Article
Chemistry, Multidisciplinary
Rodrigo Ken Kawassaki, Mariana Romano, Mayara Klimuk Uchiyama, Roberta Mansini Cardoso, Mauriicio S. Baptista, Sandra H. P. Farsky, Khallil Taverna Chaim, Robson Raphael Guimaraes, Koiti Araki
Summary: A novel ultrasmall paramagnetic nanoparticle (UPN), decorated with iron oxide on 3 nm titanium dioxide nanoparticles, has been developed as a potential alternative blood-pool contrast agent to gadoteric acid (GA) for MR angiography. It exhibits comparable relaxometric parameters to GA and has strong and prolonged contrast enhancement before renal excretion.
Article
Chemistry, Physical
Hao Zhang, Zhijia Lv, Dongzhi Xue, Tianqi Zhang, Longhai Jin, Yue Cao, Shuai Zhang, Yinghui Wang, Hongjie Zhang
Summary: A TME-responsive theranostic nanoagent was fabricated using a layer-by-layer synthesis method, which can achieve enhanced chemotherapy within tumor cells without collateral damage to normal tissues. The nanoagent efficiently kills tumor cells in both in vitro and in vivo experiments.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Masoomeh Esmaili, Hamid Dezhampanah, Mahvash Hadavi
Summary: This study demonstrates the enhancement of biocompatibility of superparamagnetic iron oxide nanoparticles (SPIONs) by coating with different materials and binding drugs on their surface for targeted drug delivery system.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Chemistry, Multidisciplinary
Jianxian Ge, Cang Li, Ning Wang, Ruru Zhang, Mohammad Javad Afshari, Can Chen, Dandan Kou, Dandan Zhou, Ling Wen, Jianfeng Zeng, Mingyuan Gao
Summary: Polyethylene glycol (PEG) is commonly used to enhance the biocompatibility and blood circulation time of iron oxide nanoparticles (IONPs) as MRI contrast agents. However, the surface effect induced by PEGylation can impact the relaxometric properties of IONPs and subsequently affect imaging results. In this study, three diphosphonate PEGs with different molecular weights were used to replace the hydrophobic oleate ligands of IONPs, and the relationship between PEG chain length and relaxometric properties of IONPs was investigated.
Review
Nanoscience & Nanotechnology
Can Chen, Jianxian Ge, Yun Gao, Lei Chen, Jiabin Cui, Jianfeng Zeng, Mingyuan Gao
Summary: USPIO nanoparticles, with their excellent MRI performance and remarkable biosafety profile, have shown considerable applications in developing T-1 contrast agents and T-2/T-1 switchable contrast agents, and have been widely used in the diagnosis of vascular pathological changes, inflammations, and malignant tumors.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Esmaeel Sharifi, Fatemeh Reisi, Satar Yousefiasl, Fatemeh Elahian, Shahrbanou Parchami Barjui, Rossella Sartorius, Najmeh Fattahi, Ehsan Nazarzadeh Zare, Navid Rabiee, Elham Pahlevani Gazi, Ana Claudia Paiva-Santos, Paola Parlanti, Mauro Gemmi, Gholam-Reza Mobini, Morteza Hashemzadeh-Chaleshtori, Piergiuseppe De Berardinis, Ibrahim Sharifi, Virgilio Mattoli, Pooyan Makvandi
Summary: This study demonstrates that chitosan-coated superparamagnetic nanoparticles exhibit anti-cancer activity, induce oxidative stress and DNA damage in cancer cells, and promote dendritic cell maturation, suggesting their potential as an effective treatment for cancer.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Vikas Nandwana, Vinayak P. Dravid
Summary: This study demonstrates the versatility and elegance of ferrite-spinel based magnetic nanostructures (MNSs) as a contrast agent in MRI. By tuning their crystal chemistry, the magnetic properties of Fe3O4 MNS can be enhanced. Doping with Mn2+ and Zn2+ at the right stoichiometry resulted in high saturation magnetization and magnetic anisotropy, which were leveraged to develop more biocompatible and efficient T-1-weighted MRI contrast agents compared to Gd-based complexes.
