Article
Medicine, General & Internal
Carolina Herrera, Jennifer Serwanga, Laura Else, Lebina Limakatso, Daniel Opoka, Andrew S. Ssemata, Azure-Dee Pillay, Patricia Namubiru, Thabiso B. Seiphetlo, Geoffrey Odoch, Susan Mugaba, Portia Seatlholo, Amara Alieu, Sujan Dilly Penchala, Richard Muhumuza, Berenice Alinde, Stefan Petkov, Kyle O'Hagan, Christian Callebaut, Janet Seeley, Helen Weiss, Saye Khoo, Francesca Chiodi, Clive M. Gray, Pontiano Kaleebu, Emily L. Webb, Neil Martinson, Julie Fox, CHAPS
Summary: This study evaluated the efficacy of on-demand HIV pre-exposure prophylaxis (PrEP) for males in sub-Saharan Africa and the dosing requirement for insertive sex. The results showed that a double dose of either F/TDF or F/TAF provided protection against HIV infection in foreskin tissue and peripheral blood mononuclear cells. Further clinical evaluation of pre-coital PrEP for insertive sex is needed.
Article
Respiratory System
Alex West, Nazia Chaudhuri, Adam Barczyk, Margaret L. Wilsher, Peter Hopkins, Ian Glaspole, Tamera Jo Corte, Martina Sterclova, Antony Veale, Ewa Jassem, Marlies S. Wijsenbeek, Christopher Grainge, Wojciech Piotrowski, Ganesh Raghu, Michele L. Shaffer, Deepthi Nair, Lisa Freeman, Kelly Otto, A. Bruce Montgomery
Summary: This study evaluated the safety, tolerability, and efficacy of inhaled pirfenidone (AP01) in patients with idiopathic pulmonary fibrosis (IPF). Results showed that AP01 had fewer side effects compared to oral pirfenidone, and the 100 mg two times per day group maintained stable forced vital capacity (FVC) % predicted. This study provides evidence for further research on the value of AP01.
Article
Medicine, General & Internal
Pamela Warner, Lucy Harriet Ravenscroft Whitaker, Richard Anthony Parker, Christopher John Weir, Anne Douglas, Christian Holm Hansen, Mayank Madhra, Stephen Gilbert Hillier, Philippa Tansy Kemp Saunders, John Peter Iredale, Scott Semple, Ov Daniel Slayden, Brian Robert Walker, Hilary Octavia Dawn Critchley
Summary: This adaptive trial on HMB showed that daily dexamethasone 1.8 mg reduced menstrual blood loss, indicating that the role of dexamethasone in HMB management warrants further investigation.
Article
Medicine, General & Internal
Ingrid M. Bistervels, Andrea Buchmueller, Hanke M. G. Wiegers, Fionnuala Ni Ainle, Bernard Tardy, Jennifer Donnelly, Peter Verhamme, Anne F. Jacobsen, Anette T. Hansen, Marc A. Rodger, Maria T. DeSancho, Roman G. Shmakov, Nick van Es, Martin H. Prins, Celine Chauleur, Saskia Middeldorp
Summary: This study indicates that low-dose low-molecular-weight heparin is an appropriate dose for the prevention of recurrent venous thromboembolism during pregnancy, as it is not associated with a significantly lower risk compared to weight-adjusted intermediate-dose low-molecular-weight heparin.
Article
Endocrinology & Metabolism
Giulia Lanzolla, Elena Sabini, Marenza Leo, Francesca Menconi, Roberto Rocchi, Angela Sframeli, Paolo Piaggi, Marco Nardi, Claudio Marcocci, Michele Marino
Summary: The addition of oral atorvastatin to an ivGC regimen improved Graves' orbitopathy outcomes in patients with moderate-to-severe, active eye disease who were hypercholesterolaemic.
By 24 weeks, 51% of patients in the ST group were responders in the composite evaluation of Graves' orbitopathy, higher than the 28% in the NST group.
Future phase 3 studies are needed to confirm this association and may recruit patients regardless of low-density lipoprotein cholesterol concentration.
LANCET DIABETES & ENDOCRINOLOGY
(2021)
Article
Hematology
Georg Gelbenegger, Juergen Grafeneder, Gloria M. Gager, Jolanta M. Siller-Matula, Michael Schwameis, Bernd Jilma, Christian Schoergenhofer
Summary: This study aimed to investigate a novel prehospital treatment strategy using cangrelor to address the problem of high on-treatment platelet reactivity (HTPR) in the acute management of ST-elevation myocardial infarction (STEMI). The results showed that weight-adapted bolus infusions followed by continuous infusion of cangrelor via an IV flow regulator can effectively and significantly inhibit platelet function in healthy individuals.
