Article
Biochemistry & Molecular Biology
Frantisek Barta, Alena Dedikova, Michaela Bebova, Sarka Duskova, Jaroslav Mraz, Heinz H. Schmeiser, Volker M. Arlt, Petr Hodek, Marie Stiborova
Summary: The exposure to AAI/AAII mixture may enhance AA-DNA adduct formation in rat livers and kidneys, partially due to inhibition of AAI detoxification and induction of NQO1. Additionally, AAII may act as an inhibitor of AAI detoxification, leading to increased AAI residues in liver and kidney tissues and enhanced AAI DNA adduct formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Liping Ma, Zhuowei Shen, Haihong Hu, Hui Zhou, Lushan Yu, Huidi Jiang, Su Zeng
Summary: The study demonstrated that co-administration with rhein significantly increased the plasma exposure of AAI and AAIa while decreasing their renal accumulation in rats. RP extract reduced the renal accumulation of AAI and AAIa, but had no significant effect on their plasma exposure levels in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Hongjian Ji, Jingyin Hu, Guozhe Zhang, Jianxiang Song, Xiaohua Zhou, Dean Guo
Summary: This study conducted a scientometric analysis of global research literature on Aristolochic acid nephropathy (AAN), indicating the significant research topic in nephrology with a focus on the mechanisms of AA-induced nephropathy.
Article
Physiology
Aleix Navarro Garrido, Young Chul Kim, Yuji Oe, Haiyan Zhang, Maria Crespo-Masip, Helen A. Goodluck, Sadhana Kanoo, Paul W. Sanders, Stefan Broer, Volker Vallon
Summary: B0AT1 plays an important role in the retention of renal glucose and albumin, but may have adverse effects on kidney response following aristolochic acid-induced kidney injury.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Biology
Chu-Kuang Chou, Yu-Shen Huang, Pei-Yu Lin, Kazuhiro Imai, Shih-Ming Chen, Jen-Ai Lee
Summary: This study revealed that Panax ginseng extract and ginsenoside saponin can significantly reduce renal injuries induced by aristolochic acid, with Rg(1) showing the best renoprotective effect among all GS-treated groups. The mechanism and renoprotective effects of Rg(1) were found to be associated with the expression of mitochondrial proteins, particularly ACO2, Usmg5, and COX5a.
Article
Oncology
Fan Lin, Yunqi Liu, Lili Tang, Xiaohui Xu, Xueli Zhang, Yifan Song, Bicheng Chen, Yeping Ren, Xiangdong Yang
Summary: The study demonstrated that rapamycin protects against aristolochic acid-induced nephropathy by activating the mTOR-autophagy axis. This finding provides evidence for rapamycin as a promising pharmacological target for the treatment of aristolochic acid nephropathy.
MOLECULAR MEDICINE REPORTS
(2021)
Review
Medicine, General & Internal
Thomas Baudoux, Ines Jadot, Anne-Emilie Decleves, Marie-Helene Antoine, Jean-Marie Colet, Olivia Botton, Eric De Prez, Agnieszka Pozdzik, Cecile Husson, Nathalie Caron, Joelle L. Nortier
Summary: This review discusses the pathogenesis of aristolochic acid nephropathy (AAN) and its mechanisms of kidney damage. By reproducing human AAN in rodent models, the researchers have discovered the process of transition from acute kidney injury (AKI) to chronic kidney disease (CKD) and identified key factors involved in this transition. These findings are important for a better understanding of the complex AKI-to-CKD transition.
FRONTIERS IN MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Gordana Kocic, Mihajlo Gajic, Katarina Tomovic, Jovan Hadzi-Djokic, Marko Anderluh, Andrija Smelcerovic
Summary: Aristolochic acid nephropathy is a progressive disease leading to end-stage renal disease and malignancies. New insights are provided on the energy crisis induced by aristolochic acid and the potential links with known mechanisms.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qian Zhang, Piao Luo, Jiayun Chen, Chuanbin Yang, Fei Xia, Junzhe Zhang, Huan Tang, Dandan Liu, Liwei Gu, Qiaoli Shi, Xueling He, Tong Yang, Jigang Wang
Summary: This study reveals the targeting molecular mechanisms of AA-induced nephrotoxicity. Key enzymes involved in metabolic processes and mitochondrial respiration were found to be directly bound by AA, disrupting metabolic biosynthesis processes and impairing mitochondrial functions. This ultimately leads to renal cell apoptosis and the development of aristolochic acid nephropathy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Immunology
Xiaoyan Wang, Ping Jia, Ting Ren, Zhouping Zou, Sujuan Xu, Yunlu Zhang, Yiqin Shi, Siyu Bao, Yingxiang Li, Yi Fang, Xiaoqiang Ding
Summary: This study reveals the involvement of miR-382 in macrophage activation during AA-induced kidney fibrosis. Knockout of miR-382 inhibits M2-like macrophage activation and kidney interstitial fibrosis, while overexpression of miR-382 promotes kidney injury. The findings highlight the important role of miR-382 in regulating kidney fibrosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Takeo Ishii, Tomohiro Kumagae, Hiromichi Wakui, Shingo Urate, Shohei Tanaka, Eriko Abe, Toru Suzuki, Takahiro Yamaji, Sho Kinguchi, Ryu Kobayashi, Kotaro Haruhara, Takashi Nakamura, Shuzo Kobayashi, Kouichi Tamura
Summary: The study found that the activity of xanthine oxidoreductase (XOR) was continuously increased in renal tissue in a mouse model of nephropathy induced by aristolochic acid, contributing to the progression of tubulo-interstitial disorders.
