Article
Multidisciplinary Sciences
Jianbo Xiu, Jiayu Li, Zeyue Liu, Hui Wei, Caiyun Zhu, Rongrong Han, Zijing Liu, Wanwan Zhu, Yan Shen, Qi Xu
Summary: Major depressive disorder (MDD) is a prevalent and devastating mental illness. The diagnosis of MDD currently lacks reliable biomarkers. This study identified and validated a potential DNA methylation biomarker for MDD in the Chinese Han population, and investigated its functional implications, which could improve the diagnosis and treatment of MDD.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Fisheries
Ahmet Topal, Selcuk Ozdemir, Harun Arslan, Selim Comakli
Summary: Water temperature is a crucial environmental factor for fish growth and survival. High water temperature stress leads to physiological changes in the fish brain, including alterations in transcription levels and oxidative stress.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuki Tomiga, Kazuya Sakai, Song-Gyu Ra, Masaki Kusano, Ai Ito, Yoshinari Uehara, Hirokazu Takahashi, Kentaro Kawanaka, Hidenobu Soejima, Yasuki Higaki
Summary: This study found that relatively short-term running exercise can reduce anxiety-like behaviors, increase brain-derived neurotrophic factor (BDNF), and decrease neuronal nitric oxide synthase (nNOS) levels through epigenetic modifications in the brain. These effects mainly occur in the ventral hippocampal region, suggesting a potential mechanism for mood regulation via alterations in epigenetic mechanisms after a brief period of exercise.
Review
Biochemistry & Molecular Biology
Magdalena Piotrowska, Mateusz Gliwinski, Piotr Trzonkowski, Dorota Iwaszkiewicz-Grzes
Summary: Regulatory T cells (Tregs) play a critical role in the immune system by exerting suppressive functions, and disturbances in their function can lead to autoimmune dysregulation. Apart from Foxp3, other genes are involved in Tregs development and function. Epigenetic changes, specifically DNA methylation, are believed to be crucial in determining Tregs function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Karen R. Mifsud, Clare L. M. Kennedy, Silvia Salatino, Eshita Sharma, Emily M. Price, Samantha N. Haque, Andriana Gialeli, Hannah M. Goss, Polina E. Panchenko, John Broxholme, Simon Engledow, Helen Lockstone, Oscar Cordero Llana, Johannes M. H. M. Reul
Summary: GCs act through hippocampal mineralocorticoid and glucocorticoid receptors to impact gene regulatory programs related to neuronal plasticity, ciliogenesis, and behavioral adaptation. The receptors MR and GR regulate genes involved in synaptic/neuro-plasticity, cell morphology and development, behavior, and neuropsychiatric disorders. These findings suggest a crucial role of GCs in maintaining brain health and adapting to changing environments.
NATURE COMMUNICATIONS
(2021)
Article
Psychiatry
Thomas L. Athey, Can Ceritoglu, Daniel J. Tward, Kwame S. Kutten, J. Raymond DePaulo, Kara Glazer, Fernando S. Goes, John R. Kelsoe, Francis Mondimore, Caroline M. Nievergelt, Kelly Rootes-Murdy, Peter P. Zandi, J. Tilak Ratnanather, Pamela B. Mahon
Summary: Research has shown that predictors of lithium response in bipolar disorder patients are difficult to pinpoint. However, this study has demonstrated potential for using detailed neuroimaging to fill this gap. Findings suggest that there are significant anatomical differences, particularly in the left hippocampus, between lithium responders and non-responders, which may help in future investigations of neuroimaging predictors for lithium response in bipolar disorder.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Hyun Seo Lee, Aeran Kwon, Seung Hwan Lee
Summary: This study investigated the interaction effect of childhood traumatic experience and epigenetic methylation of brain-derived neurotrophic factor (BDNF), as well as the moderating effect of oxytocin receptor (OXTR) gene, on PTSD. The results showed that childhood traumatic experience significantly impacted BDNF methylation, and OXTR gene had a moderating effect on this epigenetic mechanism.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Immunology
Guopeng Yu, Jiahao Bao, Ming Zhan, Jiangyi Wang, Xinjuan Li, Xin Gu, Shangqing Song, Qing Yang, Yushan Liu, Zhong Wang, Bin Xu
Summary: This study investigated the genetic, transcriptional alterations, and prognostic value of m5C regulatory genes in prostate cancer. The findings suggest that these genes may play a role in clinical features and the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ksenia Strygina, Elena Khlestkina
Summary: Flavonoids play a crucial role in plant development and stress protection, with the biosynthesis regulated by various enzymes. Methylation may impact the expression of TaCHI genes, while differences in promoter structure of TaF3H genes can affect gene expression patterns.