Article
Chemistry, Multidisciplinary
Giovanni Marco Saladino, Carmen Vogt, Bertha Brodin, Kian Shaker, Nuzhet Inci Kilic, Kenth Andersson, Marie Arsenian-Henriksson, Muhammet Sadaka Toprak, Hans Martin Hertz
Summary: In this study, hybrid ruthenium-decorated superparamagnetic iron oxide nanoparticles were designed as contrast agents for both magnetic resonance imaging (MRI) and X-ray fluorescence computed tomography (XFCT). These nanoparticles were synthesized through a one-pot polyol hot injection method. In vivo preclinical studies showed the possibility of correlative bioimaging using these contrast agents. The complementary nature of MRI and XFCT allowed for accurate localization and high specificity and resolution in nanoparticle detection, suggesting potential applications for early tumor diagnosis, improved long-term treatment monitoring, and enhanced radiotherapy planning.
Article
Chemistry, Analytical
Wei Liu, Shengyan Yin, Yingcai Hu, Ting Deng, Jishan Li
Summary: A pH-responsive T2-T1 switchable MRI nanoprobe was constructed by combining the microemulsion method with the biomineralization principle, which can achieve T1-weighted imaging in tumor environments.
ANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Mengjie Wang, Shilin Li, Zhangjian Chen, Jiangbo Zhu, Weidong Hao, Guang Jia, Wen Chen, Yuxin Zheng, Weidong Qu, Ying Liu
Summary: Safety assessments of nanoparticles in food are crucial for public health, but current reliance on traditional toxicological assessments leads to uncertainties and limits accuracy. Developing scientific evaluation procedures is necessary for safeguarding supervision and maintaining public health.
Article
Chemistry, Multidisciplinary
M. Aminul Islam, M. Razibul Hasan, M. Mahbubabl Haque, Rimi Rashid, Ishtiaque M. Syed, S. Manjura Hoque
Summary: Surface-functionalized Mg1-xCoxFe2O4 nanoparticles were synthesized and their structural and magnetic properties were studied for their potential use as MRI contrast agents and for thermotherapeutic applications. The results showed that the lattice parameter, crystallite size, and force constants of the nanoparticles changed with the cobalt content. The Mossbauer spectra and M-H hysteresis loops confirmed the transition in magnetic relaxation behavior with changing cobalt content. Cytotoxicity experiments also demonstrated the biocompatibility of the nanoparticles. Both r(2) and SLP increased with cobalt content in the Mg1-xCoxFe2O4 series due to the increased magnetization and anisotropy.
Article
Multidisciplinary Sciences
Andreina Chiu-Lam, Edward Staples, Carl J. Pepine, Carlos Rinaldi
Summary: The study reports on an mCPA containing superparamagnetic iron oxide nanoparticles that can increase the preservation time of cryopreserved organs through nanowarming, reduce damage caused by slow rewarming, and have low cytotoxicity. The results demonstrate that this formulated mCPA is suitable for perfusion, vitrification, and nanowarming of whole organs.
Article
Materials Science, Ceramics
M. P. Yeste, C. Fernandez-Ponce, E. Felix, M. Tinoco, R. Fernandez-Cisnal, C. Garcia-Villar, C. Pfaff, J. Kriwet, E. Natividad, M. A. Cauqui, F. Garcia-Cozar, R. Litran, O. Bomati-Miguel
Summary: A solvothermal route to prepare glutathione capped hybrid ytterbium/iron oxide nanoparticles has been developed and their structural and morphological characteristics were extensively studied. The functionalized nanoparticles show promising potential as a dual contrast agent in medical image techniques.
CERAMICS INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Sitong Liu, Anahita Heshmat, Jennifer Andrew, Izabella Barreto, Carlos M. M. Rinaldi-Ramos
Summary: Magnetic particle imaging (MPI) is a novel imaging modality that tracks the distribution of superparamagnetic iron oxide nanoparticles (SPIONs) for biomedical applications. However, it lacks anatomical information. Computed tomography (CT) provides high-resolution anatomical information. Combining MPI and CT could offer a multimodal imaging agent with improved diagnostic capabilities.
NANOSCALE ADVANCES
(2023)
Article
Multidisciplinary Sciences
Andrea S. Theus, Liqun Ning, Gabriella Kabboul, Boeun Hwang, Martin L. Tomov, Christopher N. LaRock, Holly Bauser-Heaton, Morteza Mahmoudi, Vahid Serpooshan
Summary: This study introduces a new generation of antibacterial bioinks for 3D bioprinting, incorporating superparamagnetic iron oxide nanoparticles (SPIONs) into gelatin methacryloyl (GelMA) scaffolds. The SPION-laden GelMA scaffolds demonstrated significant resistance against Staphylococcus aureus growth, while providing contrast in magnetic resonance imaging. The functionalized scaffolds were able to inhibit bacterial growth while maintaining cell viability and growth.
