Article
Medicine, Research & Experimental
Yasuyuki Tamai, Zhen Chen, Yue Wu, Jun Okabe, Yoshinao Kobayashi, Hitoshi Chiba, Shu-Ping Hui, Akiko Eguchi, Motoh Iwasa, Masaaki Ito, Yoshiyuki Takei
Summary: The combined treatment of BCAA and L-carnitine significantly improved hepatocellular function, reduced lipid deposition and adipophilin expression, and protected the liver by maintaining mitochondrial integrity in cirrhotic rats, supporting their therapeutic potential in human chronic liver diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Cell Biology
Michaela E. Trautman, Nicole E. Richardson, Dudley W. Lamming
Summary: The proportion of people suffering from age-related diseases is increasing worldwide. Recent research has shown that low protein diets, particularly those low in branched-chain amino acids (BCAAs), can reduce mortality and promote metabolic health and extended lifespan in both humans and rodents. This article discusses the emerging evidence that BCAAs play a crucial role in healthy metabolism and longevity, and explores the physiological and molecular mechanisms behind the benefits of restricting dietary BCAAs. The findings suggest that the quality of protein, specifically the composition of dietary protein, may be a previously overlooked factor in metabolic dysfunction and reducing dietary BCAAs could be a promising new approach to delaying and preventing age-related diseases.
Review
Medicine, General & Internal
Anne M. M. van Dijk, Alexandra S. Bruins S. Slot, Piero Portincasa, Sebastiaan N. Siegerink, Najiba Chargi, Carina J. R. Verstraete, Joep de Bruijne, Frank P. P. Vleggaar, Karel J. J. van Erpecum
Summary: Prophylactic supplementation of BCAA appears to be safe and may improve survival in cirrhotic patients.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Pharmacology & Pharmacy
Tiangang Wu, Mengling Wang, Fengling Ning, Shilin Zhou, Xuetao Hu, Hong Xin, Svetlana Reilly, Xuemei Zhang
Summary: Fibrosis, characterized by excessive production of extracellular matrix, is a common pathological feature of organ diseases. Metabolic alterations, especially in the regulation of branched-chain amino acids (BCAAs), have been found to play significant roles in fibrogenesis. Dysregulation of BCAAs metabolism has been implicated in various diseases. This review summarizes the metabolic regulation of fibrosis, changes in BCAAs metabolism associated with fibrosis, and the effects and mechanisms of BCAAs intervention in hepatic, renal, and cardiac fibrosis, with a focus on liver fibrosis and associated hepatocellular carcinoma.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Emily Kwun Kwan Lo, Felicianna, Jing-Hang Xu, Qiao Zhan, Zheng Zeng, Hani El-Nezami
Summary: Branched-chain amino acids (BCAAs) are related to chronic liver diseases, but BCAA supplementation has positive effects on cirrhosis and hepatocellular carcinoma (HCC) patients. This review aims to clarify the contradictory claims and study the role of BCAAs in liver health.
Review
Genetics & Heredity
Can Chen, Hassan Naveed, Keping Chen
Summary: This article introduces the important role of branched-chain amino acid aminotransferases in cellular metabolism, summarizes the related research in animals, plants, microorganisms, and humans, and analyzes the molecular mechanism. It has been found that disorders in branched-chain amino acid metabolism are closely related to various diseases, especially tumor development.
FRONTIERS IN GENETICS
(2023)
Article
Nutrition & Dietetics
Katarzyna Paczkowska, Dominik Rachon, Andrzej Berg, Jacek Rybka, Katarzyna Kapczynska, Marek Bolanowski, Jacek Daroszewski
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that predisposes women to metabolic disturbances. Recent research suggests that alterations in amino acid profiles may be indicative of metabolic disorders. This study found elevated levels of aromatic amino acids in PCOS women, and significant differences in amino acid concentrations between metabolically healthy and unhealthy obesity subgroups of PCOS women.