THROMBOSIS JOURNAL
(2022)
Article
Oncology
Debashis Sarker, Nancy A. Dawson, Ana M. Aparicio, Tanya B. Dorff, Allan J. Pantuck, Ulka N. Vaishampayan, Lynn Henson, Lakshmi Vasist, Sumita Roy-Ghanta, Michele Gorczyca, Whitney York, Gopinath Ganji, Jerry Tolson, Johann S. de Bono
Summary: The study investigated the combination of enzalutamide and the PI3K beta inhibitor GSK2636771 in patients with PTEN-deficient mCRPC. Results demonstrated acceptable safety and tolerability of the drug combination, but limited antitumor activity was observed.
CLINICAL CANCER RESEARCH
(2021)
Article
Psychiatry
Adem T. Can, Daniel F. Hermens, Megan Dutton, Cyrana C. Gallay, Emma Jensen, Monique Jones, Jennifer Scherman, Denise A. Beaudequin, Cian Yang, Paul E. Schwenn, Jim Lagopoulos
Summary: Oral ketamine treatment for chronic suicidality showed a significant reduction in suicidal ideation after 6 weeks, with 69% of participants achieving clinical improvement within the first 6 weeks. This suggests that oral administration could be a feasible and tolerable alternative treatment option for chronic suicidality, with results consistent with IV ketamine trials.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Biology
William H. K. Schilling, Podjanee Jittamala, James A. Watson, Maneerat Ekkapongpisit, Tanaya Siripoon, Thundon Ngamprasertchai, Viravarn Luvira, Sasithorn Pongwilai, Cintia Cruz, James J. Callery, Simon Boyd, Varaporn Kruabkontho, Thatsanun Ngernseng, Jaruwan Tubprasert, Mohammad Yazid Abdad, Nattaporn Piaraksa, Kanokon Suwannasin, Pongtorn Hanboonkunupakarn, Borimas Hanboonkunupakarn, Sakol Sookprome, Kittiyod Poovorawan, Janjira Thaipadungpanit, Stuart Blacksell, Mallika Imwong, Joel Tarning, Walter R. J. Taylor, Vasin Chotivanich, Chunlanee Sangketchon, Wiroj Ruksakul, Kesinee Chotivanich, Mauro Martins Teixeira, Sasithon Pukrittayakamee, Arjen M. Dondorp, Nicholas P. J. Day, Watcharapong Piyaphanee, Weerapong Phumratanaprapin, Nicholas J. White
Summary: There is no widely accepted method for in vivo assessment of antiviral activity in SARS-CoV-2 infections. Ivermectin has been widely recommended for the treatment of COVID-19, but its clinical significance as an antiviral agent in vivo remains uncertain. The study found that high-dose ivermectin did not demonstrate measurable antiviral activity in early symptomatic COVID-19 patients.
Article
Medicine, General & Internal
A. Alvarez-Delgado, M. L. Perez Garcia, J. M. Garcia-Gonzalez, H. Iglesias de Sena, A. J. Chamorro, M. F. Lorenzo Gomez, M. Marcos, J. A. Miron-Canelo
Summary: The study aims to improve the quality of colorectal cancer screening by evaluating the ability of colonoscopy to detect adenomas. Findings suggest that male patients, longer examination times, and higher medication dosage may be associated with adenoma detection.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Bjorn Henning Gronberg, Kristin Toftaker Killingberg, Oystein Flotten, Odd Terje Brustugun, Kjersti Hornslien, Tesfaye Madebo, Seppo Wang Langer, Tine Schytte, Jan Nyman, Signe Risum, Georgios Tsakonas, Jens Engleson, Tarje Onsoien Halvorsen
Summary: The study showed that a higher radiotherapy dose of 60 Gy significantly improved survival compared to 45 Gy in the treatment of limited stage small-cell lung cancer. There were no increased toxicities observed with the higher dose, suggesting that twice-daily thoracic radiotherapy of 60 Gy could be an alternative to existing schedules.
