Article
Biochemistry & Molecular Biology
Yu Guo, Kaimei Zhou, Xiang Zhuang, Junjie Li, Xianglin Shen
Summary: The study investigated the role of CDCA7 in stomach carcinoma and found that CDCA7 knockdown could inhibit tumor development by regulating proliferation and apoptosis. CDCA7 may regulate inflammation through the TLR4/NF-kappa B signaling pathway in stomach adenocarcinoma. This research provides insights into a potential strategy for regulating inflammation in stomach carcinoma development.
Article
Biochemistry & Molecular Biology
Sung-Hwa Sohn, Hee Jung Sul, Bum Jun Kim, Hyeong Su Kim, Dae Young Zang
Summary: In this study, the mRNA expression and mutation profiles of gastric cancer patients with neurotropic tropomyosin receptor kinase (NTRK) 1-3 overexpression were evaluated. The researchers found that entrectinib, a TRK inhibitor, showed the highest inhibitory activity against NCI-N87 and AGS cells. Mechanistic studies showed that entrectinib reduced the expression levels of phosphorylated NF kappa B, AKT, ERK, and beta-catenin in NCI-N87 and AGS cells and upregulated the expression levels of ECAD in NCI-N87 cells. These findings suggest that entrectinib has anti-cancer activity in GC cells overexpressing NTRK and VEGFR2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Yuejun Wang, Li Li, Yuting Wu, Shouping Zhang, Qianqian Ju, Yinuo Yang, Yan Jin, Hui Shi, Cheng Sun
Summary: CD44 plays a crucial role in neuroinflammation and may be involved in the progression of Parkinson's disease. This study reveals that CD44 deficiency can inhibit the expression of proinflammatory cytokines and improve behavioral defects in PD model mice. Neutralization of CD44 with antibodies produces similar effects.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Jie Xu, Shixu Li, Xuefeng Yang, Haibo Wang, Lina Ma, Yuan Shen, Jie Yu
Summary: Studies have found a positive correlation between the intake of environmental endocrine disruptors and the occurrence of gastric diseases. This study investigated the effects of nonylphenol (NP) exposure on gastric inflammation and its mechanism related to the NF-kappa B/NLRP3 signaling pathway. The findings from in vivo and in vitro experiments revealed that NP exposure induced gastric inflammation and affected the expression of genes and proteins in the NF-kappa B/NLRP3 signaling pathway. These findings provide a new perspective on the mechanism of inflammatory response caused by exposure to environmental endocrine disruptors and suggest potential therapeutic strategies for treating inflammatory diseases through targeting the NF-kappa B/NLRP3 signaling pathway.
Article
Biochemistry & Molecular Biology
Lei Xu, Yangfan Ye, Zeqiang Tao, Tian Wang, Yutian Wei, Wanzhi Cai, Xin Wan, Pengzhan Zhao, Wei Gu, Bin Gu, Liuchao Zhang, Yufei Tian, Ning Liu, Yiming Tu, Jing Ji
Summary: This study elucidated the role of MLPH in GBM radiation resistance, showing that MLPH promotes radiotherapy resistance by regulating the NF-kappa B pathway. Additionally, O-GlcNAcylation of MLPH protects it from degradation and stabilizes its presence in cells. These findings provide insights into a potential mechanism of GBM radiation resistance and suggest a therapeutic strategy for GBM treatment.
Article
Plant Sciences
Tian Lan, Hang-fei Chen, Fang Zheng, Hui Huang, Qi Wu, Xue-yu Fan, Si-wei Wang, Feng Zhang
Summary: Cinobufacini was found to inhibit the progression of pancreatic ductal adenocarcinoma by modulating the YEATS2/TAK1/NF-kappa B pathway. The results demonstrated that cinobufacini can induce cell cycle arrest and inhibit the growth of pancreatic cancer cells, as well as suppress tumor progression in mice.
