Article
Clinical Neurology
Florian Ebel, Stefan Wanderer, C. Marvin Jesse, Ralph T. Schar, Irena Zubak, Christian T. Ulrich, Andreas Raabe
Summary: A standardized in vitro model was developed to test different grafts and suture techniques for watertight dural closure. The study found that there was no significant difference between running and simple interrupted suture techniques. Adding a patch or sealant resulted in higher hydrostatic burst pressure. The highest pressure was achieved with the combination of specific grafts and sealants.
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
Lei Jiang, Alexandru Budu, Muhammad Shuaib Khan, Edward Goacher, Angelos Kolias, Rikin Trivedi, Jibin Francis
Summary: The effectiveness of different dural closure techniques in preventing cerebrospinal fluid leaks following surgery for intradural lesions was compared in this study. It was found that age, surgical indication, and dural closure with suture, sealant, and patch were factors associated with CSF leaks.
Article
Clinical Neurology
Kazim Mohammed, Javeed Iqbal, Mohsin Arshad, Ala Saleem Abu-Dayeh, Issam Albozom, Abdulnasser Alyafei, Tarek ben Zabih, Sirajeddin Belkhair
Summary: In this case series, we found that the use of ReDura as a dural substitute after emergent decompressive craniectomy can lead to excessive granulation tissue formation and potential abnormal reactions, highlighting the need for careful monitoring.
WORLD NEUROSURGERY
(2023)
Review
Medicine, General & Internal
Rong-Peng Dong, Qi Zhang, Li-Li Yang, Xue-Liang Cheng, Jian-Wu Zhao
Summary: Dural defects are common in neurosurgery and can lead to complications such as cerebrospinal fluid leakage. This review comprehensively summarizes the causes, risk factors, complications, and repair methods of dural defects. It also discusses the latest research on dural repair materials and methods, including sutures, grafts, biomaterials, non-biomaterials, and composites. The characteristics and efficacy of these substitutes are evaluated, and the challenges and future prospects of new materials are discussed.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Otorhinolaryngology
Abdulaziz AlQahtani, Abeer Albathi, Paolo Castelnuovo, Fahad Alfawwaz
Summary: This study evaluated the validity of a CSFL repair simulation model, showing that the model has face, content, and construct validity. Experts' responses to the questionnaire were high, and there were significant differences in construct validity between the two groups.
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2021)
Article
Multidisciplinary Sciences
Julien Spitaels, Justin Moore, Nathalie Zaidman, Isabel Fernandes Arroteia, Geoffrey Appelboom, Sami Barrit, Sebastien Carlot, Viviane De Maertelaer, Sergio Hassid, Olivier De Witte
Summary: This study compared the use of a fibrin-coated collagen fleece (TachoSil) with a dural sealant (DuraSeal) for preventing postoperative cerebrospinal fluid (CSF) leaks. The results showed a lower rate of postoperative CSF leaks in the TachoSil application group. Therefore, TachoSil may be an effective method for preventing postoperative CSF leaks.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Jia Xu Lim, Sharon Y. Y. Low, Lee Ping Ng, Wan Tew Seow
Summary: This article focuses on the nuances and methods of preventing and managing cerebrospinal fluid leaks in the surgical treatment of congenital complex spinal lipomas.
ACTA NEUROCHIRURGICA
(2022)
Article
Multidisciplinary Sciences
Artur Balasa, Przemyslaw Kunert, Tomasz Dziedzic, Mateusz Bielecki, Slawomir Kujawski, Andrzej Marchel
Summary: This study suggests that autologous and nonautologous dural grafts can achieve similar clinical outcomes when sutured or glued. However, the use of nonautologous grafts is associated with a higher risk of pseudomeningocele formation.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Amy Phan, Shalin Shah, Peter Joo, Addisu Mesfin
Summary: The study aims to describe the outcomes and complications of using epidural blood patches for symptomatic postoperative durotomies in our center.