Article
Nutrition & Dietetics
Huan Xu, Xuanyang Wang, Xiaoqing Xu, Lin Liu, Yuntao Zhang, Xuemin Yan, Yingfeng Zhang, Keke Dang, Ying Li
Summary: This study using Mendelian randomization analysis found that increased circulating levels of BCAAs were associated with an increased risk of squamous cell lung cancer, but no causal link was found between BCAAs and other types of cancer.
CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Yuyan Liu, Chengwen Zhang, Yuan Zhang, Xuheng Jiang, Yuanhong Liang, Huan Wang, Yongfang Li, Guifan Sun
Summary: This study aimed to investigate the relationship between dietary intake of branched-chain amino acids (BCAAs) and hypertension risk in the Chinese population. The findings showed that dietary BCAAs intake was positively associated with both systolic and diastolic blood pressure values, as well as an increased risk of hypertension.
Review
Immunology
Berkay Yahsi, Gurcan Gunaydin
Summary: Immunometabolism, especially in terms of augmenting anti-tumor immune responses, has been extensively researched. Regulatory T cells (Tregs) are known for their immunosuppressive roles in anti-tumor immune responses. Targeting Tregs specifically in the tumor microenvironment (TME) is crucial for successful and specific treatment. Recent studies have shown an association between Tregs and isoleucine, which may play a major role in affecting Tregs. Targeting the immunometabolic pathways of Tregs could be a rational approach for treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Paola Cuomo, Rosanna Capparelli, Antonio Iannelli, Domenico Iannelli
Summary: Branched-chain amino acids (BCAAs) play an important role in human health. High levels of BCAAs are associated with various metabolic diseases, while low levels are beneficial for metabolic health. However, the exact mechanisms underlying the dysregulation caused by high levels of BCAAs are still under debate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Daniel Ferguson, Sophie J. Eichler, Nicole K. H. Yiew, Jerry R. Colca, Kevin Cho, Gary J. Patti, Trevor M. Shew, Andrew J. Lutkewitte, Sandip Mukherjee, Kyle S. McCommis, Natalie M. Niemi, Brian N. Finck
Summary: The study evaluated the effects of MPC inhibitors (MPCi) on branched chain amino acid (BCAA) metabolism and found that MPCi can lower plasma BCAA concentrations and activate AMPK and mTOR signaling pathways. However, the effects on glucose homeostasis may be separate from BCAA concentrations.
MOLECULAR METABOLISM
(2023)
Review
Oncology
Georgios A. Sideris, Savvas Tsaramanidis, Aikaterini T. Vyllioti, Njogu Njuguna
Summary: Numerous studies have investigated the use of branched-chain amino acid (BCAA) supplements in patients with cirrhosis and liver cancer, with reported benefits including improved survival rates and hepatic functional reserve. However, the potential role of BCAA supplementation in conjunction with locoregional therapies for liver cancer remains unclear. A systematic review and meta-analysis of articles investigating BCAA supplementation in patients with hepatocellular carcinoma undergoing interventional radiology procedures revealed significantly higher post-treatment albumin levels, suggesting potential benefits in combination with locoregional treatments. However, current data are insufficient to support additional benefits.
Article
Nutrition & Dietetics
Alexander Christian Reisinger, Florian Posch, Gerald Hackl, Gunther Marsche, Harald Sourij, Benjamin Bourgeois, Kathrin Eller, Tobias Madl, Philipp Eller
Summary: Metabolomics using H-1 NMR spectroscopy shows promise for personalized medicine in sepsis, with distinct differences in metabolites between sepsis patients and controls, as well as between septic shock survivors and non-survivors. Branched-chain amino acids (BCAA), including valine, leucine, and isoleucine, were significantly lower in sepsis non-survivors and serve as potential early biomarkers for predicting outcomes in ICU and 28-day mortality.
