Article
Respiratory System
R. Pisi, M. Aiello, L. Calzetta, A. Frizzelli, P. Tzani, G. Bertorelli, A. Chetta
Summary: This study found a significant relationship between the COPD Assessment Test (CAT) and the Medical Research Council (mMRC) scores with maximal exercise capacity in patients with Chronic Obstructive Pulmonary Disease (COPD). CAT (>10) and mMRC (>2) were highly associated with a value of VO2 peak less than 15.7 and 15.6 mL/kg/min, respectively. The agreement between CAT (>10) and mMRC (>2) was fair in all patients but slight when subdivided based on VO2 peak levels.
Article
Pharmacology & Pharmacy
Sukanya Tongdee, Bundit Sawunyavisuth, Wattana Sukeepaisarnjaroen, Watchara Boonsawat, Sittichai Khamsai, Kittisak Sawanyawisuth
Summary: The study found that the appropriate treatment rate for COPD patients in a community setting according to the GOLD guideline was 26.47%. Factors such as number of admissions, modified Medical Research Council (mMRC) score, and CAT score were independently associated with appropriate treatment.
DRUG TARGET INSIGHTS
(2021)
Article
Immunology
Monika Fekete, Alpar Horvath, Balazs Santa, Gabor Tomisa, Gergo Szollosi, Zoltan Ungvari, Vince Fazekas-Pongor, David Major, Stefano Tarantini, Janos Tamas Varga
Summary: The aim of the study was to assess COVID-19 vaccination coverage in COPD patients. The results showed that the vaccination coverage was high and there were significant differences in quality of life, severity of dyspnea, and infection rate between unvaccinated and vaccinated patients. Therefore, COVID-19 vaccination is crucial for COPD patients.
Article
Respiratory System
Yan Shen Kee, Chee Kuan Wong, Muhammad Anis Abdul Aziz, Mohd Idzwan Zakaria, Fatimah Mohd Shaarif, Kee Seong Ng, Chong Kin Liam, Yong Kek Pang, Ee Ming Khoo
Summary: This study investigated the readmission rate and associated factors of chronic obstructive pulmonary disease (COPD) in a tertiary care hospital in Malaysia. The results showed that a history of exacerbation in the past year and a higher baseline mMRC grading were significant risk factors for 30-day readmission. Strategies for COPD management should focus on optimizing pharmacotherapy, early initiation of pulmonary rehabilitation, and integrated care programs to reduce readmission rates.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2023)
Review
Respiratory System
Josuel Ora, Emanuela Prendi, Maria Laura Attina, Mario Cazzola, Luigino Calzetta, Paola Rogliani
Summary: This study found that tele-rehabilitation is an effective alternative to center-based rehabilitation for COPD patients, improving exercise capacity and patient-reported outcomes. However, more research is needed to determine patient selection criteria and the most appropriate type of tele-rehabilitation.
MONALDI ARCHIVES FOR CHEST DISEASE
(2022)
Article
Respiratory System
Mirfarhad Ghalehbandi, Shahrzad Khosravifar, Oldooz Aloosh, Ania Rahimi-Golkhandan, Mahdi Abounoori, Amirmohammad Aloosh, Hale Afshar, Shaghayegh Khosravifar
Summary: The study found that the sleep quality of COPD patients is related to the severity of the disease, specifically associated with CAT scores and dyspnoea severity. Patients with higher CAT scores demonstrated poor sleep quality, particularly in terms of longer sleep latency, bad subjective sleep quality, lower sleep efficiency, higher sleep disturbances, daytime dysfunction, and sleep medication intake frequency per week.
CLINICAL RESPIRATORY JOURNAL
(2021)
Review
Critical Care Medicine
Deepti Singhvi, Jessica Bon
Summary: Comorbidities significantly impact COPD patients, and targeted early screening and treatment may have a significant effect on COPD outcomes. Recent studies suggest that certain radiographic features can serve as surrogate markers for comorbid disease in COPD patients.
Article
Respiratory System
Chee-Shee Chai, Diana-Leh-Ching Ng, Sumastika Bt Mos, Muhammad Amin B. Ibrahim, Seng-Beng Tan, Yong-Kek Pang, Chong-Kin Liam
Summary: This study examined the association and correlation between FEV1, exacerbations, and PROs in patients with stable COPD. The results showed that different levels of airflow limitation were not significantly associated with differences in disease severity scores, except for very severe airflow limitation which was associated with more frequent exacerbations.
