Article
Rheumatology
Tsai-Hung Yen, Yun-Wen Chen, Tsu-Yi Hsieh, Yi-Ming Chen, Wen-Nan Huang, Yi-Hsing Chen, Hsin-Hua Chen
Summary: This study aimed to assess the incidence and risk factors of major adverse cardiovascular events (MACEs) in patients with systemic sclerosis (SSc). A nationwide cohort study was conducted in Taiwan, including 1379 SSc patients and 2758 non-SSc individuals. The study found that SSc was associated with increased risk of myocardial infarction and peripheral arterial occlusion disease, but not of ischaemic stroke. Age, gender, residential area, valvular heart disease, rheumatoid arthritis, and the use of clopidogrel and aspirin were identified as independent risk factors for MACEs in SSc patients. The findings of this study are clinically significant in understanding the risk factors for MACEs in SSc patients.
Article
Critical Care Medicine
Federico C. Angriman, Laura R. Rosella, Patrick T. Lawler, Dennis M. Ko, Claudio Martin, Hannah C. Wunsch, Damon Scales
Summary: This study identified risk factors for major cardiovascular events in adult sepsis survivors, including age, sex, diabetes, hypertension, atrial fibrillation, chronic kidney disease, and sepsis characteristics. These findings have important implications for future research.
CRITICAL CARE MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Dae Young Cheon, Kyungdo Han, Ye Seul Yang, Yerim Kim, Sang-Hwa Lee, Chulho Kim, Jong-Hee Sohn, Mi Sun Oh, Byung-Chul Lee, Minwoo Lee, Kyung-Ho Yu
Summary: This study found a significant association between migraines and major cardiovascular events, including myocardial infarction, ischemic stroke, and cardiovascular death, in individuals with type 2 diabetes. The presence of aura symptoms in migraines further increased the risk of myocardial infarction.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Critical Care Medicine
Federico Angriman, Laura C. Rosella, Patrick R. Lawler, Dennis T. Ko, Hannah Wunsch, Damon C. Scales
Summary: Adult sepsis survivors experience an increased risk of major cardiovascular events compared to survivors of a non-sepsis hospitalization.
INTENSIVE CARE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Chan Soon Park, Eue-Keun Choi, Kyung-Do Han, Hyo-Jeong Ahn, Soonil Kwon, So-Ryoung Lee, Seil Oh, Gregory Y. H. Lip
Summary: This study investigated the association between mental disorders and the risk of myocardial infarction (MI) and ischaemic stroke (IS) in young patients. The results showed that patients with mental disorders had a higher risk of MI and IS. Prevention efforts should be made to reduce cardiovascular diseases in these patients.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Chinmay Sharma, Tejas P. Singh, Shivshankar Thanigaimani, Domenico Nastasi, Jonathan Golledge
Summary: This study assessed the incidence rate of major adverse cardiovascular events (MACE) in patients with unrepaired abdominal aortic aneurysm (AAA) and their association with modifiable risk factors (diabetes, hypertension) and medication use (aspirin, statins). The study found a high incidence of cardiovascular death, myocardial infarction (MI), and stroke in patients with unrepaired AAA, but the prescription rate of preventive medication was suboptimal. Therefore, greater emphasis should be placed on secondary prevention measures in this population.
Article
Hematology
Avi Leader, Noa Dagan, Noam Barda, Idan Goldberg, Pia Raanani, Galia Spectre, Ran Balicer, Anat Gafter-Gvili
Summary: The study found an increased risk of undiagnosed cancer at 12 months after arterial thrombotic events (ATE), especially in patients without documented vascular risk factors or pre-existing cardiovascular disease. The relative risk of cancer was high in all subgroups, with the highest hazard ratio observed in patients without cardiovascular risk factors.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Oncology
Peter H. Asdahl, Jens Sundboll, Kasper Adelborg, Thomas B. Rasmussen, Anouchka M. Seesaghur, Rohini K. Hernandez, Henrik T. Sorensen, Alma B. Pedersen
Summary: This study found that cancer patients with bone metastases have a significant risk of developing cardiovascular events, with VTE having the highest incidence. Any cardiovascular event occurrence was strongly associated with increased mortality rates within 5 years, especially among lung cancer patients with bone metastases.
