Article
Medicine, Research & Experimental
Sana Siddiqui, Kristina Johansson, Alex Joo, Luke R. Bonser, Kyung Duk Koh, Olivier Le Tonqueze, Samaneh Bolourchi, Rodriel A. Bautista, Lorna Zlock, Theodore L. Roth, Alexander Marson, Nirav R. Bhakta, K. Mark Ansel, Walter E. Finkbeiner, David J. Erle, Prescott G. Woodruff
Summary: The study identifies miR-141 as a key regulator of pathological airway mucus production induced by IL-13, with disruption leading to decreased goblet cell frequency and reduced mucus secretion. This miRNA may offer a novel therapeutic target for airway diseases.
Article
Biochemistry & Molecular Biology
Yu-Jen Chen, Chia-Tien Hsu, Shang-Feng Tsai, Cheng-Hsu Chen
Summary: Chronic allograft dysfunction (CAD) is a major condition affecting long-term kidney graft survival. In this study, the correlation between plasma miR-21 and the severity of CAD was investigated. RNA sequencing was performed and differentially expressed miRNAs in CAD were identified. MiR-21-5p, miR-20a-5p, and miR-101-3p were found to be associated with the TGF-beta pathway and CAD. These findings may lead to the development of early prediction miRNA biomarkers and therapeutic tools for CAD in the field of kidney transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Meng-Nan Liu, Gang Luo, Wan-Jiao Gao, Si-Jin Yang, Hua Zhou
Summary: miR-29 plays a crucial role in cardiovascular disease (CVD), particularly in maintaining arterial integrity and regulating atherosclerosis. Studies have shown the potential of miR-29 as a potential marker for prevention, treatment, and prognostic observation in CVD.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Cell Biology
Omkar Suhas Vinchure, Ritu Kulshreshtha
Summary: miR-490, a well-studied miRNA, is associated with the pathogenesis of various diseases, particularly showing potential in cancer diagnosis and prognosis. Multiple epigenetic and posttranscriptional mechanisms tightly regulate the levels of miR-490, with its targets involving cancer-related genes that impact various cancer hallmarks.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ophelie Fourdinier, Griet Glorieux, Benjamin Brigant, Momar Diouf, Anneleen Pletinck, Raymond Vanholder, Gabriel Choukroun, Francis Verbeke, Ziad A. Massy, Valerie Metzinger-Le Meuth, Laurent Metzinger
Summary: The study found a significant correlation between miR-126 levels and markers of endothelial dysfunction and uremic toxins in CKD patients, highlighting its important role in the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Fen Liu, Jintao Zhang, Dong Zhang, Quin Qi, Wenjing Cui, Yun Pan, Xiaofei Liu, Jiawei Xu, Xinrui Qiao, Zihan Wang, Liang Dong
Summary: This study reveals the crucial role of the miR-200b-3p/FSTL1 axis in regulating airway remodeling and inflammation in asthma.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Edvan do Carmo Santos, Gabriela Imbassahy Valentim Melo, Paulo Vinicius Bispo Santana, Idaiara Graziele Silva Quadros, Setondji Cocou Modeste Alexandre Yahouedehou, Caroline Conceicao da Guarda, Rayra Pereira Santiago, Luciana Magalhaes Fiuza, Suellen Pinheiro Carvalho, Elisangela Vitoria Adorno, Carla Martins Kaneto, Teresa Cristina Cardoso Fonseca, Marilda Souza Goncalves, Milena Magalhaes Aleluia
Summary: This study demonstrates that elevated expression of circulating miR-199a-5p and miR-144 and reduced expression of miR-126 are associated with sickle leg ulcers (SLU) and hemolytic biomarkers. These microRNAs have potential diagnostic and prognostic value in SLU and may play a role in the pathophysiology of the disease.