Article
Medicine, General & Internal
Charlotte E. Coles, Joanne S. Haviland, Anna M. Kirby, Clare L. Griffin, Mark A. Sydenham, Jenny C. Titley, Indrani Bhattacharya, A. Murray Brunt, H. Y. Charlie Chan, Ellen M. Donovan, David J. Eaton, Marie Emson, Penny Hopwood, Monica L. Jefford, Sara Lightowlers, Elinor J. Sawyer, Isabel Syndikus, Yat M. Tsang, Nicola Twyman, John R. Yarnold, Judith M. Bliss, IMPORT Trial Management Grp
Summary: IMPORT HIGH trial compared the efficacy and toxicity of simultaneous integrated boost and sequential boost radiotherapy regimens. The results showed that regardless of the boost sequencing, the 5-year incidence of ipsilateral breast tumor relapse was lower than the expected 5%. Simultaneous integrated boost regimen reduced patient visits and had potential benefits.
Article
Medicine, General & Internal
Ping Li, Xuefeng Sun, Dinghua Chen, Hong-li Lin, Li Zhang, Yiqing Wu, Shuting Pan, Guangyan Cai, Xiangmei Chen
Summary: This study aims to evaluate the efficacy and safety of Roxadustat in Chinese adults with chronic kidney disease anemia. The study will include 250 Chinese participants with stage 3-5 non-dialysis dependent chronic kidney disease. The primary endpoint is the change in hemoglobin level, and secondary endpoints include the proportion of subjects achieving a target hemoglobin level and safety evaluation.
Article
Oncology
Aung Naing, Fiona Thistlethwaite, Elisabeth G. E. De Vries, Ferry A. L. M. Eskens, Nataliya Uboha, Patrick A. Ott, Patricia LoRusso, Javier Garcia-Corbacho, Valentina Boni, Johanna Bendell, Karen A. Autio, Manreet Randhawa, Greg Durm, Marta Gil-Martin, Mark Stroh, Alison L. Hannah, Hendrik-Tobias Arkenau, Alexander Spira
Summary: Probody therapeutics show potential safety and anti-tumor activity in the treatment of tumors, with low immune-related toxicity and signs of efficacy even in patients with low PD-L1 expression.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Rheumatology
Arthur G. Pratt, Stefan Siebert, Michael Cole, Deborah D. Stocken, Christina Yap, Stephen Kelly, Muddassir Shaikh, Amy Cranston, Miranda Morton, Jenn Walker, Sheelagh Frame, Wan-Fai Ng, Christopher D. Buckley, Iain B. McInnes, Andrew Filer, John D. Isaacs
Summary: This study aimed to determine the maximum tolerated dose of Seliciclib in patients with rheumatoid arthritis and to evaluate its safety and pharmacokinetics. The results showed that the maximum tolerated dose of Seliciclib was 400 mg in patients refractory to TNF blockade, and no unexpected safety concerns were identified.
LANCET RHEUMATOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
G. C. Baxter, A. Selamoglu, J. W. Mackay, S. Bond, E. Gray, F. J. Gilbert
Summary: The study aimed to compare the diagnostic performance of abbreviated magnetic resonance imaging (ABB-MRI) and full diagnostic protocol MRI (FDP-MRI) in breast cancer. Results showed comparable diagnostic performance of ABB-MRI and FDP-MRI in both screening and enriched cohorts, with no significant differences in sensitivity or specificity.
CLINICAL RADIOLOGY
(2021)
Article
Clinical Neurology
Carlo Sidore, Valeria Orru, Eleonora Cocco, Maristella Steri, Jamie R. J. Inshaw, Maristella Pitzalis, Antonella Mulas, Stuart McGurnaghan, Jessica Frau, Eleonora Porcu, Fabio Busonero, Mariano Dei, Sandra Lai, Gabriella Sole, Francesca Virdis, Valentina Serra, Fausto Poddie, Alessandro Delitala, Michele Marongiu, Francesca Deidda, Mauro Pala, Matteo Floris, Marco Masala, Suna Onengut-Gumuscu, Catherine C. Robertson, Lidia Leoni, Annapaola Frongia, Maria Rossella Ricciardi, Margherita Chessa, Nazario Olla, Mario Lovicu, Annalisa Loizedda, Andrea Maschio, Luisa Mereu, Paola Ferrigno, Nicolo Curreli, Lenuta Balaci, Francesco Loi, Liana A. P. Ferreli, Maria Grazia Pilia, Antonello Pani, Maria Giovanna Marrosu, Goncalo R. Abecasis, Stephen S. Rich, Helen Colhoun, John A. Todd, David Schlessinger, Edoardo Fiorillo, Francesco Cucca, Magdalena Zoledziewska
Summary: The study aimed to investigate the impact of the hypomorph PRF1:p.A91V g.72360387 G > A allele on multiple sclerosis (MS) and type 1 diabetes (T1D). The findings reveal that this allele is associated with increased lymphocyte levels and has opposite effects on the risk of MS and T1D.
