Article
Multidisciplinary Sciences
Andreas Horn, Martin M. Reich, Siobhan Ewert, Ningfei Li, Bassam Al-Fatly, Florian Lange, Jonas Roothans, Simon Oxenford, Isabel Horn, Steffen Paschen, Joachim Runge, Fritz Wodarg, Karsten Witt, Robert C. Nickl, Matthias Wittstock, Gerd-Helge Schneider, Philipp Mahlknecht, Werner Poewe, Wilhelm Eisner, Ann-Kristin Helmers, Cordula Matthies, Joachim K. Krauss, Gunther Deuschl, Jens Volkmann, Andrea A. Kuhn
Summary: This study retrospectively investigated the clinical results of deep brain stimulation (DBS) for cervical and generalized dystonia in 80 patients. The researchers modeled the optimal stimulation sites based on imaging and found that the optimal treatment for cervical dystonia involved modulation of the striatopallidofugal axis, while pallidothalamic bundles were responsible for optimal treatment of generalized dystonia. Additionally, the study showed a common network substrate in the form of connectivity to the cerebellum and somatomotor cortex for both types of dystonia.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Psychology, Developmental
Amy Niego, Antonio Benitez-Burraco
Summary: Autism spectrum disorders and Williams syndrome exhibit opposite social features but share common underlying deficits. A comparative molecular approach found overlapping gene dysregulation in the blood of patients, with more dysregulated genes in Williams syndrome. These genes are involved in brain development and expressed in relevant brain areas for the etiopathogenesis of both conditions.
Article
Psychiatry
Yuji Yamada, Zui Narita, Takuma Inagawa, Yuma Yokoi, Naotsugu Hirabayashi, Aya Shirama, Kazuki Sueyoshi, Tomiki Sumiyoshi
Summary: This study compared the effects of anodal stimulation targeting the left dorsolateral prefrontal cortex (DLPFC) and left superior temporal sulcus (STS) in patients with schizophrenia on daily-living skills, neurocognition, and psychotic symptoms. The results showed that anodal stimulation of the left DLPFC improved higher level functional outcomes and neurocognition, while stimulation of the STS had a smaller effect.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Aaron Loh, David Gwun, Clement T. Chow, Alexandre Boutet, Jordy Tasserie, Jurgen Germann, Brendan Santyr, Gavin Elias, Kazuaki Yamamoto, Can Sarica, Artur Vetkas, Ajmal Zemmar, Radhika Madhavan, Alfonso Fasano, Andres M. Lozano
Summary: This article provides a comprehensive overview of studies that have used fMRI during active DBS to investigate its effects on various disorders. It discusses the stimulated brain regions, experimental designs, and insights gained from stimulation-induced fMRI responses.
Article
Clinical Neurology
Matteo Guidetti, Sara Marceglia, Aaron Loh, Irene E. Harmsen, Sara Meoni, Guglielmo Foffani, Andres M. Lozano, Elena Moro, Jens Volkmann, Alberto Priori
Summary: Adaptive deep brain stimulation (aDBS) shows promise in treating movement disorders, but its application in cognitive and psychiatric disorders remains challenging.
Review
Psychology, Developmental
Mark H. Johnson, Tony Charman, Andrew Pickles, Emily J. H. Jones
Summary: The AMEND framework aims to redefine the field of future research on neurodevelopmental disorders by proposing methods to separate early-stage disturbance markers from later developmental modifiers. Understanding how different perturbations and modifiers interact to produce phenotypic outcomes can advance both theoretical understanding and clinical approaches to developmental psychopathology in early childhood.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2021)
Review
Clinical Neurology
Laura Wehmeyer, Thomas Schueller, Jana Kiess, Petra Heiden, Veerle Visser-Vandewalle, Juan Carlos Baldermann, Pablo Andrade
Summary: The research indicates that deep brain stimulation (DBS) is effective in treating patients with treatment-refractory Tourette syndrome (TS). Different DBS targets show variations in reducing TS symptoms and secondary outcome measures, but overall outcomes are comparable.
