Article
Oncology
Marie Cantaloube, Mohamed Boucekine, Anne Balossier, Xavier Muracciole, Mickael Meyer, Christine Delsanti, Romain Carron, Yassine Mohamed Beltaifa, Domnique Figarella-Branger, Jean Regis, Laetitia Padovani
Summary: This study confirms that postoperative Gamma Knife radiosurgery (GK) after resection of brain metastases is an effective and well-tolerated technique for treating tumors of all sizes. In cases of intracranial relapse, iterative stereotactic radiosurgery (SRS) or salvage whole brain radiotherapy (WBRT) can be performed to delay the potential side effects of WBRT.
RADIATION ONCOLOGY
(2022)
Review
Clinical Neurology
Nida Fatima, Erqi Pollom, Scott Soltys, Steven D. Chang, Antonio Meola
Summary: The study indicates that stereotactic radiosurgery for head and neck paragangliomas is associated with good clinical and radiographic outcomes, with a 94.2% local control rate. Most patients underwent Gamma Knife Radiosurgery without significant differences in local control depending on the SRS technique. Local control was negatively correlated with several factors such as gender, tumor location, treatment modality, and initial presenting symptom of hearing loss.
NEUROSURGICAL REVIEW
(2021)
Article
Clinical Neurology
Nourou Dine Adeniran Bankole, Adyl Melhaoui, Yasser Arkha, Semmar Afaf, Khalid Bouyakhlef, Mahjouba Boutarbouch, Mohamed Jiddane, Abdeslam El Khamlichi
Summary: This study retrospectively evaluated the outcomes of patients with brain metastases treated with Leksell Gamma Knife stereotactic radiosurgery (GKSR) between 2008 and 2021. The results showed that GKSR provides good overall survival (OS) and better quality of life for patients with single or multiple brain metastases. Tumor stability and retreatment influenced the OS of patients with brain metastases.
WORLD NEUROSURGERY
(2023)
Review
Clinical Neurology
Vera Ong, Alexandre J. Bourcier, Timothy J. Florence, Khashayar Mozaffari, Mahlet Mekonnen, John P. Sheppard, Courtney Duong, Kevin Ding, Isaac Yang
Summary: This meta-analysis evaluated the effectiveness of stereotactic radiosurgery (SRS) as a treatment option for Glomus jugulare tumors (GJTs). The results showed a high tumor control rate and symptomatic improvement rate with SRS, suggesting its suitability as a treatment modality for these tumors. Further studies are needed to explore the potential role of SRS in managing GJTs.
WORLD NEUROSURGERY
(2022)
Article
Oncology
Michael T. Milano, Jimm Grimm, Andrzej Niemierko, Scott G. Soltys, Vitali Moiseenko, Kristin J. Redmond, Ellen Yorke, Arjun Sahgal, Jinyu Xue, Anand Mahadevan, Alexander Muacevic, Lawrence B. Marks, Lawrence R. Kleinberg
Summary: This study pooled data from 51 reports to investigate radiation-induced brain toxicity after hypofractionated radiation therapy. Results showed wide variability in rates of radionecrosis, with single-fraction SRS tissue volumes receiving 12 Gy associated with risks of symptomatic radionecrosis. The use of fSRS appears to reduce risks of radionecrosis for larger treatment volumes compared to SRS.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Akiyoshi Ogino, Ajay Niranjan, Hideyuki Kano, John C. Flickinger, L. Dade Lunsford
Summary: The study evaluated factors affecting tumor control and complications in craniopharyngioma SRS. Results showed that ensuring at least 85% of the tumor received >= 12 Gy improved tumor control rates, even with a distance < 3 mm from the optic system. Higher conformity index did not lead to better tumor control.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Clinical Neurology
Zheng Wang, Haining Chen, Qun Chen, Yucun Zhu, Zhennan Bai, Min Li, Weihua Zhang
Summary: The authors developed the sandwich therapy, which integrates 2-stage stereotactic radiosurgery (2-SSRS) with bevacizumab, for reducing peritumoral edema and achieving local control in large brainstem metastases. The therapy showed significant reductions in tumor volume, peritumoral edema volume, and improvement in symptoms in the study of 42 patients.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Oncology
Serena Ammendola, Paola Chiara Rizzo, Michele Longhi, Emanuele Zivelonghi, Serena Pedron, Giampietro Pinna, Francesco Sala, Antonio Nicolato, Aldo Scarpa, Valeria Barresi
Summary: The loss of H3K27me3 in meningiomas is significantly associated with tumor progression and shorter PFS after stereotactic radiosurgery (SRS), suggesting a weaker response to SRS in these cases.
