Review
Cell Biology
Andreas Bikfalvi, Joris Guyon, Thomas Daubon
Summary: Glioblastoma is a highly aggressive and vascularized malignancy. Recent studies have shown the important role of thrombospondin-1 in the development of glioblastoma.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Article
Medicine, General & Internal
Vito Andrea Capozzi, Elisa Scarpelli, Luciano Monfardini, Vincenzo Dario Mandato, Carla Merisio, Stefano Uccella, Giulio Sozzi, Marcello Ceccaroni, Vito Chiantera, Giovanna Giordano, Luigi Della Corte, Carmine Conte, Stefano Cianci, Tullio Ghi, Roberto Berretta
Summary: Borderline ovarian tumors (BOT) account for 15-20% of all epithelial ovarian tumors. This retrospective study compared patients with endophytic and exophytic growth patterns of BOT. The endophytic group had a higher early stage and less frequent peritoneal involvement compared to the exophytic group. However, recurrence rates and disease-free survival were similar between the two patterns.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
Brittany Ann Ruschkowski, Yousef Esmaeil, Kate Daniel, Chantal Gaudet, Behzad Yeganeh, David Grynspan, Robert P. Jankov
Summary: Inhibiting TSP-1-mediated TGF-beta 1 activation may be beneficial for the treatment of BPD. The study found that TSP-1 inhibited alveologenesis in neonatal rats, and increased levels of TSP-1 were observed in the lungs of infants at risk for BPD.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Jia-Li Yao, Yu-Rou Shi, Xue-Er Hu, Dai-Jun Yu, Bang-Yao Chen, Li-Jiang Wang, Xiao-Ling Xu, Meng-Lu Zhu
Summary: Androgenic alopecia (AGA) is a common form of hair loss that can have significant psychological and quality of life impacts. Exosomes, particularly stem cell-derived exosomes, have shown potential in treating AGA by repairing damaged hair follicles and promoting follicular regrowth.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sukhbir Kaur, Steven M. Bronson, Dipasmita Pal-Nath, Thomas W. Miller, David R. Soto-Pantoja, David D. Roberts
Summary: Thrombospondin-1 has diverse roles in cancer biology, including regulating angiogenesis, immune suppression, and genotoxic stress responses. Challenges remain in harnessing its therapeutic potential in cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Andreja Erman, Urska Kamensek, Urska Dragin Jerman, Mojca Pavlin, Maja Cemazar, Peter Veranic, Rok Romih
Summary: The study investigated the fate of cancer cells applied intravesically after transurethral resection of bladder tumors, revealing that these cells initially adhere to and migrate through the traumatized epithelium before reaching the basal lamina; E-cadherin and desmoplakin 1/2 were identified as potential immunohistochemical markers of tumor margins based on the labeling of various junctional proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Alicia Traughber, Gauravi M. Deshpande, Kalash Neupane, Nilam Bhandari, Mariam R. Khan, Megan R. McMullen, Shadi Swaidani, Emmanuel Opoku, Santoshi Muppala, Jonathan D. Smith, Laura E. Nagy, Kailash Gulshan
Summary: The roles of NLRP3, AIM2 inflammasomes, and Gasdermin D (GsdmD) in lung cancer progression are unclear. Using a metastatic LLC cell model, this study found that GsdmD knockout mice exhibited significantly fewer lung cancer foci, decreased metastasis, and increased median survival rate. GsdmD and IL-1 beta were detected in lung tumor tissue, indicating inflammasome activity. Conditioned media from wild-type macrophages enhanced migration and growth of LLC cells, while GsdmD(-/-) macrophages did not. Bone marrow transplantations confirmed the myeloid-specific role of GsdmD in lung cancer metastasis.