Review
Nutrition & Dietetics
Yan-Mei Hsu, Hui-Chung Kuan, Yu-An Chen, Ching-Wen Chiu, Po-Cheng Chen, Ka-Wai Tam
Summary: The benefits of branched-chain amino acid (BCAA) administration after hepatic intervention in patients with liver diseases remain unclear. However, our meta-analysis showed that BCAA supplementation significantly improved liver function, reduced ascites incidence, and increased body weight and arm circumference in selected patients undergoing liver intervention.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Medicine, General & Internal
Yiseul Choi, Heajeong Park, Namki Hong, Yumie Rhee, Wonse Park
Summary: This study examines the communication problems and current status of communication methods between patients, dentists, and physicians for the prevention and treatment of MRONJ. It identifies the lack of medical knowledge among patients, as well as the lack of expertise between dentists and physicians. The study also highlights the dissatisfaction of patients with the current communication system via letters and the need for more effective communication according to dentists and physicians.
Article
Endocrinology & Metabolism
Minyoung Lee, Kyeongseob Jeong, Yu Rang Park, Yumie Rhee
Summary: ICI therapy is associated with an increased risk of incident diabetes compared with CC. The glucose levels of patients treated with an ICI, especially males and those with prominent lymphocytosis after ICI treatment, need to be monitored regularly to detect ICI-associated diabetes as early as possible.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Endocrinology & Metabolism
K. J. Kim, N. Hong, S. Lee, S. Shin, Y. Rhee
Summary: Hajdu-Cheney syndrome (HCS) is a rare inherited skeletal disorder caused by mutations in the NOTCH2 gene. Current treatment options for HCS are limited, and previous reports have shown limited efficacy with other medications. This case report presents the first evidence of romosozumab treatment for HCS in Korea, showing significant improvements in bone mineral density and reduced markers of bone turnover. These findings suggest that romosozumab may be a promising treatment option for HCS patients with osteoporosis.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Mi Youn Seol, Seo Hee Choi, Ik Jae Lee, Hyung Soon Park, Hye Ryun Kim, Sang Kyum Kim, Hong In Yoon
Summary: This study investigated whether selective inhibition of PI3K isoforms could enhance radiosensitivity in GBM. The results from cell experiments and a mouse model demonstrated that inhibition of PI3K-alpha isoform increased radiosensitivity in GBM cells, leading to tumor growth suppression and extended survival in vivo.
YONSEI MEDICAL JOURNAL
(2023)
Article
Geriatrics & Gerontology
Jin Ryu, Sujeong Eom, Hyeon Chang Kim, Chang Oh Kim, Yumie Rhee, Seng Chan You, Namki Hong
Summary: This study aimed to develop a deep learning model based on chest X-rays to predict the presence of sarcopenia. The results showed that the model performed well in predicting muscle parameters and sarcopenia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Endocrinology & Metabolism
Sung Hye Kong, Joon-Hyop Lee, Jeong Mo Bae, Namki Hong, Hyeyoon Kim, So Young Park, Yong Jun Choi, Sihoon Lee, Yumie Rhee, Sang Wan Kim, Dohyun Han, Jung Hee Kim, Chan Soo Shin
Summary: This study aimed to identify protein signatures for the diagnosis of parathyroid carcinoma (PC) through quantitative proteomic analyses. It identified 5 proteins that can discriminate PC from parathyroid adenoma (PA) and found that the nuclear percentage of carbonic anhydrase 4 and laminin subunit beta-2 was significantly lower in PC tissue. The findings of this study can contribute to the accurate diagnosis of PC and the discovery of potential therapeutic targets.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Namki Hong, Seung Won Burm, Hyeon Chang Kim, Chang Oh Kim, Yumie Rhee
Summary: Low countermovement jump power is associated with prevalent fracture, osteoporosis, and sarcopenia in older adults. However, whether jump power predicts incident fracture risk remains uninvestigated. This study found that low jump power is associated with a higher risk of fracture in older adults and can predict fracture risk independently of sarcopenia and osteoporosis.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Namki Hong, Sang Wouk Cho, Sungjae Shin, Seunghyun Lee, Seol A. Jang, Seunghyun Roh, Young Han Lee, Yumie Rhee, Steven R. R. Cummings, Hwiyoung Kim, Kyoung Min Kim
Summary: By using deep learning methods on lateral spine radiography, osteoporosis and vertebral fractures can be better diagnosed, leading to improved referral of high-risk individuals to bone-density testing.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
Craig F. Munns, Han-Wook Yoo, Muhammad Yazid Jalaludin, Rashida Vasanwala, Manju Chandran, Yumie Rhee, Wai Man But, Alice Pik-Shan Kong, Pen-Hua Su, Nawaporn Numbenjapon, Noriyuki Namba, Yasuo Imanishi, Roderick J. Clifton-Bligh, Xiaoping Luo, Weibo Xia
Summary: X-linked hypophosphatemia (XLH) is a rare, inherited, multisystem disorder characterized by hypophosphatemia that occurs secondary to renal phosphate wasting. XLH has a significant impact on physical function, mobility, and quality of life, and is associated with substantial socioeconomic burden and health care resource utilization. This study aims to provide evidence-based recommendations for optimizing XLH care in the Asia-Pacific (APAC) context.