Article
Biochemistry & Molecular Biology
Nina P. Jordan, Samuel J. Tingle, Victoria G. Shuttleworth, Katie Cooke, Rachael E. Redgrave, Esha Singh, Emily K. Glover, Hafiza B. Ahmad Tajuddin, John A. Kirby, Helen M. Arthur, Chris Ward, Neil S. Sheerin, Simi Ali
Summary: The down-regulation of miR-126-3p is associated with EndMT, with its over-expression preventing the process and maintaining endothelial characteristics while repressing fibronectin expression. Lineage tracing in cardiac and kidney fibrosis models revealed that a significant subpopulation of endothelial-derived cells undergo EndMT and express mesenchymal markers. MiR-126-3p expression is restricted to endothelial cells and down-regulated in fibrotic kidney and heart tissue, making it a potential target for miRNA-based therapeutics in fibrotic organs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Carolina Kymie Vasques Nonaka, Gabriela Louise Sampaio, Luciana de Aragao Franca, Bruno Raphael Cavalcante, Katia Nunes Silva, Ricardo Khouri, Felipe Guimaraes Torres, Cassio Santana Meira, Emanuelle de Souza Santos, Carolina The Macedo, Bruno Diaz Paredes, Vinicius Pinto Costa Rocha, Silvia Regina Rogatto, Ricardo Ribeiro dos Santos, Bruno Solano de Freitas Souza, Milena Botelho Pereira Soares
Summary: The study found upregulation of miR-21 in chronic Chagas disease patients and mouse heart samples, indicating its important role in regulating cardiac fibrosis. Experimental validation showed that inhibiting miR-21 significantly reduced cardiac fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Stephanie He, Davindra Singh, Hossein Yusefi, Brandon Helfield
Summary: This study investigates the feasibility of delivering the angiogenesis-promoting miR-126 using ultrasound-stimulated microbubbles. The results show that by stimulating miR-126-decorated microbubbles, the intracellular levels of miR-126 can be increased while decreasing the expression of its target genes. This delivery method has the potential to stimulate therapeutic angiogenesis while minimizing endothelial damage.
Article
Cell Biology
Anthony Tam, Emmanuel Twumasi Osei, Chung Y. Cheung, Michael Hughes, Chen X. Yang, Kelly M. McNagny, Delbert R. Dorscheid, Gurpreet K. Singhera, Teal S. Hallstrand, Stephanie Warner, James C. Hogg, Tillie L. Hackett, Chinten J. Lim, Don D. Sin
Summary: This study found that the Hedgehog signaling pathway is involved in the process of airway remodeling in asthma, which is partially mediated via the PTCH1-SMO-GLI axis. This provides hope for finding new targets for treating airway tissue remodeling in patients with allergic airways disease.
Article
Immunology
Jin-ya Wang, Xiaoyan Dong, Zhiwei Yu, Lei Ge, Lu Lu, Ling Ding, Weihua Gan
Summary: The study demonstrated that borneol alleviated asthma in mice by downregulating miR-26a and miR-142-3p, which reduced CD4+ T cells infiltration, thereby attenuating disease progression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Pathology
Abduladheem Turki Jalil, Mohanad Ali Abdulhadi, Lubna R. Al-Ameer, Hussein Abdullah Abbas, Muna. S. Merza, Rahman S. Zabibah, Ali A. Fadhil
Summary: MicroRNA-126 (miR-126) has diverse functions in cancer, affecting tumor angiogenesis, invasion, metastasis, cell proliferation, apoptosis, and treatment resistance. Dysregulation of miR-126 is associated with increased cancer risk and worse prognosis. Targeting miR-126 or its downstream effectors presents a potential therapeutic approach for inhibiting tumor development and combating drug resistance. Further investigation is needed to fully understand the mechanisms behind miR-126 dysregulation and develop efficient therapies.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
William C. C. Cho, Chi F. F. Wong, Kwan P. P. Li, Alvin H. H. Fong, King Y. Y. Fung, Joseph S. S. Au
Summary: Our previous study showed that miR-145 is downregulated in NSCLC tissues and inhibits cell proliferation. In this study, we found that miR-145 is also downregulated in NSCLC plasma samples and is associated with NSCLC in patients. Additionally, we discovered that transfection of miR-145 inhibits the proliferation, migration, and invasion of NSCLC cells and delays tumor growth in a mouse model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Francesca Pontis, Luca Roz, Mavis Mensah, Miriam Segale, Massimo Moro, Giulia Bertolini, Ilaria Petraroia, Giovanni Centonze, Anna Maria Ferretti, Paola Suatoni, Ugo Pastorino, Orazio Fortunato, Gabriella Sozzi