FRONTIERS IN NEUROLOGY
(2021)
Article
Behavioral Sciences
Michal Hajduk, Amy E. Pinkham, David L. Penn, Philip D. Harvey, Noah J. Sasson
Summary: Autistic adults and those with schizophrenia demonstrate similar levels of reduced social cognitive performance at the group level, but a significant portion of both groups still exhibit normative performance. Nearly half of autistic participants performed in the normal range, while over a third of participants with schizophrenia also did, accompanied by a hostility bias not commonly found in autistic individuals. These findings challenge the assumption that difficulties in social cognition are a uniform characteristic of these clinical conditions in those without intellectual disability.
Article
Health Care Sciences & Services
Yuji Yamada, Takuma Inagawa, Yuma Yokoi, Aya Shirama, Kazuki Sueyoshi, Ayumu Wada, Naotsugu Hirabayashi, Hideki Oi, Tomiki Sumiyoshi
Summary: This study aims to investigate the effects of multi-session transcranial direct current stimulation on the superior temporal sulcus in improving social cognition deficits in patients with schizophrenia. The efficacy and safety will be evaluated through various measures including the Social Cognition Screening Questionnaire.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Substance Abuse
Sensen Song, Anna Zilverstand, Wenjun Gui, Xuefei Pan, Xiaolin Zhou
Summary: Excitatory neuromodulation targeting the dorsolateral prefrontal cortex can lead to immediate reduction in craving and consumption, as well as sustained effects during short-, mid- and long-term abstinence periods, across different populations and stimulation techniques.
Article
Psychiatry
Karin Prillinger, Stefan T. Radev, Gabriel Amador de Lara, Manfred Kloebl, Rupert Lanzenberger, Paul L. Plener, Luise Poustka, Lilian Konicar
Summary: The study aims to investigate the effects of transcranial direct current stimulation (tDCS) on ASD symptoms and their neural correlates in children and adolescents with ASD. Using a double-blind, randomized, and sham-controlled trial design, the research seeks to determine if tDCS can improve social difficulties in individuals with ASD. The results will provide insights into the variability of social impairments in ASD and the potential of tDCS as a new treatment approach.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Joan A. Camprodon, Tina Chou, Abigail A. Testo, Thilo Deckersbach, Jeremiah M. Scharf, Darin D. Dougherty
Summary: Deep Brain Stimulation (DBS) is an invasive neuromodulation technique approved for the treatment of movement disorders and obsessive-compulsive disorder. A patient with Major Depressive Disorder (MDD) who received DBS therapy developed voltage-dependent Tourette-like symptoms, leading to the diagnosis of iatrogenic voltage-dependent activation of cortico-subcortical circuits.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Johan Lundin Kleberg, Charlotte Willfors, Hanna Bjorlin Avdic, Deborah Riby, Martyna A. Galazka, Mona Guath, Ann Nordgren, Claes Strannegard
Summary: Williams syndrome (WS) is a rare genetic condition characterized by high social interest and approach motivation as well as intellectual disability and anxiety. Social feedback improves reward learning in individuals with WS but not in typically developing controls or individuals with other intellectual disabilities. Computational modeling suggests that this effect is mediated by a shift towards higher weight given to rewards and increased choice consistency.
SCIENTIFIC REPORTS
(2023)
Review
Neurosciences
Valentina D'Onofrio, Nicoletta Manzo, Andrea Guerra, Andrea Landi, Valentina Baro, Sara Maeaettae, Luca Weis, Camillo Porcaro, Maurizio Corbetta, Angelo Antonini, Florinda Ferreri
Summary: Deep brain stimulation (DBS) is a promising treatment for neurological disorders, but its mechanisms of action are not fully understood. Transcranial magnetic stimulation (TMS) combined with DBS provides a unique approach to investigate the neurophysiology of the brain. Experimental studies have shown that DBS modulates cortical excitability and plasticity, which may contribute to its therapeutic effects. However, safety concerns limit the application of the TMS-DBS approach.