BMC PULMONARY MEDICINE
(2023)
Article
Medicine, General & Internal
Alexey Nizov, Anna Ermachkova, Maria Dzhurdzhevich, Irina Ponomareva, Sergey Glotov, Anton Shakhanov
Summary: The study in Russian primary health care revealed a high prevalence of COPD among adults with mild to moderate severity, with most patients having mild symptoms.
PAKISTAN JOURNAL OF MEDICAL & HEALTH SCIENCES
(2021)
Article
Respiratory System
Ji-Ho Lee, Won-Yeon Lee, Suk Joong Yong, Woo Jin Kim, Sooim Sin, Chang Youl Lee, Youlim Kim, Ji Ye Jung, Sang-Ha Kim
Summary: This study investigated the prevalence of depression and its associated factors in patients with bronchiectasis. The findings revealed significant associations between depression and disease severity, quality of life, and fatigue severity. Dyspnea and exacerbations were closely linked to depression, emphasizing the importance of actively screening for depression to optimize bronchiectasis treatment.
BMC PULMONARY MEDICINE
(2021)
Article
Respiratory System
Jie Cen, Lei Weng
Summary: This study compared the ability of peak expiratory flow (PEF) and COPD assessment test (CAT) to assess COPD exacerbations requiring hospitalization. The results showed that both PEF and CAT were independently associated with the risk of hospitalized exacerbation. PEF was found to be superior to CAT in identifying hospitalized exacerbations. The combination of PEF and CAT was more effective in identifying hospitalized exacerbations than using either measure alone.
CHRONIC RESPIRATORY DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Jeevanandham Anandan, Dharm Prakash Dwivedi, Vishnukanth Govindaraj
Summary: This study aimed to estimate the prevalence of different COPD phenotypes and their disease-specific Health-Related Quality of Life (HRQoL). The results showed that the Non-Exacerbator (NE) phenotype was the most common, while the Exacerbator Chronic Bronchitis (ECB) and Exacerbator Emphysema (EEM) phenotypes had poorer quality of life. Further research is needed to determine whether phenotype-specific therapies can improve clinical outcomes.
RESPIRATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Arto Yuwono Soeroto, Dadan Setiawan, Nabila Nauli Asriputri, Guntur Darmawan, Geraldo Laurus, Prayudi Santoso
Summary: The study showed that low levels of vitamin D in stable COPD patients in Indonesia were associated with more frequent exacerbations and higher CAT scores, but not with FEV1 (%) predicted value.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Ching-Hsiung Lin, Yi-Rong Li, Bing-Yen Wang, Sheng-Hao Lin, Kuo-Yang Huang, Cheng-Hsiung Chen, Chew-Teng Kor
Summary: This study aimed to assess the impact of the duration of integrated disease management (IDM) on COPD-related outcomes. The findings showed that continued IDM intervention resulted in sustained improvement in health status for COPD patients, especially those with a CAT score ≥ 10. Additionally, patients who achieved improvement in CAT score had a reduced risk of subsequent COPD exacerbations.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Respiratory System
D. Nugmanova, Y. Feshchenko, L. Iashyna, M. Polianska, K. Malynovska, I. Stafeyeva, J. Makarova, A. Vasylyev
Summary: The study found a higher proportion of respiratory impairment and lower activity levels in overweight/obese populations in Ukraine, Kazakhstan, and Azerbaijan. CAT and mMRC tools can assess respiratory function, while IPAQ may be useful for measuring activity levels. More objective studies are needed to evaluate the relationship between BMI and physical activity.
BMC PULMONARY MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Seung Wan Kang, Won Gi Jeong, Jong Eun Lee, In-Jae Oh, Sang Yun Song, Byung Chan Lee, Yun-Hyeon Kim
Summary: This study aimed to determine the prognostic significance of central lung cancer in resected T1-sized early-stage non-small cell lung cancer (NSCLC). The results showed that central lung cancer, defined by a location index, was adversely associated with relapse-free survival and overall survival. It was found to be an independent adverse prognostic factor in early-stage NSCLC.