WORLD NEUROSURGERY
(2022)
Review
Clinical Neurology
Alessandro Carretta, Mirka Epskamp, Linus Ledermann, Victor E. Staartjes, Marian C. Neidert, Luca Regli, Martin N. Stienen
Summary: This study analyzed the effects of using collagen-bound fibrin sealant TachoSil on postoperative complications and outcomes in craniotomy patients. The results showed that the addition of TachoSil did not significantly affect the rate of postoperative complications associated with cerebrospinal fluid leakage. The systematic review also found no superiority of additional sealants over standard techniques in terms of complications, rates of revision surgery, or outcomes.
NEUROSURGICAL REVIEW
(2022)
Article
Clinical Neurology
Andrew L. Callen, Peter Lennarson, Ian R. Carroll
Summary: A 24-year-old woman developed a postdural puncture headache after a labor epidural, which improved with bedrest. However, 12 years later, she developed daily holocephalic headache that was relieved by recumbency. Imaging tests showed no CSF leaks or fistulas, but a subcentimeter dural outpouching was discovered and repaired, resulting in remission of headache. This case suggests the role of a distant dural puncture in the delayed onset of new daily persistent headache.
Article
Clinical Neurology
Daniel C. Kreatsoulas, Varun S. Shah, Bradley A. Otto, Ricardo L. Carrau, Daniel M. Prevedello, Douglas A. Hardesty
Summary: Spontaneous CSF leaks are rare and can lead to meningitis. Traditional craniotomy repair has been the standard treatment, but the endonasal endoscopic approach (EEA) offers potential benefits with lower surgical morbidity. The study found that morbid obesity is a significant risk factor for postoperative CSF diversion, suggesting implications for future surgical management as obesity rates increase worldwide.
JOURNAL OF NEUROSURGERY
(2021)
Review
Neurosciences
Jason Gandhi, Andrew DiMatteoa, Gunjan Joshi, Noel L. Smith, Sardar Ali Khan
Summary: Damage to the dura mater often leads to cerebrospinal fluid leakage and intracranial hypotension, presenting with diverse clinical symptoms. Accurate evaluation, diagnosis, and prompt treatment are crucial for patients suspected of dural tears.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Tyler Ball, Chase Knibbe, Mayur Sharma, Abigail P. McCallum, Emily P. Sieg
Summary: This case report describes a rare symptomatic post-infectious intrathecal to prevertebral fistula in a 38-year-old chronically paraplegic male. The patient was successfully treated with an interventional radiology procedure, and it was noted that thecal sac ligation could be a viable treatment option in select circumstances with symptomatic CSF fistula.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Surgery
Stefan Aspalter, Wolfgang Senker, Christian Radl, Martin Aichholzer, Kathrin Aufschnaiter-Hiessboeck, Clemens Leitner, Nico Stroh, Wolfgang Trutschnig, Andreas Gruber, Harald Stefanits
Summary: This study reviewed 187 patients who underwent degenerative lumbar spinal surgery using minimally invasive spinal fusions techniques and found that the rate of ADTs was 11.764%. ADTs were more frequent in cases of previous surgery. The study suggests that MAST provides a certain level of protection in reducing ADTs.
