Article
Environmental Sciences
Kajsa Ugelvig Petersen, Katia Keglberg Haervig, Esben Meulengracht Flachs, Jens Peter Bonde, Christian Lindh, Karin Sorig Hougaard, Gunnar Toft, Cecilia Host Ramlau-Hansen, Sandra Sogaard Tottenborg
Summary: This study examined the impact of PFAS exposure on reproductive function in young adult males. The results showed a slight association between higher levels of PFAS and follicle-stimulating hormone (FSH) levels, but no consistent associations with semen quality and testicular volume were found.
ENVIRONMENTAL RESEARCH
(2022)
Article
Andrology
Anne Gaml-Sorensen, Maria Kongerslev Frolich, Nis Brix, Andreas Ernst, Jens Peter Ellekilde Bonde, Karin Sorig Hougaard, Sandra Sogaard Tottenborg, Pernille Jul Clemmensen, Gunnar Toft, Cecilia Host Ramlau-Hansen
Summary: This study investigated the association between sleep duration and biomarkers of male fecundity in young men, finding that maintaining a recommended sleep duration may be beneficial for reproductive health in young men.
Article
Andrology
Ludmila Osadchuk, Larisa Shantanova, Ivan Troev, Maxim Kleshchev, Alexander Osadchuk
Summary: The study compared semen quality and reproductive hormone levels in young men from different cities and ethnic groups in the Siberian region of Russia, finding significant regional and ethnic differences. Ethnicity and environment were suggested to play key roles in these differences.
Article
Endocrinology & Metabolism
Ludmila Osadchuk, Maxim Kleshchev, Alexander Osadchuk
Summary: The study found that heavy smokers among young Russian men had poorer semen quality compared to non-smokers, with reductions in sperm volume, count, concentration, and motility, and increases in sperm DNA fragmentation and teratozoospermia. Smoking also led to decreased serum and seminal zinc levels, and impaired metabolic health. The effects of smoking on reproductive function were ethnically specific, with the most significant impact observed in smoking Slavs.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Laerke Priskorn, Ulla Nordstrom Joensen, Jorgen Holm Petersen, Tina Kold Jensen, Niels Erik Skakkebaek, Niels Jorgensen
Summary: This study found familial resemblance in testis volume and serum markers of spermatogenesis between fathers and sons, suggesting an impact of paternal genetics on testicular function in the son, while highlighting the importance of other factors as well.
HUMAN REPRODUCTION
(2021)
Article
Environmental Sciences
Yangchang Zhang, Jing Wei, Chong Liu, Wangnan Cao, Zhenyu Zhang, Yufeng Li, Qiang Zeng, Shengzhi Sun
Summary: This study investigated the association between exposure to PM1 and sperm quality in Chinese men attending an infertility clinic. The results showed that exposure to PM1 was associated with decreased sperm concentration, sperm count, total motility, and progressive motility. The effects were more pronounced when exposure occurred 70-90 days before ejaculation.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Obstetrics & Gynecology
A. H. Hansen, L. Priskorn, L. S. Hansen, E. Carlsen, U. N. Joensen, F. M. Jacobsen, C. F. S. Jensen, N. Jorgensen
Summary: This study aimed to investigate whether prior testicular torsion is associated with testicular function in young men from the general population. The results showed no differences in semen parameters between men who had experienced testicular torsion and controls. However, subtle alterations in reproductive hormones were observed, with higher FSH and lower inhibin B levels in men with prior testicular torsion. Follow-up studies are needed to assess any long-term consequences for fertility.
HUMAN REPRODUCTION
(2023)
Article
Biology
Marc K. Pedersen, Elvira V. Brauner, Ann H. Hansen, Laura S. Hansen, Tina K. Jensen, Niels Jorgensen, Laerke Priskorn
Summary: In this cross-sectional study, the association between self-reported asthma and testicular function was investigated. The results showed that men with self-reported asthma had poorer testicular function, specifically lower total sperm count and borderline lower sperm concentration compared to men without asthma. However, the causality cannot be determined due to the study's design limitations.
