Article
Engineering, Biomedical
Lauren J. Delaney, John R. Eisenbrey, David Brown, Jonathan R. Brody, Masaya Jimbo, Brian E. Oeffinger, Maria Stanczak, Flemming Forsberg, Ji-Bin Liu, Margaret A. Wheatley
Summary: Ultrasound imaging has many advantages, and the development of microbubble contrast agents presents new opportunities for drug delivery. Gemcitabine-loaded microbubbles show potential therapeutic effects for pancreatic cancer.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
Richard Browning, Nia Thomas, Laura K. Marsh, Louise R. Tear, Joshua Owen, Eleanor Stride, Nicola J. Farrer
Summary: Active loading of the Pt-IV prodrug iproplatin into liposomes using a calcium acetate gradient resulted in a 3-fold enhancement in drug concentration compared to passive loading strategies. Ultrasound-triggered release of iproplatin from microbubble-liposome construct offers greater control over drug delivery, leading to increased platinum concentration in breast cancer cells.
Article
Instruments & Instrumentation
Carlos A. Franco-Urquijo, J. Angel Navarro-Becerra, Amelia Rios, Bruno Escalante
Summary: The study evaluated a hybrid delivery system consisting of liposomes loaded with vascular agonists conjugated to microbubbles for targeted release using UMMD.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Yang Qin, Xiaorui Geng, Yue Sun, Yitong Zhao, Wenyu Chai, Xiaobing Wang, Pan Wang
Summary: Ultrasound (US) is a mechanical wave that can penetrate biological tissues and has diverse applications in diagnosis and treatment. With the advancements in nanotechnology, US has found wider applications in precision medicine, particularly in tumor theranostics. This review focuses on the combination of US with micro and nanoparticles for tumor theranostics, discussing topics such as US-assisted drug delivery and sonodynamic antitumor strategy. The collaborative efficiency and physicochemical processes of US and nano-sensitizers are also analyzed. Furthermore, the review highlights the new applications of US and diagnostic nanoparticles in tumor monitoring and image-guided combined therapy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Hui Li, Yao Zhang, Hong Shu, Wenhao Lv, Chunhong Su, Fang Nie
Summary: This article reviews recent developments in the application of UTMD-mediated gene and drug delivery in the diagnosis and treatment of tumors, including the concept, mechanism of action, clinical application status, and advantages of UTMD. Furthermore, future perspectives in this field are also discussed.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Simone A. G. Langeveld, Bram Meijlink, Klazina Kooiman
Summary: Phospholipid-coated microbubbles, when functionalized, can adhere to specific biomarkers on cells, and recent developments in targeting strategies have enhanced their use for ultrasound molecular imaging and therapy. Targeted microbubbles have shown promising results in the treatment of cardiovascular diseases and cancer, consistently outperforming non-targeted microbubbles in therapeutic outcomes, whether in vitro or in vivo.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2021)
Review
Acoustics
Francois Avry, Coralie Mousset, Edward Oujagir, Ayache Bouakaz, Valerie Gouilleux-gruart, Rose-anne Thepault, Sylvaine Renault, Sylviane Marouillat, Laurent Machet, Jean-michel Escoffrea
Summary: Technological developments in ultrasound imaging and ultrasound contrast agents have improved diagnostic confidence and led to the emergence of sonoporation as a non-invasive and targeted method for drug delivery in melanoma.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Engineering, Biomedical
In Jae Chung, Hyungwon Moon, Seong Ik Jeon, Hak Jong Lee, Cheol-Hee Ahn
Summary: Co-delivering microbubbles (MBs) with anticancer drugs holds promise as a theranostic approach to enhance ultrasound contrast and drug extravasation. In this study, MB-self-aggregate complexes (MB-SAs) were fabricated for encapsulating hydrophobic drugs, demonstrating enhanced cellular uptake and tumor accumulation in vivo. The novel GC@MBs could serve as both an ultrasound contrast agent and drug carrier, with increased cytotoxicity under ultrasound flash.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2022)
Article
Acoustics
Xiaoxiao Zhao, Alex Wright, David E. Goertz
Summary: Therapeutic focused ultrasound combined with encapsulated microbubbles have the ability to induce different bioeffects in the microvasculature. This study examines how the behavior and emissions of microbubbles change with different channel diameters and pressures. The results provide new insights into microbubble behavior in small vessels at higher pressures.
