BRCA1 tumor suppressor network: focusing on its tail

BRCA1 RING Function Is Essential for Tumor Suppression but Dispensable for Therapy Resistance

(2011) Rinske Drost et al.   CANCER CELL

Factors determining DNA double-strand break repair pathway choice in G2 phase

(2011) Atsushi Shibata et al.   EMBO JOURNAL

Hereditary breast cancer and the BRCA1-associated FANCJ/BACH1/BRIP1

(2011) Sharon B Cantor et al.   Future Oncology

RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci

(2011) Y. Hu et al.   GENES & DEVELOPMENT

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

NBA1/MERIT40 and BRE Interaction Is Required for the Integrity of Two Distinct Deubiquitinating Enzyme BRCC36-containing Complexes

(2011) Xin Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The BRCA1-RAP80 Complex Regulates DNA Repair Mechanism Utilization by Restricting End Resection

(2011) Kara A. Coleman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BRCA1 Is Required for Postreplication Repair after UV-Induced DNA Damage

(2011) Shailja Pathania et al.   MOLECULAR CELL

HDACs link the DNA damage response, processing of double-strand breaks and autophagy

(2011) Thomas Robert et al.   NATURE

BRCA1 tumour suppression occurs via heterochromatin-mediated silencing

(2011) Quan Zhu et al.   NATURE

Mutations in BRIP1 confer high risk of ovarian cancer

(2011) Thorunn Rafnar et al.   NATURE GENETICS

BRCA1 Tumor Suppression Depends on BRCT Phosphoprotein Binding, But Not Its E3 Ligase Activity

(2011) R. Shakya et al.   SCIENCE

CtIP Mutations Cause Seckel and Jawad Syndromes

(2011) Per Qvist et al.   PLoS Genetics

HERC2 Is an E3 Ligase That Targets BRCA1 for Degradation

(2010) W. Wu et al.   CANCER RESEARCH

Differential Regulation of JAMM Domain Deubiquitinating Enzyme Activity within the RAP80 Complex

(2010) Jeffrey Patterson-Fortin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Lys63-specific Deubiquitinating Enzyme BRCC36 Is Regulated by Two Scaffold Proteins Localizing in Different Subcellular Compartments

(2010) Lin Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair

(2010) Ismail Hassan Ismail et al.   JOURNAL OF CELL BIOLOGY

BACH1/FANCJ Acts with TopBP1 and Participates Early in DNA Replication Checkpoint Control

(2010) Zihua Gong et al.   MOLECULAR CELL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

CtIP promotes microhomology-mediated alternative end joining during class-switch recombination

(2010) Mieun Lee-Theilen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway

(2010) Yu Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Targeting the FANCJ–BRCA1 interaction promotes a switch from recombination to polη-dependent bypass

(2010) J Xie et al.   ONCOGENE

Human SIRT6 Promotes DNA End Resection Through CtIP Deacetylation

(2010) Abderrahmane Kaidi et al.   SCIENCE

Collaborative Action of Brca1 and CtIP in Elimination of Covalent Modifications from Double-Strand Breaks to Facilitate Subsequent Break Repair

(2010) Kyoko Nakamura et al.   PLoS Genetics

Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes

(2009) Francisca E. Reyes-Turcu et al.   Annual Review of Biochemistry

How the Fanconi Anemia Pathway Guards the Genome

(2009) George-Lucian Moldovan et al.   Annual Review of Genetics

RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

(2009) Carsten Doil et al.   CELL

The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage

(2009) Grant S. Stewart et al.   CELL

PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response

(2009) Feng Zhang et al.   CURRENT BIOLOGY

K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1

(2009) Eric M Cooper et al.   EMBO JOURNAL

Dynamic interactions of proteins in complex networks: identifying the complete set of interacting E2s for functional investigation of E3-dependent protein ubiquitination

(2009) Devin E. Christensen et al.   FEBS Journal

MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks

(2009) G. Shao et al.   GENES & DEVELOPMENT

MERIT40 facilitates BRCA1 localization and DNA damage repair

(2009) L. Feng et al.   GENES & DEVELOPMENT

NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control

(2009) B. Wang et al.   GENES & DEVELOPMENT

Specificity of the BRISC Deubiquitinating Enzyme Is Not Due to Selective Binding to Lys63-linked Polyubiquitin

(2009) Eric M. Cooper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N Terminus of CtIP Is Critical for Homologous Recombination-mediated Double-strand Break Repair

(2009) Jingsong Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair

(2009) Pablo Huertas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PALB2 Regulates Recombinational Repair through Chromatin Association and Oligomerization

(2009) Shirley M.-H. Sy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PALB2 Functionally Connects the Breast Cancer Susceptibility Proteins BRCA1 and BRCA2

(2009) F. Zhang et al.   MOLECULAR CANCER RESEARCH

CtIP Links DNA Double-Strand Break Sensing to Resection

(2009) Zhongsheng You et al.   MOLECULAR CELL

CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle

(2009) Maximina H. Yun et al.   NATURE

HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

(2009) Simon Bekker-Jensen et al.   NATURE CELL BIOLOGY

BRCA1 and its toolbox for the maintenance of genome integrity

(2009) Michael S.Y. Huen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function

(2009) J Nikkilä et al.   ONCOGENE

The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

(2009) G. Shao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein partners of deubiquitinating enzymes

(2008) Karen H. Ventii et al.   BIOCHEMICAL JOURNAL

Reverse the curse—the role of deubiquitination in cell cycle control

(2008) Ling Song et al.   CURRENT OPINION IN CELL BIOLOGY

Cell Cycle-dependent Complex Formation of BRCA1·CtIP·MRN Is Important for DNA Double-strand Break Repair

(2008) Longchuan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CDK targets Sae2 to control DNA-end resection and homologous recombination

(2008) Pablo Huertas et al.   NATURE

E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks

(2008) L. J. Reid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ubiquitin E3 ligase activity of BRCA1 and its biological functions

(2008) Wenwen Wu et al.   Cell Division