Article
Fisheries
Hui Shen, Xianping Fan, Yi Qiao, Ge Jiang, Xihe Wan, Jie Cheng, Haolan Li, Yabin Dou, Hui Li, Libao Wang, Wenjun Shi, Yali Qin, Jing Shen
Summary: The study showed that Enterocytozoon hepatopenaei (EHP) infection affects the growth and intestinal microbiota of shrimp, with more severe infection leading to greater impact on intestinal microbiota. Additionally, different sizes of shrimp were found to be a result of varying periods of EHP infection.
AQUACULTURE REPORTS
(2021)
Article
Microbiology
Eliska Valeckova, Li Sun, Helen Wang, Faruk Dube, Emma Ivarsson, Kamyar Mogodiniyai Kasmaei, Patrik Ellstrom, Helena Wall
Summary: This study evaluated the effects of daily intake of LP256 on C. jejuni loads in the ceca and feces of broilers and the changes in the gut microbiota. The results showed that LP256 significantly reduced C. jejuni colonization in the ceca at the beginning of the experiment, but no treatment effect was observed at the end. The colonization dynamics of C. jejuni and the cecal microbiota composition were not affected by LP256 intake.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Marine & Freshwater Biology
Darren Garland, Frances Lucy, Nicolas Touzet
Summary: This study investigated cyanobacterial diversity and associated environmental factors in a lake in north-west Ireland that had previously been affected by algal blooms. The results showed spatial heterogeneity in photosynthetic pigment concentrations, which became more homogeneous towards the end of the survey. Temperature and photosynthetic pigments were found to be correlated with an increase in cyanobacterial richness. PCR-DGGE analysis also identified patterns in community composition, including the presence of toxigenic species similar to Microcystis sp.
Article
Genetics & Heredity
Rosa Escudero-Sanchez, Manuel Ponce-Alonso, Hugo Barragan-Prada, Maria Isabel Morosini, Rafael Canton, Javier Cobo, Rosa del Campo
Summary: The study aimed to evaluate the safety of suppressive antibiotic therapy (SAT) and its effect on gut microbiota. Although high variability in bacterial distribution was observed among patients, there was a clustering of microbiota composition in patients treated with beta-lactams and sulfonamides. Detection of antibiotic resistant bacteria was minimal, with only two subjects showing CTX-M-15-producing E. coli. Overall, SAT was considered safe and had a low impact on selection of multidrug-resistant bacteria.
Article
Food Science & Technology
Vasiliki C. Bikouli, Agapi I. Doulgeraki, Panagiotis N. Skandamis
Summary: This study aimed to evaluate the freshness of gilthead seabream based on microbiological data, and found that the presence of specific microorganisms can serve as a potential marker of freshness, fishing origin, and whether the fish has been frozen or not. The results showed that Pseudomonas, H2S-producing, and non H2S-producing microorganisms were dominant in freshly caught and chilled or frozen stored fish.
Article
Environmental Sciences
Jinmei Li, Irfan Ali Phulpoto, Lizheng Guo, Jie Zeng, Zhisheng Yu
Summary: This study investigated the reservoirs and spread of antibiotic resistance genes (ARGs) in the Xilingol grassland system using high-throughput quantitative PCR and sequencing. A large number of different ARGs were observed in manure, soil, and water samples, with only 12 ARGs shared among all samples. The water environment was found to be a critical transmission source of ARGs in the grassland.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Bin Wang, Xuheng Chen, Zhiyuan Chen, Huiwen Xiao, Jiali Dong, Yuan Li, Xiaozhou Zeng, Jinjian Liu, Guoyun Wan, Saijun Fan, Ming Cui
Summary: In this study, the researchers found that stable colonization of live A. muciniphila at lesion sites is essential for its anti-inflammatory function. They also developed a modified A. muciniphila that had enhanced inflammation targeting and intestinal colonization under an external magnetic field, leading to improved therapeutic efficacy against intestinal diseases. The findings further revealed that this modified A. muciniphila could drive M2 macrophage polarization by upregulating the protein level of IL-4 at inflammatory loci. These results demonstrate the importance of A. muciniphila in treating intestinal diseases.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Immunology
Linglian Kong, Zhenhua Wang, Chuanpi Xiao, Qidong Zhu, Zhigang Song
Summary: The study demonstrated that appropriate doses of glycerol monolaurate (GML) enhanced growth performance and immunity, improved intestinal morphology and barrier function in broiler chicks, and modulated the composition of cecal microbiota.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Xinyi Gu, Tao Yu, Tingting Guo, Jian Kong
Summary: This study developed and validated a qPCR-based method for rapid assessment of the health status of microbial communities, especially suitable for monitoring colorectal cancer patients. Results showed that the method accurately quantified the amounts of six bacterial genera relevant to intestinal homeostasis in fecal samples.