ULTRASONICS SONOCHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Rachel Chapla, Katherine T. Huynh, Carolyn E. Schutt
Summary: Targeted delivery of therapeutics is crucial for reducing systemic toxicity and optimizing therapeutic efficacy. Ultrasound-controlled targeting is an externally-stimulated drug delivery strategy, using ultrasound waves to stimulate gas-filled microbubbles and deliver attached cargo to surrounding cells. The attachment of nanocarrier particles to microbubbles greatly enhances drug delivery capabilities.
Article
Pharmacology & Pharmacy
Hwankyu Lee, Hyungwon Moon, Hyun-Ryoung Kim
Summary: Cholesterol-lipid interactions restrict the lateral dynamics of bilayers but promote bilayer curvature, while lyso-lipids effectively pack the vacancies in cone-shaped lipid bilayers, reducing dynamics and curvature.
Article
Biochemistry & Molecular Biology
Felicia Roffo, Alfonso Maria Ponsiglione, Paolo Antonio Netti, Enza Torino
Summary: An innovative hybrid nanocarrier based on lipid-polymer coupling was proposed and validated for theranostics and multimodal imaging applications. The nanocarrier, prepared using Microfluidics, consists of a core-shell structure with a lipid bilayer enveloping a polymeric chitosan core, capable of co-encapsulating different compounds. The hybrid nanocarriers exhibit monodispersity, structural integrity in different environmental conditions, and high biocompatibility, making them suitable for MRI and Optical applications.
Review
Nanoscience & Nanotechnology
Sinan Sabuncu, Adem Yildirim
Summary: Ultrasound has long been used in the clinic for cancer detection and therapy, with stabilized fluorocarbon microbubbles as contrast agents. However, the limitations of microbubbles in terms of size, stability, and cavitation activity have led to the exploration of gas-stabilizing nanoparticles as an alternative material for improved methods in molecular ultrasound imaging and cancer therapy.
Article
Pharmacology & Pharmacy
Jieqiong Wang, Yuanyuan Wang, Jie Jia, Chenxing Liu, Dong Ni, Litao Sun, Zhijie Guo
Summary: In this study, we fabricated iRGD-QDLM complexes that combined ultrasound imaging with optical imaging for dual-modality molecular imaging of alpha v beta 3 integrin in tumor tissue. It was found that the complexes exhibited excellent binding capability and significantly enhanced signals in ultrasound molecular imaging.
Review
Pharmacology & Pharmacy
Kibeom Kim, Jungmin Lee, Myoung-Hwan Park
Summary: The blood-brain barrier is an important barrier that protects the brain and maintains homeostasis. Traditional drug delivery methods face limitations such as low diversity and efficiency. Microbubble-based drug delivery systems, which utilize ultrasound-induced physical changes, have gained attention in recent years for their ability to enhance drug delivery by disrupting the blood-brain barrier.
Article
Urology & Nephrology
Myong Kim, Hoyoung Ryu, Hak Jong Lee, Sung Il Hwang, Gheeyoung Choe, Sung Kyu Hong
Summary: This study identified age, PSA density, prior biopsy history, and PI-RADS score as significant predictors for the absence of clinically significant prostate cancer in MRI fusion-targeted biopsies. Patients with low PSA density may safely evade MRIFTB, while those with high PSA density need to be more cautious.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyungwoo Ahn, Sung Il Hwang, Hak Jong Lee, Gheeyoung Choe, Jong Jin Oh, Seong Jin Jeong, Seok-Soo Byun, Jung Kwon Kim
Summary: The study examined the diagnostic performance of VIRADS in predicting muscle layer invasion in bladder cancer patients and identified a quantitative indicator for predicting this invasion. VIRADS score and tumor-wall interface were found to be independently associated with muscle layer invasion. VIRADS showed good predictive ability for muscle layer invasion.
