Article
Biochemistry & Molecular Biology
Jin Kono, Masakatsu Ueda, Atsushi Sengiku, Sylvia O. Suadicani, Osamu Ogawa, Hiromitsu Negoro
Summary: The study suggests that urothelial Cx43 mediated ATP signaling and coordination of urothelial activity are essential for proper perception and regulation of responses to bladder distension in the animals' awake, active phase. This research highlights the significant role of Cx43 in bladder function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Zhi-Cheng Gong, Zhi-Liang Wu, Yao-An Wen, Jie-Peng Zou, Xisheng Wang, Xiaoyan Leng, Anthony J. Bleyer, Chunhua Deng, Michael P. Feloney, Yuanyuan Zhang, Shan-Chao Zhao
Summary: Male patients with bladder stones often experience sexual dysfunction and lower urinary tract symptoms, which can be significantly improved by surgical removal of the stones. Patients with BPH are more likely to have sexual dysfunction.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mafalda S. L. Aresta Branco, Alejandro Gutierrez Cruz, Mahsa Borhani Peikani, Violeta N. Mutafova-Yambolieva
Summary: The urinary bladder requires proper concentrations of extracellular ATP and other purines at receptor sites for normal functioning. Ectonucleotidases play a crucial role in dephosphorylation of ATP to ADP, AMP and ADO. The activation of metabolic pathways can restrict the release of ectonucleotidases and prevent excessive hydrolysis of ATP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Xu Li, Junwei Hu, Xuedan Zhao, Juanjuan Li, Yuelai Chen
Summary: Understanding the role of piezo channel proteins in the urinary system could lead to novel treatments for urinary system diseases. These proteins convert mechanical signals into biological signals and mutations or disruption to them may trigger diseases. Further investigations are needed to fully understand their mechanisms of action.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Neurosciences
Christopher H. Fry, Karen D. McCloskey
Summary: This passage summarizes the research on the role of ATP and purines in urinary tract physiology over the past fifty years, focusing on the modulation of urinary tract function by purines and purinergic signaling mechanisms.
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2021)
Article
Biochemistry & Molecular Biology
Jia-Fong Jhang, Han-Chen Ho, Yuan-Hsiang Hsu, Yuan-Hong Jiang, Hann-Chorng Kuo
Summary: This study found that patients with recurrent urinary tract infection (rUTI) have bladder defects and elevated urine inflammatory markers. After treatment with platelet-rich plasma (PRP) injections, some patients showed improvement in bladder defects.
Article
Food Science & Technology
Hodan Ibrahim, Jacquie Maignel, Fraser Hornby, Donna Daly, Matthew Beard
Summary: This review discusses the current evidence of BoNT/A's effect on bladder sensation, potential mechanisms by which it exerts these effects, and recent advances in understanding its action in bladder tissue.
Article
Physiology
B. Malique Jones, Gerald C. Mingin, Nathan R. Tykocki
Summary: Mast cells and degranulation of inflammatory mediators contribute to lower urinary tract symptoms. This study found that the mast cell stimulator compound 48/80 alters urinary bladder smooth muscle contractility via urothelium-dependent inflammatory pathways, independent of mast cells. These findings suggest that compound 48/80 could be used to manage inflammatory nonneurogenic bladder hyperactivity.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Article
Physiology
Mafalda S. L. Aresta Branco, Alejandro Gutierrez Cruz, Jacob Dayton, Brian A. Perrino, Violeta N. Mutafova-Yambolieva
Summary: Prior studies indicate that ATP released by the urothelium plays an important role in bladder mechanotransduction and undergoes hydrolysis during bladder filling. Experimental results show that the hydrolysis of ATP and ADP is significantly greater in distended bladders compared to non-distended bladders, while the hydrolysis of AMP remains unchanged. Furthermore, the activity of nucleotidases is also higher in the extraluminal solution from distended bladders. These findings suggest that the hydrolysis reaction during bladder filling is mechanosensitive.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alejandro Gutierrez Cruz, Mafalda S. L. Aresta Branco, Brian A. Perrino, Kenton M. Sanders, Violeta N. Mutafova-Yambolieva
Summary: Adenosine 5'-triphosphate (ATP) is released in the bladder lumen during filling to regulate bladder excitability. Increased urinary ATP is suggested as a biomarker for bladder dysfunctions including overactive bladder, interstitial cystitis, and bladder pain syndrome. Altered urinary ATP might also be associated with voiding dysfunctions linked to disease states associated with metabolic syndrome.
Article
Immunology
Nicole M. Gilbert, Valerie P. O'Brien, Chevaughn Waller, Ekatherina Batourina, Cathy Lee Mendelsohn, Amanda L. Lewis
Summary: Gardnerella, a common member of the female urinary microbiome, is associated with urological disorders in women. In a mouse model, Gardnerella inoculation leads to urothelial exfoliation and activation of pathways involved in inflammation and immunity. Bladder exposure to Gardnerella also increases susceptibility to subsequent urinary tract infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alejandro Gutierrez Cruz, Mafalda S. L. Aresta Branco, Mahsa Borhani Peikani, Violeta N. Mutafova-Yambolieva
Summary: The bladder urothelium and suburothelium/lamina propria play important roles in sensory and transducer functions, with the involvement of afferent neurons and urothelium-derived purine mediators. The effective concentrations of purines at receptor targets depend on the degradation of ATP by ectonucleotidases. This study explores the interactions between peptidergic and purinergic signaling mechanisms in the bladder and suggests that they have an impact on bladder excitability and functions by regulating the concentrations of adenine purines at effector cells in the lamina propria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Environmental
Yucheng Tian, Hang Chen, Liping Chen, Xuhan Deng, Zekun Hu, Cenchao Wang, Chaohai Wei, Guanglei Qiu, Stefan Wuertz
Summary: Glycine does not appear to be an effective carbon source for the majority of PAOs and GAOs in full-scale and lab-scale systems, and other community members do not utilize glycine under anaerobic or aerobic conditions.
