Article
Nutrition & Dietetics
Glen D. Lawrence
Summary: PUFAs regulate cholesterol synthesis and uptake through various mechanisms, while genetic variations in proteins involved in cholesterol homeostasis can affect serum cholesterol levels. PUFAs are susceptible to lipid peroxidation, leading to oxidative stress, inflammation, and various diseases.
ADVANCES IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Pere Rehues, Marina Rodriguez, Judith Alvarez, Marta Jimenez, Alba Melia, Mar Sempere, Clara Balsells, Gemma Castillejo, Montse Guardiola, Antoni Castro, Josep Ribalta
Summary: Atherosclerosis is a chronic inflammatory disease caused by the accumulation of LDL particles in the intima, leading to immune cell activation and inflammation. This study investigated the distribution of LPS and its immunogenic portion (3OHFAs) among different lipoprotein types in healthy men. The results showed that LDL and HDL fractions had the highest concentration of LPS, while VLDL particles carried more LPS molecules per particle. The distribution of LPS and 3OHFAs among lipoprotein fractions showed high variability, suggesting their potential as biomarkers for atherosclerosis.
Review
Biochemistry & Molecular Biology
Julia Nowowiejska, Anna Baran, Iwona Flisiak
Summary: Psoriasis is a common skin disease affecting about 1%-3% of the general population, often accompanied by cardiometabolic disorders. Research indicates that lipid expression and metabolism disorders are more common in psoriatic patients, playing a significant role in the pathogenesis of psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Himani Thakkar, Vinnyfred Vincent, Ambuj Roy, Ajay Kumar Gautam, Rintu Kutum, Lakshmy Ramakrishnan, Sandeep Singh, Archna Singh
Summary: Impairments in high-density lipoprotein (HDL) function are linked to coronary artery disease development. This study found distinct lipid and protein profiles in HDL from ACS patients, suggesting a potential contribution to HDL dysfunction beyond inflammatory conditions.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Agriculture, Dairy & Animal Science
Lam Phuoc Thanh, Juan J. Loor, Duong Tran Tuyet Mai, Tran Thi Thuy Hang
Summary: This study aimed to evaluate the effect of incorporating linseed oil and fish oil in the diet on intake, ruminal fermentation, milk yield, and milk fatty acid profiles in dairy goats. The results showed that adding 4.16% linseed oil and fish oil significantly increased the levels of health-promoting fatty acids in milk but decreased milk total saturated fatty acids. Oil addition did not have a negative effect on intake, milk yield, and milk fat content.
Article
Clinical Neurology
Pierre C. Amarenco, Philippa S. Lavallee, Jong Kim, Julien Labreuche, Hugo Charles, Maurice Giroud, Byung-Chul Lee, Marie-Helene Mahagne, Elena Meseguer, Norbert Nighoghossian, Philippe Gabriel Steg, Eric Vicaut, Eric Bruckert, Treat Stroke Target Invest
Summary: This study investigated the effects of two different strategies for reducing low-density lipoprotein (LDL) cholesterol on reducing cardiovascular risk. The results showed that among patients with a target LDL cholesterol level of <70 mg/dL, a reduction in LDL cholesterol of >50% from baseline significantly reduced the risk of the primary outcome.
Article
Biochemistry & Molecular Biology
Gediz Dogay Us, Sohail Mushtaq
Summary: The study demonstrates that high-dose intake of omega-3 fatty acids in combination with statins has a positive effect on improving lipid profiles in hyperlipidemic patients, particularly in reducing LDL III, non-HDL-C, TG, and VLDL-C. Further research is needed to validate these findings.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Nutrition & Dietetics
Qixin Wu, Dandan Shi, Ting Dong, Zhuolin Zhang, Qingjian Ou, Yujing Fang, Caixia Zhang
Summary: This study investigated the association between circulating saturated fatty acids (SFAs) including very long-chain SFAs (VLCSFAs) and the risk of colorectal cancer (CRC). The results showed that higher levels of total SFAs were associated with an increased risk of CRC, while higher levels of VLCSFAs were associated with a decreased risk of CRC. Specifically, certain types of SFAs like lauric acid, myristic acid, palmitic acid, heptadecanoic acid, and arachidic acid were positively associated with CRC risk.
