Review
Biochemistry & Molecular Biology
Caterina Anania, Giulia Brindisi, Ivana Martinelli, Edoardo Bonucci, Miriam D'Orsi, Sara Ialongo, Anna Nyffenegger, Tonia Raso, Mattia Spatuzzo, Giovanna De Castro, Anna Maria Zicari, Carlo Carraro, Maria Grazia Piccioni, Francesca Olivero
Summary: Atopic dermatitis is a chronic inflammatory skin disorder with increasing prevalence in children and adults. The potential role of probiotics in preventing atopic dermatitis has generated considerable interest, as they can modulate systemic inflammation and immune responses. However, the molecular mechanisms and efficacy of probiotics in anti-allergic effects are still unclear and controversial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Camila Stofella Sodre, Mayra Stambovsky Vieira, Juliany Lima Estefan, Cristiane Moraes, Fernanda Sampaio Cavalcante, Katia Regina Netto dos Santos, Dennis de Carvalho Ferreira
Summary: A literature review found that probiotics have the potential to improve symptoms of atopic dermatitis in adult patients, reducing itchiness and severity as measured by SCORAD. However, there is still controversy and divergence regarding the actual benefits of probiotics in this context.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Pediatrics
Yue Liu, Xiaofan Du, Shujie Zhai, Xiaodong Tang, Cuiling Liu, Weihong Li
Summary: This scoping literature review explores the relationship between gut microbiota and atopic dermatitis (AD) in children. Current research indicates that disturbance of intestinal microbiota is closely associated with the occurrence and development of AD, and probiotics may play a role in the prevention and treatment of AD. However, there is still a lack of high-quality research on the efficacy and safety of probiotics in children with AD.
Article
Allergy
Sukyung Kim, Song-Yi Han, Jinyoung Lee, Na-Rae Kim, Bo Ra Lee, Hyunmi Kim, Mijeoung Kwon, Kangmo Ahn, Youngbae Noh, Sang Jong Kim, Phyrim Lee, Dongki Kim, Byung Eui Kim, Jihyun Kim
Summary: The combination therapy using Bifidobacterium longum and galactooligosaccharide (GOS) has been found to improve atopic dermatitis (AD) and increase the expression of epidermal barrier proteins.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2022)
Review
Pediatrics
Feina Wang, Fangru Wu, Hong Chen, Bibo Tang
Summary: This study used a meta-analysis method to evaluate the clinical efficacy of probiotics in preventing atopic dermatitis (AD) in children. The results showed that probiotics had a significant effect in preventing AD, especially in studies involving mothers and infants, before and after childbirth, using Lactobacillus rhamnosus or mixed probiotics, follow-up time ≤ 2 years, and conducted in Europe.
TRANSLATIONAL PEDIATRICS
(2023)
Article
Immunology
Gary P. Hubbard, Kiranjit Atwal, Lynne Graham, Sankara Narayanan, Lisa Cooke, Catherine Casewell, Sally-Ann Denton, Joan Gavin, Robert M. Browne, Fiona J. Kinnear, Ailsa J. McHardy, Debbie Evans, Rachel Vallis, Devasmitha Venkataraman, Abbie L. Cawood, Sarah Donohoe, Victoria Steele, Sonia Armstrong, Rebecca J. Stratton
Summary: In this pilot study, the use of a synbiotic-containing, whey-based extensively hydrolyzed formula (SeHF) showed significant improvements in gastrointestinal symptoms, atopic dermatitis, and quality of life in infants with non-IgE mediated cow's milk allergy (CMA). Hospital visits and medication use also significantly decreased in the 6 months after SeHF initiation.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Review
Medicine, Research & Experimental
Ionut Serban Fanfaret, Daniel Boda, Laura Mihaela Ion, Daniela Hosseyni, Poliana Leru, Selda Ali, Sabina Corcea, Roxana Bumbacea
Summary: Atopic dermatitis is a chronic inflammatory skin condition characterized by impaired skin barrier and increased permeability, leading to a higher risk of allergic sensitization. Studies on the use of prebiotics and probiotics in treating AD show conflicting data, with some studies reporting positive effects while others show no efficacy. More research is needed to determine the effectiveness of these treatments in patients with moderate to severe AD.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Microbiology
Chi Tung Choy, Pui Ling Kella Siu, Junwei Zhou, Chi Ho Wong, Yuk Wai Lee, Ho Wang Chan, Joseph Chi Ching Tsui, Claudia Jun Yi Lo, Steven King Fan Loo, Stephen Kwok Wing Tsui
Summary: This study focused on pediatric atopic dermatitis (AD) patients in southern China and used targeted 16S rRNA sequencing and bioinformatic analysis to investigate the impact of orally administered probiotics on the gut microbiome. After an 8-week course of probiotics, a significant improvement in the Eczema Area and Severity Index (EASI) was observed, with no adverse effects. The relative abundances of key microbial drivers also increased. The study provides preliminary evidence supporting targeted probiotic supplementation for childhood AD management.