Article
Biochemistry & Molecular Biology
Tiago Ferreira, Elisabete Nascimento-Goncalves, Sara Macedo, Ines Borges, Adelina Gama, Rui M. Gil da Costa, Maria J. Neuparth, Germano Lanzarin, Carlos Venancio, Luis Felix, Isabel Gaivao, Antonieta Alvarado, Maria J. Pires, Margarida M. S. M. Bastos, Rui Medeiros, Antonio Nogueira, Lillian Barros, Isabel C. F. R. Ferreira, Eduardo Rosa, Paula A. Oliveira
Summary: The study evaluated the therapeutic properties of a hydroethanolic extract obtained from Tilia platyphyllos in HPV16-transgenic mice, showing a favorable toxicological profile in terms of kidney and liver damage. Additional studies are needed to determine the chemopreventive potential of the extract.
Review
Endocrinology & Metabolism
Yu Gu, Tung Bui, William J. Muller
Summary: Breast cancer recurrence and metastasis remain major challenges for disease treatment. Understanding the biology of dormant tumors and cancer cells is crucial for overcoming clinical obstacles. Mouse models, particularly immunocompetent transgenic models, offer versatility and potential for studying the mechanisms of dormancy and developing therapeutic strategies.
Review
Cell Biology
Hui-Jin Li, Xue Gong, Zheng-Kun Li, Wei Qin, Chun-Xia He, Lu Xing, Xin Zhou, Dong Zhao, Hui-Ling Cao
Summary: Bladder cancer is characterized by dysregulated lncRNAs, which play key roles in tumorigenesis, progression, and prognosis. These lncRNAs can serve as potential diagnostic and prognostic biomarkers for bladder cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jeehye Maeng, Kyunglim Lee
Summary: Translationally controlled tumor protein (TCTP) is a multifunctional protein that plays various roles in physiological and pathological processes, including inhibiting Na,K-ATPase. Overexpression of TCTP and inhibition of Na,K-ATPase increase cytoplasmic Ca2+ levels, leading to increased vascular contractility and hypertension. TCTP-induced hypertension also worsens the severity of atherosclerotic lesions.
Article
Immunology
Noemi Alejandra Saavedra-Avila, Paolo Dellabona, Giulia Casorati, Natacha Veerapen, Gurdyal S. Besra, Amy R. Howell, Steven A. Porcelli
Summary: A genetically modified mouse model allows for more accurate prediction of human iNKT cell responses, providing opportunities for preclinical evaluation of iNKT cell-based therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tanja Klaus, Alicia Wilson, Michael Fichter, Matthias Bros, Tobias Bopp, Stephan Grabbe
Summary: Regulatory T cells (Treg) are important for peripheral tolerance, and b(2)-integrins play a role in leukocyte migration and signaling. Loss-of-function mutations in CD18 can result in leukocyte adhesion deficiency type-1 (LAD-1) with leukocytosis and recurrent infections. This mini-review discusses the role of LFA-1 in Treg induction, maintenance, and regulatory function using various beta(2)-integrin-deficient mouse models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Clara Garcia-Vallicrosa, Juan M. Falcon-Perez, Felix Royo
Summary: The human CERS2 gene encodes a protein called CERS2, which has been found to have antitumor effects in various types of cancer, but promotes tumor growth in adenocarcinoma. This review focuses on the influence of CERS2 in bladder cancer, including its structure, activity, and the miRNAs that regulate its expression. Mechanistically, CERS2 may act as an antitumor protein through the production of long-chain ceramides, interaction with vacuolar ATPase, and inhibition of mitochondrial fission. Additionally, the expression of CERS2 in bladder cancer and its association with disease progression are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Surashri Shinde-Jadhav, Jose Joao Mansure, Roni F. Rayes, Gautier Marcq, Mina Ayoub, Rodrigo Skowronski, Ronald Kool, France Bourdeau, Fadi Brimo, Jonathan Spicer, Wassim Kassouf
Summary: Radioresistance in bladder cancer treatment is linked to the recruitment of neutrophil extracellular traps (NETs) to the tumor immune microenvironment post-radiation therapy, as demonstrated in a mouse model. Inhibition of NETs can improve radiation response, suggesting NETs as a potential therapeutic target to enhance radiation efficacy.
NATURE COMMUNICATIONS
(2021)