期刊
FRONTIERS IN PHYSIOLOGY
卷 6, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2015.00325
关键词
skeletal muscle; transcriptional regulation; PGC-1 alpha; exercise; metabolism; co-regulator
类别
资金
- ERC [616830-MUSCLE NET]
- Swiss National Science Foundation, SystemsX.ch
- Swiss Society for Research on Muscle Diseases (SSEM)
- Novartis Stiftung fur medizinisch-biologische Forschung
- University of Basel
- Biozentrum
- Biozentrum Basel International PhD Program Fellowships for Excellence
Skeletal muscle cells exhibit an enormous plastic capacity in order to adapt to external stimuli. Even though our overall understanding of the molecular mechanisms that underlie phenotypic changes in skeletal muscle cells remains poor, several factors involved in the regulation and coordination of relevant transcriptional programs have been identified in recent years. For example, the peroxisome proliferator-activated receptor gamma coactiyator-1 alpha (PGC-1 alpha) is a central regulatory nexus in the adaptation of muscle to endurance training. Intriguingly, PGC-1 alpha integrates numerous signaling pathways and translates their activity into various transcriptional programs. This selectivity is in part controlled by differential expression of PGC-10 variants and post-translational modifications of the PGC-1 alpha protein. PGC-1 alpha-controlled activation of transcriptional networks subsequently enables a spatio-temporal specification and hence allows a complex coordination of changes in metabolic and contractile properties, protein synthesis and degradation rates and other features of trained muscle. In this review, we discuss recent advances in our understanding of PGC-1 alpha-regulated skeletal muscle cell plasticity in health and disease.
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