Review
Clinical Neurology
Othman Bin-Alamer, Arka N. Mallela, Paolo Palmisciano, Zachary C. Gersey, Turki Elarjani, Mohamed A. Labib, Georgios A. Zenonos, Amir R. Dehdashti, Jason P. Sheehan, William T. Couldwell, L. Dade Lunsford, Hussam Abou-Al-Shaar
Summary: This retrospective study aimed to compare the survival outcomes of patients with biopsy-proven skull base chordoma who underwent stereotactic radiosurgery (SRS) with or without prior fractionated radiation therapy (RT). The systematic review of relevant articles revealed that tumor control and survival rates for SRS alone after chordoma surgery were comparable to those for SRS plus fractionated RT.
NEUROSURGICAL FOCUS
(2022)
Article
Oncology
Sergej Telentschak, Daniel Ruess, Stefan Grau, Roland Goldbrunner, Niklas von Spreckelsen, Karolina Jablonska, Harald Treuer, Martin Kocher, Maximilian Ruge
Summary: The study retrospectively analyzed 34 patients treated with CK-hSRS, showing good treatment effectiveness with high local control rates but a 12% complication rate.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Clinical Neurology
Othman Bin-Alamer, David Fogg, Zhishuo Wei, James Duehr, Arka N. Mallela, Ajay Niranjan, L. Dade Lunsford, Hussam Abou-Al-Shaar
Summary: This study retrospectively reviewed 2058 patients who underwent stereotactic radiosurgery for vestibular schwannomas, and found a cumulative incidence rate of 0.26% for intra-tumoral hemorrhage. Most patients could achieve stable or improved condition through observation or delayed resection, although one patient required urgent surgical intervention.
JOURNAL OF NEUROSURGERY
(2023)
Article
Biology
Yi-Han Huang, Huai-Che Yang, Chi-Lu Chiang, Hsiu-Mei Wu, Yung-Hung Luo, Yong-Sin Hu, Chung-Jung Lin, Wen-Yuh Chung, Cheng-Ying Shiau, Wan-Yuo Guo, Cheng-Chia Lee
Summary: Administering stereotactic radiosurgery to the surgical cavity after surgery can improve local tumor control, but it does not have a significant effect on overall survival.
Article
Clinical Neurology
Anne-Marie Langlois, Christian Iorio-Morin, Andrew Faramand, Ajay Niranjan, L. Dade Lunsford, Nasser Mohammed, Jason P. Sheehan, Roman Liscak, Dusan Urgosik, Douglas Kondziolka, Cheng-chia Lee, Huai-che Yang, Ahmet F. Atik, David Mathieu
Summary: SRS treatment for schwannomas of the oculomotor, trochlear, and abducens nerves is effective, providing tumor control rates similar to those for other cranial nerve schwannomas. SRS allows improvement of diplopia in the majority of patients and should be considered a first-line treatment option for oculomotor nerve schwannomas.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Yavuz Samanci, M. Orbay Askeroglu, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Khaled Abdelkarim, Amr M. N. El-Shehaby, Reem M. Emad, Andrew Legarreta, David Fernandes Cabral, Sharath Anand, Ajay Niranjan, L. Dade Lunsford, Manjul Tripathi, Narendra Kumar, Roman Liscak, Jaromir May, Cheng-chia Lee, Huai-che Yang, Nuria Martinez Moreno, Roberto Martinez Alvarez, Keiss Douri, David Mathieu, Stylianos Pikis, Georgios Mantziaris, Jason P. Sheehan, Kenneth Bernstein, Douglas Kondziolka, Selcuk Peker
Summary: This study evaluated the safety and efficacy of SRS in managing pediatric meningiomas. The results suggest that SRS may be a safe and effective treatment option for surgically inaccessible, recurrent, or residual pediatric meningiomas.
