Article
Biochemistry & Molecular Biology
Rania Elsayed, Salwa Fayez, Laila Ahmed Rashed, Marwa Farghali, Marwa AbdelHamid, Marwa Alkaffas
Summary: This study aimed to investigate the plasma level of miRNA-155 in RRMS patients and its relationship with inflammatory and anti-inflammatory mediators. The results showed no significant difference in miRNA-155 expression between MS patients and controls, but there was a significant increase in TNF-alpha, INF-gamma, and TGF-beta levels. IL-10 levels did not differ significantly between the two groups. Furthermore, miRNA-155 had a positive correlation with TNF-alpha, INF-gamma, and iNOS, and an inverse correlation with IL-10, TGF-beta, and SMAD2.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Neurosciences
Bo Lei, Jiaxin Liu, Zhihui Yao, Yan Xiao, Xiaoling Zhang, Yueting Zhang, Jianguo Xu
Summary: The study revealed that NF-kappa B-induced upregulation of miR-146a-5p promoted oxidative stress and pyroptosis in AD-HNNs by targeting TIGAR. Knockdown of NF-kappa B or overexpression of TIGAR significantly attenuated oxidative stress and pyroptosis in AD-HHNs, while concurrent overexpression of miR-146a-5p inhibited these effects.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Karina Maciak, Angela Dziedzic, Elzbieta Miller, Joanna Saluk-Bijak
Summary: miR-155 plays a crucial role in regulating inflammation and autoimmune responses in multiple sclerosis, impacting processes such as blood-brain barrier disruption and neuropathic pain. Its dysregulation has also been linked to neuropsychiatric symptoms associated with the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Kosar Shahsavar, Ehsan Shokri, Morteza Hosseini
Summary: A new colorimetric platform based on spherical nucleic acid (SNA) and G-quadruplex DNAzymes has been developed for rapid and sensitive detection of specific miRNAs. The platform utilizes hybridization between target miRNA and capture probes to achieve detection. The method is capable of detecting miRNA-155 at concentrations as low as 0.7 nM and can be applied to real human serum samples.
Review
Neurosciences
Teresa Jover-Mengual, Jee-Yeon Hwang, Hyae-Ran Byun, Brenda L. Court-Vazquez, Jose M. Centeno, Maria C. Burguete, R. Suzanne Zukin
Summary: This article discusses the impact of inflammatory response triggered by cerebral ischemia on neuronal death and the dual role of NF-κB in that context. NF-κB may play both protective and potentially damaging roles in cerebral ischemia, leading to conflicting observations regarding its function. Further research is needed to clarify the exact role of NF-κB in mediating inflammation and neuronal death in cerebral ischemia.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Immunology
Zilong Wang, Chucun Fang, Mengting Yao, Dongwen Wu, Maga Chen, Tianting Guo, Jianwen Mo
Summary: Venous thromboembolism is a common and costly health problem. Deep-vein thrombosis can cause severe consequences. Inflammatory response is considered an important pathway for triggering venous thromboembolism, and regulating it through the NF-kappa B signaling pathway may provide new solutions for prevention and treatment of thrombosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Duo Wang, Zheng Liu, Ziyan Yan, Xinxin Liang, Xiaochang Liu, Yuhao Liu, Ping Wang, Chenjun Bai, Yongqing Gu, Ping-Kun Zhou
Summary: This study demonstrated the critical role of miR-155-5p in radiation-induced EMT and RIPF, with its regulation through the GSK-3 beta/NF-kappa B pathway. The downregulation of miR-155-5p induced EMT and contributed to RIPF formation, while ectopic expression of miR-155-5p alleviated RIPF in mice. These findings provide further insights into the regulation of RIPF and potential therapeutic targets.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Neurosciences
Pranav Mishra, Don A. Davies, Benedict C. Albensi
Summary: Post-menopausal women have a higher risk of developing Alzheimer's disease compared to men due to the decline in estrogen levels. Estrogen downregulates inflammatory cytokines in the central nervous system, providing neuroprotection against neurodegenerative diseases like AD. Neuroinflammation is associated with neurodegeneration and contributes to AD. The transcription factor NF-kappa B interacts with estrogen to modulate inflammation and influence the progression of AD. Further research on the interaction between NF-kappa B and estrogen could lead to the development of novel therapeutics.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Immunology
