Article
Immunology
Yibin Yang, Xia Zhu, Haixin Zhang, Yuhua Chen, Yi Song, Xiaohui Ai
Summary: The study on the host-pathogen interaction between channel catfish and Yersinia ruckeri revealed the dynamic regulation of the transcriptome during infection, with significant upregulation of immune-related pathways. Specifically, the infection was found to be closely related to metabolic pathways, and the pathogenesis promoted by Y. ruckeri in channel catfish was mainly through the flagellum gene fliC. This research contributes to understanding how catfish respond to infection and develop enteric red mouth disease (ERM) through a transcriptional perspective.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Elizabeth A. Latham, Robin C. Anderson, Lauren R. Wottlin, Toni L. Poole, Tawni L. Crippen, Wayne D. Schlosser, Roger B. Harvey, Michael E. Hume
Summary: Yersinia ruckeri is an important fish pathogen, and the traditional use of antibiotics to control this pathogen has raised concerns about antibiotic resistance. This study tested the effects of chlorate and certain nitrocompounds on Y. ruckeri and a related species, Y. aleksiciae. The results showed that some of the tested compounds had inhibitory effects on these pathogens, suggesting their potential as alternative interventions.
Article
Fisheries
Richard S. Taylor, Roberto Carvalheiro, Amanda L. Patchett, Klara L. Verbyla, Jeremy Carson, James W. Wynne, Brad S. Evans, Curtis E. Lind, Harry King
Summary: This study found that resistance to yersiniosis is a heritable trait and that two consecutive year classes of salmon were highly correlated in terms of disease resistance. Genomic prediction was more accurate than traditional pedigree-based selective breeding, with an improvement of 9-14%. GWAS analysis confirmed that resistance to yersiniosis is a polygenic trait with no major QTL. Candidate genes identified suggest altered host interactions, inflammatory responses, and clearance of Y. ruckeri infection.
Article
Fisheries
Tao Liu, Zheng-Yang Zhou, Chen-wang Lu, Shang-Jie Bai, Jun Wang, Gao-Xue Wang
Summary: In this study, the researchers found that the T4SS of Yersinia ruckeri SC09 mediated bacterial virulence and immune evasion, possibly through the secretion of molecules such as STIR-1, STIR-2, and STIR-3. These findings contribute to a better understanding of the general rules of bacterial pathogenicity.
Article
Infectious Diseases
Janet Velazquez, Tania Rodriguez-Cornejo, Tania Rodriguez-Ramos, Geysi Perez-Rodriguez, Laura Rivera, James Hugh Campbell, Lowia Al-Hussinee, Yamila Carpio, Mario Pablo Estrada, Brian Dixon
Summary: PACAP has been found to have antimicrobial and immunomodulatory effects in fish, making it a potential alternative to antibiotics in the aquaculture industry. The study demonstrates that PACAP can directly inhibit bacterial growth and pre-treatment with low concentrations of the peptide significantly suppresses infection.
Article
Biotechnology & Applied Microbiology
Di Wang, Simeng Sun, Shaowu Li, Tongyan Lu, Dongfang Shi
Summary: This study conducted transcriptomic profiling of spleen samples from rainbow trout at 24 h post-Y. ruckeri infection and identified 2498 differentially expressed genes related to immune response pathways. The findings provide insight into the molecular mechanisms of rainbow trout immune responses to Y. ruckeri infection.
Article
Microbiology
Lillian G. Acuna, M. Jose Barros, Fernanda Montt, Diego Penaloza, Paula Nunez, Ivan Valdes, Fernando Gil, Juan A. Fuentes, Ivan L. Calderon
Summary: Small noncoding RNAs, such as RyhB, play vital roles in gene expression and physiology regulation in bacteria. In this study, two RyhB homologs, RyhB-1 and RyhB-2, were identified and characterized in the fish pathogen Yersinia ruckeri. Despite similar expression patterns under iron starvation, mutant strains lacking RyhB-1 or RyhB-2 exhibited distinct phenotypes, indicating non-redundant roles in modulating bacterial physiology.
MICROBIOLOGICAL RESEARCH
(2021)
Article
Microbiology
Katarzyna Morka, Ewa Walecka-Zacharska, Justyna Schubert, Bartlomiej Dudek, Anna Wozniak-Biel, Maciej Kuczkowski, Alina Wieliczko, Jaroslaw Bystron, Jacek Bania, Gabriela Bugla-Ploskonska
Summary: The study aimed to evaluate the genetic similarity of Y. enterocolitica strains from various hosts and analyze the prevalence of virulence genes. Different virulence genes were identified among Yersinia sp. strains, with some strains showing potential pathogenicity based on the presence of certain genes. The study also found clustering tendencies among VNTR/PFGE profiles of different origins, suggesting the role of pigs as a potential source of infection for humans.