Review
Health Care Sciences & Services
Anton Shkundin, Angelos Halaris
Summary: This review article comprehensively discusses the significance of single nucleotide polymorphisms (SNPs) in the brain-derived neurotrophic factor (BDNF) and BDNF antisense RNA (BDNF-AS) genes in psychiatric conditions, specifically focusing on their associations with depression, schizophrenia, and bipolar disorder. The variations in these genes, as well as their interactions with environmental factors and other genes, can alter brain structure and function, shaping vulnerability to mental health disorders.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Pradip Paul, Ravi Kumar Nadella, Somdatta Sen, Dhruva Ithal, Jayant Mahadevan, Janardhan Y. C. Reddy, Sanjeev Jain, Meera Purushottam, Biju Viswanath
Summary: The Val(G) allele of the BDNF Val66Met polymorphism is associated with the risk of bipolar disorder but does not affect the response to lithium treatment.
JOURNAL OF PSYCHOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Himanshu K. Mishra, Heather Wei, Kayla E. Rohr, Insu Ko, Caroline M. Nievergelt, Adam X. Maihofer, Paul D. Shilling, Martin Alda, Wade H. Berrettini, Kristen J. Brennand, Joseph R. Calabrese, William H. Coryell, Mark Frye, Fred Gage, Elliot Gershon, Melvin G. McInnis, John Nurnberger, Ketil J. Oedegaard, Peter P. Zandi, John R. Kelsoe, Michael J. McCarthy
Summary: Bipolar disorder (BD) is characterized by mood episodes, disrupted circadian rhythms, and gray matter reduction in the brain. Lithium, an effective pharmacotherapy for BD, has neuroprotective properties and beneficial effects on circadian rhythms that may distinguish lithium responders (Li-R) from non-responders (Li-NR). Patterns of co-expression among circadian clock and cell survival genes were found in BD patients and controls, as well as in Li-R vs. Li-NR cells. The coordination between circadian clock and cell survival genes in BD may help predict lithium response.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Xin-Yu Fan, Guang Shi, Ping Zhao
Summary: Research has shown that neonatal exposure to sevoflurane can impair learning and memory by inducing DNA methylation of specific synaptic genes, resulting in decreased expression of synaptic proteins and ultimately leading to reduced synaptic density.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Behavioral Sciences
Mina Jahandideh, Erfan Ebrahimi, Mohammad Hosein Farzaei, Ebrahim Barzegari
Summary: This study aimed to investigate the genomics underlying the enlarged volume of the hippocampus in bipolar disorder patients after long-term lithium administration. The results suggest that lithium may promote the generation of new neurons and their differentiation into neuroblasts, neurons, or microglia, leading to hippocampal enlargement. Several genes, including CCND1, LOXL2, and PRNP, were identified as being involved in the drug response and chronic effects of lithium in hippocampal cells. GSK-3β was also found to be a key hub in the pharmacogenomic network of lithium.
BRAIN AND BEHAVIOR
(2023)
Article
Agriculture, Dairy & Animal Science
Yang Yang, Wei Cong, Jie Liu, Mindie Zhao, Peirong Xu, Wanwan Han, Deyun Wang, Ruqian Zhao
Summary: Constant light exposure in early life suppresses melatonin secretion and disrupts the expression of genes related to circadian clock and BDNF/ERK pathway, leading to fear-related behaviors in chickens.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)