Article
Physiology
B. Malique Jones, Gerald C. Mingin, Nathan R. Tykocki
Summary: Histamine can transiently contract urinary bladder smooth muscle (UBSM), but this response quickly desensitizes and does not affect bladder excitability or responses to nerve input. This desensitization is not caused by receptor internalization or histamine metabolism.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Krystyna Makowska, Piotr Lech, Mariusz Majewski, Andrzej Rychlik, Slawomir Gonkowski
Summary: This study aimed to determine the influence of various doses of BPA on the distribution pattern of VIP-positive neural structures located in the wall of the porcine urinary bladder trigone using the double-immunofluorescence method. The obtained results show that BPA influence leads to an increase in the number of both neurons and nerve fibers containing VIP in the porcine urinary bladder trigone, indicating that VIP participates in adaptive processes of the urinary bladder evoked by BPA.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Legal
Amy S. Holmes, Rachel Houston, Kyleen Elwick, David Gangitano, Sheree Hughes-Stamm
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2018)
Article
Medicine, Legal
Michelle Harrel, David Gangitano, Sheree Hughes-Stamm
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2019)
Article
Urology & Nephrology
Betsy H. Salazar, Kristopher A. Hoffman, Chuan Zhang, Yingchun Zhang, Yolanda Cruz, Timothy B. Boone, Alvaro Munoz
Article
Medicine, Legal
Jaime Solano, Leonardo Anabalon, Sylvia Figueroa, Cristian Lizama, Luis Chavez Reyes, David Gangitano
Article
Medicine, Legal
Xiangpei Zeng, Kyleen Elwick, Carrie Mayes, Maiko Takahashi, Jonathan L. King, David Gangitano, Bruce Budowle, Sheree Hughes-Stamm
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2019)
Article
Urology & Nephrology
Nancy Mirto-Aguilar, Jose L. Palacios, Alvaro Munoz, Margarita Juarez, Yolanda Cruz
NEUROUROLOGY AND URODYNAMICS
(2019)
Article
Medicine, Legal
Madeline G. Roman, David Gangitano, Rachel Houston
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2019)
Article
Medicine, Legal
Blake Young, Madeline G. Roman, Bobby LaRue, David Gangitano, Rachel Houston
Article
Medicine, Legal
Jaime Solano, Leonardo Anabalon, Alejandra Figueroa, David Gangitano
FORENSIC SCIENCE INTERNATIONAL
(2020)
Article
Medicine, Legal
M. Di Nunzio, V. Agostini, F. Alessandrini, C. Barrot-Feixat, A. Berti, C. Bini, M. Bottinelli, E. Carnevali, B. Corradini, M. Fabbri, P. Fattorini, P. Garofano, S. Gino, A. Mameli, A. Marino, C. Previdere, C. Robino, C. Romano, P. Tozzo, A. Verzeletti, L. Buscemi, D. Gangitano, C. Di Nunzio
Summary: Cannabis sativa is the most commonly used controlled substance in Europe, with an increase in indoor cannabis crops due to new laws. A collaborative exercise was conducted to test the reliability of a 13-locus multiplex cannabis STR kit, resulting in overall genotype success ratio of 96% with minor issues observed. The exercise demonstrated the robustness and applicability of the 13-locus system for forensic cannabis DNA profiling.
FORENSIC SCIENCE INTERNATIONAL
(2021)
Article
Urology & Nephrology
Cynthia K. Gandara, Jose L. Palacios, J. Luis Quintanar, Yingchun Zhang, Xuhong Li, Alvaro Munoz
Summary: A small amount of BoNT/A injection at the epicenter of SCI could potentially attenuate the impairments on sensory and locomotive functions as well stereotyped micturition. The mechanism may involve a reduction in the release of neurotoxic neurotransmitters to improve the survival of spinal cord cells involved in micturition.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Pharmacology & Pharmacy
Leonardo Anabalon, Jaime Solano, Francisco Encina-Montoya, Marco Bustos, Alejandra Figueroa, David Gangitano
Summary: A rapid, effective, and low-cost method based on nuclear DNA and chloroplast DNA was developed to screen and detect contamination in commercial cannabis seeds. This method can serve as a quality control tool for cannabis seeds and other plant materials.
CANNABIS AND CANNABINOID RESEARCH
(2022)
Article
Medicine, Legal
Madeline G. Roman, David Gangitano, Alejandra Figueroa, Jaime Solano, Leonardo Anabalon, Rachel Houston
Article
Urology & Nephrology
Chuan Zhang, Xuhong Li, Timothy B. Boone, Yolanda Cruz, Yingchun Zhang, Alvaro Munoz
INTERNATIONAL NEUROUROLOGY JOURNAL
(2020)
Article
Genetics & Heredity
Michele Di Nunzio, Madeline Roman, Rachel Houston, Ciro Di Nunzio, David Gangitano, Carme Barrot-Feixat
FORENSIC SCIENCE INTERNATIONAL GENETICS SUPPLEMENT SERIES
(2019)