期刊
GENES
卷 6, 期 4, 页码 1053-1075出版社
MDPI
DOI: 10.3390/genes6041053
关键词
circulating tumor cells; CTC; molecular analyses; epigenetics; DNA methylation
资金
- Dusseldorf School of Oncology (Comprehensive Cancer Center Dusseldorf/Deutsche Krebshilfe)
- Deutsche Krebshilfe [109600/110429]
- Innovative Medicines Initiative Joint Undertaking (IMIJU) (Project CANCER-ID) [CANCER-ID]
- Dusseldorf School of Oncology (Medical Faculty HHU Dusseldorf)
Epigenetics contributes to molecular mechanisms leading to tumor cell transformation and systemic progression of cancer. However, the dynamics of epigenetic remodeling during metastasis remains unexplored. In this context, circulating tumor cells (CTCs) might enable a direct insight into epigenetic mechanisms relevant for metastasis by providing direct access to systemic cancer. CTCs can be used as prognostic markers in cancer patients and are regarded as potential metastatic precursor cells. However, despite substantial technical progress, the detection and molecular characterization of CTCs remain challenging, in particular the analysis of DNA methylation. As recent studies have started to address the epigenetic state of CTCs, we discuss here the potential of such investigations to elucidate mechanisms of metastasis and to develop tumor biomarkers.
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