype, most other tissues are unaffected, except for minor abnormalities in the spleen.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Jiho Park, Song Y. Yeu, Sangjin Paik, Hyungmin Kim, Si-Young Choi, Junyeop Lee, Jinho Jang, Semin Lee, Youngil Koh, Hyunsook Lee
Summary: Loss of BubR1 acetylation leads to chromosomal rearrangement and genetic instability in mice, with replication stress playing a key role in these processes. Moreover, defects in BubR1 acetylation in mitosis contribute to tumorigenesis, as observed in human cancer cells with whole-arm translocations demonstrating similar defects.
Article
Multidisciplinary Sciences
Christy Hong, Michael Schubert, Andrea E. Tijhuis, Marta Requesens, Maurits Roorda, Anouk van den Brink, Lorena Andrade Ruiz, Petra L. Bakker, Tineke van der Sluis, Wietske Pieters, Mengting Chen, Rene Wardenaar, Bert van der Vegt, Diana C. J. Spierings, Marco de Bruyn, Marcel A. T. M. van Vugt, Floris Foijer
Summary: Chromosomal instability (CIN) drives cancer cell evolution, metastasis, and therapy resistance. This study reveals that the inactivation of cGAS-STING signaling selectively impairs the survival of triple-negative breast cancer cells with CIN. Furthermore, blockade of IL-6 signaling using tocilizumab selectively impairs the growth of triple-negative breast cancer cells with CIN.
Article
Oncology
Saisai Chen, Kai Lu, Yue Hou, Zonghao You, Chuanjun Shu, Xiaoying Wei, Tiange Wu, Naipeng Shi, Guangyuan Zhang, Jianping Wu, Shuqiu Chen, Lihua Zhang, Wenchao Li, Dingxiao Zhang, Shenghong Ju, Ming Chen, Bin Xu
Summary: The study found that high expression of YY1 is closely associated with M2 macrophages in prostate cancer, promoting tumor development. The study also revealed that treatment targeting YY1 can suppress tumor metastasis and generate synergistic anti-tumor effects. Furthermore, the study revealed that YY1 upregulates IL-6 expression by regulating enhancer-promoter interactions, thereby promoting tumor progression.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Vera Dugina, Galina Shagieva, Mariya Novikova, Svetlana Lavrushkina, Olga Sokova, Igor Kireev, Pavel Kopnin
Summary: This study investigates the diverse roles of cytoplasmic actins in the progression of chromosomal instability in human breast cancer cells. Beta-cytoplasmic actin depletion leads to chromosomal instability progression, while downregulating gamma-cytoplasmic actin results in chromosome stability and reduced polyploidy and aneuploidy.
Article
Genetics & Heredity
Sheldon Decombe, Francois Loll, Laura Caccianini, Kevin Affannoukoue, Ignacio Izeddin, Julien Mozziconacci, Christophe Escude, Judith Lopes
Summary: The centromeres of human chromosomes are rich in tandemly repeated alpha-satellite sequences covered with constitutive heterochromatin marked by trimethylation of histone H3 on lysine 9 (H3K9me3). By using TALEs fused to a histone lysine demethylase (KDM4B), researchers were able to decrease the level of H3K9me3 on alpha-satellite repeats of chromosome 7, affecting chromatin structure, recruitment of HP1 alpha and CPC proteins, and the stability of chromosome 7 during mitosis. This study highlights the importance of H3K9me3 in centromere integrity and chromosome stability in a natural context.
EPIGENETICS & CHROMATIN
(2021)
Article
Cell Biology
Ahmed Shamloul, Gustav Steinemann, Kerrin Roos, Celine Huajia Liem, Jonathan Bernd, Thorsten Braun, Andreas Zakrzewicz, Janine Berkholz
Summary: The methyltransferase Smyd1 plays a crucial role in regulating IL-6 expression and secretion in endothelial cells by increasing NF-kappa B activity and promoting H3K4 trimethylation within the IL-6 promoter in response to LPS stimulation.