Article
Nutrition & Dietetics
Matina Kouvari, Evangelia Damigou, Matilda Florentin, Rena Kosti, Christina Chrysohoou, Christos S. Pitsavos, Demosthenes B. Panagiotakos
Summary: This study aimed to explore the association between egg intake and 10-year risk of cardiovascular disease (CVD) and other cardiometabolic risk factors. The findings showed that moderate egg consumption was associated with a lower risk of CVD, but this association became non-significant when adjusted for total saturated fatty acid intake.
Article
Agriculture, Dairy & Animal Science
Katarzyna Roman, Martyna Wilk, Piotr Ksiazek, Katarzyna Czyz, Adam Roman
Summary: The study aims to evaluate the impact of environmental conditions, season, and linseed oil supplementation on rabbit blood parameters. The results show that these factors have some influence on blood parameters, while the linseed oil supplement does not have adverse effects on rabbit health.
Article
Pharmacology & Pharmacy
Elsbet J. Pieterman, Hans M. G. Princen, Annica Jarke, Ralf Nilsson, Anders Cavallin, Linnea Bergenholm, Marcus Henricsson, V. Sashi Gopaul, Rahul Agrawal, Steven E. Nissen, Eva Hurt-Camejo
Summary: Chronic oral administration of mineral oil in APOE*3-Leiden.CETP mice increased intestinal permeability and plasma LBP levels, while decreasing plasma cholesterol and triglyceride levels and increasing fecal cholesterol excretion. It may raise concerns about the use of mineral oil as a placebo in clinical studies.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Xiaoying Wang, Bingqian Sun, Lengyun Wei, Xiao Jian, Kai Shan, Qingwen He, Fengjiao Huang, Xiaosong Ge, Xiang Gao, Ninghan Feng, Yong Q. Chen
Summary: This study found that prostate cancer patients have significantly higher levels of lipoproteins, apolipoproteins, triglycerides, and free fatty acids in their blood. Furthermore, the expression of certain genes related to fatty acid metabolism and cholesterol synthesis is also higher in prostate cancer tissues and positively correlated with the severity of cancer. Mouse models showed that overexpression of fatty acid synthase and knockout of cholesterol efflux pump resulted in the progression of prostate cancer, accompanied by an increase in cancer stem cells and activation of specific signaling pathways. These findings suggest that the combination of fatty acid and cholesterol may contribute to the rising incidence of prostate cancer, and reducing fat and cholesterol intake could slow down disease progression.
Article
Biochemistry & Molecular Biology
Naoki Nanashima, Kayo Horie, Maiko Kitajima, Shizuka Takamagi, Kasumi Mikami, Naoya In, Toshiko Tomisawa
Summary: The daily intake of blackcurrant extract for 29 days can lower total cholesterol levels in healthy women, particularly affecting total very-low-density lipoprotein (VLDL) cholesterol, small VLDL cholesterol, and large low-density lipoprotein cholesterol, showing efficacy in preventing arteriosclerosis.
Article
Agriculture, Dairy & Animal Science
Ignacio Contreras-Solis, Valeria Pasciu, Cristian Porcu, Francesca D. Sotgiu, Neda Todorova, Elena Baralla, Laura Mara, Marilia Gallus, Andrea Cabiddu, Maria Dattena, Jose Alfonso Abecia, Fiammetta Berlinguer
Summary: This study investigated the effects of dietary supplementation with by-pass linseed oil (LO) on maternal antioxidant systems in pregnant Sarda ewes. The results showed that supplementation with LO enhanced maternal antioxidant defenses.