EUROPEAN RADIOLOGY
(2021)
Article
Obstetrics & Gynecology
Jae Young Lee, Kidong Kim, Sung Il Hwang, Maria Lee, Keonho Son, Daeseung Kim, Sun Kim, Yong Beom Kim
Summary: This study aimed to evaluate the efficacy and safety of transvaginal high-intensity focused ultrasound (vHIFU) therapy in women with symptomatic uterine leiomyomas. The results showed promising efficacy in reducing symptoms severity, improving quality of life, and decreasing dysmenorrhea pain. The reduction in uterine leiomyoma volume and absence of subsequent therapy needs were also positive outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Adrian P. Brady, Sung Il Hwang, Faisal Khosa, Bettina Siewert, Yu-Dong Zhang
AMERICAN JOURNAL OF ROENTGENOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hae Young Kim, Won Chang, Yoon Jin Lee, Ji Hoon Park, Jungheum Cho, Hee Young Na, Hyungwoo Ahn, Sung Il Hwang, Hak Jong Lee, Young Hoon Kim, Kyoung Ho Lee
Summary: This retrospective study aimed to measure the prevalence of adrenal nodules and the proportion of malignant nodules among patients with potentially resectable gastric cancer detected at staging CT. The results showed that the prevalence of adrenal nodules was 4.5% and the proportion of malignant nodules was low. This suggests the need for more accurate screening methods in the evaluation of adrenal nodules to avoid unnecessary additional imaging and examinations.
Article
Oncology
Hyungwoo Ahn, Sung Il Hwang, Taek Min Kim, Hak Jong Lee, Gheeyoung Choe, Sung Kyu Hong, Seok-Soo Byun, Hakmin Lee
Summary: This study evaluated the diagnostic performance of follow-up multiparametric MRI after high-intensity focused ultrasound (HIFU) for predicting recurrent prostate cancer and identified other clinical or radiological predictors. The post-HIFU MRIs of 110 patients who underwent follow-up biopsies were analyzed, and the likelihood of recurrence was assessed using a Likert scale. Results showed that high suspicion on post-HIFU MRI and a higher number of cancer-positive cores on initial biopsy were independent predictors of recurrence. Although the sensitivity of post-HIFU MRI was low, its high specificity suggests clinical significance, especially considering the possibility of sampling error in biopsies.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Urology & Nephrology
Minsu Kim, Sung Il Hwang, Hyungwoo Ahn, Hak Jong Lee, Seok Soo Byun, Sung Kyu Hong, Sangchul Lee
Summary: This study aimed to validate the diagnostic yield of multiparametric magnetic resonance imaging (mpMRI) for local biochemical recurrence after radical prostatectomy in patients with biochemical recurrence. The results showed that the diagnostic accuracy of mpMRI was low, and selective use of mpMRI should be considered in patients with a higher prostate-specific antigen threshold.
PROSTATE INTERNATIONAL
(2022)
Article
Urology & Nephrology
Jung Kwon Kim, Yoo Sung Song, Won Woo Lee, Hak Jong Lee, Sung Il Hwang, Sung Kyu Hong
Summary: This study investigated the diagnostic efficacy of F-18-Fluorocholine PET/CT and mpMRI in the detection and localization of prostate tumors. The results showed that mpMRI had superior results in assessing tumor localization, while F-18-Fluorocholine PET/CT showed better specificity. Therefore, using both imaging modalities together could provide better treatment planning.
PROSTATE INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Yong-Su Kwon, Min Zheng, Alice Yang Zhang, Zongchao Han
Summary: Melanin is a natural pigment with antioxidant and photoprotective properties. However, its protective effects decline with age, contributing to the development of age-related macular degeneration (AMD). To enhance the effects of melanin, researchers developed synthetic melanin-like nanoparticles (MNPs) that can replace natural melanin in the retinal pigment epithelium (RPE). These MNPs have demonstrated biocompatibility, powerful antioxidant properties, and the ability to selectively target reactive oxygen species (ROS) in cellular and mouse models of AMD. The findings suggest the potential efficacy of MNPs as a natural radical scavenger in ROS-related diseases like AMD.