MULTIPLE SCLEROSIS JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Maya Ghoussaini, Edward Mountjoy, Miguel Carmona, Gareth Peat, Ellen M. Schmidt, Andrew Hercules, Luca Fumis, Alfredo Miranda, Denise Carvalho-Silva, Annalisa Buniello, Tony Burdett, James Hayhurst, Jarrod Baker, Javier Ferrer, Asier Gonzalez-Uriarte, Simon Jupp, Mohd Anisul Karim, Gautier Koscielny, Sandra Machlitt-Northen, Cinzia Malangone, Zoe May Pendlington, Paola Roncaglia, Daniel Suveges, Daniel Wright, Olga Vrousgou, Eliseo Papa, Helen Parkinson, Jacqueline A. L. MacArthur, John A. Todd, Jeffrey C. Barrett, Jeremy Schwartzentruber, David G. Hulcoop, David Ochoa, Ellen M. McDonagh, Ian Dunham
Summary: Open Targets Genetics is an open-access integrative resource that aggregates human GWAS and functional genomics data to make connections between GWAS-associated loci and likely causal genes. Users can search, prioritize, and explore GWAS signals through data visualizations provided by the portal.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Multidisciplinary Sciences
Dami A. Collier, Anna De Marco, Isabella A. T. M. Ferreira, Bo Meng, Rawlings P. Datir, Alexandra C. Walls, Steven A. Kemp, Jessica Bassi, Dora Pinto, Chiara Silacci-Fregni, Siro Bianchi, M. Alejandra Tortorici, John Bowen, Katja Culap, Stefano Jaconi, Elisabetta Cameroni, Gyorgy Snell, Matteo S. Pizzuto, Alessandra Franzetti Pellanda, Christian Garzoni, Agostino Riva, Anne Elmer, Nathalie Kingston, Barbara Graves, Laura E. Mccoy, Kenneth G. C. Smith, John R. Bradley, Nigel Temperton, Lourdes Ceron-Gutierrez, Gabriela Barcenas-Morales, William Harvey, Herbert W. Virgin, Antonio Lanzavecchia, Luca Piccoli, Rainer Doffinger, Mark Wills, David Veesler, Davide Corti, Ravindra K. Gupta
Summary: The B.1.1.7 variant of SARS-CoV-2 exhibited reduced neutralization by vaccines and antibodies from recovered COVID-19 patients, with a more substantial loss seen when introducing the E484K mutation. This mutation poses a threat to the efficacy of the BNT162b2 vaccine.
Article
Multidisciplinary Sciences
Steven A. Kemp, Dami A. Collier, Rawlings P. Datir, Isabella A. T. M. Ferreira, Salma Gayed, Aminu Jahun, Myra Hosmillo, Chloe Rees-Spear, Petra Mlcochova, Ines Ushiro Lumb, David J. Roberts, Anita Chandra, Nigel Temperton, Katherine Sharrocks, Elizabeth Blane, Yorgo Modis, Kendra E. Leigh, John A. G. Briggs, Marit J. van Gils, Kenneth G. C. Smith, John R. Bradley, Chris Smith, Rainer Doffinger, Lourdes Ceron-Gutierrez, Gabriela Barcenas-Morales, David D. Pollock, Richard A. Goldstein, Anna Smielewska, Jordan P. Skittrall, Theodore Gouliouris, Ian G. Goodfellow, Effrossyni Gkrania-Klotsas, Christopher J. R. Illingworth, Laura E. McCoy, Ravindra K. Gupta
Summary: Chronic infection with SARS-CoV-2 can lead to viral evolution and increased resistance to neutralizing antibodies in immunosuppressed individuals treated with convalescent plasma. During convalescent plasma therapy, there were significant shifts in the viral population structure and sensitivity, suggesting strong selection pressure on the virus during treatment.