Article
Geriatrics & Gerontology
Permal Deo, Varinderpal S. Dhillon, Philip Thomas, Michael Fenech
Summary: The study found a negative association between saturated fatty acids and a blood biomarker of AGE, while unsaturated fatty acids showed a positive association with it. However, these associations weakened after adjusting for age, BMI, and gender.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Modele O. Ogunniyi, Zainab Mahmoud, Yvonne Commodore-Mensah, Jerome L. Fleg, Yetunde A. Fatade, Odayme Quesada, Niti R. Aggarwal, Deirdre J. Mattina, Glaucia Maria Moraes De Oliveira, Kathryn J. Lindley, Bruce Ovbiagele, Robert O. Roswell, Paul L. Douglass, Dipti Itchhaporia, Sharonne N. Hayes
Summary: Black women are disproportionately affected by cardiovascular disease, and the racial structure of the United States influences cardiovascular disease research and healthcare for this population. It is crucial to implement innovative and culturally tailored strategies to improve cardiovascular health in Black women, taking into account their ethnic diversity and cultural backgrounds.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Glaucia Maria Moraes de Oliveira, Maria Cristina Costa de Almeida, Celi Marques-Santos, Maria Elizabeth Navegantes Caetano Costa, Regina Coeli Marques de Carvalho, Claudia Maria Vilas Freire, Lucelia Batista Neves Cunha Magalhaes, Ludhmila Abrahao Hajjar, Maria Alayde Mendonca Rivera, Marildes Luiza de Castro, Walkiria Samuel Avila, Alexandre Jorge Gomes de Lucena, Andrea Araujo Brandao, Ariane Vieira Scarlatelli Macedo, Carla Janice Baister Lantieri, Carisi Anne Polanczyk, Carlos Japhet da Matta Albuquerque, Daniel Born, Eduardo Belisario Falcheto, Erika Olivier Vilela Braganca, Fabiana Goulart Marcondes Braga, Fernanda M. Consolim Colombo, Ieda Biscegli Jatene, Isabela Bispo Santos da Silva Costa, Ivan Romero Rivera, Jaqueline Ribeiro Scholz, Jose Xavier de Melo Filho, Magaly Arrais dos Santos, Marcia de Melo Barbosa, Maria Cristina de Oliveira Izar, Maria Fatima Azevedo, Maria Sanali Moura, Milena dos Santos Barros Campos, Olga Ferreira de Souza, Orlando Otavio de Medeiros, Sheyla Cristina Tonheiro Ferro da Silva, Stephanie Itala Rizk, Thais de Carvalho Vieira Rodrigues, Thais Rocha Salim, Viviana de Mello Guzzo Lemke, Elisabeth Regina Giunco Alexandre
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2022)
Article
Medicine, General & Internal
Rodrigo B. Serafim, Felipe Dal-Pizzol, Vicente Souza-Dantas, Marcio Soares, Fernando A. Bozza, Pedro Povoa, Ronir Raggio Luiz, Jose R. Lapa E. Silva, Jorge I. F. Salluh
Summary: Despite recent advances in the field, the association between subsyndromal delirium (SSD) in the ICU and poor outcomes is not entirely clear. Our findings support the association of SSD with increased ICU length of stay (LOS), but not with ICU mortality. Monitoring the trajectory of SSD early at ICU admission can help to identify patients with increased risk of conversion from SSD to delirium or coma.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Otorhinolaryngology
Flavia Viegas, Zuleica Camargo, Danieli Viegas, Glaucio Serra Guimaraes, Ronir Raggio Luiz, Fabio Ritto, Marcia Simoes-Zenari, Katia Nemr
Summary: This study investigated the acoustic measurements of fundamental frequency and formant frequencies in the pronunciation of Brazilian Portuguese vowels by individuals with Angle Class II, Division 1 malocclusion compared to those with Angle Class I malocclusion. The results showed significant differences in fundamental frequency and formant frequencies, indicating the importance of voice and speech production data in the assessment of malocclusion patients.
INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Glaucia Maria Moraes de Oliveira, Nanette Kass Wenger
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2023)
Article
Immunology
Renata Moll-Bernardes, Juliana R. Ferreira, Eduardo B. Schaustz, Andrea S. Sousa, Joao D. Mattos, Mariana B. Tortelly, Adriana L. Pimentel, Ana Cristina B. S. Figueiredo, Marcia M. Noya-Rabelo, Sergio Fortier, Flavia A. Matos e Silva, Narendra Vera, Luciana Conde, Mauro Jorge Cabral-Castro, Denilson C. Albuquerque, Paulo Henrique Rosado-de-Castro, Gabriel C. Camargo, Martha V. T. Pinheiro, Daniele O. L. Freitas, Ana M. Pittella, Jose Afonso M. Araujo, Andre C. Marques, Elias P. Gouvea, Flavia V. O. Terzi, Cleverson N. Zukowski, Ronaldo A. O. C. Gismondi, Bruno S. S. Bandeira, Renee S. Oliveira, Barbara E. J. Abufaiad, Jacqueline S. Miranda, Luiz Guilherme Miranda, Olga F. Souza, Fernando A. Bozza, Ronir R. Luiz, Emiliano Medei
Summary: Myocardial injury is common in hypertensive patients with COVID-19, and immune dysregulation may be associated with it. This study identified lymphopenia, CD8(+)CD38(+)MFI, and CD8(+)HLA-DR+MFI as immune biomarkers of myocardial injury in these patients.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Glaucia Maria Moraes de Oliveira, Ricardo Fontes-Carvalho, Nuno Cardim, Carlos Eduardo Rochitte
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2023)
Article
Cardiac & Cardiovascular Systems
Viviana Guzzo Lemke, Maria Sanali Souza Paiva, Giordana Zeferino Mariano, Thales Siqueira Alves, Esmeralci Ferreira, Leonardo Avany Nunes, Flavio Roberto Azevedo Oliveira, Rodrigo Cantarelli, Emilia Matos do Nascimento, Glaucia Maria Moraes de Oliveira
Summary: During the COVID-19 pandemic, patients with MI delayed seeking medical care due to contamination fears and difficulties in accessing healthcare. The presence of COVID-19 was associated with death and nonfatal complications among patients undergoing interventional cardiology procedures during the pandemic.
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2023)
Article
Cardiac & Cardiovascular Systems
Sandra Chagas da Costa Feliciano, Paolo Blanco Villela, Glaucia Maria Moraes de Oliveira
Summary: This study analyzed the mortality rates from chronic noncommunicable diseases (CNCDs) in Brazil from 1980 to 2019 and their association with socioeconomic indicators. The results showed a decrease in mortality rates due to circulatory system diseases, except in the Northeast region. There was an increase in mortality rates from neoplasms and diabetes, while rates of chronic respiratory diseases showed little variation. Socioeconomic indicators were inversely correlated with CNCD mortality rates.
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2023)
Article
Dentistry, Oral Surgery & Medicine
Monica Gentil Mattos, Ronir Raggio Luiz, Lucianne Cople Maia, Aline de Almeida Neves
Summary: The objective of this study is to examine the association between caregivers' sense of coherence (SOC) and untreated caries with oral health status in children. The study found that there is a correlation between caregivers' SOC and children's untreated caries. These findings suggest that caregivers' SOC and untreated caries can be used as indicators of dental treatment needs in children.
PESQUISA BRASILEIRA EM ODONTOPEDIATRIA E CLINICA INTEGRADA
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Antonio Luis Eiras-Araujo, Daniella Braz Parente, Alexandre Cerqueira da Silva, Ferreira da Motta Rezende Guilherme, Gustavo Braga Mendes, Ronir Raggio Luiz, Rebecca de Oliveira Souza, Stefanos da Costa Generalis, Rosana Souza Rodrigues, Renata Mello Perez
Summary: MRI with gadoxetic acid can be used to quantify liver function in cirrhotic patients using the relative enhancement index (REI), which shows good correlations with other liver function biomarkers. REI can be easily calculated and can be used to stratify cirrhotic patients into good and poor liver function groups.
