Review
Biochemistry & Molecular Biology
Matin Chehelgerdi, Fereshteh Behdarvand Dehkordi, Mohammad Chehelgerdi, Hamidreza Kabiri, Hosein Salehian-Dehkordi, Mohammad Abdolvand, Sharareh Salmanizadeh, Mohsen Rashidi, Anoosha Niazmand, Saba Ahmadi, Sara Feizbakhshan, Saber Kabiri, Nasimeh Vatandoost, Tayebeh Ranjbarnejad
Summary: The emergence of iPSCs has revolutionized stem cell research and opened up new avenues for cancer treatment. iPSCs provide a unique platform for investigating the origin of cancer and can be used for personalized treatment and drug testing. This review article discusses the science behind iPSCs, the limitations and challenges in iPSC-based cancer therapy, ethical and social implications, and a comparative analysis with other stem cell types for cancer treatment. It also explores the applications of iPSCs in tumorigenesis and the future of iPSC research in this field.
Article
Biochemistry & Molecular Biology
Mohamed Nabil, Dina H. Kassem, Azza A. Ali, Hala O. El-Mesallamy
Summary: This study aimed to investigate the therapeutic potential of adipose tissue-derived mesenchymal stem cells (Ad-MSCs) in an Alzheimer's disease (AD) rat model and explore the role of SIRT1. The results demonstrated that transplantation of Ad-MSCs alleviated cognitive impairment in AD rats and exhibited anti-amyloidogenic, antiapoptotic, anti-inflammatory, and neurogenic effects. Furthermore, Ad-MSCs were found to possibly mediate their therapeutic effects through modulating both central and systemic SIRT1 levels.
Article
Cell Biology
Glyn Nigel Stacey, Jie Hao
Summary: In recent years, significant progress has been made in China in establishing hPSCs for the manufacture of cell therapies. The National Stem Cell Resource Center and its partner organizations have over 600 hPSC lines formally recorded, with 47 of them also registered for European Commission funded research projects. This national and international coordination aims to promote the translation of Chinese hPSC-based products into clinical use according to established standards.
CELL PROLIFERATION
(2022)
Article
Cell Biology
Tzu-Cheng Sung, Yi-Peng Jiang, Jhe-Yu Hsu, Qing-Dong Ling, Hao Chen, Suresh S. Kumar, Yung Chang, Shih-Tien Hsu, Qingsong Ye, Akon Higuchi
Summary: This study successfully generated universal hiPSCs without gene editing and evaluated their resistance to immune reactions, demonstrating that the cells maintained stable characteristics even after continuous passages.
CELL PROLIFERATION
(2021)
Review
Pharmacology & Pharmacy
Lu Zhang, Xiao-Jing-Nan Ma, Yuan-Yuan Fei, Heng-Tong Han, Jun Xu, Lu Cheng, Xun Li
Summary: The liver has the ability to repair itself, but pathological changes can impair its regenerative capacity and lead to liver failure. Mesenchymal stem cells (MSCs) have shown promise in liver regeneration, and induced pluripotent stem cells have made progress in organoid establishment and drug screening.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Agnieszka Fus-Kujawa, Barbara Mendrek, Anna Trybus, Karolina Bajdak-Rusinek, Karolina L. Stepien, Aleksander L. Sieron
Summary: Induced pluripotent stem cells (iPSCs) show potential in gene therapy and disease modeling. To safely apply this technology in clinical settings, optimal reprogramming factors and vectors must be considered to reduce the risk of insertional tumorigenesis.
Review
Cell Biology
Michal S. Lach, Monika A. Rosochowicz, Magdalena Richter, Inga Jagiello, Wiktoria M. Suchorska, Tomasz Trzeciak
Summary: The development of induced pluripotent stem cells has opened up unlimited possibilities for regenerative medicine. This technology can be used to treat skeletal diseases such as osteoarthritis and has the potential to replace current short-term solutions. Additionally, using patient-specific tissue for reprogramming purposes can provide a platform for drug screening and modeling skeletal abnormalities.
Review
Veterinary Sciences
Laura Barrachina, Tarlan Eslami Arshaghi, Aisling O'Brien, Ana Ivanovska, Frank Barry
Summary: The article discusses the generation and application of induced pluripotent stem cells (iPSCs) in companion animals. It provides a step-by-step approach for generating iPSCs in companion animals and summarizes the current applications and future directions. Understanding iPSCs in animal species is crucial for advancing veterinary medicine and gaining pre-clinical knowledge transferable to human medicine.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Giuliana Minani Bertolino, Marie Maumus, Christian Jorgensen, Daniele Noel
Summary: Extracellular vesicles (EVs) isolated from induced pluripotent stem cells (iMSCs) show promise in regenerative medicine for the treatment of various diseases. However, the heterogeneity between MSC donors may lead to batch-to-batch variability in the use of EVs as cell-free therapeutic agents.
Article
Computer Science, Interdisciplinary Applications
Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama
Summary: This study presents a model-based assessment of temperature profiles in slow freezing for human induced pluripotent stem cells, which can estimate cell survival rate and required freezing time based on given freezing temperature profiles to achieve quality and productivity objectives. Simulation results indicate different cooling rates in dehydration, nucleation-promoting, and further cooling zones.
COMPUTERS & CHEMICAL ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Summer A. Helmi, Leili Rohani, Ahmed R. Zaher, Youssry M. El Hawary, Derrick E. Rancourt
Summary: Bone healing is a well-organized process regulated by multiple factors. The Notch signaling pathway plays a significant role in controlling bone mesenchymal stem cell differentiation. Inhibiting the Notch pathway can greatly enhance the differentiation of both embryonic and induced pluripotent stem cells, potentially improving overall healing outcomes. Stem cell transplantations are prominent candidates for treating critical-sized bone defects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Abbas Shafiee, Jane Sun, Imaan A. Ahmed, Felicia Phua, Gustavo R. Rossi, Cheng-Yu Lin, Fernando Souza-Fonseca-Guimaraes, Ernst J. Wolvetang, Jason Brown, Kiarash Khosrotehrani
Summary: This study successfully generated skin organoids with appendages from induced pluripotent stem cells, providing a valuable platform for researching human skin development, disease modeling, or reconstructive surgeries.
Article
Biophysics
M. R. Poorna, S. Sudhindran, M. Thampi, Ullas Mony
Summary: The study demonstrated that cellulose nanofibril gel can efficiently differentiate human induced pluripotent stem cells into hepatocyte-like cells. The differentiated HLCs from both CNF and matrigel substrates expressed specific hepatocyte markers and exhibited functional maturity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Biochemistry & Molecular Biology
Aline Yen Ling Wang
Summary: Induced pluripotent stem cells (iPSCs) and iPSC-derived exosomes demonstrate therapeutic effects through paracrine mechanisms, with potential applications in various disease models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Biomaterials
Yoshiki Nakashima, Shinsuke Yoshida, Masayoshi Tsukahara
Summary: Previous belief regarding the compatibility of human induced pluripotent stem cells (hiPSCs) and the coating material Laminin 221 has been challenged by this study. It was found that hiPSCs derived from human mononuclear cells can form peninsular-like colonies when cultured on Laminin 221, and these colonies can be passaged multiple times. The expression of undifferentiated markers tends to be higher in hiPSCs cultured on Laminin 221, and these cells also showed the ability to differentiate into cardiomyocytes on Laminin 221.
REGENERATIVE BIOMATERIALS
(2022)