Article
Oncology
Toshinori Hasegawa, Takenori Kato, Takehiro Naito, Takafumi Tanei, Kazuki Ishii, Eisuke Tsukamoto, Kou Okada, Risa Ito, Yuuta Kouketsu
Summary: SRS is an acceptable treatment option for selected patients with Koos grade 4 VSs. Risk group classification based on patient age and MCP compression is useful in decision-making for Koos grade 4 VSs.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Orthopedics
Matthew J. Johnson, Dane K. Wukich, Paul A. Nakonezny, Lawrence A. Lavery, Javier La Fontaine, Junho Ahn, David H. Truong, George Tye Liu, Michael VanPelt, Paul J. Kim, Katherine M. Raspovic
Summary: This study aimed to evaluate the impact of diabetic foot infections (DFI) on patient-reported health-related quality of life (HRQOL). The results showed that hospitalized patients with DFI reported significantly worse HRQOL in physical function, anxiety, depression, fatigue, social role, and pain intensity compared to outpatients with diabetes receiving routine foot care.
JOURNAL OF FOOT & ANKLE SURGERY
(2022)
Article
Psychology, Multidisciplinary
Paul Youngbin Kim
Summary: This study examines the association between endorsement of the model minority stereotype by Asian Americans and mental health, and explores the moderating roles of religion and God representation. The findings suggest that both authoritarian and benevolent God representations play a role in moderating this association. This novel integration of the model minority and religiosity literature has promising implications for professionals working with Asian Americans in Christian settings.
PSYCHOLOGY OF RELIGION AND SPIRITUALITY
(2023)
Article
Ethnic Studies
Kyu Jin Yon, Hun Je Jo, Paul Youngbin Kim
Summary: This study found that adhering to certain East Asian cultural values is associated with life satisfaction among Korean college students, and these associations differ by gender. The study highlights the importance of considering the interaction between cultural values and gender when assisting Asian college students in the context of cultural shifts.
ASIAN AMERICAN JOURNAL OF PSYCHOLOGY
(2023)
Article
Dermatology
Paul J. Kim, Siobhan Lookess, Christine Bongards, Leah Passmore Griffin, Allen Gabriel
Summary: The study examined the effectiveness and cost of negative pressure wound therapy with instillation compared to control therapies for complex acute and chronic wounds. Results showed a potential cost savings with fewer operating room visits and shorter therapy duration in the negative pressure wound therapy with instillation group.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Min-Jeong Lee, Ji-Yoon Kim, Paul Kim, In-Seo Lee, Medard E. Mswahili, Young-Seob Jeong, Guang J. Choi
Summary: In this study, artificial neural network (ANN)-based machine learning model was used to screen potential coformers for Vonoprazan (VPZ) cocrystals. The selected coformers were confirmed to create new solid forms with VPZ through experimental screening. Three novel cocrystals, VPZ-RES, VPZ-CAT, and VPZ-GAL, were successfully prepared and characterized. These cocrystals demonstrated improved solubility and stability, indicating their potential for enhanced pharmaceutical performance.
Article
Ethnic Studies
Paul Youngbin Kim, Brittany M. Tausen
Summary: This study found that white students' empathy towards Asian and Asian American experiences of racism during COVID-19 was related to how their peers talked about and responded to this issue, especially for white men. The findings suggest practical ways to help non-Asians better understand the experiences of racism among Asians and Asian Americans.
ASIAN AMERICAN JOURNAL OF PSYCHOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Paul Y. Kim, Yige Gao, Zachary Fink, Alexander E. Ribbe, David A. Hoagland, Thomas P. Russell
Summary: In this study, the structural reorganizations and jamming/unjamming processes of Gibbs monolayers of nanoparticles were observed in real time using in-situ scanning electron microscopy. The findings provide important mechanistic insights into the solidification of nanoparticles under mechanical stress.