FUTURE MICROBIOLOGY
(2021)
Review
Gastroenterology & Hepatology
Rohma Ghani, Benjamin H. Mullish, Lauren A. Roberts, Frances J. Davies, Julian R. Marchesi
Summary: Disruption to the intestinal microbiota increases the risk of infection, and restoring its composition is a potential strategy to mitigate this risk. Fecal microbiota transplantation is currently the major therapeutic approach, with potential use in treating other infectious diseases.
Article
Biochemistry & Molecular Biology
Hao Ding, Xichen Zhao, Md Abul Kalam Azad, Cui Ma, Qiankun Gao, Jianhua He, Xiangfeng Kong
Summary: The study found that feeding XOS can improve piglets' growth performance, while feeding BS or XOS can influence intestinal health by improving intestinal morphology, microbial community, and metabolites. Additionally, there are interactions between BS and XOS in intestinal metabolites.
Article
Food Science & Technology
Wanzhong Liao, Huafeng Wu, Liangcheng Pang, Bizuan He, Jianjun Tong, Jiuyun Qin, Liang Li, Wei Liu, Xianqiang Zhou, Sihua Huang, Weizhe Jiang, Shujie Fu
Summary: The Hylocereus undatus flower (HUF) has significant anti-inflammatory and immunomodulatory activity. It alleviates colitis by restoring the integrity of the intestinal barrier, reducing the inflammatory response, and regulating gut and lung microbiota.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Agriculture, Dairy & Animal Science
Marcos Elias Duarte, Sung Woo Kim
Summary: This review article provides updated scientific information on the interaction among intestinal microbiota, dietary components, and intestinal health of pigs. The composition of the microbiota is mainly influenced by diet and feed additives, and plays a key role in modulating the immune system. The evaluation of mucosa-associated microbiota is more effective in assessing its impact on health parameters.
Article
Engineering, Environmental
Hao Zhang, Ani Yan, Xiaoyun Liu, Yi Ma, Fangfang Zhao, Mengzhi Wang, Jaun J. Loor, Hongrong Wang
Summary: The study found that oral melatonin supplementation can improve mitophagy in the liver and reverse gut microbiota dysbiosis. In antibiotic-treated mice, melatonin and OTA failed to induce mitophagy in the liver. Through gut microbiota transplantation experiments, the involvement of intestinal microbiota in liver inflammation and mitophagy induced by OTA was elucidated.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Cell Biology
Qian Ji, Shengqiao Fu, Hao Zuo, Yumeng Huang, Liangmei Chu, Yanyan Zhu, Jing Hu, Yuting Wu, Shuangwei Chen, Yue Wang, Yongfei Ren, Xi Pu, Na Liu, Rongkun Li, Xu Wang, Chunhua Dai
Summary: Lipid peroxidation-induced ferroptosis is a newly recognized type of programmed cell death. In this study, it was found that irradiation increased the expression of ferroptosis promotive genes and decreased the expression of ferroptosis suppressive genes in murine intestine tissues. Further experiments showed that ACSL4 is an important component for ferroptosis execution and its expression was upregulated in irradiated intestine tissues. Additionally, the ACSL4 inhibitor troglitazone was able to suppress lipid peroxidation and protect against tissue damage after irradiation.