Article
Oncology
Yong-Hyub Kim, Sung-Ja Ahn, Sung Ho Moon, Jin Hee Kim, Young-Chul Kim, In-Jae Oh, Cheol Kyu Park, Jae-Uk Jeong, Mee Sun Yoon, Ju-Young Song, Chang-Ok Suh, Kwan Ho Cho, Sun Hyo Park
Summary: We conducted a clinical trial to compare the efficacy of accelerated hypofractionated radiation therapy (RT) with conventionally fractionated 60-Gy RT in patients with stage III unresectable non-small cell lung cancer (NSCLC). The results showed no significant differences in treatment response, overall survival, progression-free survival, and local tumor control rates between the two groups. This suggests that accelerated hypofractionated RT may not be superior to conventional fractionation in patients with unresectable stage III NSCLC undergoing concurrent chemoradiation therapy.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Allergy
Seong Mi Moon, Hayoung Choi, Hyung Koo Kang, Sei Won Lee, Yun Su Sim, Hye Yun Park, Yong-Soo Kwon, Sang-Heon Kim, Yeon-Mok Oh, Hyun Lee
Summary: This study evaluated 598 patients from the Korean Bronchiectasis Registry and found that bronchiectasis patients with asthma had higher BMI, more dyspnea, larger sputum volume, and lower FEV1 than those without asthma. Asthma was also associated with lower quality of life. Therefore, understanding the impacts of asthma in bronchiectasis is crucial for appropriate management.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Jieun Kang, Man Pyo Chung, Moo Suk Park, In Jae Oh, Heung Bum Lee, Young Whan Kim, Jong Sun Park, Soo Taek Uh, Yun Seong Kim, Yangjin Jegal, Jin Woo Song
Summary: This study evaluated the impact of reduced dose of pirfenidone on clinical outcomes in patients with IPF. The results showed that reduced doses did not have a negative impact on clinical outcomes compared to standard-dose pirfenidone, suggesting that dose reduction may be a useful method to manage adverse events while maintaining therapeutic efficacy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemical Research Methods
Seungwon Oh, Sae-Ryung Kang, In-Jae Oh, Min-Soo Kim
Summary: The study aimed to improve survival prediction in patients with non-small cell lung cancer (NSCLC) by incorporating prognostic information from F-18 fluorodeoxyglucose positron emission tomography (FDG PET) images into a traditional survival prediction model using clinical data. The multimodal deep learning model showed the best performance, with a C-index and mean absolute error of 0.756 and 399 days under a five-fold cross-validation, respectively, followed by ResNet3D for PET (0.749 and 405 days) and CPH for clinical data (0.747 and 583 days).
BMC BIOINFORMATICS
(2023)
Article
Oncology
Cheol-Kyu Park, Nakyung Jeon, Hwa-Kyung Park, Hyung-Joo Oh, Young-Chul Kim, Ha-Lim Jeon, Yong-Hyub Kim, Sung-Ja Ahn, In-Jae Oh
Summary: In this retrospective cohort study, durvalumab consolidation (DC) after concurrent chemoradiotherapy (CCRT) was found to be associated with survival benefits in real-world contexts, supporting its establishment as a new standard of care for stage III NSCLC. The study aimed to provide real-world evidence regarding the effectiveness and safety of DC after CCRT in the treatment of unresectable stage III NSCLC.
Article
Oncology
Cheol-Kyu Park, Sung-Woo Lee, Hyun-Ju Cho, Hyung-Joo Oh, Young-Chul Kim, Yong-Hyub Kim, Sung-Ja Ahn, Jae-Ho Cho, In-Jae Oh
Summary: A total of 50 patients with unresectable stage III NSCLC who received CCRT between March 2020 and March 2021 were recruited. Durvalumab consolidation (DC) was administered to patients (n=23) without progression after CCRT and programmed death-ligand 1 (PD-L1) ≥1%. Blood samples collected before (C0) and after CCRT (C1) were analyzed to calculate PBC counts and examine CTCs. The study found that the presence of residual CTC clusters at C1 and high platelet counts at C1 (PLThi) were independent risk factors for worse progression-free survival (PFS). The study suggests that the clearance of CTC clusters and platelet counts at C1 could serve as potential biomarkers for predicting survival.