Article
Psychiatry
Yuji Yamada, Kazuki Sueyoshi, Yuma Yokoi, Takuma Inagawa, Naotsugu Hirabayashi, Hideki Oi, Aya Shirama, Tomiki Sumiyoshi
Summary: This study aimed to investigate the effects of multisession tDCS targeting the superior temporal sulcus (STS) on social cognitive performance in patients with schizophrenia. The results showed significant improvements in theory of mind after multisession tDCS, which were not correlated with neurocognition or psychotic symptoms. The study also demonstrated the safety of tDCS with no serious adverse events.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Mirella Manfredi, Alice Mado Proverbio, Lucas Murrins Marques, Beatriz Ribeiro, Leticia Yumi Nakao Morello, Paulo Sergio Boggio
SOCIAL NEUROSCIENCE
(2020)
Article
Psychology, Biological
Jay J. Van Bavel, Katherine Baicker, Paulo S. Boggio, Valerio Capraro, Aleksandra Cichocka, Mina Cikara, Molly J. Crockett, Alia J. Crum, Karen M. Douglas, James N. Druckman, John Drury, Oeindrila Dube, Naomi Ellemers, Eli J. Finkel, James H. Fowler, Michele Gelfand, Shihui Han, S. Alexander Haslam, Jolanda Jetten, Shinobu Kitayama, Dean Mobbs, Lucy E. Napper, Dominic J. Packer, Gordon Pennycook, Ellen Peters, Richard E. Petty, David G. Rand, Stephen D. Reicher, Simone Schnall, Azim Shariff, Linda J. Skitka, Sandra Susan Smith, Cass R. Sunstein, Nassim Tabri, Joshua A. Tucker, Sander van der Linden, Paul van Lange, Kim A. Weeden, Michael J. A. Wohl, Jamil Zaki, Sean R. Zion, Robb Willer
NATURE HUMAN BEHAVIOUR
(2020)
Article
Psychology, Biological
Yue Huang, Jia Zhao, Manish Kumar Asthana, Kun Zuo, William Edgar Comfort, Zhan Xu
Article
Public, Environmental & Occupational Health
Emma Motrico, Rena Bina, Sara Dominguez-Salas, Vera Mateus, Yolanda Contreras-Garcia, Mercedes Carrasco-Portino, Erilda Ajaz, Gisele Apter, Andri Christoforou, Pelin Dikmen-Yildiz, Ethel Felice, Camellia Hancheva, Eleni Vousoura, Claire A. Wilson, Rachel Buhagiar, Carmen Cadarso-Suarez, Raquel Costa, Emmanuel Devouche, Ana Ganho-Avila, Diego Gomez-Baya, Francisco Gude, Eleni Hadjigeorgiou, Drorit Levy, Ana Osorio, Maria Fe Rodriguez, Sandra Saldivia, Maria Fernanda Gonzalez, Marina Mattioli, Ana Mesquita
Summary: This study aims to evaluate the impact of COVID-19 on perinatal mental health, compare the results between countries, and identify potential risk and protective factors using machine learning techniques.
Review
Psychiatry
Francisca Pacheco, Raquel Guiomar, Andre R. Brunoni, Rachel Buhagiar, Olympia Evagorou, Alba Roca-Lecumberri, Anna Poleszczyk, Mijke Lambregtse-van den Berg, Rafael A. Caparros-Gonzalez, Ana Fonseca, Ana Osorio, Mahmoud Soliman, Ana Ganho-Avila
Summary: Currently, there is insufficient research on the effectiveness, safety, and acceptability of NIBS in treating peripartum depression. While repetitive transcranial magnetic stimulation shows promising results and good acceptability in treating PPD, caution is advised during pregnancy. Evidence on the efficacy of transcranial electric stimulation mostly derives from single-arm studies, requiring further investigation.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Neurosciences
Vera Mateus, Ana Osorio, Helga O. Miguel, Sara Cruz, Adriana Sampaio
Summary: This study investigated the relationship between maternal sensitivity and infants' cortical activation patterns to touch, with findings indicating that infants of less sensitive mothers showed different neural responses when processing tactile stimuli.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2022)
Review
Endocrinology & Metabolism
Lalit Sharma, Aditi Sharma, Deepak Kumar, Manish Kumar Asthana, H. Lalhlenmawia, Ashwani Kumar, Sanjib Bhattacharyya, Deepak Kumar
Summary: Alzheimer's disease is a multifactorial disease that leads to cognitive impairments through the devastation of neurons, with proteins playing a crucial role. Efforts are being made to target proteins like amyloid precursor protein and tau protein for developing effective anti-AD therapies. The importance of proteins in the early diagnosis and treatment of AD is emphasized in current research.