CELL DEATH DISCOVERY
(2022)
Article
Microbiology
Zheng Sun, Meng Zhang, Min Li, Yogendra Bhaskar, Jinshan Zhao, Youran Ji, Hongbing Cui, Heping Zhang, Zhihong Sun
Summary: This study investigated the relationship between the gut microbiome and the sub-optimal health status of crew members during long ocean voyages. The study identified a syndrome called seafaring syndrome (SS) characterized by five core symptoms and found a significant correlation between SS and the gut microbiome. Microbial signatures for SS were identified and a prediction model for SS was developed. The findings of this study provide insights into potential predictors and therapeutic targets for dysbiosis-related diseases.
MICROBIOLOGY SPECTRUM
(2022)
Article
Agriculture, Dairy & Animal Science
Yaru Sun, Chuantao Peng, Jicheng Wang, Shuai Guo, ZhiHong Sun, Heping Zhang
Summary: This study analyzed the growth behavior and metabolomic characteristics of probiotic fermented milk under different fermentation temperatures. The results showed that the growth of probiotic strains was significantly increased at 37 degrees C, and there may be a potential relationship between riboflavin, starch, and sucrose metabolism and the growth of probiotics. The fermentation temperature also had a significant impact on the flavor compounds and short-chain fatty acids in the fermented products.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Microbiology
Hao Jin, Keyu Quan, Qiuwen He, Lai-Yu Kwok, Teng Ma, Yalin Li, Feiyan Zhao, Lijun You, Heping Zhang, Zhihong Sun
Summary: By using hybrid long-read and short-read sequencing, we characterized the gut microbiota of 60 individuals from Inner Mongolia and constructed the Inner Mongolian Gut Genome catalogue, which includes 802 closed and 5,927 high-quality metagenome-assembled genomes. This study provides a high-quality, large-scale resource for studying the human gut microbiota.
NATURE MICROBIOLOGY
(2023)
Article
Microbiology
Ye Chen, Xin Shen, Teng Ma, Xia Yu, Lai-Yu Kwok, Yalin Li, Zhihong Sun, Dongmei Li, Heping Zhang
Summary: This study found that the coadministration of probiotics with metformin significantly reduced glycated hemoglobin levels in patients with type 2 diabetes mellitus. This was achieved by modulating the gut microbiome and enhancing the effects of metformin through short-chain fatty acid and bile acid metabolism. The findings support the beneficial use of probiotics in combination with metformin for the management of type 2 diabetes mellitus.
Article
Microbiology
Y. R. Sun, R. S. Jayawardena, J. E. Sun, Y. Wang
Summary: This study reports 17 pestalotioid species related to medicinal plants based on morphology and molecular analyses, enriching the species richness of this fungal group and providing a basis for future studies.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Yue Sun, Shuai Guo, Jingfang Yang, Yingmeng Li, Zhihong Sun, Lai-Yu Kwok, Tiansong Sun, Wenjun Liu, Wenjun Liu
Summary: This study investigated the effect of space exposure on the probiotic bacterium Lacticaseibacillus rhamnosus Probio-M9. It was found that the space-exposed bacteria had the ability to produce capsular polysaccharide (CPS), which can enhance the probiotic effects. The space-induced genomic changes and acquired CPS-producing ability can be stably inherited, indicating the potential of space mutagenesis in inducing stable changes in probiotics.
MICROBIOLOGY SPECTRUM
(2023)
Article
Food Science & Technology
Yaru Sun, Shuai Guo, Ting Wu, Jingwen Zhang, Lai-Yu Kwok, Zhihong Sun, Heping Zhang, Jicheng Wang
Summary: This study used metabolomics technology to analyze the changes in metabolites during the fermentation process. It found that the probiotic strains showed significant metabolic changes, especially in organic acids, amino acids, and fatty acids. The levels of pyruvic acid, gamma-aminobutyric acid, and capric acid increased at the end of fermentation, contributing to the nutritional and functional properties of probiotic fermented milk.