Article
Multidisciplinary Sciences
Katrina A. Lythgoe, Matthew Hall, Luca Ferretti, Mariateresa de Cesare, George MacIntyre-Cockett, Amy Trebes, Monique Andersson, Newton Otecko, Emma L. Wise, Nathan Moore, Jessica Lynch, Stephen Kidd, Nicholas Cortes, Matilde Mori, Rebecca Williams, Gabrielle Vernet, Anita Justice, Angie Green, Samuel M. Nicholls, M. Azim Ansari, Lucie Abeler-Dorner, Catrin E. Moore, Timothy E. A. Peto, David W. Eyre, Robert Shaw, Peter Simmonds, David Buck, John A. Todd, Thomas R. Connor, Shirin Ashraf, Ana da Silva Filipe, James Shepherd, Emma C. Thomson, David Bonsall, Christophe Fraser, Tanya Golubchik
Summary: The study found that SARS-CoV-2 infections in clinical samples in the UK are characterized by low levels of within-host diversity and a narrow bottleneck at transmission. Most variants are either lost or occasionally fixed at the point of transmission, with shared diversity not persisting.
Article
Endocrinology & Metabolism
Jamie R. J. Inshaw, Carlo Sidore, Francesco Cucca, M. Irina Stefana, Daniel J. M. Crouch, Mark I. McCarthy, Anubha Mahajan, John A. Todd
Summary: This study identified genetic regions associated with both type 1 and type 2 diabetes, with four association signals co-localising between the two diseases in opposite directions, suggesting a complex genetic relationship between them.
Article
Multidisciplinary Sciences
Bo Meng, Adam Abdullahi, Isabella A. T. M. Ferreira, Niluka Goonawardane, Akatsuki Saito, Izumi Kimura, Daichi Yamasoba, Pehuen Pereyra Gerber, Saman Fatihi, Surabhi Rathore, Samantha K. Zepeda, Guido Papa, Steven A. Kemp, Terumasa Ikeda, Mako Toyoda, Toong Seng Tan, Jin Kuramochi, Shigeki Mitsunaga, Takamasa Ueno, Kotaro Shirakawa, Akifumi Takaori-Kondo, Teresa Brevini, Donna L. Mallery, Oscar J. Charles, John E. Bowen, Anshu Joshi, Alexandra C. Walls, Laurelle Jackson, Darren Martin, Kenneth G. C. Smith, John Bradley, John A. G. Briggs, Jinwook Choi, Elo Madissoon, Kerstin B. Meyer, Petra Mlcochova, Lourdes Ceron-Gutierrez, Rainer Doffinger, Sarah A. Teichmann, Andrew J. Fisher, Matteo S. Pizzuto, Anna de Marco, Davide Corti, Myra Hosmillo, Joo Hyeon Lee, Leo C. James, Lipi Thukral, David Veesler, Alex Sigal, Fotios Sampaziotis, Ian G. Goodfellow, Nicholas J. Matheson, Kei Sato, Ravindra K. Gupta
Summary: The Omicron variant of SARS-CoV-2 has a higher affinity for ACE2 and can evade neutralizing antibodies more effectively compared to the Delta variant. A third dose of mRNA vaccine can provide enhanced protection. Omicron has lower replication in lung and gut cells and less efficiently cleaves its spike protein compared to Delta.
Article
Medicine, General & Internal
Victoria Homer, Christina Yap, Simon Bond, Jane Holmes, Deborah Stocken, Katrina Walker, Emily J. Robinson, Graham Wheeler, Sarah Brown, Samantha Hinsley, Matthew Schipper, Christopher J. Weir, Khadija Rantell, Thomas Prior, Ly-Mee Yu, John Kirkpatrick, Alun Bedding, Carrol Gamble, Piers Gaunt
Summary: This paper presents guidelines for the content of statistical analysis plans for early phase clinical trials. These guidelines specify the minimum reporting analysis requirements by providing extensions and modifications to existing guidance based on a review by various stakeholders.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Rachel Phillips, Suzie Cro, Graham Wheeler, Simon Bond, Tim P. Morris, Siobhan Creanor, Catherine Hewitt, Sharon Love, Andre Lopes, Iryna Schlackow, Carrol Gamble, Graeme MacLennan, Chris Habron, Anthony C. Gordon, Nikhil Vergis, Tianjing Li, Riaz Qureshi, Colin C. Everett, Jane Holmes, Amanda Kirkham, Clare Peckitt, Sarah Pirrie, Norin Ahmed, Laura Collett, Victoria Cornelius
Summary: This study aims to improve the communication of harm outcomes in publications of randomised controlled trials through the development of recommendations for visually presenting harm outcomes. Through a consensus study, experts in clinical trials identified and recommended 10 visualisations, along with a decision tree to assist trialists in choosing appropriate visualisations. Visualisations provide a powerful tool for communicating harm in clinical trials, offering clearer presentation of information and more informative interpretations.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Prasanti Kotagiri, Federica Mescia, Aimee L. Hanson, Lorinda Turner, Laura Bergamaschi, Ana Penalver, Nathan Richoz, Stephen D. Moore, Brian M. Ortmann, Benjamin J. Dunmore, Michael D. Morgan, Zewen Kelvin Tuong, Berthold Gottgens, Mark Toshner, Christoph Hess, Patrick H. Maxwell, Menna R. Clatworthy, James A. Nathan, John R. Bradley, Paul A. Lyons, Natalie Burrows, Kenneth G. C. Smith
Summary: Early and persistent defects in B cell subsets in COVID-19 are associated with hypoxia. Early oxygen therapy may be beneficial in correcting these immune deficiencies and improving outcomes.
