期刊
CHINESE JOURNAL OF CANCER
卷 34, 期 2, 页码 70-78出版社
SUN YAT SEN UNIV MED SCI WHO
DOI: 10.5732/cjc.014.10124
关键词
Interim PET/CT; diffuse large B-cell lymphoma; predictive value
类别
Interim F-16-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (I-PET/CT) is a powerful tool for monitoring the response to therapy in diffuse large B-cell lymphoma (DLBCL), This retrospective study aimed to determine when and how to use I-PET/CT in DLBCL, A total of 197 patients treated with rituximab cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) were enrolled between October 2005 and July 2011; PET/CT was performed at the time of diagnosis (PET/CT0), after 2 and 4 cycles of chemotherapy (PET/CT2 and PET/CT4, respectively), and at the end of treatment (F-PET/CT), According to the International Harmonization Project for Response Criteria in Lymphoma, 110 patients had negative PET/CT2 scans, and 87 had positive PET/CT2 scans. The PET/CT2-negative patients had significantly higher 3-year progression-free survival rate (75.8% vs. 38.2%) and 3-year overall survival rate (93.5% vs. 55.6%) than PET/CT2-positive patients, All PET/CT2-negative patients remained negative at PET/CT4, but 3 were positive at F-PET/CT, Among the 87 PET/CT2-positive patients. 57 remained positive at F-PET/CT, and 32 progressed during chemotherapy (15 at PET/CT4 and 17 at F-PET/CT). Comparing PET/CT4 with PET/CO, 7 patients exhibited progression, and 8 achieved partial remission. Comparing F-PET/CT with PET/CT, 10 patients exhibited progression, and 7 achieved partial remission. In conclusion, our results indicate that I-PET/CT should be performed after 2 rather than 4 cycles of immunochemotherapy in DLBCL patients. There is a limited role for subsequent PET/CT in the detection of relapse in PET/CT2-negative patients, but repeat PET/CT is required if the PET/CT2 findings are positive,
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据