A unique array of neuroprotective effects of pyruvate in neuropathology

Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of Alzheimer's disease without reducing amyloid and tau pathology

(2015) Elisa Isopi et al.   NEUROBIOLOGY OF DISEASE

Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis

(2014) S. A. Andrabi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures

(2013) Kristina A. Simeone et al.   EXPERIMENTAL NEUROLOGY

Oxidative stress, DNA damage, and the telomeric complex as therapeutic targets in acute neurodegeneration

(2013) Joshua A. Smith et al.   NEUROCHEMISTRY INTERNATIONAL

Metabolic Dysfunction in Alzheimers Disease and Related Neurodegenerative Disorders

(2012) Huan Cai et al.   Current Alzheimer Research

NAD+ Metabolism and NAD+-Dependent Enzymes: Promising Therapeutic Targets for Neurological Diseases

(2012) Yingxin Ma et al.   CURRENT DRUG TARGETS

Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease

(2012) Misha Zilberter et al.   JOURNAL OF NEUROCHEMISTRY

Activation of PARP by Oxidative Stress Induced by β-Amyloid: Implications for Alzheimer’s Disease

(2012) Rosella Abeti et al.   NEUROCHEMICAL RESEARCH

The dynamic regulation of NAD metabolism in mitochondria

(2012) Liana Roberts Stein et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Effect of Glutamate and Blood Glutamate Scavengers Oxaloacetate and Pyruvate on Neurological Outcome and Pathohistology of the Hippocampus after Traumatic Brain Injury in Rats

(2011) Alexander Zlotnik et al.   ANESTHESIOLOGY

β-amyloid activates PARP causing astrocytic metabolic failure and neuronal death

(2011) Rosella Abeti et al.   BRAIN

A perfect storm: Converging paths of epilepsy and Alzheimer’s dementia intersect in the hippocampal formation

(2011) Jeffrey Noebels   EPILEPSIA

Pyruvate incubation enhances glycogen stores and sustains neuronal function during subsequent glucose deprivation

(2011) Pavan K. Shetty et al.   NEUROBIOLOGY OF DISEASE

Oxidative Stress in Neurodegenerative Diseases: Mechanisms and Therapeutic Perspectives

(2011) Ailton Melo et al.   Oxidative Medicine and Cellular Longevity

Molecular and cellular mechanisms of excitotoxic neuronal death

(2010) Yan Wang et al.   APOPTOSIS

The biochemical basis for the anti-inflammatory and cytoprotective actions of ethyl pyruvate and related compounds

(2010) Kenneth K. Kao et al.   BIOCHEMICAL PHARMACOLOGY

Neuroprotective effect of pyruvate and oxaloacetate during pilocarpine induced status epilepticus in rats

(2010) Andrezza Sossai Rodrigues Carvalho et al.   NEUROCHEMISTRY INTERNATIONAL

Notice sur l'action de l'eau oxygénée sur les acides α-cétoniques et sur les dicétones 1. 2

(2010) A. F. Holleman   RECUEIL DES TRAVAUX CHIMIQUES DES PAYS-BAS ET DE LA BELGIQUE

Epilepsy and Cognitive Impairments in Alzheimer Disease

(2009) Jorge J. Palop   ARCHIVES OF NEUROLOGY

Mitochondria, oxidative stress, and temporal lobe epilepsy

(2009) Simon Waldbaum et al.   EPILEPSY RESEARCH

Amyloid  -Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy

(2009) R. Minkeviciene et al.   JOURNAL OF NEUROSCIENCE

Metabolic and Histologic Effects of Sodium Pyruvate Treatment in the Rat after Cortical Contusion Injury

(2009) Masamichi Fukushima et al.   JOURNAL OF NEUROTRAUMA

Post-ischemic brain damage: targeting PARP-1 within the ischemic neurovascular units as a realistic avenue to stroke treatment

(2008) Flavio Moroni et al.   FEBS Journal

Homeostasis of glutamate in brain fluids: An accelerated brain-to-blood efflux of excess glutamate is produced by blood glutamate scavenging and offers protection from neuropathologies

(2008) V.I. Teichberg et al.   NEUROSCIENCE