FRONTIERS IN SURGERY
(2021)
Article
Clinical Neurology
Nico Golfre Andreasi, Luigi Michele Romito, Roberta Telese, Roberto Cilia, Antonio Emanuele Elia, Alessio Novelli, Giovanni Tringali, Giuseppe Messina, Vincenzo Levi, Grazia Devigili, Sara Rinaldo, Angelo Amato Franzini, Roberto Eleopra
Summary: STN-DBS has a long-lasting effect on motor complications in both male and female PD patients, but there may be slight differences in certain aspects that require further investigation.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Mario Stanziano, Nico Golfre Andreasi, Giuseppe Messina, Sara Rinaldo, Sara Palermo, Mattia Verri, Greta Demichelis, Jean Paul Medina, Francesco Ghielmetti, Salvatore Bonvegna, Anna Nigri, Giulia Frazzetta, Ludovico D'Incerti, Giovanni Tringali, Francesco DiMeco, Roberto Eleopra, Maria Grazia Bruzzone
Summary: Magnetic resonance-guided high-intensity focused ultrasound is a non-invasive alternative treatment for tremor. This study found that the treatment modulated resting state functional connectivity within the tremor network and these changes were associated with clinical outcomes.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Isabella Giachetti, Francesco Padelli, Domenico Aquino, Rita Garbelli, Dalia De Santis, Laura Rossini, Francesco Deleo, Riccardo Pascuzzo, Roland Coras, Gianluca Marucci, Giovanni Tringali, Carmelo Maccagnano, Marco De Curtis, Maria Grazia Bruzzone, Giuseppe Didato
Summary: This study investigates the role of neurite orientation dispersion and density imaging (NODDI) in understanding hippocampal microstructure in patients with temporal lobe epilepsy (TLE). The results show that NODDI can better highlight fiber reorganization in sclerotic hippocampi. This study demonstrates the ability of diffusion MRI metrics to detect hippocampal alterations.
Article
Neurosciences
Francesco Acerbi, Elio Mazzapicchi, Jacopo Falco, Ignazio Gaspare Vetrano, Francesco Restelli, Giuseppe Farago, Emanuele La Corte, Giulio Bonomo, Anna Bersano, Isabella Canavero, Marco Gemma, Morgan Broggi, Marco Schiariti, Vanessa Ziliani, Gabriella Raccuia, Salvatore Mangiafico, Giuseppe Ganci, Elisa Ciceri, Paolo Ferroli
Summary: Despite the popularity of flow diverters (FDs) as an option for treating intracranial aneurysms, complex aneurysms still pose a challenge. The use of combined strategies involving flow-preservation bypass may be considered in selected cases where a simpler direct approach is not feasible.
Article
Clinical Neurology
Jacopo Falco, Morgan Broggi, Marco Schiariti, Ignazio Gaspare Vetrano, Silvia Esposito, Paolo Ferroli, Francesco Acerbi
Summary: This retrospective analysis of 33 pediatric patients with supratentorial lesions found that fluorescein-guided surgery with a dedicated filter on the microscope is a safe and effective technique to improve visualization and resection of different pediatric brain tumors, without any adverse effects.
CHILDS NERVOUS SYSTEM
(2023)
Article
Biochemistry & Molecular Biology
Gemma Gorla, Tatiana Carrozzini, Giuliana Pollaci, Antonella Potenza, Sara Nava, Francesco Acerbi, Paolo Ferroli, Silvia Esposito, Veronica Saletti, Emilio Ciusani, Aida Zulueta, Eugenio A. Parati, Anna Bersano, Laura Gatti, Ignazio G. Vetrano
Summary: This study aimed to assess the levels of circulating endothelial progenitor cells (cEPC) and the release of selected proteins in the plasma and CSF of pediatric MMA patients to clarify the pathogenesis and progression of the disease. The study found increased levels of cEPC in peripheral blood and an upregulation of angiogenic markers in CSF. These findings provide valuable insights into the disease's mechanism and progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Luisa Chiapparini, Valentina Opancina, Alessandra Erbetta, Bianca Pollo, Morgan Broggi, Elisa Ciceri
Summary: A 49-year-old man presented with right foot drop, bilateral cruralgia mainly on the left side, and genital and perianal hypoesthesia. Neurologic examination showed hypoesthesia in the L5 root region on the right side and right foot drop. Laboratory results showed abnormal levels of C-reactive protein, erythrocyte sedimentation rate, aspartate transaminase, alanine transaminase, lymphocytes, and neutrophils. CT and MRI of the lumbosacral spine were performed.
