Instability of (CTG)n•(CAG)n trinucleotide repeats and DNA synthesis

Structure of Even/Odd Trinucleotide Repeat Sequences Modulates Persistence of Non-B Conformations and Conversion to Duplex

(2011) Amalia Ávila Figueroa et al.   BIOCHEMISTRY

Transcription-induced DNA toxicity at trinucleotide repeats

(2011) Yunfu Lin et al.   CELL CYCLE

Myotonic dystrophy, when simple repeats reveal complex pathogenic entities: new findings and future challenges

(2011) G. Sicot et al.   HUMAN MOLECULAR GENETICS

Maternal germline-specific effect of DNA ligase I on CTG/CAG instability

(2011) S. Tome et al.   HUMAN MOLECULAR GENETICS

Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1

(2011) Leroy Hubert et al.   HUMAN MOLECULAR GENETICS

Topoisomerase 1 and Single-Strand Break Repair Modulate Transcription-Induced CAG Repeat Contraction in Human Cells

(2011) L. Hubert et al.   MOLECULAR AND CELLULAR BIOLOGY

Collisions between Replication and Transcription Complexes Cause Common Fragile Site Instability at the Longest Human Genes

(2011) Anne Helmrich et al.   MOLECULAR CELL

RNase H and Multiple RNA Biogenesis Factors Cooperate to Prevent RNA:DNA Hybrids from Generating Genome Instability

(2011) Lamia Wahba et al.   MOLECULAR CELL

The structural basis for MCM2–7 helicase activation by GINS and Cdc45

(2011) Alessandro Costa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Role of XPG in Processing (CAG)n/(CTG)n DNA Hairpins

(2011) Caixia Hou et al.   Cell and Bioscience

New Functions of Ctf18-RFC in Preserving Genome Stability outside Its Role in Sister Chromatid Cohesion

(2011) Lionel Gellon et al.   PLoS Genetics

A novel approach to investigate tissue-specific trinucleotide repeat instability

(2010) Jong-Min Lee et al.   BMC Systems Biology

DNA Slippage Occurs at Microsatellite Loci without Minimal Threshold Length in Humans: A Comparative Genomic Approach

(2010) S. Leclercq et al.   Genome Biology and Evolution

Huntington's and myotonic dystrophy hESCs: down-regulated trinucleotide repeat instability and mismatch repair machinery expression upon differentiation

(2010) Anna Seriola et al.   HUMAN MOLECULAR GENETICS

Bidirectional transcription stimulates expansion and contraction of expanded (CTG)•(CAG) repeats

(2010) Masayuki Nakamori et al.   HUMAN MOLECULAR GENETICS

Repeat Expansion Affects Both Transcription Initiation and Elongation in Friedreich Ataxia Cells

(2010) Daman Kumari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic Studies of Hairpin to Duplex Conversion for Trinucleotide Repeat Sequences

(2010) Amalia Ávila Figueroa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Convergent Transcription through a Long CAG Tract Destabilizes Repeats and Induces Apoptosis

(2010) Y. Lin et al.   MOLECULAR AND CELLULAR BIOLOGY

Activation of the MCM2-7 Helicase by Association with Cdc45 and GINS Proteins

(2010) Ivar Ilves et al.   MOLECULAR CELL

Replication-dependent instability at (CTG)•(CAG) repeat hairpins in human cells

(2010) Guoqi Liu et al.   Nature Chemical Biology

Tissue- and age-specific DNA replication patterns at the CTG/CAG-expanded human myotonic dystrophy type 1 locus

(2010) John D Cleary et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Determinants of R-loop formation at convergent bidirectionally transcribed trinucleotide repeats

(2010) Kaalak Reddy et al.   NUCLEIC ACIDS RESEARCH

Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSβ, but clustered slip-outs are poorly repaired

(2010) Gagan B. Panigrahi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA tandem repeat instability in the Escherichia coli chromosome is stimulated by mismatch repair at an adjacent CAG{middle dot}CTG trinucleotide repeat

