期刊
CELL REPORTS
卷 1, 期 6, 页码 608-616出版社
CELL PRESS
DOI: 10.1016/j.celrep.2012.05.013
关键词
-
类别
资金
- Kahn Family Research Center for Systems Biology
- Harris Foundation
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- Wellcome Trust
- Cancer Research UK
- Weizmann-UK Making Connections program
- MRC [G0601943, G0500288, G0400149] Funding Source: UKRI
- Medical Research Council [G0400149, G0500288, G0601943] Funding Source: researchfish
Size homeostasis is fundamental in cell biology, but it is not clear how large cells such as neurons can assess their own size or length. We examined a role for molecular motors in intracellular length sensing. Computational simulations suggest that spatial information can be encoded by the frequency of an oscillating retrograde signal arising from a composite negative feedback loop between bidirectional motor-dependent signals. The model predicts that decreasing either or both anterograde or retrograde signals should increase cell length, and this prediction was confirmed upon application of siRNAs for specific kinesin and/or dynein heavy chains in adult sensory neurons. Heterozygous dynein heavy chain 1 mutant sensory neurons also exhibited increased lengths both in vitro and during embryonic development. Moreover, similar length increases were observed in mouse embryonic fibroblasts upon partial downregulation of dynein heavy chain 1. Thus, molecular motors critically influence cell-length sensing and growth control.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据