METABOLIC BRAIN DISEASE
(2022)
Article
Education, Special
Mirella Manfredi, Elisabete Fernandes Rodrigues Pereira, Julia Horta Tabosa do Egito, Julia Scarano de Mendonca, Ana Alexandra Caldas Osorio
Summary: The study found that young children with ASD engage less frequently in altruistic behavior compared to those with Down syndrome. It also showed a significant negative correlation between the severity of autism symptoms and altruistic behavior in the ASD group. Nonverbal IQ level did not show significant correlations with performance in altruistic behavior tasks for either group. Overall, the study suggests that regardless of intellectual skills, the ability to engage in altruistic behavior is compromised in young children with ASD.
RESEARCH IN DEVELOPMENTAL DISABILITIES
(2021)
Article
Public, Environmental & Occupational Health
Sharmili Mitra, Anshita Singh, Sambath Rajendran Deepam, Manish Kumar Asthana
Summary: In developing countries like India, older people's acceptance and use of ICT is limited. This qualitative study explored the needs, attitudes, and perceived limitations of ICT platforms among older people. The findings suggest that psychological factors such as anxiety, motivation, interest, and self-efficacy play a role in older people's technology acceptance. User-friendly interfaces and technology training may enhance technology acceptance among older users.
HEALTH & SOCIAL CARE IN THE COMMUNITY
(2022)
Article
Education & Educational Research
Sucharita Maji, Sharmili Mitra, Manish Kumar Asthana
Summary: This research aims to explore the gender dimension of STEM in India's premier institutions. Through in-depth interviews with twenty female doctoral/postdoctoral researchers, it reveals that individual and contextual factors greatly influence their decision to pursue higher studies in STEM. Furthermore, it shows that gendering in STEM leads to self-doubt and diminished sense of belonging among the researchers.
EUROPEAN JOURNAL OF ENGINEERING EDUCATION
(2023)
Article
Psychology, Multidisciplinary
Juliana Gioia Negrao, Ana Alexandra Caldas Osorio, Rinaldo Focaccia Siciliano, Vivian Renne Gerber Lederman, Elisa Harumi Kozasa, Maria Eloisa Fama D'Antino, Anderson Tamborim, Vitor Santos, David Leonardo Barsand de Leucas, Paulo Sergio Camargo, Daniel C. Mograbi, Tatiana Pontrelli Mecca, Jose Salomao Schwartzman
Summary: This study developed a database of photos and videos of 4-to-6-year-olds expressing seven universal emotions and a neutral expression. The findings show that this database can facilitate research on early childhood recognition of facial emotions and contribute to understanding facial emotion recognition deficits in neurodevelopmental and psychiatric disorders.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Psychology, Developmental
Mirella Manfredi, Neil Cohn, Pamella Sanchez Mello, Elizabeth Fernandez, Paulo Sergio Boggio
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2020)
Article
Psychology, Multidisciplinary
Paulo Sergio Boggio, Ana Carolina Alem Giglio, Caroline Kimie Nakao, Tanja Stefanie Helga Wingenbach, Lucas Murrins Marques, Silvia Koller, June Gruber
JOURNAL OF POSITIVE PSYCHOLOGY
(2020)
Article
Psychology, Experimental
Tanja S. H. Wingenbach, Beatriz Ribeiro, Caroline Nakao, June Gruber, Paulo S. Boggio
Summary: Affiliative touch influences evaluations of affective stimuli, with receiving touch reducing negativity in negative contexts and the presence of others amplifying positivity in positive situations. Hand-squeezing and forearm-stroking have differential effects on affective image evaluations depending on the valence of the image and who provided the touch.
Article
Psychology, Multidisciplinary
Lucas Murrins Marques, Scott Clifford, Vijeth Iyengar, Graziela Vieira Bonato, Patricia Moraes Cabral, Rafaela Barreto dos Santos, Roberto Cabeza, Walter Sinnott-Armstrong, Paulo Sergio Boggio
JUDGMENT AND DECISION MAKING
(2020)