Article
Multidisciplinary Sciences
Jun Wang, Prasanti Kotagiri, Paul A. Lyons, Rafia S. Al-Lamki, Federica Mescia, Laura Bergamaschi, Lorinda Turner, Michael D. Morgan, Fernando J. Calero-Nieto, Karsten Bach, Nicole Mende, Nicola K. Wilson, Emily R. Watts, Patrick H. Maxwell, Patrick F. Chinnery, Nathalie Kingston, Sofia Papadia, Kathleen E. Stirrups, Neil Walker, Ravindra K. Gupta, David K. Menon, Kieren Allinson, Sarah J. Aitken, Mark Toshner, Michael P. Weekes, James A. Nathan, Sarah R. Walmsley, Willem H. Ouwehand, Mary Kasanicki, Berthold Gottgens, John C. Marioni, Kenneth G. C. Smith, Jordan S. Pober, John R. Bradley
Summary: The increased expression of Factor V in leukocytes correlates with severe COVID-19 and T-cell lymphopenia. Anticoagulants may suppress the adaptive immune system.
Article
Endocrinology & Metabolism
Amir-Babak Sioofy-Khojine, Sarah J. Richardson, Jonathan M. Locke, Sami Oikarinen, Noora Nurminen, Antti-Pekka Laine, Kate Downes, Johanna Lempainen, John A. Todd, Riitta Veijola, Jorma Ilonen, Mikael Knip, Noel G. Morgan, Heikki Hyoty, Mark Peakman, Martin Eichmann
Summary: This study found a correlation between enteroviral infection and autoimmune diseases, as well as type 1 diabetes. The study also revealed a link between genetic predisposition and disease stage with enterovirus infection.
Article
Medicine, General & Internal
Benjamin A. Krishna, Eleanor Y. Lim, Lenette Mactavous, Paul A. Lyons, Rainer Doffinger, John R. Bradley, Kenneth G. C. Smith, John Sinclair, Nicholas J. Matheson, Paul J. Lehner, Mark R. Wills, Nyaradzai Sithole
Summary: There is currently no consensus on the diagnosis, definition, symptoms, or duration of COVID-19 illness. Given the diagnostic challenges of Long COVID, this study investigated SARS-CoV-2-specific T cell responses in patients with confirmed SARS-CoV-2 infection and/or Long COVID. The findings suggest that IL-2 release from T cells may be a sensitive and specific marker for previous SARS-CoV-2 infection, even in patients without detectable SARS-CoV-2 antibodies.
Article
Infectious Diseases
Daniel J. Cooper, Sara Lear, Laura Watson, Ashley Shaw, Mark Ferris, Rainer Doffinger, Rachel Bousfield, Katherine Sharrocks, Michael P. Weekes, Ben Warne, Dominic Sparkes, Nick K. Jones, Lucy Rivett, Matthew Routledge, Afzal Chaudhry, Katherine Dempsey, Montgomery Matson, Adil Lakha, George Gathercole, Olivia O'Connor, Emily Wilson, Orthi Shahzad, Kieran Toms, Rachel Thompson, Ian Halsall, David Halsall, Sally Houghton, Sofia Papadia, Nathalie Kingston, Kathleen E. Stirrups, Barbara Graves, Paul Townsend, Neil Walker, Hannah Stark, Daniela De Angelis, Shaun Seaman, Gordon Dougan, John R. Bradley, M. Estee Torok, Ian Goodfellow, Stephen Baker
Summary: The risk of SARS-CoV-2 infection among UK healthcare workers is highly heterogeneous and influenced by COVID-19 working location, role, age, and ethnicity. The increased risk among Black, Asian, and minority ethnic staff cannot be solely attributed to occupational factors.
JOURNAL OF INFECTION
(2022)