Article
Oncology
Amrendra Kumar, Vijay Ramani, Vijaya Bharti, Daniel de Lima Bellan, Nabil Saleh, Roman Uzhachenko, Chengli Shen, Carlos Arteaga, Ann Richmond, Sangeetha M. Reddy, Anna Vilgelm
Summary: CDK4/6 inhibitors in combination with endocrine therapy are effective for hormone receptor-positive breast cancer. However, combining these inhibitors with immune checkpoint blockade has not shown definitive benefits in patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Xin Lou, Heli Gao, Xiaowu Xu, Zeng Ye, Wuhu Zhang, Fei Wang, Jie Chen, Yue Zhang, Xuemin Chen, Yi Qin, Xianjun Yu, Shunrong Ji
Summary: This study provides a comprehensive analysis of the four major pathways in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) and demonstrates the potential role of pathway-related molecules in immune landscapes. The findings indicate that primary and metastatic GEP-NENs have distinct antitumor phenotypes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yu-Fu Zhou, Shu-Shu Song, Meng-Xin Tian, Zheng Tang, Han Wang, Yuan Fang, Wei-Feng Qu, Xi-Fei Jiang, Chen-Yang Tao, Run Huang, Pei-Yun Zhou, Shi-Guo Zhu, Jian Zhou, Jia Fan, Wei-Ren Liu, Ying-Hong Shi
Summary: The study revealed that CBS plays an anti-tumor role in HCC by promoting cellular apoptosis, inhibiting tumor growth through inactivation of the PRRX2/IL-6/STAT3 pathway. Additionally, CBS can reduce the abundance of tumor-infiltrating Tregs, thus suppressing immune evasion.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
In Soo Kim, Sang Yeon Cho, Miso Yang, Songyeon Han, Kyung-ha Lee, Ji Yeon Kim, Jin Man Kim, Sora Kang, Eun-Kyeong Jo, Hyewon Ryu
Summary: This study found that ATG9B has the highest expression levels among ATGs in colon adenocarcinoma (COAD), and it is associated with advanced stage and poor prognosis. Additionally, ATG9B expression is positively correlated with consensus molecular subtype 4 and chromosomal instability, but negatively correlated with tumor mutation burden. High ATG9B expression levels are associated with low immune cell infiltration and decreased expression of natural killer cell activation genes.
ANTICANCER RESEARCH
(2023)
Article
Hematology
Manjola Balliu, Laura Calabresi, Niccolo Bartalucci, Simone Romagnoli, Laura Maggi, Rossella Manfredini, Matteo Lulli, Paola Guglielmelli, Alessandro Maria Vannucchi
Summary: Research shows that CALR mutations lead to abnormal activation of the IL-6 signaling pathway, promoting JAK2/STAT5 signaling through interaction with MPL. Targeting IL-6 signaling can inhibit proliferation of CALR DEL and CALR knockout cells, demonstrating therapeutic potential for treating MPNs.
Article
Immunology
Timothy S. Kountz, Amit Jairaman, Candace D. Kountz, Kenneth A. Stauderman, Robert P. Schleimer, Murali Prakriya
Summary: The study found that human AECs require CRAC channels for the production of both PGE(2) and IL-6 in response to extracellular ATP stimulation. The synthesis of PGE(2) involves activation of P2Y2 receptors and cytosolic phospholipase A(2) signaling mediated by CRAC channels, while the synthesis of IL-6 occurs through activation of P2X receptors and calcineurin/NFAT signaling mediated by CRAC channels. It highlights P2Y2 receptors, CRAC channels, and P2X receptors as potential targets for intervention in airway diseases.
JOURNAL OF IMMUNOLOGY
(2021)
Retraction
Chemistry, Multidisciplinary
Laura Fisher
Summary: The study claiming that exosomal miR-25-3p derived from hypoxia tumor mediates IL-6 secretion and stimulates cell viability and migration in breast cancer has been retracted.
Article
Oncology
Daniel R. Matson, Ryan A. Denu, Lauren M. Zasadil, Mark E. Burkard, Beth A. Weaver, Christopher Flynn, P. Todd Stukenberg
Summary: TPX2 nuclear expression is strongly associated with high grade morphology, clinical stage, negative ER and PR status, as well as disease-specific and overall survival in breast cancer. Increased TPX2 nuclear expression correlates with elevated ploidy, supernumerary centrosomes, and TP53 mutation. However, TPX2 expression is not an independent predictor of chromosomal instability compared to other clinical and pathologic metrics.