Article
Cell Biology
Cheol-Kyu Park, Ha Ra Jun, Hyung-Joo Oh, Ji-Young Lee, Hyun-Ju Cho, Young-Chul Kim, Jeong Eun Lee, Seong Hoon Yoon, Chang Min Choi, Jae Cheol Lee, Sung Yong Lee, Shin Yup Lee, Sung-Min Chun, In-Jae Oh
Summary: This study aimed to investigate the feasibility of blood-based biomarkers, including blood tumor mutation burden (bTMB), to predict atezolizumab efficacy in relapsed and advanced non-small cell lung cancer (NSCLC). The results suggest that baseline levels and dynamic changes of blood-based biomarkers can predict atezolizumab efficacy in previously treated NSCLC patients.
Article
Oncology
Ha-Young Park, Joo-Heon Park, Myung-Geun Shin, Seung Jung Han, Yong-Sok Ji, Hyung-Joo Oh, Young-Chul Kim, Taebum Lee, Yoo-Duk Choi, In-Jae Oh
Summary: This case report presents a rare case of ultra-late recurrence of NSCLC with choroidal metastasis and KIF13A-RET fusion in a 48-year-old female never-smoker. The patient had undergone lobectomy followed by adjuvant chemotherapy 14 years prior. Choroidal metastatic lesions were observed, along with bone and uterine metastases. Liquid-based NGS confirmed the presence of KIF13A-RET fusion, and the patient showed a partial response to selpercatinib therapy.
FRONTIERS IN ONCOLOGY
(2023)
Letter
Oncology
Cheol-Kyu Park, In-Jae Oh, Young-Chul Kim
TRANSLATIONAL LUNG CANCER RESEARCH
(2023)
Article
Oncology
In-Jae Oh, Cheol-Kyu Park, Kyoung-Bok Min, Jin-Young Min, Chaeuk Chung, Seong-Hoon Yoon, Changsoo Kim, Sei-Hoon Yang
Summary: A study in Korea found that lung cancer patients exposed to high concentrations of PM2.5 had significantly increased healthcare utilization and drug prescriptions.
Article
Medicine, General & Internal
Min-Gwan Sun, Sue Jee Park, Yeong Jin Kim, Kyung-Sub Moon, In-Young Kim, Shin Jung, Hyung-Joo Oh, In-Jae Oh, Tae-Young Jung
Summary: There is ongoing controversy regarding whether to use radiologic follow-up or local treatment for asymptomatic small-sized brain metastases from primary lung cancer. This study evaluated the potential factors related to brain progression and the effectiveness of systemic therapy in controlling tumors without local treatment. The results showed that targeted therapy was superior to cytotoxic chemotherapy in the treatment of these brain metastases, offering the opportunity to determine the optimal timing for local treatment while reducing the risk of brain-related mortality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Respiratory System
Chang-Seok Yoon, Hwa-Kyung Park, Jae-Kyeong Lee, Bo -Gun Kho, Tae-Ok Kim, Hong-Joon Shin, Yong -Soo Kwon
Summary: This study presented a case of NTM pulmonary disease caused by a rare congenital lung disease. The patient was successfully treated with a combination of drugs for 16 months and achieved culture conversion without recurrence for 6 months.
RESPIRATORY MEDICINE CASE REPORTS
(2023)
Article
Oncology
Hwa Kyung Park, Yoo Duk Choi, Ju-Sik Yun, Sang-Yun Song, Kook-Joo Na, Joon Young Yoon, Chang-Seok Yoon, Hyung-Joo Oh, Young-Chul Kim, In-Jae Oh
Summary: This study investigated the prevalence of genetic alterations in early-stage non-small cell lung cancer (NSCLC) and the association between EGFR mutations and recurrence after surgical resection. The presence of EGFR mutations was found to be an independent risk factor for recurrence and was associated with systemic recurrence. Targeted therapy should be considered more actively as an adjuvant or neoadjuvant treatment option.
Article
Oncology
Wonjun Ji, In-Jae Oh, Cheol-Kyu Park, Sung Yong Lee, Juwhan Choi, Jae Cheol Lee, Jiwon Kim, Seung Hyeun Lee
Summary: This study provides real-world evidence of the effectiveness and safety of afatinib as a treatment option for patients with squamous cell carcinoma of the lung (LSCC) who have progressed after chemotherapy and immunotherapy. The study also highlights the potential predictive value of the ERBB2 mutation as a biomarker in clinical settings.