Article
Environmental Sciences
Xiaoli Shen, Ming Zhan, Yuqing Wang, Weifeng Tang, Qianlong Zhang, Jun Zhang
Summary: This study investigates the associations between individual paraben exposure and paraben mixture with semen quality parameters. The results suggest negative associations between paraben mixture and sperm concentration, total sperm count, and sperm motility.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Multidisciplinary Sciences
Hanran Mai, Junyi Ke, Miaomiao Li, Menghua He, Yanxia Qu, Fan Jiang, Simian Cai, Yufen Xu, Lanyan Fu, Lei Pi, Huazhong Zhou, Hongyan Yu, Di Che, Xiaoqiong Gu, Jinxin Zhang, Liandong Zuo
Summary: Living environment and occupational factors can influence sperm quality. This study found that factors such as proximity to high voltage lines, substations, chemical plants, and computer use were associated with sperm quality. It is recommended that couples trying to conceive avoid exposure to these risk factors.
SCIENTIFIC REPORTS
(2023)
Article
Public, Environmental & Occupational Health
Anne Gaml-Sorensen, Nis Brix, Katia Keglberg Haervig, Christian Lindh, Sandra Sogaard Tottenborg, Karin Sorig Hougaard, Birgit Bjerre Hoyer, Andreas Ernst, Linn Hakonsen Arendt, Pernille Jul Clemmensen, Jens Peter Ellekilde Bonde, Tine Brink Henriksen, Gunnar Toft, Onyebuchi A. A. Arah, Cecilia Host Ramlau-Hansen
Summary: Maternal vitamin D levels during pregnancy may have an impact on reproductive health in male offspring, affecting testes volume and total sperm count. This study found that lower maternal vitamin D levels during pregnancy were associated with decreased testes volume and lower total sperm count in adult sons. The findings were supported by continuous models, spline plots, and instrumental variable analysis. Maternal vitamin D levels above 75 nmol/L during pregnancy may be beneficial for testes function in adult sons.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Environmental Sciences
Pan-Pan Chen, Chong Liu, Min Zhang, Yu Miao, Fei-Peng Cui, Yan-Ling Deng, Qiong Luo, Jia-Yue Zeng, Tian Shi, Ting-Ting Lu, Wen-Jun Yin, Wen-Qing Lu, Gui-Lin Yi, GaoKun Qiu, Qiang Zeng
Summary: This study investigated the association between exposure to bisphenol A (BPA), bisphenol F (BPF), bisphenol S (BPS) individually or in mixtures and semen quality among Chinese men. The results showed that higher exposure to individual BPA, BPS, and bisphenol mixtures was associated with impaired semen quality.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Obstetrics & Gynecology
Nis Brix, Anne Gaml-Sorensen, Andreas Ernst, Linn Hakonsen Arendt, Lea Lykke Harrits Lunddorf, Gunnar Toft, Sandra S. Tottenborg, Katia Keglberg Haervig, Birgit Bjerre Hoyer, Karin S. Hougaard, Jens Peter E. Bonde, Cecilia Host Ramlau-Hansen
Summary: The timing of puberty is associated with semen characteristics, testicular volume, and reproductive hormone levels.
FERTILITY AND STERILITY
(2023)
Article
Environmental Sciences
Yuting Cheng, Qiuqin Tang, Yiwen Lu, Mei Li, Yijie Zhou, Peihao Wu, Jinhui Li, Feng Pan, Xiumei Han, Minjian Chen, Chuncheng Lu, Xinru Wang, Wei Wu, Yankai Xia
Summary: This study examined the association between long-term exposure to air pollution and semen quality. The results showed that PM10, PM2.5, SO2, and NO2 were negatively associated with sperm total motility. Co-exposure to the six air pollutants also reduced sperm total motility. Additionally, PM10 exposure was found to decrease sperm DNA methylation.