Article
Environmental Sciences
Elham Alsadat Banihashemi, Siyavash Soltanian, Amin Gholamhosseini, Mahdi Banaee
Summary: This study suggests that exposure to MPs and simultaneous challenge with Y. ruckeri could synergistically affect clinical parameters in fish.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Microbiology
Ivan L. Calderon, Maria Jose Barros, Fernanda Montt, Fernando Gil, Juan A. Fuentes, Lillian G. Acuna
Summary: The RNA chaperone Hfq plays an important role in antibiotic persistence in Yersinia ruckeri, as demonstrated by faster replication and decreased antibiotic tolerance in the hfq-knockout mutant. Hfq is also dependent on the (p)ppGpp synthetase RelA for persister cells production, with the Delta relA and Delta relA Delta hfq strains showing defects in persister cells formation compared to the wild type. The findings shed light on the participation of Hfq in antibiotic persistence in Y. ruckeri.
Article
Fisheries
He Yang, Ding Zhujin, Moonika H. Marana, Inger Dalsgaard, Jaafar Rzgar, Mathiessen Heidi, Karami M. Asma, Kania W. Per, Buchmann Kurt
Summary: Both autogenous and commercial ERM vaccines were effective in protecting rainbow trout from live Y. ruckeri bacteria. Fish receiving a high dosage of commercial vaccine showed increased levels of IgM expression post-challenge, indicating a correlation between vaccine dosage and protection.
JOURNAL OF FISH DISEASES
(2021)
Article
Microbiology
David Balderas, Erin Mettert, Hanh N. Lam, Rajdeep Banerjee, Tomas Gverzdys, Pablo Alvarez, Geetha Saarunya, Natasha Tanner, Adam Zoubedi, Yahan Wei, Patricia J. Kiley, Victoria Auerbuch
Summary: The research revealed the significance of the iron-sulfur cluster regulator IscR in pathogenic Yersinia, showing its ability to regulate multiple pathways related to iron metabolism, reactive oxygen species metabolism, and cell envelope remodeling, contributing to bacterial survival during infection.
Article
Biochemistry & Molecular Biology
Anna Pawlik, Beata Ciolek, Justyna Sulej, Andrzej Mazur, Przemyslaw Grela, Magdalena Staszczak, Mateusz Niscior, Magdalena Jaszek, Anna Matuszewska, Grzegorz Janusz, Andrzej Paszczynski
Summary: The study found that laccases released by Cerrena unicolor are regulated at transcriptional, translational, and post-translational steps of gene expression, helping the fungus adapt to environmental changes.
Article
Microbiology
Yuwei Zhang, Stephen L. W. On
Summary: Yersinia enterocolitica and Y. pseudotuberculosis are important causes of enteric illness worldwide. The use of cold enrichment methods for their detection is time-consuming, and there is limited evidence to support the claim that key pathogenicity markers are lost at higher temperatures. A study found that an enrichment step at 37 degrees C did not result in the loss of important markers, suggesting that this method could be used for more rapid detection of these pathogens.
Article
Fisheries
Ivana Cingelova Maruscakova, Petra Schusterova, Peter Popelka, Sona Gancarcikova, Tomas Csank, Adriana Feckaninova, Marek Ratvaj, Dagmar Mudronova
Summary: This study examined the impact of probiotic bacteria on the immune response of trout intestinal cells infected with pathogenic bacteria. The results showed that the probiotic strain could reduce inflammation and modulate the immune response. Further in vivo experiments are needed to confirm its immunomodulatory potential.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Review
Immunology
Jose A. Guijarro, Ana I. Garcia-Torrico, Desiree Cascales, Jessica Mendez
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2018)
Article
Microbiology
Jessica Mendez, Desiree Cascales, Ana I. Garcia-Torrico, Jose A. Guijarro
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Biotechnology & Applied Microbiology
T. Rochat, D. Perez-Pascual, H. Nilsen, M. Carpentier, S. Bridel, J-F Bernardet, E. Duchaud
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2019)
Article
Infectious Diseases
Andrei Nicoli Gebieluca Dabul, Juliana Sposto Avaca-Crusca, Roberto Barranco Navais, Thais Panhan Merlo, Daria Van Tyne, Michael S. Gilmore, Ilana Lopes Baratella da Cunha Camargo
INFECTION GENETICS AND EVOLUTION
(2019)
Article
Fisheries
Ana Isabel Garcia-Torrico, Jose A. Guijarro, Desiree Cascales, Jessica Mendez
JOURNAL OF FISH DISEASES
(2019)
Article
Ecology
Franziska A. Stressmann, Joaquin Bernal-Bayard, David Perez-Pascual, Bianca Audrain, Olaya Rendueles, Valerie Briolat, Sebastian Bruchmann, Stevenn Volant, Amine Ghozlane, Susanne Haeussler, Eric Duchaud, Jean-Pierre Levraud, Jean-Marc Ghigo
Summary: This study identified a small consortium of culturable bacterial species that can protect zebrafish, as well as specific endogenous species and a bacterial assembly that contribute to community-level resistance against infection. The research demonstrates the importance of understanding the role of key endogenous bacteria in protecting hosts and the potential for engineering microbial communities for enhanced resilience against pathogens through direct experimental analysis.