Article
Medicine, General & Internal
Jacopo Falco, Emanuele Rubiu, Morgan Broggi, Mariangela Farinotti, Ignazio G. Vetrano, Marco Schiariti, Elena Anghileri, Marica Eoli, Bianca Pollo, Marco Moscatelli, Francesco Restelli, Elio Mazzapicchi, Emanuele La Corte, Giulio Bonomo, Marco Gemma, Giovanni Broggi, Paolo Ferroli, Francesco Acerbi
Summary: Maximizing surgical resection using fluorescein-guided surgery has been shown to improve overall survival in patients with glioblastoma. In this retrospective analysis, we evaluated the role of fluorescein-guided surgery in tumor resection, survival, and complications. The study results demonstrated a high rate of complete resection without any adverse effects related to fluorescein. The survival and progression-free survival were significantly improved compared to previous studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Elio Mazzapicchi, Francesco Restelli, Jacopo Falco, Morgan Broggi, Laura Gatti, Pierpaolo Alongi, Laura Valentini, Paolo Ferroli, Ignazio G. Vetrano, Francesco DiMeco, Francesco Acerbi
Summary: This study provides a systematic overview of clinical and radiological data of central nervous system hemangioblastomas (HBs) and highlights the importance of intraoperative multimodal imaging in surgical strategy.
Article
Oncology
Paolo Ferroli, Francesco Restelli, Giacomo Bertolini, Emanuele Monti, Jacopo Falco, Giulio Bonomo, Irene Tramacere, Bianca Pollo, Chiara Calatozzolo, Monica Patane, Silvia Schiavolin, Morgan Broggi, Francesco Acerbi, Alessandra Erbetta, Silvia Esposito, Elio Mazzapicchi, Emanuele La Corte, Ignazio Gaspare Vetrano, Giovanni Broggi, Marco Schiariti
Summary: This retrospective study analyzed the associations between possible prognostic factors and survival rate. Surgical resection, tumor volume, histological grade, extent of resection, and 3-month postoperative performance status were identified as important prognostic factors. Surgery for thalamic gliomas improves overall survival, and patients with stable performance status after 3 months have better prognosis. Therefore, accurate evaluation of predictors of 3-month postoperative performance status is crucial in deciding between biopsy or surgical removal.
Review
Oncology
Emanuele Rubiu, Emanuele La Corte, Giulio Bonomo, Francesco Restelli, Jacopo Falco, Elio Mazzapicchi, Morgan Broggi, Marco Paolo Schiariti, Bianca Pollo, Valentina Pinzi, Maria Grazia Bruzzone, Francesco Di Meco, Francesco Acerbi, Paolo Ferroli
Summary: This study reports a case of intracranial angioleiomyoma, providing a comprehensive evaluation of its clinical and radiological features. In addition, the use of intraoperative confocal microscopy in angioleiomyoma and its short-term recurrence are discussed. A scoping literature review is also conducted to summarize the major clinical and diagnostic features, as well as proposed therapeutic strategies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tatiana Carrozzini, Giuliana Pollaci, Gemma Gorla, Antonella Potenza, Nicola Rifino, Francesco Acerbi, Ignazio G. G. Vetrano, Paolo Ferroli, Anna Bersano, Erica Gianazza, Cristina Banfi, Laura Gatti
Summary: Moyamoya angiopathy (MMA) is a rare cerebrovascular disease characterized by progressive steno-occlusive lesions and collateral vessel development. Surgical treatment, particularly indirect revascularization, is preferred. By performing proteomic characterization, a potential gene, Filamin A, was identified, suggesting a role in MMA pathogenesis. This study provides insights into the molecular understanding of this disabling intracranial vasculopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Guilu He, Jianhao Lin, Jing Ye, Fobao Huang, Changzhi Yan, Zesi Liu, Xiuming Zhou, Qiao Li, Liang Zhang
Summary: This article introduces long tunneled external ventricular drain (LTEVD), which effectively avoids multiple surgeries by connecting an external shunt valve. It allows visual control of drainage flow, prolongs catheter indwelling time, and eliminates the need for multiple surgeries.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Vinay Suresh, H. S. Suresh, Bharath Raju, Himanshu Jindal, Ahmad Ozair
