Article
Chemistry, Multidisciplinary
Anne-Catherine Lehnen, Johannes Gurke, Alain M. Bapolisi, Martin Reifarth, Marek Bekir, Matthias Hartlieb
Summary: XPI-RAFT is introduced as a fast and versatile photo-polymerization strategy. It enables efficient chain extension directly by irradiation and decouples photo-activation from polymerization control, making it an elegant tool for the synthesis of defined and complex macromolecules.
Article
Green & Sustainable Science & Technology
Bingbing Liu, Yizhuang Wang, Guihong Han, Li Zhang, Yanfang Huang
Summary: In this study, microwave-assisted heating was used to synthesize magnetic ferrite ceramics at a reduced temperature. The microwave absorptivity and temperature rise characteristics of the MnO2-Fe2O3 system were evaluated, and the phase transformation, microstructure evolution, and magnetism change of the materials were compared under conventional and MW-assisted heating. The results showed that the synthesis temperature of ferrite could be significantly reduced by MW-assisted heating, and the resulting ferrite exhibited good electromagnetic performance. This study also demonstrated the clean and value-added utilization of low-grade ferruginous manganese ores via MW-assisted heating.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Chemistry, Organic
Mingjun Zhang, Mo Yu, Ziwen Wang, Yuxiu Liu, Qingmin Wang
Summary: Here, we report a mild, rapid, and direct method for the visible-light-mediated ethylation of sulfonamides to synthesize compounds with diverse C(sp(3))-sulfonamide skeletons. This method utilizes inexpensive, abundant, commercially available primary, secondary, and tertiary alkyl carboxylic acids and alkyl iodides as substrates and has a broad scope of applicability. It shows potential utility for the late-stage functionalization of natural products and synthetic medicines, allowing for rapid structural diversification of biologically active molecules.
Article
Chemistry, Organic
Mengbi Guo, Xin Wang, Yitong Wang, Zhuang Hou, Chun Guo, Ping Gong
Summary: A facile and efficient method for synthesizing C1-aminosugar derivatives under catalyst-free conditions is described. The method utilizes readily available benzoyl glycosyl bromides to smoothly obtain a broad scope of C1-aminosugar derivatives with good yields. It offers the advantages of short reaction time, high yield, and a wide substrate scope.
TETRAHEDRON LETTERS
(2022)
Article
Chemistry, Organic
Yi Fang, Xin Li, Chunyi Liu, Jie Tang, Zhengping Chen
Summary: A facile method for synthesizing bromodifluoromethylated selenides under metal-free conditions has been described, with short reaction time, absence of toxic waste, good scalability, and successful late-stage modification of bioactive molecules. The resulting products can be easily converted to different fluorinated and F-18-labeled selenides.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Materials Science, Biomaterials
Varnakumar Gayathri, Nitin P. Lobo, Vijan Lal Vikash, Numbi Ramudu Kamini, Debasis Samanta
Summary: Bacterial cellulose and related materials have attracted significant attention due to their abundance and biocompatibility. Chemical modification of bacterial cellulose often involves harsh conditions that may alter its properties. In this work, we adopted the Suzuki coupling methodology to chemically modify bacterial cellulose under mild conditions. We used a thermoresponsive catalyst for the reaction and chose boronic acid derivatives to alter the wettability behavior. The methodology was demonstrated to be useful for fluorescent labeling and hydrophobic modification of bacterial cellulose-based materials.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Polymer Science
Naganath Patil, Yves Gnanou, Xiaoshuang Feng
Summary: By adding Lewis acid such as triethylborane (TEB), the copolymerization of o-phthalaldehyde (OPA) with various epoxides has been successfully carried out under ambient conditions, resulting in the formation of polyacetals. The role and effect of TEB, its amount, and the feeding ratio of OPA to epoxides during their copolymerizations were investigated. The successful copolymerization was further extended to the synthesis of polyether-b-polyacetal block copolymers with different structure and properties.