Article
Microbiology
David Perez-Pascual, Jordi Estelle, Gilbert Dutto, Charles Rodde, Jean-Francois Bernardet, Yann Marchand, Eric Duchaud, Cyrille Przybyla, Jean-Marc Ghigo
Article
Microbiology
David Perez-Pascual, Sol Vendrell-Fernandez, Bianca Audrain, Joaquin Bernal-Bayard, Rafael Patino-Navarrete, Vincent Petit, Dimitri Rigaudeau, Jean-Marc Ghigo
Summary: The study focused on host-microbiota-pathogen interactions in rainbow trout, demonstrating the importance of specific probiotic bacterial strains in conferring resistance against Flavobacterium columnare infections.
Article
Biotechnology & Applied Microbiology
Nicole C. Thunes, Rachel A. Conrad, Haitham H. Mohammed, Yongtao Zhu, Paul Barbier, Jason P. Evenhuis, David Perez-Pascual, Jean-Marc Ghigo, Ryan S. Lipscomb, John R. Schneider, Nan Li, Devon H. Erbes, Clayton Birkett, Benjamin R. LaFrentz, Timothy J. Welch, Mark J. McBride
Summary: Flavobacterium columnare, a pathogen that causes columnaris disease in freshwater fish, poses a major threat to sustainable aquaculture. Researchers have identified a genetically manipulable strain, MS-FC-4, which has facilitated the identification of virulence factors. Deletion of core genes eliminates virulence, and several secreted proteins have been identified as important for pathogenicity.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Immunology
Rachel A. Conrad, Jason P. Evenhuis, Ryan S. Lipscomb, David Perez-Pascual, Rebecca J. Stevick, Clayton Birkett, Jean-Marc Ghigo, Mark J. McBride
Summary: Flavobacterium columnare, a costly pathogen in the freshwater fish-farming industry, produces siderophores for iron uptake. This study identifies genes involved in iron uptake and reveals their importance for growth under iron-limited conditions. Mutants with deletions in these genes showed decreased virulence but still caused infection. Survivors of exposure to these mutants were partially protected against later infection by the wild-type pathogen.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Nicole C. Thunes, Haitham H. Mohammed, Jason P. Evenhuis, Ryan S. Lipscomb, David Perez-Pascual, Rebecca J. Stevick, Clayton Birkett, Rachel A. Conrad, Jean-Marc Ghigo, Mark J. McBride
Summary: Flavobacterium columnare is a pathogen that causes columnaris disease in freshwater fish, both in natural water bodies and aquaculture settings. This disease is often fatal, especially in high fish population density, and current control options, such as vaccines, are limited. The type IX secretion system (T9SS) is crucial for the virulence of F. columnare, but the specific virulence factors that are secreted through this system are not fully known. This study found that peptidases, which are commonly known virulence factors in other pathogens, may also play a role in F. columnare virulence.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Yuliaxis Ramayo-Caldas, Laura M. Zingaretti, David Perez-Pascual, Pamela A. Alexandre, Antonio Reverter, Antoni Dalmau, Raquel Quintanilla, Maria Ballester
Summary: This study identified microbial signatures linked to immunity traits and characterized the contribution of host-genome and gut microbiota to immunocompetence in healthy pigs. Results showed a polymicrobial nature of immunocompetence in pigs and associations between gut microbiota composition and analyzed traits. The findings highlight the importance of considering both host genome and microbial levels to accurately characterize immunocompetence in pigs.
Article
Microbiology
David Perez-Pascual, Ana Elena Perez-Cobas, Dimitri Rigaudeau, Tatiana Rochat, Jean-Francois Bernardet, Sandrine Skiba-Cassy, Yann Marchand, Eric Duchaud, Jean-Marc Ghigo
Summary: The study found that diets supplemented with insect and yeast proteins can increase gut bacterial richness, improve growth performance, and maintain fish health in rainbow trout. These findings provide promising alternative dietary options to enhance the sustainability of aquaculture.
Article
Microbiology
A. K. M. Firoj Mahmud, Kristina Nilsson, Anna Fahlgren, Roberto Navais, Rajdeep Choudhury, Kemal Avican, Maria Fallman