Article
Pharmacology & Pharmacy
Linda B. Ou, Laurent Azoulay, Pauline Reynier, Robert W. Platt, Sarah Yoon, Roland Grad, Kristian B. Filion
Summary: The study found that short-term use of tramadol, compared with codeine, did not increase the risk of cardiac events among patients with non-cancer pain.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Tiberiu A. Pana, Mamas A. Mamas, Nicholas J. Wareham, Kay-Tee Khaw, Dana K. Dawson, Phyo K. Myint
Summary: This study aims to understand the sex-specific lifetime trajectories of different heart and circulatory disorders and their relationship with death from heart disease. The results of the study show that men have a higher lifetime risk of heart and circulatory disorders compared with women. Men are more likely to experience myocardial infarction as the first manifestation, while women are more likely to develop atrial fibrillation and stroke after a certain age. The excess risk of death from heart disease observed in men with pre-existing heart disease is attenuated compared with those free of heart disease at baseline. In conclusion, our study highlights the marked sex disparities in heart disease and death over the very long-term, emphasizing the need for tailored heart disease prevention efforts for both men and women.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Psychiatry
Regina Prigge, Sarah H. Wild, Caroline A. Jackson
Summary: This large prospective cohort study aimed to investigate the associations between depression, low socioeconomic status (SES), and the risk of major cardiovascular events (MCVE). The study found that depression, low education, high deprivation, and low income were individually associated with increased risks of MCVE. Depression was associated with increased risks of MCVE in individuals with both high and low SES, with particularly high risks among those living in areas of high deprivation.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2022)
Article
Medicine, General & Internal
Raquel Martin-Iguacel, Mari Carmen Vazquez-Friol, Joaquin Burgos, Andreu Bruguera, Juliana Reyes-Uruena, Sergio Moreno-Fornes, Jordi Aceiton, Yesika Diaz, Pere Domingo, Maria Saumoy, Hernando Knobel, David Dalmau, Beatriz Borjabad, Isik Somuncu Johansen, Jose M. Miro, Jordi Casabona, Josep M. Llibre
Summary: It remains unclear whether late HIV presenters have a higher risk of cardiovascular disease compared to those diagnosed early. This study found that late presenters without prior cardiovascular disease did not have an increased risk of incident cardiovascular events following ART initiation compared to non-late presenters.
FRONTIERS IN MEDICINE
(2023)
Article
Endocrinology & Metabolism
Yo Nam Jang, Jun Hyeok Lee, Jin Sil Moon, Dae Ryong Kang, Seong Yong Park, Jerim Cho, Jang-Young Kim, Ji Hye Huh
Summary: A newly developed continuous MS score specifically for the Korean population has been found to be an independent predictor of ischemic stroke and MI in Korean middle-aged adults. The MS score showed superior model fitness and performance in predicting CV events compared to conventional metabolic syndrome diagnostic criteria (ATP-III).
DIABETES & METABOLISM JOURNAL
(2021)
Article
Clinical Neurology
Yoo Hyun Um, Kyung-Do Han, Tae-Won Kim, Jong-Hyun Jeong, Seung-Chul Hong, Ho-Jun Seo
Summary: In patients with type 2 diabetes, panic disorder may not increase the risk of future myocardial infarction (MI) and stroke, but it may increase the risk of death. For the age group of 40-64 years, the panic disorder group had a higher risk of stroke compared to the non-panic disorder group.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Endocrinology & Metabolism
Thomas R. Berni, Christopher L. Morgan, D. Aled Rees
Summary: The study found that young women with PCOS have an increased risk of developing myocardial infarction, angina, and revascularization. Weight gain and type 2 diabetes were identified as modifiable risk factors that can be intervened upon.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Primary Health Care
Bente Kjaer Lyngsoe, Dorte Rytter, Trine Munk-Olsen, Claus Hostrup Vestergaard, Kaj Sparle Christensen, Bodil Hammer Bech
Summary: Maternal depression is associated with daily health complaints and low self-assessed health in the offspring, especially when the mother has continued depression or experiences a relapse. Girls tend to have higher prevalence of mental and somatic health complaints compared to boys.