Summary: This study investigated the outcomes of postoperative discitis treated with debridement and a novel technique focused on reducing outpatient antibiotic requirement in a low- and middle-income country (LMIC) setting. The results showed that patients with medically refractory postoperative discitis potentially have good outcomes after debridement plus 2-week local antibiotic instillation in LMICs.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Beatrice C. Bono, Davide Milani, Fabio Ferreli, Simone Olei, Luca Raspagliesi, Maria Pia Tropeano, Giovanni B. Lasio, Federico Pessina
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Avi A. Gajjar, Shrey Patel, Raj Swaroop Lavadi, Rida Mitha, Rohit Prem Kumar, Tavis Taylor, Galal A. Elsayed, D. Kojo Hamilton, Nitin Agarwal
Summary: Art in neurosurgery has played a crucial role in the discipline for centuries. Medical illustrations help visualize anatomy and surgical procedures, contributing to education, surgical planning, and navigation.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Joaquin Perez Zabala, Yamila Basilotta Marquez, Romina Arganaraz, Beatriz Mantese
Summary: We present a low-cost and easily accessible adaptation system for stereotactic procedures in infants. By using a headband cast technique, a stereotactic biopsy was successfully performed in a 5-month-old patient, achieving precise targeting, histopathological diagnosis, and no associated complications.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Muhammad Kusdiansah, Arnau Benet, Yosuke Suzuki, Kenichi Haraguchi, Nakao Ota, Kosumo Noda, Rokuya Tanikawa
Summary: Fusiform vertebral artery aneurysms are difficult to treat, and endovascular and open microsurgical treatments are used for different situations. This report presents a case with complex anatomy and branch involvement and describes the treatment strategy used.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Victor M. Lu
Summary: This review emphasizes four essential domains that should be considered when interpreting pediatric neurosurgical SRMAs and provides examples to ensure accurate and effective interpretation of findings in this niche.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Lapo Bonosi, Angelo Torrente, Filippo Brighina, Cateno Concetto Tito Petralia, Pietro Merlino, Chiara Avallone, Vincenzo Gulino, Roberta Costanzo, Lara Brunasso, Domenico Gerardo Iacopino, Rosario Maugeri
Summary: Corticocortical evoked potentials (CCEPs) have emerged as a valuable intraoperative monitoring technique in eloquent brain tumor surgery, aiding in preserving critical functional areas. Current research shows the potential of CCEPs in guiding surgical decision making, reducing the risk of postoperative neurological deficits, and mapping functional connectivity, but further research and standardization are needed.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Yuchen Duan, Dagang Feng, Min Zhu, Heng Qiu, Tong Li, Zhen Chen, Leiming Jiang, Yong Huang
Summary: This study aimed to compare the effect of different Modic changes (MC) grades on the cage subsidence rate after spinal interbody fusion surgery. A meta-analysis was conducted on relevant randomized controlled trials and cohort studies. The results showed that MC may be associated with a higher cage subsidence rate. With the increase in MC grades, the incidence of subsidence decreased gradually, but it was always higher than that in the non-Modic changes (NMC). Oblique lumbar interbody fusion may be a better treatment choice for lumbar degenerative disease with MC.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Brian F. Saway, Conor M. Cunningham, Mustafa Ismail, Alejandro M. Spiotta
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Joanna M. Roy, Michael M. Covell, Carmelo Venero Jr, Christian A. Bowers
Summary: Early exposure to neurosurgery during medical school is critical for improving recruitment into the specialty. However, about 30% of medical schools in the U.S. lack a neurosurgery program, limiting students' exposure to the field. Virtual education, facilitated by webinars during the pandemic, has advantages such as global outreach and accessibility for international medical students. This review identifies and describes 16 educational resources, serving as a guide for medical students interested in neurosurgery.
WORLD NEUROSURGERY
(2024)