Article
Clinical Neurology
Guilu He, Jianhao Lin, Jing Ye, Fobao Huang, Changzhi Yan, Zesi Liu, Xiuming Zhou, Qiao Li, Liang Zhang
Summary: This article introduces long tunneled external ventricular drain (LTEVD), which effectively avoids multiple surgeries by connecting an external shunt valve. It allows visual control of drainage flow, prolongs catheter indwelling time, and eliminates the need for multiple surgeries.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Vinay Suresh, H. S. Suresh, Bharath Raju, Himanshu Jindal, Ahmad Ozair
Summary: This study investigated the outcomes of postoperative discitis treated with debridement and a novel technique focused on reducing outpatient antibiotic requirement in a low- and middle-income country (LMIC) setting. The results showed that patients with medically refractory postoperative discitis potentially have good outcomes after debridement plus 2-week local antibiotic instillation in LMICs.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Beatrice C. Bono, Davide Milani, Fabio Ferreli, Simone Olei, Luca Raspagliesi, Maria Pia Tropeano, Giovanni B. Lasio, Federico Pessina
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Avi A. Gajjar, Shrey Patel, Raj Swaroop Lavadi, Rida Mitha, Rohit Prem Kumar, Tavis Taylor, Galal A. Elsayed, D. Kojo Hamilton, Nitin Agarwal
Summary: Art in neurosurgery has played a crucial role in the discipline for centuries. Medical illustrations help visualize anatomy and surgical procedures, contributing to education, surgical planning, and navigation.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Joaquin Perez Zabala, Yamila Basilotta Marquez, Romina Arganaraz, Beatriz Mantese
Summary: We present a low-cost and easily accessible adaptation system for stereotactic procedures in infants. By using a headband cast technique, a stereotactic biopsy was successfully performed in a 5-month-old patient, achieving precise targeting, histopathological diagnosis, and no associated complications.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Muhammad Kusdiansah, Arnau Benet, Yosuke Suzuki, Kenichi Haraguchi, Nakao Ota, Kosumo Noda, Rokuya Tanikawa
Summary: Fusiform vertebral artery aneurysms are difficult to treat, and endovascular and open microsurgical treatments are used for different situations. This report presents a case with complex anatomy and branch involvement and describes the treatment strategy used.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Victor M. Lu
Summary: This review emphasizes four essential domains that should be considered when interpreting pediatric neurosurgical SRMAs and provides examples to ensure accurate and effective interpretation of findings in this niche.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Lapo Bonosi, Angelo Torrente, Filippo Brighina, Cateno Concetto Tito Petralia, Pietro Merlino, Chiara Avallone, Vincenzo Gulino, Roberta Costanzo, Lara Brunasso, Domenico Gerardo Iacopino, Rosario Maugeri
Summary: Corticocortical evoked potentials (CCEPs) have emerged as a valuable intraoperative monitoring technique in eloquent brain tumor surgery, aiding in preserving critical functional areas. Current research shows the potential of CCEPs in guiding surgical decision making, reducing the risk of postoperative neurological deficits, and mapping functional connectivity, but further research and standardization are needed.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Yuchen Duan, Dagang Feng, Min Zhu, Heng Qiu, Tong Li, Zhen Chen, Leiming Jiang, Yong Huang
Summary: This study aimed to compare the effect of different Modic changes (MC) grades on the cage subsidence rate after spinal interbody fusion surgery. A meta-analysis was conducted on relevant randomized controlled trials and cohort studies. The results showed that MC may be associated with a higher cage subsidence rate. With the increase in MC grades, the incidence of subsidence decreased gradually, but it was always higher than that in the non-Modic changes (NMC). Oblique lumbar interbody fusion may be a better treatment choice for lumbar degenerative disease with MC.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Brian F. Saway, Conor M. Cunningham, Mustafa Ismail, Alejandro M. Spiotta
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Joanna M. Roy, Michael M. Covell, Carmelo Venero Jr, Christian A. Bowers
Summary: Early exposure to neurosurgery during medical school is critical for improving recruitment into the specialty. However, about 30% of medical schools in the U.S. lack a neurosurgery program, limiting students' exposure to the field. Virtual education, facilitated by webinars during the pandemic, has advantages such as global outreach and accessibility for international medical students. This review identifies and describes 16 educational resources, serving as a guide for medical students interested in neurosurgery.
WORLD NEUROSURGERY
(2024)