Article
Toxicology
Qi Zhang, Lei Tian, Yongkang Hu, Wenjuan Jiang, Xian Wang, Langqun Chen, Siyu Cheng, Jiahui Ying, Baoping Jiang, Liang Zhang
Summary: This study investigated the potential role of Apurinic/apyrimidine endonuclease 1 (APE1) in aristolochic acid I (AAI)-induced nephrotoxicity. The results showed that AAI inhibited the expression of APE1, leading to oxidative damage and apoptosis. Inhibition of APE1 further decreased the expression of Nrf2 and HO-1 proteins, and aggravated AAI-induced apoptosis. In contrast, overexpression of APE1 promoted the expression of Nrf2 and HO-1, and alleviated AAI-induced apoptosis and renal injury. Targeting APE1 could be an effective therapeutic strategy for treating AAI nephrotoxicity.
TOXICOLOGY MECHANISMS AND METHODS
(2023)
Article
Biochemistry & Molecular Biology
Yu Wang, Zhihui Liu, Jun Ma, Qingyang Xv, Hongxin Gao, Hang Yin, Ge Yan, Xiaowen Jiang, Wenhui Yu
Summary: This study investigated the potential of lycopene in attenuating aristolochic acid-induced chronic kidney disease. Results showed that lycopene activated antioxidant signaling pathways, inhibited inflammatory response and apoptosis, and alleviated renal injury in mice.
Article
Cell & Tissue Engineering
Yuanjun Yang, Xiaodong Geng, Kun Chi, Chao Liu, Ran Liu, Xiangmei Chen, Quan Hong, Guangyan Cai
Summary: This study demonstrated that ultrasound-guided injection of MSCs into the greater omentum surrounding the kidney improved renal function, attenuated kidney injury, and mitigated renal interstitial fibrosis and inflammatory responses, making it a potentially safe and effective therapy for chronic kidney disease.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Oncology
Samrat Das, Shefali Thakur, Michael Korenjak, Viktoriya S. Sidorenko, Felicia Fei-Lei Chung, Jiri Zavadil
Summary: In this Review, Das et al. describe the evidence for aristolochic acid as a potent carcinogen and explore the impact of public health measures on preventing aristolochic acid-linked cancers and nephropathy, with a call to action for the implementation of further preventative measures.
NATURE REVIEWS CANCER
(2022)
Article
Immunology
N. Garrido-Mesa, J-H. Schroeder, E. Stolarczyk, A. L. Gallagher, J. W. Lo, C. Bailey, L. Campbell, V. Sexl, T. T. MacDonald, J. K. Howard, R. K. Grencis, N. Powell, G. M. Lord
MUCOSAL IMMUNOLOGY
(2019)
Article
Surgery
Caragh P. Stapleton, Andreas Heinzel, Weihua Guan, Peter J. van der Most, Jessica van Setten, Graham M. Lord, Brendan J. Keating, Ajay K. Israni, Martin H. de Borst, Stephan J. L. Bakker, Harold Snieder, Michael E. Weale, Florence Delaney, Maria P. Hernandez-Fuentes, Roman Reindl-Schwaighofer, Rainer Oberbauer, Pamala A. Jacobson, Patrick B. Mark, Fiona A. Chapman, Paul J. Phelan, Claire Kennedy, Donal Sexton, Susan Murray, Alan Jardine, Jamie P. Traynor, Amy Jayne McKnight, Alexander P. McKnight, Laura J. Smyth, William S. Oetting, Arthur J. Matas, Roslyn B. Mannon, David P. Schladt, David N. Ikle, Gianpiero L. Cavalleri, Peter J. Conlon, Christopher Franklin, Irene Rebollo-Mesa, Jennifer Mollon, Esperanza Perucha, Richard Borrows, Catherine Byrne, Brendan Clarke, Menna Clatworthy, John Feehally, Susan Fuggle, Sarah A. Gagliano, Sian Griffin, Abdul Hammad, Robert Higgins, Mary Keogan, Timothy Leach, Iain MacPhee, James Marsh, Peter Maxwell, William McKane, Adam McLean, Charles Newstead, Titus Augustine, Steve Powis, Peter Rowe, Neil Sheerin, Ellen Solomon, Henry Stephens, Raj Thuraisingham, Richard Trembath, Peter Topham, Steven H. Sacks, Peter Conlon, Gerhard Opelz, Nicole Soranzo, J. Michael Cecka, John Connett, Fernando G. Cosio, Robert Gaston, Sita Gourishankar, Joseph P. Grande, Lawrence Hunsicker, Bertram Kasiske, David Rush