BRITISH JOURNAL OF GENERAL PRACTICE
(2021)
Article
Behavioral Sciences
Bente Kjaer Lyngsoe, Trine Munk-Olsen, Claus Hostrup Vestergaard, Dorte Rytter, Kaj Sparle Christensen, Bodil Hammer Bech
Summary: The study shows that maternal depression is linked to increased injury risk in offspring, especially during the first year of life. Children of mothers with depression remain vulnerable to injuries even years after depression onset and treatment cessation.
BRAIN AND BEHAVIOR
(2021)
Article
Geriatrics & Gerontology
Danilo Carrozzino, Kaj Sparle Christensen, Chiara Patierno, Chiara Siri, Anna Zecchinelli, Gianni Pezzoli, Fiammetta Cosci
Summary: The study applied CLIPROM criteria to evaluate the validity, sensitivity, and utility of SCL-90-R in PD patients, finding the total score to be sensitive for screening and recommending the use of brief versions of subscales without misfitting items for assessing specific symptoms.
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2022)
Article
Psychiatry
L. K. Klastrup, M. Rosendal, M. T. Rask, K. S. Christensen, C. U. Rask
Summary: This study compared the management of functional somatic symptoms (FSS) in youths and adults in general practice and found that the prevalence of FSS was lower in youths (4.4%) compared to adults (9.0%). However, healthcare providers perceived both youths and adults with FSS as time consuming, emphasizing the need for supportive management strategies.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2022)
Article
Clinical Neurology
Kaj Sparle Christensen, Aake Packness, Henrik Schou Pedersen, Erik Simonsen
Summary: This study assessed the psychometric properties of the ten-item Anxiety Symptom Scale (ASS) using Rasch analysis. The results showed that, after modifying the scoring system, the ASS demonstrated effective measurement of anxiety symptoms. The study found no significant differential item functioning for sex, age group, and educational level. However, the total ASS was poorly targeted for the overall sample, indicating low reliability, and may be more suitable for use in clinical samples.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Oncology
Astrid Boennelykke, Henry Jensen, Lene Sofie Granfeldt Ostgard, Alina Zalounina Falborg, Anette Tarp Hansen, Kaj Sparle Christensen, Peter Vedsted
Summary: The study shows that persons with new-onset anaemia detected in general practice have a high risk of cancer, with a significantly higher risk for 'combined inflammatory iron deficiency anaemia' and 'anaemia of inflammation'. Increased awareness and action are needed for anaemia as a sign of cancer, and there is a call for research to improve initial pathway for new-onset anaemia in general practice.
Article
Clinical Neurology
Danilo Carrozzino, Kaj Sparle Christensen, Chiara Patierno, Agnieszka Wozniewicz, Stine Bjerrum Moller, Ida-Marie T. P. Arendt, Yuqun Zhang, Yonggui Yuan, Natsu Sasaki, Daisuke Nishi, Carmen Berrocal Montiel, Sara Ceccatelli, Giovanni Mansueto, Fiammetta Cosci
Summary: The assessment of psychological well-being and euthymia is becoming increasingly important in clinical psychology and psychiatry. This study aimed to evaluate the cross-cultural validity and sensitivity of different versions of the WHO-5 and ES. The findings suggest that the WHO-5 can be used for cross-cultural comparisons in international studies, and the ES can serve as a cross-cultural screening tool.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Geriatrics & Gerontology
Kazi Ishtiak-Ahmed, Xiaoqin Liu, Kaj Sparle Christensen, Christiane Gasse
Summary: This study aimed to investigate the potential off-label use of antidepressants among adults aged 65 and older. The findings showed that nearly one-third of antidepressant prescriptions redeemed by older adults in Denmark had missing or unspecified treatment indications. The study found associations between missing and unspecified indications and factors such as non-western ethnicity, female sex, lower educational attainment, older age, and hospital psychiatric diagnosis.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Psychiatry
Aake Packness, Kaj Sparle Christensen, Erik Simonsen
Summary: The purpose of this study is to examine the prevalence of anxiety disorders in a general population and its association with socioeconomic position (SEP) in a Danish context. Data analysis shows that anxiety disorder is strongly associated with SEP, especially for individuals who are temporarily out of a job or experiencing financial strain.