Yu Xiao, Jiaqi Liang, Kenneth W. Witwer, Ying Zhang, Qian Wang, Hang Yin
Summary: In our study, we discovered that extracellular vesicles (EVs) play a crucial role in aging, as they can induce chronic inflammation by activating immune cells. We found that EVs derived from senescent cells contain miR-30b-5p, which downregulates SIRT1 and enhances pro-inflammatory cytokine production. Additionally, we observed increased levels of miR-30b-5p in both the aging animal model and EVs harvested from tissues. EVs carrying pro-inflammatory signals can alter immune cell activity in the aging microenvironment, leading to an increase in inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Bin Lin, Hui Zhao, Li Li, Zhenzhen Zhang, Nan Jiang, Xiaowei Yang, Tao Zhang, Bowen Lian, Yaokai Liu, Chi Zhang, Jiaxiang Wang, Feng Wang, Deguang Feng, Jing Xu
Summary: The findings suggest that Sirt1 plays a role in alleviating heart failure in rats through the NF-kappa B p65/miR-155/BDNF signaling cascade. Inhibition of Sirt1 increased acetylation of NF-kappa B p65, leading to elevated NF-KB p65 expression, while silencing NF-kappa B p65 improved heart functions and reduced cardiomyocyte apoptosis.
Article
Neurosciences
Mahdad Abdi, Parichehr Pasbakhsh, Maryam Shabani, Saied Nekoonam, Asie Sadeghi, Fardin Fathi, Morteza Abouzaripour, Wael Mohamed, Kazem Zibara, Iraj Ragerdi Kashani, Adib Zendedel
Summary: In summary, metformin treatment can reduce demyelination, reactive microgliosis, and pro-inflammatory gene expression while increasing AMPK activation and reducing NF-kappa B activity in a mouse model of MS induced by cuprizone. This suggests that metformin may offer potential therapeutic benefits for inflammatory neurodegenerative diseases like MS.
NEUROTOXICITY RESEARCH
(2021)
Article
Medicine, Research & Experimental
Liang He, Zhuoran Wang, Rui Zhou, Wei Xiong, Yuqiao Yang, Ning Song, Jinqiao Qian
Summary: Myocardial ischemia/reperfusion (I/R) injury is a common cause of mortality. Cardiac miR-146a is emerging as a potent regulator of myocardial function. Dexmedetomidine preconditioning provides cardioprotective effects, of which mechanisms related to miR-146a-3p targeting IRAK1 and TRAF6 through inhibition of NF-kappa B signaling pathway and ROS emission.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Joel Gruchot, Ferdinand Lein, Isabel Lewen, Laura Reiche, Vivien Weyers, Patrick Petzsch, Peter Goettle, Karl Koehrer, Hans-Peter Hartung, Patrick Kuery, David Kremer
Summary: Siponimod, a modulator of S1PR, can selectively modulate the reaction of microglia in the central nervous system. It has the potential to be a treatment option for multiple sclerosis, as it can promote neurorepair while inhibiting autoimmune inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Huibin Yu, Chen Peng, Chi Zhang, Ana M. M. Stoian, Loubna Tazi, Greg Brennan, Stefan Rothenburg
Summary: This study investigates the interaction between the Myxoma virus and the host protein kinase R (PKR). The results show that the MYXV M156 protein inhibits PKR in brush rabbits more strongly than in European rabbits. The moderate inhibition of PKR in European rabbits leads to the activation of the proinflammatory nuclear factor kappa B (NF-kappa B) pathway, which may contribute to the increased virulence of MYXV in European rabbits.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Rasha S. Albeltagy, Farah Mumtaz, Ahmed E. Abdel Moneim, Ola H. El-Habit
Summary: The study showed a significant restoration of inflammatory processes and mitochondrial biogenesis after treatment with NAC and CdCl2, with decreased expression of miR146a and NF-kappa B p65. CdCl2 caused mtDNA release due to Tfam loss, and co-treatment with NAC alleviated Cd-induced genotoxicity in liver tissue. Adding NAC to CdCl2 resulted in decreased signaling of the NF-kappa B p65 pathway.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)