Article
Surgery
Margaret Lauerman, Emily Esposito, Chance Spalding, Joshua Simpson, Julie A. Dunn, Linda Zier, Sigrid Burruss, Paul Kim, Lewis E. Jacobson, Jamie Williams, Jeffry Nahmias, Areg Grigorian, Laura Harmon, Anna Gergen, Matthew Chatoor, Rishi Rattan, Andrew J. Young, Jose L. Pascual, Jason Murry, Adrian W. Ong, Alison Muller, Rovinder S. Sandhu, Rachel Appelbaum, Nikolay Bugaev, Antony Tatar, Khaled Zreik, Mark J. Lieser, Thomas M. Scalea, Deborah M. Stein
Summary: This study aimed to analyze the use of endovascular intervention (EI) for blunt cerebrovascular injury (BCVI) patients. The results showed that pseudoaneurysm size was associated with the use of EI. The incidence of stroke was higher in patients receiving EI, but all strokes occurred before or at the same time as EI use.
Article
Surgery
Sarah Yang, Emily Esposito, Chance Spalding, Joshua Simpson, Julie A. Dunn, Linda Zier, Sigrid Burruss, Paul Kim, Lewis E. Jacobson, Jamie Williams, Jeffry Nahmias, Areg Grigorian, Laura Harmon, Anna Gergen, Matthew Chatoor, Rishi Rattan, Andrew J. Young, Jose L. Pascual, Jason Murry, Adrian W. Ong, Alison Muller, Rovinder S. Sandhu, Rachel Appelbaum, Nikolay Bugaev, Antony Tatar, Khaled Zreik, Mark J. Lieser, Thomas M. Scalea, Deborah M. Stein, Margaret Lauerman
Summary: The study aims to investigate the stroke risk factors specific to grade 1 ICA BCVI. It found that persistence of injury may increase the risk of stroke, and some strokes still occurred despite initiation of medical therapy. Repeat imaging is recommended to evaluate the progression or resolution of injury in grade 1 ICA BCVI.
Article
Orthopedics
Andrew Adamczyk, Pierre Laboudie, Hamid Nessek, Paul R. Kim, Wade T. Gofton, Robert Feibel, George Grammatopoulos
Summary: This study retrospectively reviewed 204 patients (220 hips) who underwent elective total hip arthroplasty (THA) between November 2016 and December 2019. The study analyzed templates from 5 different surgeons and compared the accuracy of preoperative digital templating for different stem designs and surgical approaches. The results showed that the accuracy of femoral component size templating was significantly improved with a single-wedge mid-short stem design. The precision of cup sizing was better in the posterior approach group. Accuracy of templating was found to be dependent on the presence of a calibration marker and the stem design.
Article
Orthopedics
Niall P. McGoldrick, Michael J. Cochran, Brook Biniam, Raman S. Bhullar, Paul E. Beaule, Paul R. Kim, Wade T. Gofton, George Grammatopoulos
Summary: This study aimed to evaluate the influence of patient-specific femoral and pelvic morphology and surgical technique on the perioperative fracture risk in short cementless stem total hip arthroplasty (THA) using the anterior approach (AA). The results showed that specific anatomical parameters can serve as predictors of fracture risk, highlighting the importance of careful selection of stem type.
JOURNAL OF ARTHROPLASTY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Mian H. Hanif, Justin Turcotte, Paul Kim, Adrian Park
Article
Chemistry, Multidisciplinary
Paul Kim, In-Seo Lee, Ji-Yoon Kim, Medard E. Mswahili, Young-Seob Jeong, Woo-Jin Yoon, Ho-Seop Yun, Min-Jeong Lee, Guang J. Choi
Summary: Using artificial neural network and pK(a) rule, potential coformers of PF to form cocrystals were predicted and experimentally verified. The resulting PF-INA and PF-NCA cocrystals exhibited improved solubility and dissolution behaviors compared to pure PF in acidic and neutral solutions. Combination of machine learning-based and knowledge-based coformer screening with subsequent synthetic experiments could be a potential approach for discovering novel pharmaceutical cocrystals in the future.
