期刊
THERANOSTICS
卷 4, 期 2, 页码 119-133出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.7552
关键词
microRNA-206; Theranostic Marker
资金
- European Regional Development Fund - Project FNUSA-ICRC [CZ.1.05/1.1.00/02.0123]
- [MUNI/A/0951/2012]
MicroRNAs (miRs) are small non-coding RNAs that negatively regulate gene expression by binding to the 3 ' untranslated regions (3 ' UTR) of their target mRNAs. MiRs were shown to play pivotal roles in tissue development and function and are also involved in the pathogenesis of various diseases including cancer. MicroRNA-206, which belongs to the group of so-called myomiRs, is one of the most studied miRs thus far. In addition to being involved in skeletal muscle development and pathology, it has also been established that it is involved in the pathogenesis of numerous diseases including heart failure, chronic obstructive pulmonary disease, Alzheimer's disease and various types of cancers. The aim of this review is to provide a complex overview of microRNA-206, including regulating its expression, a brief description of its known functions in skeletal muscle and a complex overview of its roles in the biology and pathology of other tissues, emphasizing its significant diagnostic and therapeutic potential.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据