NPJ SCIENCE OF FOOD
(2023)
Correction
Food Science & Technology
Tao Zhang, Weiqin Zhang, Cuijiao Feng, Lai-Yu Kwok, Qiuwen He, Zhihong Sun
NPJ SCIENCE OF FOOD
(2023)
Article
Microbiology
Yong Zhang, Tingting Zheng, Da Ma, Peng Shi, Heping Zhang, Jun Li, Zhihong Sun
Summary: This study investigated the antihypertensive effect of Bifidobacterium lactis M8 and Lactobacillus rhamnosus M9 in high-fructose-treated mice. The results showed that these probiotics significantly reduced blood pressure and were associated with specific gut microbes and metabolic pathways. This study provides a potential mechanistic understanding of probiotics modulated blood pressure and their therapeutic potential in hypertension management.
Article
Biotechnology & Applied Microbiology
Teng Ma, Weiqiang Huang, Yalin Li, Hao Jin, Lai-Yu Kwok, Zhihong Sun, Heping Zhang
Summary: Probiotic supplementation in late pregnant sows can alleviate constipation, reduce inflammation, and improve piglets' growth performance. This is achieved by reshaping the sow gut bacteriome and phageome structure, increasing potentially beneficial bacteria, and altering metabolic potential and metabolism.
NPJ BIOFILMS AND MICROBIOMES
(2023)
Review
Food Science & Technology
Weicheng Li, Qiong Wu, Lai-yu Kwok, Heping Zhang, Renyou Gan, Zhihong Sun
Summary: This review summarizes the research progress of the population and functional genomics of lactic acid bacteria (LAB). It elucidates the formation mechanism and driving forces of LAB characteristics, highlights the application of LAB genome in food safety and properties, and provides suggestions for improving resource exploitation and application.
Article
Mathematical & Computational Biology
Yi Jing, Baiyang Feng, Jing Gao, Jin Li, Ganghui Zhou, Zhihong Sun, Yufei Wang
Summary: Lactic acid bacteria are Gram-positive bacteria that can produce lactic acid by utilizing fermentable carbohydrates. They are widely used in essential fields and closely related to human health. The potential of LAB in cancer treatment has attracted attention.
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
(2023)
Review
Gastroenterology & Hepatology
Tao Zhang, Guangqi Gao, Lai-Yu Kwok, Zhihong Sun
Summary: The advent of high-throughput 'omics' technologies has improved our understanding of the connection between gut microbiome and Alzheimer's disease (AD). Modulating the gut microbiota has emerged as a novel approach for clinical management of AD. This review provides an overview of the association between gut dysbiosis and AD, the mechanisms of gut microbiota in driving AD progression, and the success and challenges of gut microbiome-targeted therapies in AD studies.
Article
Food Science & Technology
Tao Zhang, Weiqin Zhang, Cuijiao Feng, Lai-Yu Kwok, Qiuwen He, Zhihong Sun
Summary: This study compared the benefits of probiotics and postbiotics in an experimental colitis mouse model. Both probiotics and postbiotics were effective in ameliorating colitis, but postbiotics showed stronger effects on modulating the gut microbiota and metabolic pathways. Therefore, postbiotics may be considered as next-generation biotherapeutics for managing ulcerative colitis or other diseases.
NPJ SCIENCE OF FOOD
(2022)
Article
Agriculture, Dairy & Animal Science
Shujuan Yang, Chenglin Deng, Yao Li, Weicheng Li, Qiong Wu, Zhihong Sun, Zhenhui Cao, Qiuye Lin
Summary: In this study, a potential probiotic strain L. plantarum ST was isolated from De'ang pickled tea in Yunnan Province, China, and its genome was fully sequenced and analyzed. The results showed that L. plantarum ST exhibited strong tolerance and antibacterial activity, indicating its potential application in animal breeding.
JOURNAL OF ANIMAL SCIENCE AND TECHNOLOGY
(2022)