Article
Pharmacology & Pharmacy
Shravan Sreenivasan, Wim Jiskoot, Anurag S. Rathore
Summary: The degradation of therapeutic monoclonal antibodies (mAb) due to interfacial agitation through air bubbling was investigated. It was found that exposure to air/liquid interfacial stress effectively generated sub-visible and visible aggregates in mAb samples, impacting protein structure and activity.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Polymer Science
Wei-Wei Yu, Wen-Zhe Xu, Yan-Chan Wei, Shuangquan Liao, Ming-Chao Luo
Summary: This study introduces a novel, easy strategy to construct sacrificial networks driven by interfacial interactions, which improves the strength and toughness of materials.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Polymer Science
Chuanjie Liu, Meng Tang, Fenglun Zhang, Fuhou Lei, Pengfei Li, Kun Wang, Hongbo Zeng, Jianxin Jiang
Summary: Sandy soil has poor water-holding capacity, leading to difficulties for plant survival and exacerbating ecological degradation. The study developed borax cross-linked Gleditsia microphylla galactomannan hydrogel (GMGH) as a water-retaining agent, which demonstrated fast self-healing capability and high swelling index. Mixing GMGH with sandy soil improved its water absorption and retention properties, with increased porous structure and prolonged water-holding time. GMGH shows promising application prospects in desertification control.
Article
Chemistry, Multidisciplinary
Olivia L. Garry, Michael Heilmann, Jingjia Chen, Yufan Liang, Xiaheng Zhang, Xiaoshen Ma, Charles S. Yeung, David Jonathan Bennett, David W. C. MacMillan
Summary: Replacing aryl rings with saturated carbocyclic structures is of great interest in drug discovery for improved pharmacokinetic properties. However, the synthesis of 2-substituted BCPs remains challenging and nonmodular. This study presents a generalizable strategy for bridge functionalization and demonstrates a streamlined pathway to diverse 2-substituted BCPs through radical C-H abstraction and metallaphotoredox protocols.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Polymer Science
Maksim Hulnik, Olga Kuharenko, Peter Timashev, Irina V. Vasilenko, Sergei Kostjuk
Summary: The AlCl3 x OPh2-co-initiated cationic polymerization of anethole, a biomass-derived vinyl monomer, was successfully conducted in less toxic solvents compared to traditionally used chlorinated solvents. The synthesis of high molecular weight polyanethole with moderate polydispersity was achieved by controlling temperature, solvent nature, proton trap addition, and co-initiator concentration. The synthesized polymers contained a high molecular weight fraction generated through chain transfer to monomer and subsequent copolymerization with anethole. The content of the high molecular weight fraction could be reduced by increasing reaction temperature and using less polar solvents. The synthesized polyanetholes exhibited high glass transition temperature, thermal stability, and Young modulus, making them promising for high-performance materials.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Chemistry, Inorganic & Nuclear
Hao Gao, Qianli Li, Ping Cui, Chen-Ho Tung, Lingbing Kong
Summary: Researchers have developed a facile route to synthesize B = C double-bonded systems, obtaining corresponding compounds through experiments and further analyzing their electronic structures through theoretical calculations and comparisons.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Yuping Zhu, Tianqi Liu, Bingxin Liu, Houguang Shi, Qitao Tan, Bin Xu
Summary: In this study, alpha-Keto acids were used as novel precursors of nitrile oxides upon treatment with copper nitrate, which reacted with maleimides via [3 + 2] dipolar cycloaddition to form pharmacologically interesting fused isoxazolines. Compared with previous methods, this approach provides a unique and complementary strategy for the convenient synthesis of alkyl substituted nitrile oxides. Mechanistic studies revealed a novel carbon-carbon bond cleavage in alpha-keto acids leading to key gem-dinitroalkane intermediates for the transformation to nitrile oxides in 1,3-dipolar cycloadditions.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Polymer Science
Qiankun Li, Hongliang Mu, Zhongbao Jian
Summary: A new family of neutral salicylaldiminato nickel(II) catalysts (Ni1-Ni5) with well designed ortho substituents to the phenoxy moiety is developed, showing moderate to high activity for ethylene polymerization. By using these catalysts, polyethylene materials with lower molecular weight and significantly higher branching degree can be obtained, facilitating the synthesis of various polyethylene products ranging from solid plastic to wax and oil. The upgraded catalysts Ni6 and Ni7 produce polymers with high molecular weight and high branching degree, resulting in polyethylenes with excellent elastic properties.