EUROPEAN RADIOLOGY
(2023)
Article
Microbiology
Maria Cristina Schneider, Kyung-Duk Min, Phyllis Catharina Romijn, Nelio Batista De Morais, Lucia Montebello, Silene Manrique Rocha, Sofia Sciancalepore, Patricia Najera Hamrick, Wilson Uieda, Volney de Magalhaes Camara, Ronir Raggio Luiz, Albino Belotto
Summary: The National Rabies Program in Brazil has successfully controlled dog-mediated human rabies cases through various actions, but now faces challenges in human cases transmitted by wild animals. A correlation between higher temperatures and human cases in the Northeast region was found, and primary healthcare coverage was identified as a protective factor.
Article
Cardiac & Cardiovascular Systems
Glaucia Maria Moraes de Oliveira, Maria Cristina Costa de Almeida, Daniela do Carmo Rassi, Erika Olivier Vilela Braganca, Lidia Zytynski Moura, Magaly Arrais, Milena dos Santos Barros Campos, Viviana Guzzo Lemke, Walkiria Samuel Avila, Alexandre Jorge Gomes de Lucena, Andre Luiz Cerqueira de Almeida, Andrea Araujo Brandaeo, Andrea Dumsch de Aragon Ferreira, Andreia Biolo, Ariane Vieira Scarlatelli Macedo, Breno de Alencar Araripe Falcaeo, Carisi Anne Polanczyk, Carla Janice Baister Lantieri, Celi Marques-Santos, Claudia Maria Vilas Freire, Denise Pellegrini, Elizabeth Regina Giunco Alexandre, Fabiana Goulart Marcondes Braga, Fabiana Michelle Feitosa de Oliveira, Fatima Dumas Cintra, Isabela Bispo Santos da Silva Costa, Jose Sergio Nascimento Silva, Lara Terra F. Carreira, Lucelia Batista Neves Cunha Magalhaees, Luciana Diniz Nagem Janot de Matos, Marcelo Heitor Vieira Assad, Marcia M. Barbosa, Marconi Gomes da Silva, Maria Alayde Mendonca Rivera, Maria Cristina de Oliveira Izar, Maria Elizabeth Navegantes Caetano Costa, Maria Sanali Moura de Oliveira Paiva, Marildes Luiza de Castro, Marly Uellendahl, Mucio Tavares de Oliveira Junior, Olga Ferreira de Souza, Ricardo Alves da Costa, Ricardo Quental Coutinho, Sheyla Cristina Tonheiro Ferro da Silva, Silvia Marinho Martins, Simone Cristina Soares Brandaeo, Susimeire Buglia, Tatiana Maia Jorge de UlhoaBar Bosa, Thais Aguiar do Nascimento, Thais Vieira, Valquiria Pelisser Campagnucci, Antonio Carlos Palandri Chagas
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2023)
Review
Cardiac & Cardiovascular Systems
Jyoti Sharma, Jan McAlister, Niti R. Aggarwal, Janet Wei, Puja K. Mehta, Odayme Quesada, Deirdre Mattina, Nandita S. Scott, Erin D. Michos, Zainab Mahmoud, Karla Kurrelmeyer, Glaucia Maria Moraes De Oliveira, Kathryn J. Lindley
Summary: There are currently no sex-specific guidelines for blood lipid evaluation and management, but this review focuses on the impact of normal hormonal changes on lipid levels throughout a woman's life cycle. It discusses sex-specific cardiovascular risk factors and the use of statins and non-statin therapies for primary prevention of cardiovascular disease in women.
AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Elizabeth Balbi, Jessica Pronestino de Lima Moreira, Ronir Raggio Luiz, Renata de Mello Perez, Heitor Siffert Pereira de Souza
Summary: The incidence of hepatocellular carcinoma (HCC) is increasing in Brazil, particularly among individuals above 50 years old and in rural areas. However, the lethality rate remains stable, suggesting changes in environmental and socioeconomic factors.