Article
Oncology
Yang Lyu, Bowen Duan, Ziming Liu, Fan Yang, Chen Chen, Xuejiao Jiang, Xiang Liu
Summary: This study found that Sparstolonin B inhibits the growth and induces apoptosis of pancreatic cancer cells through the NFxB signaling pathway, making it a potential novel drug for pancreatic cancer treatment.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Oncology
Jhih-Yun Ho, Hsin-Ying Lu, Hsing-Hsien Cheng, Yu-Chieh Kuo, Yu-Lin Amy Lee, Chia-Hsiung Cheng
Summary: The study showed that higher UBE2S expression in lung adenocarcinomas leads to increased binding with I kappa B alpha to activate NF-kappa B signaling and promote adenocarcinoma cell metastasis. UBE2S may serve as a potential therapeutic target for lung adenocarcinomas.
Article
Plant Sciences
Yanzhen Mai, Siyuan Xu, Ru Shen, Bairu Feng, Hong He, Yifei Xu
Summary: The water extract of A. rugosum (WEA) has been found to have gastroprotective effects, reducing the size of gastric ulcers and exhibiting anti-inflammatory properties. Pre-treatment with WEA decreased the concentration of inflammatory factors in the stomach and did not have a significant impact on gastric acid and mucus secretion.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Oncology
Sung-Hsin Kuo, Shih-Hung Yang, Ming-Feng Wei, Hsiao-Wei Lee, Yu-Wen Tien, Ann-Lii Cheng, Kun-Huei Yeh
Summary: The study showed that nuclear BCL10 translocation activates NF-kappa B signaling and contributes to tumor progression and poor prognosis of advanced/metastatic PDAC.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Venugopal Gunda, Yashpal S. Chhonker, Nagabhishek Sirpu Natesh, Pratima Raut, Sakthivel Muniyan, Todd A. Wyatt, Daryl J. Murry, Surinder K. Batra, Satyanarayana Rachagani
Summary: This study revealed that cigarette smoke exposure enhances glutathione synthesis and activates NF-kappa B pathway in PDAC cells, promoting cell survival. Inhibition of NF-kappa B or depletion of cysteine impairs cell survival in smoke exposed conditions, but can be reversed by glutathione supplementation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Longhua Feng, Pengjiang Cheng, Zhengyun Feng, Xiaoyu Zhang
Summary: The overexpression of TMED2 in LUAD is negatively correlated with malignant survival and apoptosis. Knockdown of TMED2 inhibits LUAD development and increases the levels of inflammatory factors. In addition, TMED2 is associated with TME-associated immune cells, their target markers, and some mechanisms and pathways.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Xianze Wang, Hao Chen, Rui Jiang, Xiafei Hong, Junya Peng, Wenyan Chen, Jialin Jiang, Jie Li, Dan Huang, Hongmei Dai, Wenze Wang, Junliang Lu, Yupei Zhao, Wenming Wu
Summary: The study confirmed the pro-tumor effects of IL-17 and Notch pathways in PanIN/PDAC progression and identified a positive correlation between IL-17 and Notch. Furthermore, co-inhibition of IL-17 and Notch pathways was shown to enhance therapeutic efficacy by restricting tumor growth.
Article
Cell Biology
Wenfei Pan, Limei Deng, Haitao Wang, Vivien Ya-Fan Wang
Summary: The NF-kappa B family of dimeric transcription factors regulate various biological functions. A study has revealed that the atypical I kappa B protein, Bcl3, plays a crucial role in enhancing the population of the p52:p52 homodimer within the NF-kappa B family. Bcl3 competes with other NF-kappa B subunits for efficient p52:p52 homodimer formation, leading to the upregulation of target genes involved in cell proliferation, migration, and inflammation. The aberrant activation of Bcl3 and p52 contributes to cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Dianbo Long, Yiyang Xu, Guping Mao, Ruobing Xin, Zengfa Deng, Hongyi Liao, Zhiwen Li, Zhi Yang, Baoxi Yu, Zhijian Yang, Aishan He, Ziji Zhang, Yan Kang
Summary: tRNA-derived fragments (tRFs) have been shown to play important roles in cell metabolism by regulating gene expression. This study investigates the role of tRFs in the cellular metabolism of the anterior cruciate ligament (ACL). The findings reveal that TRF365 regulates ACL cell metabolism by targeting IKBKB.
CELL DEATH DISCOVERY
(2022)