NORDIC JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Kasper Therman Soerensen, Kazi Ishtiak-Ahmed, Christiane Gasse, Kaj Sparle Christensen
Summary: This study investigated the association between the initiation of antidepressant treatment and public sick leave compensation (PLSC) in Denmark. The results showed that mirtazapine and mianserin were associated with the highest risk of PLSC in the year following treatment initiation, while citalopram, venlafaxine, and duloxetine were associated with increased PLSC. In contrast, paroxetine, fluoxetine, and vortioxetine were associated with a significantly lower risk of PLSC.
NORDIC JOURNAL OF PSYCHIATRY
(2023)
Article
Psychology, Applied
Danilo Carrozzino, Chiara Patierno, Claudia Pignolo, Kaj Sparle Christensen
Summary: Many studies have been conducted to investigate psychological distress, but there is still debate on how to define and measure this phenomenon. Clinimetrics, the science of clinical measurements, may offer insights on conceptualizing and assessing psychological distress. A study used Rasch analysis to validate the Symptom Checklist-90-Revised (SCL-90-R) as a measure of underlying dimensions of psychological distress. The findings suggest that the SCL-90-R total score doesn't fit the Rasch model but is reliable, and the subscales can assess specific symptoms of psychological distress.
INTERNATIONAL JOURNAL OF STRESS MANAGEMENT
(2023)
Article
Psychiatry
Aake Packness, Kaj Sparle Christensen, Erik Simonsen
Summary: This study aimed to validate the Anxiety Symptom-scale against two well-being scales and identify cut-off points for the sum score. The results showed high concordance between the Anxiety Symptom-scale and the Cantril Ladder and WHO-5. A sum score of 3-4 on the scale indicated low well-being with a sensitivity of 0.85-0.99. The Anxiety Symptom-scale is considered a sensitive and valid tool for identifying anxiety symptoms in patients with low well-being.
NORDIC JOURNAL OF PSYCHIATRY
(2023)
Article
Public, Environmental & Occupational Health
Henrik Schou Pedersen, Kaj Sparle Christensen, Anders Prior
Summary: This study aimed to assess the use of psychometric tests in Danish general practice and estimate their impact on further treatment and death by suicide. The study found considerable variation in the use of psychometric tests among general practices, with a positive association between test use and talk therapy. The use of psychometric tests was also associated with prescriptions for anxiolytics, antidementia drugs, and antidepressants.
CLINICAL EPIDEMIOLOGY
(2023)
Editorial Material
Clinical Neurology
Kazi Ishtiak-Ahmed, Kaj Sparle Christensen, Christiane Gasse
Summary: This study investigated the first-choice antidepressant selection for older adults in Denmark. The study found that over two-thirds of older adults chose alternative antidepressants, primarily escitalopram/citalopram or mirtazapine, instead of the nationally recommended sertraline. Socially disadvantaged older adults and clinically vulnerable older adults were more likely to use alternative antidepressants.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Kaj Sparle Christensen, Minna Sparle-Christensen
Summary: The study assessed and compared the construct validity of the PHQ-9 and the MDI using Rasch analysis. Both instruments showed measurement problems, but modifying the items and reducing the response categories could potentially improve their measurement capabilities.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