(2010) J. K. Blackwood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human embryonic stem cell models of Huntington disease

(2010) JC Niclis et al.   REPRODUCTIVE BIOMEDICINE ONLINE

A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase α within the eukaryotic replisome

(2009) Agnieszka Gambus et al.   EMBO JOURNAL

Double-Strand Break Repair Pathways Protect against CAG/CTG Repeat Expansions, Contractions and Repeat-Mediated Chromosomal Fragility in Saccharomyces cerevisiae

(2009) R. Sundararajan et al.   GENETICS

Mismatch Recognition Protein MutSβ Does Not Hijack (CAG)nHairpin Repairin Vitro

(2009) Lei Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordination between Polymerase β and FEN1 Can Modulate CAG Repeat Expansion

(2009) Yuan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myotonic Dystrophy Transgenic Mice Exhibit Pathologic Abnormalities in Diaphragm Neuromuscular Junctions and Phrenic Nerves

(2009) Petrica-Adrian Panaite et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Models for chromosomal replication-independent non-B DNA structure-induced genetic instability

(2009) Guliang Wang et al.   MOLECULAR CARCINOGENESIS

Large-Scale Expansions of Friedreich's Ataxia GAA Repeats in Yeast

(2009) Alexander A. Shishkin et al.   MOLECULAR CELL

Incision-dependent and error-free repair of (CAG) n /(CTG) n hairpins in human cell extracts

(2009) Caixia Hou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SRS2 and SGS1 prevent chromosomal breaks and stabilize triplet repeats by restraining recombination

(2009) Alix Kerrest et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Replisome stalling and stabilization at CGG repeats, which are responsible for chromosomal fragility

(2009) Irina Voineagu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATM and ATR protect the genome against two different types of tandem repeat instability in Fragile X premutation mice

(2009) A. Entezam et al.   NUCLEIC ACIDS RESEARCH

R loops stimulate genetic instability of CTG{middle dot}CAG repeats

(2009) Y. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MSH2 ATPase Domain Mutation Affects CTG•CAG Repeat Instability in Transgenic Mice

(2009) Stéphanie Tomé et al.   PLoS Genetics

Stoichiometry of Base Excision Repair Proteins Correlates with Increased Somatic CAG Instability in Striatum over Cerebellum in Huntington's Disease Transgenic Mice

(2009) Agathi-Vassiliki Goula et al.   PLoS Genetics

Chromatin Remodeling in the Noncoding Repeat Expansion Diseases

(2008) Daman Kumari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-stranded DNA-binding Proteinin VitroEliminates the Orientation-dependent Impediment to Polymerase Passage on CAG/CTG Repeats

(2008) Emmanuelle Delagoutte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcription destabilizes triplet repeats

(2008) Yunfu Lin et al.   MOLECULAR CARCINOGENESIS

Mus81-Dependent Double-Strand DNA Breaks at In Vivo-Generated Cruciform Structures in S. cerevisiae

(2008) Atina G. Coté et al.   MOLECULAR CELL

Mrc1 and DNA Polymerase ɛ Function Together in Linking DNA Replication and the S Phase Checkpoint

(2008) Huiqiang Lou et al.   MOLECULAR CELL

CTG repeat instability in a human embryonic stem cell line carrying the myotonic dystrophy type 1 mutation

(2008) N. De Temmerman et al.   MOLECULAR HUMAN REPRODUCTION

Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes

(2008) Ella Dragileva et al.   NEUROBIOLOGY OF DISEASE

DNA instability in postmitotic neurons

(2008) R. Gonitel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Replication stalling at unstable inverted repeats: Interplay between DNA hairpins and fork stabilizing proteins

(2008) I. Voineagu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CTCF cis-Regulates Trinucleotide Repeat Instability in an Epigenetic Manner: A Novel Basis for Mutational Hot Spot Determination

(2008) Randell T. Libby et al.   PLoS Genetics