ENVIRONMENTAL POLLUTION
(2022)
Article
Nutrition & Dietetics
Adi-Lukas Kurniawan, Chien-Yeh Hsu, Jane C-J Chao, Rathi Paramastri, Hsiu-An Lee, Pao-Chin Lai, Nan-Chen Hsieh, Shu-Fang Vivienne Wu
Summary: This study found that adherence to a testosterone-related dietary pattern may lead to poor testicular function in men, including lower testosterone levels and decreased sperm concentration.
Article
Psychiatry
Emily Cantio, Niels Bilenberg, Signe Monrad Norgaard, Iben Have Beck, Soren Moller, Cathriona Cantio, Tina Kold Jensen, Nicoline Bebe Mortensen, Asta Rasmussen, Henrik Boye Thybo Christesen
Summary: This study investigates the association between blood concentrations of serum 25-hydroxyvitamin D at different time points and intelligence quotient score at the age of 7, and explores potential differences in the association based on child sex.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Maria Skaalum Petersen, Laura Perez-Alos, Jose Juan A. Armenteros, Cecilie B. Hansen, Jogvan Pall Fjallsbak, Solrun Larsen, Johanna L. Hansen, Ida Jarlhelt, Marnar F. Kristiansen, Frioa Vio Streym, Bjarni A. Steig, Debes H. Christiansen, Lars F. Moller, Marin Strom, Guorio Andorsdottir, Shahin Gaini, Pal Weihe, Peter Garred
Summary: This nationwide longitudinal study investigated long-term humoral immunity to SARS-CoV-2. After 15 months, 94% of individuals still had detectable antibodies, mainly IgG, and 92% had detectable neutralizing antibodies. The strength of the antibody response was influenced by smoking and hospitalization, with lower IgG levels in smokers and higher levels in hospitalized individuals. Antibody stability over time was mainly associated with male sex and older age with higher initial levels but more marked decrease.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Andrology
Nina Morup, Ailsa Maria Main, Niels Jorgensen, Gedske Daugaard, Anders Juul, Kristian Almstrup
Summary: This study is the first to report the identification of microbiome species in the seminal plasma of men with TGCT and GCNIS-only, and has found some species differences that may be involved in the pathogenesis of TGCTs. Further studies are needed to confirm these findings.
Article
Oncology
Julie Abildgaard, Hein Vincent Stroomberg, A. Kirstine Bang, Jakob Albrethsen, Laura Smedegaard Kruuse, Anders Juul, Klaus Brasso, Andreas Roder, Niels Jorgensen
Summary: Men with high-risk, non-metastatic prostate cancer receive adjuvant androgen deprivation therapy (ADT) for at least 2 years according to Danish guidelines. It remains unclarified if patients regain the function of the pituitary-testis axis after cessation of ADT. Our study investigated the function of the pituitary-testis axis following adjuvant ADT and found that persistent testosterone deficiency (TD) is a common long-term consequence, equally distributed between pituitary and testicular dysfunction. The study emphasizes the necessity for systematic follow-up of full pituitary-testis axis function in patients receiving adjuvant ADT.
