Article
Cell Biology
Yin Celeste Cheuk, Shihao Xu, Dong Zhu, Yongsheng Luo, Tian Chen, Juntao Chen, Jiawei Li, Yi Shi, Yi Zhang, Ruiming Rong
Summary: The supernatant derived from myeloid-derived suppressor cells (MDSCs) inhibits the transforming growth factor beta 1 (TGF-beta 1)-induced myofibroblastic differentiation of mesenchymal stem cells (MSCs) through IL-15. This finding provides a new perspective for the development of treatment strategies for renal fibrosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria Yoshida, Ayumu Nakashima, Naoki Ishiuchi, Kisho Miyasako, Keisuke Morimoto, Yoshiki Tanaka, Kensuke Sasaki, Satoshi Maeda, Takao Masaki
Summary: Both adipose-derived and bone marrow-derived mesenchymal stem cells (ADSCs and BMSCs) can suppress renal fibrosis, with ADSCs showing a stronger effect under serum-containing culture conditions. However, ADSC infusion in mice may lead to a higher death rate from pulmonary embolism. Therefore, the selection of ADSCs or BMSCs for clinical applications should consider the target disease and culture method.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Kyu Hwan Kwack, Lixia Zhang, Elliot D. Kramer, Ramkumar Thiyagarajan, Natalie A. Lamb, Yukitomo Arao, Jonathan E. Bard, Kenneth L. Seldeen, Bruce R. Troen, Perry J. Blackshear, Scott I. Abrams, Keith L. Kirkwood
Summary: The study revealed that aging leads to increased myelopoiesis, resulting in higher prevalence of myeloid leukemias and myeloid-derived suppressor cells (MDSCs). Furthermore, the research identified the crucial role of tristetraprolin (TTP) in regulating age-related myelopoiesis by expanding specific myeloid progenitors and M-MDSCs, and recruiting them to sites of injury, inflammation, or other pathologic perturbations.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell & Tissue Engineering
Jiahui Jin, Qingjian Ou, Zhe Wang, Haibin Tian, Jing-Ying Xu, Furong Gao, Shuqin Hu, Jie Chen, Juan Wang, Jieping Zhang, Lixia Lu, Caixia Jin, Guo-Tong Xu, Jingjun Zhao
Summary: BMSC-derived EVs, carrying miRNAs, have shown similar efficacy to BMSCs in treating skin dysfunction in SSc, by regulating the WNT and TGF beta signaling pathways.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Environmental Sciences
Qiuyan Zhao, Changfu Hao, Jingjing Wei, Ruoxuan Huang, Chao Li, Wu Yao
Summary: BMSCs were found to significantly reduce lung inflammation, collagen deposition, and the production of fibronectin, primarily through the inhibition of apoptosis and pyroptosis rather than autophagy. This provides a new insight into the treatment of lung fibrosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Immunology
Samantha L. Tucker, Demba Sarr, Balazs Rada
Summary: Cystic Fibrosis is a genetic disease that causes chronic lung inflammation and infections, leading to high mortality rates. Immune system disruption in CF results in impaired immune responses, chronic infections with pathogens, and alterations in T cell and neutrophil functions. The role of P. aeruginosa and gMDSCs in T cell suppression and immune evasion in CF remains a subject of ongoing research.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Faten A. M. Abo-Aziza, Basma M. Wasfy, Sanaa M. R. Wahba, Sahar S. Abd-Elhalem
Summary: There is limited research on the biological relationship between myeloid-derived suppressor cells (MDSCs) and mesenchymal stem cells (MSCs). This study examined their cooperation in a rat model of adjuvant-induced arthritis (AIA). Results showed that MDSCs played various roles in autoimmunity and MSCs administration improved cytokine levels, suggesting their potential application in immunotherapy for arthritis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Cell Biology
Zhenya Tan, Chen Kan, Mandy Wong, Minqiong Sun, Yakun Liu, Fan Yang, Siying Wang, Hong Zheng
Summary: The bone marrow microenvironment plays a crucial role in both normal hematopoietic stem cells and pathological leukemic stem cells. Mesenchymal stem cells (MSCs) are particularly involved in leukemia progression, chemoresistance, and relapse. The abnormal behavior of MSCs can contribute to the initiation and development of leukemia. This article summarizes the detailed relationship between MSCs and leukemia, including how MSCs actively and passively regulate leukemia progression through various mechanisms. The recent advances in therapy targeting MSCs are also discussed, aiming to provide new perspectives and therapeutic strategies for leukemia treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Medicine, General & Internal
Suncica Kapor, Juan F. Santibanez
Summary: This review discusses the main features of MDSCs and MSCs in myeloid malignancies, revealing that MDSCs are elevated in numbers and exhibit strong immunosuppressive capabilities, while MSCs not only have immunosuppressive properties but also regulate the growth, apoptosis, and chemotherapy resistance of myeloid leukemia cells.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Hyun Hee Jang, Youngsook Son, Gabee Park, Ki-Sook Park
Summary: This study demonstrates that bone marrow-derived mesenchymal stem cells (MSCs) have vasculogenic properties. Different populations of MSCs vary in angiogenic factor expression and vasculogenic properties. The vasculogenic MSCs (vMSCs), distinct from endothelial progenitor cells (EPCs), may contribute to neovascularization and could be a promising cellular therapy for cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Maria Velegraki, Andrew Stiff, Helen A. Papadaki, Zihai Li
Summary: This article summarizes the key findings regarding the expansion of myeloid-derived suppressor cells (MDSCs) in MDS, their role in MDS pathogenesis and immune dysregulation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Szu-Hsien Wu, Yu-Ting Liao, Chi-Han Huang, Yi-Chou Chen, En-Rung Chiang, Jung-Pan Wang
Summary: ADSCs tend to spontaneously differentiate into neuron-like cells during high confluence culture, with enhanced expression of neuronal markers and neurotrophins, while BMSCs do not show this tendency. Additionally, ADSCs do not exhibit spontaneous adipogenic and osteogenic differentiation during this process.
Article
Medicine, General & Internal
Tao Yang, Wei Li, Anquan Peng, Jia Liu, Qin Wang
Summary: In this study, it was found that hypoxic BMSCs-derived exosomes (hypBMSC-Exo) could alleviate cisplatin-induced ototoxicity and had better therapeutic effects compared to BMSC-Exo. This may be achieved by up-regulating the expression of SOD1 and SOD2 to protect auditory function.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Xishuai Wang, Shiyu Zhao, Junhui Lai, Weijun Guan, Yang Gao
Summary: This study demonstrates that gingival-derived mesenchymal stem cells (GMSCs) intervene and protect against bleomycin-induced pulmonary fibrosis, while exhibiting anti-inflammatory and antioxidant capacities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Rishi Man Chugh, Payel Bhanja, Ximena Diaz Olea, Fang Tao, Kealan Schroeder, Ryan Zitter, Tanu Arora, Harsh Pathak, Bruce F. Kimler, Andrew K. Godwin, John M. Perry, Subhrajit Saha
Summary: The study showed that myeloid committed progenitor cells derived from human peripheral blood mononuclear cells can mitigate radiation-induced bone marrow toxicity and improve survival in mice, offering a natural polypharmacy solution against complex injury processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)