Summary: This study investigated the role of extracellular vesicles (EVs) in lung cancer, finding that high-risk MSCpos-EVs had different membrane composition, biological cargo, and pro-tumorigenic activity compared to low-risk MSCneg-EVs. The study also showed that specific miRNAs inside EVs, such as miR-126 and miR-320, could promote angiogenesis and M2 polarization in endothelial cells and macrophages, respectively. Additionally, EVs containing miR-320 were identified as a new prognostic biomarker in lung cancer patients, with higher levels correlating with shorter overall survival.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Engineering, Environmental
Sonam Paliya, Ashootosh Mandpe, Manukonda Suresh Kumar, Sunil Kumar, Rakesh Kumar
Summary: This study assesses the contamination of polybrominated diphenyl ethers (PBDEs) in municipal solid waste (MSW) dumping sites in India and evaluates the associated exposure and health risks. The results show that PBDE concentrations are higher in dumping sites of more populous cities, and children have a higher risk of exposure and health effects compared to adults.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2022)
Article
Computer Science, Interdisciplinary Applications
Rakesh Kumar, Vimal Kumar Pathak
Summary: The present study aims to develop an adaptive neuro-fuzzy inference system (ANFIS) model to find a relationship between loading parameters and bone remodelling rate. The results indicate that the ANFIS model outperformed other models in predicting the mineral apposition rate (MAR) at periosteal and endosteal surfaces. This study provides a way to accurately predict site-specific osteogenesis based on the loading parameters.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2023)
Article
Optics
Rakesh Ranjan Kumar, Andreas Hansel, Monica Far Brusatori, Lars Nielsen, Luc M. Augustin, Nicolas Volet, Martijn J. R. Heck
Summary: We report a monolithically integrated coupled extended-cavity distributed Bragg reflector laser with the lowest reported intrinsic linewidth of similar to 10 kHz, realized on an InP generic foundry platform. The experimentally measured linewidth was 45 kHz. The laser has high optical output power and operates in a single-mode regime.
Article
Engineering, Biomedical
Sushil Kumar Saroj, Rakesh Kumar, Nagendra Pratap Singh
Summary: This study proposes a new method for the enhancement and segmentation of retinal vessels, which achieves better performance compared to existing methods by using the Multiscale switching morphological operator and a new matched filter based on the Wald probability distribution function.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING-IMAGING AND VISUALIZATION
(2023)
Article
Thermodynamics
Ashif Perwez, Rakesh Kumar, Abhishek Bhushan
Summary: This study investigated the thermal performance of inclined elliptical dimpled plates through experimental and numerical analysis. It was found that staggered and inline patterns of the dimples have different effects on flow patterns and heat transfer characteristics.
NUMERICAL HEAT TRANSFER PART A-APPLICATIONS
(2023)
Article
Thermodynamics
Sudharani Panda, Rakesh Kumar
Summary: The thermal and flow characteristics of a dimple imprinted absorber plate solar air-heater were investigated numerically in this study. The results showed that the dimpled surface demonstrated a significant improvement in heat transfer and friction characteristics compared to the smooth surface.
NUMERICAL HEAT TRANSFER PART A-APPLICATIONS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vandana Kumar Dhingra, Dikhra Khan, Rakesh Kumar, Sandip Basu
Article
Radiology, Nuclear Medicine & Medical Imaging
Esha Baidya Kayal, Jayendra Tiru Alampally, Raju Sharma, Sameer Bakhshi, Amit Mehndiratta, Rakesh Kumar, S. H. Chandrashekhara, Manisha Jana, Ashu Seith Bhalla, Mehar Chand Sharma, Asit Ranjan Mridha, Sreenivas Vishnubhatla, Devasenathipathy Kandasamy
Summary: This study assessed the role of diffusion-weighted magnetic resonance imaging (MRI) in the early evaluation of chemotherapeutic response in Ewing sarcoma family of tumors (ESFT). The results suggest that baseline nADC and its change after the first cycle of chemotherapy can serve as reliable markers for early chemotherapeutic response in ESFT patients.