Review
Urology & Nephrology
Hyungwoo Ahn, Sung Il Hwang, Hak Jong Lee, Sang Youn Kim, Jeong Yeon Cho, Hakmin Lee, Sung Kyu Hong, Seok-Soo Byun, Taek Min Kim
Summary: This study evaluated the diagnostic performance of MRI in predicting recurrent prostate cancer after high-intensity focused ultrasound (HIFU). Nineteen studies including 703 patients were included in the analysis. The results showed that MRI had adequate diagnostic performance for predicting PCa recurrence after HIFU, but the results may have been exaggerated.
PROSTATE INTERNATIONAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Taek Min Kim, Hyungwoo Ahn, Sang Youn Kim, Sung Il Hwang, Myoung Seok Lee, Jeong Yeon Cho, Min Hoan Moon
Summary: The purpose of this study was to evaluate MRI findings for distinguishing ovarian lymphomas from other solid ovarian tumors. Homogeneous high signal intensity on T2-weighted imaging and the presence of peripheral ovarian follicles were found to be characteristic of ovarian lymphomas.
ABDOMINAL RADIOLOGY
(2023)
Article
Materials Science, Biomaterials
Chaemin Lim, Subin Lee, Yuseon Shin, Seongmin Cho, Chanho Park, Yungyeong Shin, Ee Chan Song, Wan Ki Kim, Cheolmin Ham, Sang Bum Kim, Yong-Su Kwon, Kyung Taek Oh
Summary: Atopic dermatitis is a chronic inflammatory skin condition that requires new treatments. This study discovered a peptide-based therapy using the IDDT platform, which identified peptides with anti-inflammatory effects as potential treatment options for atopic dermatitis.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Urology & Nephrology
Changhee Ye, Jin-Nyoung Ho, Dan Hyo Kim, Sang Hun Song, Hwanik Kim, Hakmin Lee, Seong Jin Jeong, Sung Kyu Hong, Seok-Soo Byun, Hyungwoo Ahn, Sung Hwang, Hak Jong Lee, Sangchul Lee
Summary: This study evaluated the effectiveness of PHI and mpMRI in predicting prostate cancer and clinically significant prostate cancer. The results showed that combining PHI and mpMRI provides the most accurate prediction of both types of prostate cancer. In the absence of mpMRI, PHI is superior to PSA alone as a predictor of prostate cancer, and adding PHI to PSA can increase the detection rate of both prostate cancer and clinically significant prostate cancer.
INVESTIGATIVE AND CLINICAL UROLOGY
(2022)
Article
Medicine, General & Internal
Byeongdo Song, Sung Il Hwang, Hak Jong Lee, Seong Jin Jeong, Sung Kyu Hong, Seok-Soo Byun, Sangchul Lee
Summary: This study compared the complications and pathological outcomes between TRUS-PB and MRI-TRUS FTPB, and found that MRI-TRUS FTPB is as safe as TRUS-PB in terms of complications. Additionally, the study showed that prostate volume is an important predictor of complications after prostate biopsy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Taek Min Kim, Hyungwoo Ahn, Hyo Jeong Lee, Min Gwan Kim, Jeong Yeon Cho, Sung Il Hwang, Sang Youn Kim
Summary: This study aims to assess the CT findings of renal epithelioid angiomyolipoma (EAML) and develop a radiomics-based model for differentiating EAMLs and clear cell renal cell carcinomas (RCCs). The shape of the tumor and the tumor-to-cortex enhancement ratio were found to be significant factors for identifying EAMLs. The radiomics model showed better diagnostic performance than an inexperienced radiologist.
ABDOMINAL RADIOLOGY
(2022)