Article
Anesthesiology
Luca J. Wachtendorf, Tim M. Tartler, Elena Ahrens, Annika S. Witt, Omid Azimaraghi, Philipp Fassbender, Aiman Suleiman, Felix C. Linhardt, Michael Blank, Sarah Y. Nabel, Jerry Y. Chao, Pavel Goriacko, Parsa Mirhaji, Timothy T. Houle, Maximilian S. Schaefer, Matthias Eikermann
Summary: This study evaluated the effects of sugammadex on hospital costs and found that it was associated with lower direct costs compared to neostigmine. However, in high-risk patients, sugammadex was associated with higher total costs.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Anesthesiology
Marc Schmidt, Julian Rossler, Jack Brooker, Valentina Lara-Erazo, Elyad Ekrami, Xuan Pu, Alparslan Turan, Daniel I. Sessler, Kurt Ruetzler
Summary: This study aimed to compare the postoperative lung function of patients undergoing neuromuscular block reversal using sugammadex versus neostigmine. The results showed similar lung function with both methods, but patients given sugammadex had more minor pulmonary complications.
JOURNAL OF CLINICAL ANESTHESIA
(2023)
Article
Anesthesiology
Thomas Ledowski, Zoltan Szabo-Maak, Pui San Loh, Berwin A. Turlach, Hong Seuk Yang, Hans D. de Boer, Laszlo Asztalos, Ina Ismiarti Shariffuddin, Lucy Chan, Bela Fulesdi
Summary: In high-risk older patients, reversing rocuronium neuromuscular block with sugammadex may result in a reduced risk of postoperative pulmonary complications on Day 7.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Medicine, General & Internal
Juan Fiorda Diaz, Marco Echeverria-Villalobos, Alan Esparza Gutierrez, Olufunke Dada, Nicoleta Stoicea, Wiebke Ackermann, Mahmoud Abdel-Rasoul, Jarrett Heard, Alberto Uribe, Sergio D. D. Bergese
Summary: This study compared the effectiveness and cost-effectiveness of sugammadex and neostigmine for moderate neuromuscular blockade reversal. The results showed that sugammadex achieved faster reversal without increasing perioperative costs.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Jae-Woo Ju, In Eob Hwang, Hye-Yeon Cho, Seong Mi Yang, Won Ho Kim, Ho-Jin Lee
Summary: This study aimed to compare the effect of sugammadex and neostigmine on postoperative nausea and vomiting (PONV) within the first 24 hours after general anesthesia. The retrospective cohort study included patients who underwent elective surgery in Seoul, South Korea. The results showed that sugammadex had a significantly lower incidence of PONV compared to neostigmine/glycopyrrolate. In conclusion, the use of sugammadex decreases the risk of PONV within the first 24 hours after general anesthesia.
SCIENTIFIC REPORTS
(2023)
Article
Anesthesiology
Jia-Feng Wang, Zhen-Zhen Zhao, Zheng-Yu Jiang, Hui-Xing Liu, Xiao-Ming Deng
Summary: A meta-analysis found that using sugammadex to reverse NMB was associated with a lower risk of postoperative pulmonary complications, specifically a lower incidence of postoperative respiratory failure.
PERIOPERATIVE MEDICINE
(2021)
Article
Anesthesiology
T. Andrew Bowdle, Kishanee J. Haththotuwegama, Srdjan Jelacic, Sharon T. Nguyen, Kei Togashi, Kelly E. Michaelsen
Summary: Sugammadex dose titration is necessary for effective reversal of neuromuscular blockade after rocuronium administration. Most patients require less than the recommended dose, but some may need more, and recurrent paralysis can occur.
Article
Anesthesiology
Yulong Yu, Huijun Wang, Qianqian Bao, Tao Zhang, Beini Chen, Jinfeng Ding
Summary: This study compared the effects of sugammadex and neostigmine on the reversal of neuromuscular block and the incidence of post-operative pulmonary complications in lung cancer resection patients. The results showed that sugammadex provided faster recovery of neuromuscular block and reduced the incidence of postoperative lung complications and duration of hospital stay.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2022)
Article
Anesthesiology
Roland Kaddoum, Said Tarraf, Fadia M. Shebbo, Arwa Bou Ali, Cynthia Karam, Carol Abi Shadid, Joanna Bouez, Marie T. Aouad
Summary: Nonoperative time (NOT) is a crucial factor in the operating room that can greatly impact efficiency and satisfaction. Parallel processing and the use of sugammadex can effectively reduce NOT and improve surgeon satisfaction.
ANESTHESIA AND ANALGESIA
(2022)
Article
Multidisciplinary Sciences
Jeayoun Kim, Doyeon Kim, Inho Kim, Ji Seon Jeong
Summary: This study compared the changes in BIS and PSI values caused by the use of sugammadex for neuromuscular blockade reversal. The results showed that there were no significant differences in the changes of BIS and PSI values compared to baseline after sugammadex administration. However, the maximum BIS and PSI values were significantly higher than baseline. Weak positive correlations were found between BIS and BIS-EMG, as well as PSI and PSI-EMG, indicating that both BIS and PSI were affected by EMG artifacts.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Lori D. Bash, Vladimir Turzhitsky, Wynona Black, Richard D. Urman
Summary: This study analyzed the changes in the use of NMB and NMB reversal agents among surgical inpatients in the US since the introduction of sugammadex. The study found complex relationships between patient, site, procedural characteristics, and NMB management choices. Factors such as patient characteristics, hospital size, and time since 2016 influenced the choice of NMB reversal agent used. Overall, the study highlights the evolution of NMB management practices over time and the impact of various factors on treatment choices.
ADVANCES IN THERAPY
(2021)
Article
Anesthesiology
Omid Azimaraghi, Elena Ahrens, Karuna Wongtangman, Annika S. Witt, Samuel Rupp, Aiman Suleiman, Tim M. Tartler, Luca J. Wachtendorf, Philipp Fassbender, Curtis Choice, Timothy T. Houle, Matthias Eikermann, Maximilian S. Schaefer
Summary: The use of sugammadex in ambulatory surgery can reverse neuromuscular block faster and reduce post-operative length of stay and costs compared to neostigmine, especially in older and high-risk patients.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Review
Oncology
Wentao Ji, Xiaoting Zhang, Jia Liu, Guolin Sun, Xiandong Wang, Lulong Bo, Xiaoming Deng
Summary: Neostigmine has been shown to effectively reduce post-anesthesia care unit stay, time to recovery of train-of-four ratio =0.9, and extubation time in patients recovering from general anesthesia. However, there were no significant differences in adverse events between the neostigmine and control groups. Subgroup analyses based on neostigmine dosage did not affect the overall results. Neostigmine can safely enhance neuromuscular recovery from nondepolarizing muscle relaxants in patients under general anesthesia.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, General & Internal
Joshua A. Goodner, Eric J. Likar, Abigail L. Hoff, Jeffrey M. Quedado, Arpan Kohli, Pavithra Ellison
Summary: The study aimed to evaluate the perioperative efficiency of Sugammadex compared to the traditional regimen. Results showed similar extubation times and reintubation rates between Sugammadex and neostigmine groups, with deviations in dosage observed.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Medicine, General & Internal
Nik Izyan Syaizana Nik Mat, Chih Nie Yeoh, Muhammad Maaya, Jaafar Md Zain, Joanna Su Min Ooi
Summary: Sugammadex has a lower incidence of postoperative nausea and vomiting (PONV) within the first 6 hours post-reversal compared to neostigmine-atropine mixture.
FRONTIERS IN MEDICINE
(2022)