Article
Endocrinology & Metabolism
Namki Hong, Jung Ho Kim, Graham Treece, Hyeon Chang Kim, Jun Yong Choi, Yumie Rhee
Summary: Middle-aged men living with human immunodeficiency virus (MLWH) have a significantly higher risk of hip fracture, almost a decade earlier than those without infection. Limited data on cortical and trabecular bone deficit in MLWH were observed. This study found that MLWH had lower hip bone density and deficits in certain bone parameters compared to age and body mass index-matched controls.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Namki Hong, Sungjae Shin, Seunghyun Lee, Yumie Rhee
Summary: This study found that romosozumab may be more effective in improving trabecular bone score compared to denosumab therapy in postmenopausal women who have previously received antiresorptive agents. Notably, romosozumab treatment resulted in similar improvement in trabecular bone score in patients previously treated with antiresorptive agents compared to drug-naive patients.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Seung-Rok Kim, Ey-In Lee, Yongnyun Kim, Sang Wouk Cho, Namki Hong, Yumie Rhee, Jin-Woo Park
Summary: This study presents a new jumping-power assessment tool in a preclinical rodent model to study sarcopenia. The device utilizes electrical stimulation and load cell to capture the jumping data of mice, and has various potential utilities.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Namki Hong, Kyoung Jin Kim, Min Heui Yu, Seong Ho Jeong, Seunghyun Lee, Jung Soo Lim, Yumie Rhee
Summary: This study examined the risk of dementia in patients with primary aldosteronism (PA) compared to patients with essential hypertension (EH). The findings revealed that treated PA patients were more likely to develop all-cause dementia compared to EH patients. Among PA patients, those using mineralocorticoid receptor antagonists (MRA) had a higher risk, especially for vascular dementia.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Endocrinology & Metabolism
Kyoung Jin Kim, Ji Eun Song, Ji Hyun Kim, Namki Hong, Sin Gon Kim, Juneyoung Lee, Yumie Rhee
Summary: This study investigated the prevalence and long-term health outcomes of chronic idiopathic hypophosphatemia (CIH) patients in South Korea. The results showed that CIH patients had a higher risk of various complications, including cardiovascular outcomes and chronic kidney disease. The study also found higher risks of mortality and hospitalization among CIH patients compared to the control group.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Se-Young Jo, Namki Hong, Seunghyun Lee, Jong Ju Jeong, Jeongsoo Won, Jiho Park, Gi Jeong Kim, Sang Kyum Kim, Sangwoo Kim, Yumie Rhee
Summary: Genomic and transcriptomic profiling of parathyroid tissues revealed multiple two-hit mutation patterns in the CDC73 gene, suggesting potential therapeutic targets. Transcriptomic analysis identified upregulated expression of E2F targets, KRAS and TNF-alpha signaling, and epithelial-mesenchymal transition pathways in parathyroid carcinomas. A molecular classification model based on carcinoma-specific genes could effectively distinguish between carcinomas, adenomas, and normal tissues, with potential clinical utility.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