Meeting Abstract
Cardiac & Cardiovascular Systems
Patrick Azcarate, Paul Kim
JOURNAL OF CARDIAC FAILURE
(2022)
Meeting Abstract
Dermatology
Shyon Parsa, Christine E. Wamsley, Paul Kim, Jeffrey M. Kenkel, Yucel Akgul
LASERS IN SURGERY AND MEDICINE
(2022)
Article
Clinical Neurology
Guilu He, Jianhao Lin, Jing Ye, Fobao Huang, Changzhi Yan, Zesi Liu, Xiuming Zhou, Qiao Li, Liang Zhang
Summary: This article introduces long tunneled external ventricular drain (LTEVD), which effectively avoids multiple surgeries by connecting an external shunt valve. It allows visual control of drainage flow, prolongs catheter indwelling time, and eliminates the need for multiple surgeries.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Vinay Suresh, H. S. Suresh, Bharath Raju, Himanshu Jindal, Ahmad Ozair
Summary: This study investigated the outcomes of postoperative discitis treated with debridement and a novel technique focused on reducing outpatient antibiotic requirement in a low- and middle-income country (LMIC) setting. The results showed that patients with medically refractory postoperative discitis potentially have good outcomes after debridement plus 2-week local antibiotic instillation in LMICs.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Beatrice C. Bono, Davide Milani, Fabio Ferreli, Simone Olei, Luca Raspagliesi, Maria Pia Tropeano, Giovanni B. Lasio, Federico Pessina
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Avi A. Gajjar, Shrey Patel, Raj Swaroop Lavadi, Rida Mitha, Rohit Prem Kumar, Tavis Taylor, Galal A. Elsayed, D. Kojo Hamilton, Nitin Agarwal
Summary: Art in neurosurgery has played a crucial role in the discipline for centuries. Medical illustrations help visualize anatomy and surgical procedures, contributing to education, surgical planning, and navigation.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Joaquin Perez Zabala, Yamila Basilotta Marquez, Romina Arganaraz, Beatriz Mantese
Summary: We present a low-cost and easily accessible adaptation system for stereotactic procedures in infants. By using a headband cast technique, a stereotactic biopsy was successfully performed in a 5-month-old patient, achieving precise targeting, histopathological diagnosis, and no associated complications.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Muhammad Kusdiansah, Arnau Benet, Yosuke Suzuki, Kenichi Haraguchi, Nakao Ota, Kosumo Noda, Rokuya Tanikawa
Summary: Fusiform vertebral artery aneurysms are difficult to treat, and endovascular and open microsurgical treatments are used for different situations. This report presents a case with complex anatomy and branch involvement and describes the treatment strategy used.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Victor M. Lu
Summary: This review emphasizes four essential domains that should be considered when interpreting pediatric neurosurgical SRMAs and provides examples to ensure accurate and effective interpretation of findings in this niche.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Lapo Bonosi, Angelo Torrente, Filippo Brighina, Cateno Concetto Tito Petralia, Pietro Merlino, Chiara Avallone, Vincenzo Gulino, Roberta Costanzo, Lara Brunasso, Domenico Gerardo Iacopino, Rosario Maugeri
Summary: Corticocortical evoked potentials (CCEPs) have emerged as a valuable intraoperative monitoring technique in eloquent brain tumor surgery, aiding in preserving critical functional areas. Current research shows the potential of CCEPs in guiding surgical decision making, reducing the risk of postoperative neurological deficits, and mapping functional connectivity, but further research and standardization are needed.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Yuchen Duan, Dagang Feng, Min Zhu, Heng Qiu, Tong Li, Zhen Chen, Leiming Jiang, Yong Huang
Summary: This study aimed to compare the effect of different Modic changes (MC) grades on the cage subsidence rate after spinal interbody fusion surgery. A meta-analysis was conducted on relevant randomized controlled trials and cohort studies. The results showed that MC may be associated with a higher cage subsidence rate. With the increase in MC grades, the incidence of subsidence decreased gradually, but it was always higher than that in the non-Modic changes (NMC). Oblique lumbar interbody fusion may be a better treatment choice for lumbar degenerative disease with MC.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Brian F. Saway, Conor M. Cunningham, Mustafa Ismail, Alejandro M. Spiotta
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Joanna M. Roy, Michael M. Covell, Carmelo Venero Jr, Christian A. Bowers
Summary: Early exposure to neurosurgery during medical school is critical for improving recruitment into the specialty. However, about 30% of medical schools in the U.S. lack a neurosurgery program, limiting students' exposure to the field. Virtual education, facilitated by webinars during the pandemic, has advantages such as global outreach and accessibility for international medical students. This review identifies and describes 16 educational resources, serving as a guide for medical students interested in neurosurgery.
WORLD NEUROSURGERY
(2024)