ENDOCRINE-RELATED CANCER
(2023)
Correction
Environmental Sciences
Annelise Blomberg, Jann Mortensen, Pal Weihe, Philippe Grandjean
ENVIRONMENTAL HEALTH
(2023)
Article
Clinical Neurology
Eva-Juliane Vollstedt, Susen Schaake, Katja Lohmann, Shalini Padmanabhan, Alexis Brice, Suzanne Lesage, Christelle Tesson, Marie Vidailhet, Isabel Wurster, Faycel Hentati, Anat Mirelman, Nir Giladi, Karen Marder, Cheryl Waters, Stanley Fahn, Meike Kasten, Norbert Bruggemann, Max Borsche, Tatiana Foroud, Eduardo Tolosa, Alicia Garrido, Grazia Annesi, Monica Gagliardi, Maria Bozi, Leonidas Stefanis, Joaquim J. Ferreira, Leonor Correia Guedes, Micol Avenali, Simona Petrucci, Lorraine Clark, Ekaterina Y. Fedotova, Natalya Y. Abramycheva, Victoria Alvarez, Manuel Menendez-Gonzalez, Silvia Jesus Maestre, Pilar Gomez-Garre, Pablo Mir, Andrea Carmine Belin, Caroline Ran, Chin-Hsien Lin, Ming-Che Kuo, David Crosiers, Zbigniew K. Wszolek, Owen A. Ross, Joseph Jankovic, Kenya Nishioka, Manabu Funayama, Jordi Clarimon, Caroline H. Williams-Gray, Marta Camacho, Mario Cornejo-Olivas, Luis Torres-Ramirez, Yih-Ru Wu, Guey-Jen Lee-Chen, Ana Morgadinho, Teeratorn Pulkes, Pichet Termsarasab, Daniela Berg, Gregor Kuhlenbaumer, Andrea A. Kuhn, Friederike Borngraeber, Giuseppe de Michele, Anna De Rosa, Alexander Zimprich, Andreas Puschmann, George D. Mellick, Jolanta Dorszewska, Jonathan Carr, Rosangela Ferese, Stefano Gambardella, Bruce Chase, Katerina Markopoulou, Wataru Satake, Tatsushi Toda, Malco Rossi, Marcelo Merello, Timothy Lynch, Diana A. Olszewska, Shen-Yang Lim, Azlina Ahmad-Annuar, Ai Huey Tan, Bashayer Al-Mubarak, Hasmet Hanagasi, Dariusz Koziorowski, Sibel Ertan, Gencer Genc, Patricia de Carvalho Aguiar, Melinda Barkhuizen, Marcia M. G. Pimentel, Rachel Saunders-Pullman, Bart van de Warrenburg, Susan Bressman, Mathias Toft, Silke Appel-Cresswell, Anthony E. Lang, Matej Skorvanek, Agnita J. W. Boon, Rejko Kruger, Esther M. Sammler, Vitor Tumas, Bao-Rong Zhang, Gaetan Garraux, Sun Ju Chung, Yun Joong Kim, Juliane Winkelmann, Carolyn M. Sue, Eng-King Tan, Joana Damasio, Peter Klivenyi, Vladimir S. Kostic, David Arkadir, Mika Martikainen, Vanderci Borges, Jens Michael Hertz, Laura Brighina, Mariana Spitz, Oksana Suchowersky, Olaf Riess, Parimal Das, Brit Mollenhauer, Emilia M. Gatto, Maria Skaalum Petersen, Nobutaka Hattori, Ruey-Meei Wu, Sergey N. Illarioshkin, Enza Maria Valente, Jan O. Aasly, Anna Aasly, Roy N. Alcalay, Avner Thaler, Matthew J. Farrer, Kathrin Brockmann, Jean-Christophe Corvol, Christine Klein
Summary: Through a worldwide online survey, we established an international cohort of individuals with PD-linked variants, providing harmonized and quality-controlled clinical and genetic data for each participant and promoting collaboration among researchers in the field of monogenic PD.
MOVEMENT DISORDERS
(2023)
Article
Andrology
Laura Smidt Hansen, Laerke Priskorn, Stine A. Holmboe, Tina Kold Jensen, Ann Holm Hansen, Anna-Maria Andersson, Niels Jorgensen
Summary: This study found an association between testicular function and markers of metabolic and cardiovascular health in young men. Reproductive hormone levels and semen quality may serve as early biomarkers of cardiovascular health in healthy men.
Article
Biology
Marc K. Pedersen, Elvira V. Brauner, Ann H. Hansen, Laura S. Hansen, Tina K. Jensen, Niels Jorgensen, Laerke Priskorn
Summary: In this cross-sectional study, the association between self-reported asthma and testicular function was investigated. The results showed that men with self-reported asthma had poorer testicular function, specifically lower total sperm count and borderline lower sperm concentration compared to men without asthma. However, the causality cannot be determined due to the study's design limitations.
