期刊
VIRULENCE
卷 1, 期 1, 页码 42-44出版社
LANDES BIOSCIENCE
DOI: 10.4161/viru.1.1.10229
关键词
antimicrobial peptides; peptide antibiotics; alpha-helical peptides; single particle tracking; single molecule detection; quantum dots; nanoparticle conjugate; amphipathicity; biological activity; structure-function relationship; endotoxin; lipopolysaccharide
Antimicrobial peptides (AMPs) are a crucial part of the innate immune system of eukaryotes and present a possible alternative to common antibiotics. It is therefore of great importance to understand their modes of action. Using a single-molecule approach in combination with high resolution imaging and bio-functional assays we were able to determine the different steps occurring during the action of the alpha-helical AMP Sushi 1 during bacterial lysis in spatial and temporal resolution in a biologically relevant context. Furthermore, we comment on the use of Sushi 1 as a template for new peptides to learn more about structure-function relationship of AMPs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据