Article
Telecommunications
Sweta Singh, Rakesh Kumar
Summary: This paper introduces a method for optimizing energy efficiency and resource utilization in the field of cloud computing. By utilizing the proposed MAMFO algorithm and DT-ESAR method, workflow planning and VM consolidation can be effectively performed, improving the energy efficiency and time efficiency of the system. Experimental results show significant improvements compared to existing methods.
WIRELESS PERSONAL COMMUNICATIONS
(2023)
Article
Oncology
Suresh Mani, Rajeev Kumar, Aanchal Kakkar, Adarsh Barwad, Kondamudi Dheeraj, Prem Sagar, Rakesh Kumar
Summary: Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous sarcoma with low metastatic potential but high local recurrence rate. Surgical excision with adequate margins is the preferred treatment, with possible adjuvant radiotherapy or chemotherapy. This retrospective analysis of head and neck DFSP cases revealed that incomplete excision margins may increase the risk of recurrence.
INDIAN JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Optics
Rakesh Ranjan Kumar, Lars Nielsen, Nicolas Volet, Martijn J. R. Heck
Summary: We present a study on the intra-cavity coherent combining of two DBR lasers on an InP platform, achieving a combining efficiency of 84%. The combined DBR lasers exhibit an on-chip power of 9.5 mW at an injection current of 42 mA in both gain sections simultaneously. This monolithic approach enables the operation of compact and high-power lasers in a single-mode regime with a side-mode suppression ratio of 38 dB, providing a promising direction for integrated photonic technologies.
Article
Chemistry, Multidisciplinary
Prerna Gupta, Rekha Garg Solanki, Pushpanjali Patel, K. M. Sujata, Rakesh Kumar, Abhay Pandit
Summary: Microorganisms can cause health issues, but semiconductor nanostructures have potential for antimicrobial properties. This study synthesized ZnSe nanostructures using a green coprecipitation method and annealed them at different temperatures. The samples were analyzed for structural, morphological, optical, and antibacterial properties. The results showed that the annealing process enhanced the photoluminescence and antimicrobial activities of ZnSe nanostructures, making them suitable for blue LEDs and lasers for medical applications. The as-synthesized and annealed ZnSe nanostructures were found to be effective against microbial growth, indicating their potential for developing new drugs against bacterial infections.
Article
Computer Science, Artificial Intelligence
Rakesh Kumar, Satish Kumar
Summary: This article discusses the distance and similarity measures as two interrelated information measures that can effectively quantify the deviation and similarity between pairs of objects. It proposes a novel similarity measure that overcomes the limitations of existing measures and analyzes its characteristics through numerical experiments. Furthermore, it develops an algorithm for pattern recognition and examines the efficiency of the suggested measure in clustering analysis and decision-making.
GRANULAR COMPUTING
(2023)
Article
Surgery
Avinash Shekhar Jaiswal, Rajeev Kumar, Rakesh Kumar, Arvind Kumar Kairo, Sarath Raveendran, Prem Sagar
Summary: This study retrospectively investigated the clinico-demographical profile and outcomes of cochlear implantation in adult patients with post-lingual hearing loss in a tertiary care hospital in north India. The study included 21 patients, with a mean age of 38.6 years and a male-to-female ratio of 15:6. The major cause of deafness was infections, and the complication rate was 4.8%. The mean postoperative speech intelligibility score was 74%, and there were no device malfunctions in the average follow-up of 44 months. Cochlear implantation is a safe and effective surgical intervention for post-lingually deafened adults, with infections being the major cause of deafness.
INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anil Kumar Pandey, Jagrati Chaudhary, Akshima Sharma, Hemakshi Chetan Patel, Param Dev Sharma, Vivek Baghel, Rakesh Kumar
Summary: This study aimed to find the optimum value of scale and threshold for compressing 99mTc-MDP bone scan images using Haar wavelet transform. The values of scale 2 and 90 percentiles were determined to be the best based on experiments and evaluations.
INDIAN JOURNAL OF NUCLEAR MEDICINE
(2022)