Article
Medicine, General & Internal
Rune Holt, Sam Kafai Yahyavi, Ireen Kooij, Christine Hjorth Andreassen, Anna-Maria Andersson, Anders Juul, Niels Jorgensen, Martin Blomberg Jensen
Summary: This study investigated the role of circulating AMH in men and found that low serum AMH is associated with severely impaired gonadal function. Vitamin D supplementation had no effect on serum AMH.
Article
Public, Environmental & Occupational Health
Nina Vogel, Hanne Frederiksen, Rosa Lange, Niels Jorgensen, Holger M. Koch, Till Weber, Anna-Maria Andersson, Marike Kolossa-Gehring
Summary: It has been observed over the past 25 years that exposure to certain phthalates can have negative effects on human health, such as disrupting the endocrine system. As a result, the EU implemented regulations which led to a decrease in production of restricted phthalates and an increase in the production of substitutes. A recent study examined the impact of these regulations on exposure patterns in two European populations.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Pediatrics
Philippe Grandjean, Yu-Hsuan Shih, Louise Helskov Jorgensen, Flemming Nielsen, Pal Weihe, Esben Budtz-Jorgensen
Summary: A study found that early exposure to perfluoroalkyl substances (PFASs) was associated with lower resistin concentrations at the age of 9, suggesting that infancy may be a vulnerable time window for metabolic programming affected by PFAS exposure.
PEDIATRIC RESEARCH
(2023)
Article
Nutrition & Dietetics
Kamil Demircan, Richard Christian Jensen, Thilo Samson Chillon, Tina Kold Jensen, Qian Sun, Steen Joop Bonnema, Julian Hackler, Tim I. M. Korevaar, Dorte Glintborg, Lutz Schomburg, Marianne Skovsager Andersen
Summary: This study found that low serum selenium levels during pregnancy, particularly low selenoprotein P (SELENOP) and glutathione peroxidase 3 (GPX3) activity, were associated with an increased risk of gestational diabetes mellitus (GDM) and large for gestational-age offspring. Offering selenium status assessment during pregnancy can identify high-risk women for GDM who may benefit from selenium substitution.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Obstetrics & Gynecology
Camilla V. B. Palm, Anja F. Dreyer, Henriette Boye, Jan S. Jorgensen, Chunsen Wu, Frederik D. Hojsager, Tina K. Jensen, Dorte Glintborg, Marianne S. Andersen
Summary: This study found associations between maternal testosterone levels and birth anthropometrics in offspring. Higher levels of maternal testosterone were linked to lower birth weight, length, and abdominal circumference in boys, but no associations were found in girls.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Environmental Sciences
Valentina Rosolen, Elisa Giordani, Marika Mariuz, Maria Parpinel, Vicente Mustieles, Liese Gilles, Eva Govarts, Laura Rodriguez Martin, Kirsten Baken, Greet Schoeters, Ovnair Sepai, Eva Sovcikova, Lucia Fabelova, Jiri Kohoutek, Tina Kold Jensen, Adrian Covaci, Maarten Roggeman, Lisa Melymuk, Jana Klanova, Argelia Castano, Marta Esteban Lopez, Fabio Barbone
Summary: The knowledge about the effects of organophosphate flame retardants on children's neurodevelopment is limited. This research aimed to evaluate the association between exposure to these flame retardants and children's neurodevelopment. The study found a small, negative trend between neurodevelopment and exposure to BDCIPP and DPHP, but the evidence is limited. Further investigations are needed to explore the timing of exposure and the effect of other metabolites.
Article
Nutrition & Dietetics
Herborg Liggjasardottir Johannesen, Stig Andersen, Stine Linding Andersen, Kari Rubek Nielsen, Pal Weihe, Maria Skaalum Petersen, Anna Sofia Veyhe
Summary: Iodine nutrition is critical for human health. This study focused on iodine nutrition among teenagers in the Faroe Islands, where younger generations tend to abandon local foods. The study found that Faroese teenagers were iodine-replete, but the changing dietary habits emphasize the need for continuous monitoring and surveying of iodine nutrition and deficiency disorders.
JOURNAL OF NUTRITIONAL SCIENCE
(2023)