Review
Pediatrics
Thulja Trikamjee, Pasquale Comberiati, Enza D'Auria, Diego Peroni, Gian Vincenzo Zuccotti
Summary: Atopic dermatitis, a common chronic skin disease, is influenced by genetic predisposition, environmental factors, and nutrition. Recent research emphasizes the importance of understanding the role of skin in allergies, as well as the potential of nutrition in preventing atopic dermatitis.
FRONTIERS IN PEDIATRICS
(2021)
Article
Nutrition & Dietetics
Paula Danielle Santa Maria Albuquerque de Andrade, Jorgete Silva, Vanessa Carregaro, Lais Amorim Sacramento, Luciana Rodrigues Roberti, Davi Casale Aragon, Fabio Carmona, Persio Roxo-Junior
Summary: This study evaluated the clinical efficacy of a mixture of Lactobacillus and Bifidobacterium probiotics in children and adolescents with atopic dermatitis. The results showed that this probiotic mixture significantly reduced skin symptoms and the need for immunosuppressants.
FRONTIERS IN NUTRITION
(2022)
Review
Pharmacology & Pharmacy
Sabina Fijan, Nina Kolc, Metka Hrasovec, Gro Jamtvedt, Maja Sikic Pogacar, Dusanka Micetic Turk, Uros Maver
Summary: This study evaluated the effect of single-strain probiotic lactobacilli on treating children's atopic dermatitis. The results showed that certain strains were more effective in reducing the severity of atopic dermatitis, and treatment time and patient age also played a role.
Review
Dermatology
Husein Husein-ElAhmed, Martin Steinhoff
Summary: Although the effect of probiotic administration on atopic dermatitis (AD) shows conflicting results, this study found that probiotic supplementation can reduce the incidence and severity of AD. Probiotics given to pregnant and lactating mothers can decrease the incidence by 49%. L. paracasei and L. sakei showed the greatest reduction in SCORAD.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2023)
Review
Dermatology
Husein Husein-ElAhmed, Martin Steinhoff
Summary: Despite conflicting results from previous research, this study found that probiotic supplementation can reduce the incidence and severity of atopic dermatitis (AD). The incidence of AD was 22% lower in the probiotic group. The greatest reduction in AD incidence (39%) was observed when probiotics were administered to pregnant-breastfeeding mothers and infants. Significant differences in SCORAD were observed, with L. paracasei and L. sakei showing the most significant decrease in SCORAD.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2023)
Review
Biochemistry & Molecular Biology
Karina Polak, Antal Jobbagy, Tomasz Muszynski, Kamila Wojciechowska, Aleksandra Fratczak, Andras Banvolgyi, Beata Bergler-Czop, Norbert Kiss
Summary: The review analyzed the literature on microbiome modulation in skin diseases, focusing on the effects and mechanisms of probiotics, prebiotics, and synbiotics in conditions like atopic dermatitis and psoriasis. While the evaluated studies showed significant health benefits and promising results, further investigation is warranted due to the limited research and ambiguous outcomes in the area of microbiome modulation as a therapeutic approach in skin diseases.
Review
Nutrition & Dietetics
Melissa Basso, Nicola Johnstone, Paul Knytl, Arjen Nauta, Andre Groeneveld, Kathrin Cohen Kadosh
Summary: This article reviews psychobiotic interventions in children and adolescents, aiming to evaluate the effectiveness of pre- and probiotic supplements on stress, anxiety, and cognitive outcomes. The findings indicate limited consistent effects of psychobiotics in developing human populations, possibly due to trial heterogeneity.