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Article
Gastroenterology & Hepatology
Rimma Goldberg, Cristiano Scotta, Dianne Cooper, Einat Nissim-Eliraz, Eilam Nir, Scott Tasker, Peter M. Irving, Jeremy Sanderson, Paul Lavender, Fowzia Ibrahim, Jonathan Corcoran, Toby Prevost, Nahum Y. Shpigel, Federica Marelli-Berg, Giovanna Lombardi, Graham M. Lord
Article
Medicine, Research & Experimental
Nelomi Anandagoda, Joanna C. D. Willis, Arnulf Hertweck, Luke B. Roberts, Ian Jackson, M. Refik Gokmen, Richard G. Jenner, Jane K. Howard, Graham M. Lord
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Medicine, General & Internal
Sofia Christakoudi, Manohursingh Runglall, Paula Mobillo, Tjir-Li Tsui, Claire Duff, Clara Domingo-Vila, Yogesh Kamra, Florence Delaney, Rosa Montero, Anastasia Spiridou, Theodoros Kassimatis, Sui Phin-Kon, Beatriz Tucker, Christopher Farmer, Terry B. Strom, Graham M. Lord, Irene Rebollo-Mesa, Daniel Stahl, Steven Sacks, Maria P. Hernandez-Fuentes, Paramit Chowdhury
Article
Pharmacology & Pharmacy
Efta Triastuti, Ardiansah Bayu Nugroho, Min Zi, Sukhpal Prehar, Yulia Suciati Kohar, Thuy Anh Bui, Nicholas Stafford, Elizabeth J. Cartwright, Sabu Abraham, Delvac Oceandy
BRITISH JOURNAL OF PHARMACOLOGY
(2019)
Article
Multidisciplinary Sciences
Marija Zaric, Pablo D. Becker, Catherine Hervouet, Petya Kalcheva, Andor Doszpoly, Negin Blattman, Lauren A. O'Neill, Barbara Ibarzo Yus, Clement Cocita, Sung-Yun Kwon, Andrew H. Baker, Graham M. Lord, Linda S. Klavinskis
NATURE COMMUNICATIONS
(2019)
Letter
Gastroenterology & Hepatology
Rimma Goldberg, Graham M. Lord
Article
Medicine, General & Internal
Amit Kaura, Vasileios Panoulas, Benjamin Glampson, Jim Davies, Abdulrahim Mulla, Kerrie Woods, Joe Omigie, Anoop D. Shah, Keith M. Channon, Jonathan N. Weber, Mark R. Thursz, Paul Elliott, Harry Hemingway, Bryan Williams, Folkert Asselbergs, Michael O'Sullivan, Rajesh Kharbanda, Graham M. Lord, Narbeh Melikian, Riyaz S. Patel, Divaka Perera, Ajay M. Shah, Darrel P. Francis, Jamil Mayet
BMJ-BRITISH MEDICAL JOURNAL
(2019)
Article
Gastroenterology & Hepatology
Jennie N. Clough, Omer S. Omer, Scott Tasker, Graham M. Lord, Peter M. Irving
Article
Gastroenterology & Hepatology
Nick Powell, Eirini Pantazi, Polychronis Pavlidis, Anastasia Tsakmaki, Katherine Li, Feifei Yang, Aimee Parker, Carmen Pin, Domenico Cozzetto, Danielle Minns, Emilie Stolarczyk, Svetlana Saveljeva, Rami Mohamed, Paul Lavender, Behdad Afzali, Jonathan Digby-Bell, Tsui Tjir-Li, Arthur Kaser, Joshua Friedman, Thomas T. MacDonald, Gavin A. Bewick, Graham M. Lord
Article
Immunology
Anna Sledzinska, Maria Vila de Mucha, Katharina Bergerhoff, Alastair Hotblack, Dafne Franz Demane, Ehsan Ghorani, Ayse U. Akarca, Maria A. Marzolini, Isabelle Solomon, Frederick Arce Vargas, Martin Pule, Masahiro Ono, Benedict Seddon, George Kassiotis, Charlotte E. Ariyan, Thomas Kom, Teresa Marafioti, Graham M. Lord, Hans Stauss, Richard G. Jenner, Karl S. Peggs, Sergio A. Quezada
Editorial Material
Biochemistry & Molecular Biology
Yingjuan Liu, Mun-kit Choy, Sabu Abraham, Gennadiy Tenin, Graeme C. Black, Bernard D. Keavney
Meeting Abstract
Biochemistry & Molecular Biology
S. C. Borland, G. Tenin, R. Monaghan, S. Williams, M. Zi, C. Wilson, S. Prehar, E. Cartwright, S. Abraham, B. Keavney
EUROPEAN JOURNAL OF HUMAN GENETICS
(2020)
Meeting Abstract
Cardiac & Cardiovascular Systems
Shona Borland, Gennadiy Tenin, Simon Williams, Richard Monaghan, Matthew Baxter, David Ray, Sabu Abraham, Bernard Keavney
