Review
Medicine, General & Internal
Allison S. Dobry, Sonia Himed, Margo Waters, Benjamin H. Kaffenberger
Summary: Epidermal necrolysis, a severe cutaneous drug reaction, requires standardized clinical assessment and research tools due to limited large-scale studies.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Maren Paulmann, Felix Reinkemeier, Marcus Lehnhardt, Maja Mockenhaupt
Summary: A 42-year-old male patient was initially diagnosed with epidermal necrolysis but later confirmed to have generalized bullous fixed drug eruption. The importance of medical history, clinical presentation, and detailed medication history in accurate diagnosis was highlighted.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Muna Shakhashiro, Taylor R. Bradley, Stuart Tobin
Summary: We report a case of BP with TEN-like manifestations in the oldest known patient. Atypical presentations of blistering disorders require detailed clinical and laboratory analysis. Proper diagnosis is crucial for appropriate management and patient care.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Review
Medicine, General & Internal
Eri Tsukagoshi, Yoichi Tanaka, Yoshiro Saito
Summary: Drug-related Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are rare but severe adverse drug reactions, with predicting their onset remaining challenging. Pharmacogenomic information on drug labels may differ among countries, but CPIC guidelines provide a scientifically sound goal for future pharmacogenomic implementation.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Peng-Yu Chen, Zi-Yun Li, Sui-Qing Cai
Summary: Cadonilimab is the first approved bi-specific antibody for certain malignancies in June 2022, with a modified Fc structure to reduce immune-related adverse events. This report presents the first case of TEN-like reactions during the treatment of hepatocellular carcinoma with Cadonilimab, successfully treated with supplemental Adalimumab. The case highlights the potential risk of Cadonilimab-induced TEN and suggests Adalimumab as a favorable option for refractory Cadonilimab-related TEN treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Gang Li, Sheng Gong, Ning Wang, Xiaojun Yao
Summary: This report discusses a case of a patient with advanced non-small cell lung cancer (NSCLC) and comorbid pulmonary tuberculosis who developed toxic epidermal necrolysis (TEN) after receiving immunotherapy and chemotherapy. The importance of monitoring rare but severe cutaneous toxicities in patients treated with Sintilimab is emphasized.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Lin Cheng
Summary: Adverse drug reactions, particularly SJS and TEN, are a significant public health concern with high mortality rates and ineffective treatment options. Factors such as infections, mutations in drug metabolic enzymes, and immune responses contribute to SJS/TEN development. Future research directions include epigenetics, metabolites, and regulatory T cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Wei Yang, Yansong Lu, Ze Wu, Jun Niu
Summary: This case report describes a patient with metastatic non-small cell lung cancer who developed afatinib-induced toxic epidermal necrosis (TEN). The effects of afatinib were evaluated using the ALDEN algorithm. Treatment with corticosteroids resulted in significant improvement and complete remission of the clinical symptoms.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Omair Farooq, Akifa Abbas, Muhammad Ahmad, Abu Bakr Manzoor
Summary: Toxic Epidermal Necrolysis (TEN) is a rare but serious dermatologic emergency that affects the skin and mucous membranes. Drugs are the most common cause, and the management options include nutritional support, care of denuded skin and mucosa, and IVIG treatment.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Bretislav Lipovy, Martin Hladik, Petr Stourac, Serhiy Forostyak
Summary: The case report highlights the use of lyophilized amniotic membrane in accelerating wound healing in a patient with TEN, showing significant results in the facial area. The application of amniotic membrane did not result in side effects or infections, demonstrating excellent biocompatibility and accelerated re-epithelialization.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Medicine, General & Internal
Qingzi Yan, Xiang Liu, Haibo Lei, Renzhu Liu, Yixiang Hu
Summary: This study investigated the clinical features of oxcarbazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis. The study found that males have a higher prevalence of these diseases and they usually occur within two weeks of medication. The main clinical manifestations include rashes, fever, mucosal lesions, conjunctivitis, and blisters. Stopping medication and other treatments can lead to good outcomes.
FRONTIERS IN MEDICINE
(2023)
Article
Dermatology
J-P Lefaucheur, L. Valeyrie-Allanore, S. Ng Wing Tin, G. Abgrall, A. Colin, C. Hajj, N. de Prost, P. Wolkenstein, S. Ingen-Housz-Oro, O. Chosidow
Summary: Chronic pain is a common long-term sequela of SJS/TEN, with sensory descriptors indicating sensitization of nerve fibers and affective-emotional components playing a predominant role in the pain experience.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hua-Ching Chang, Tsung-Jen Wang, Ming-Hsiu Lin, Ting-Jui Chen
Summary: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening diseases caused by drugs. The effectiveness of systemic immunomodulating treatments for SJS/TEN is still controversial, but cyclosporine and biologic anti-TNF-alpha have shown promising results. Combination treatments are also being explored. Large-scale randomized controlled trials are needed for more definitive evidence. Advances in understanding the pathogenesis of SJS/TEN may inspire the discovery of potential therapeutic targets.
Article
Multidisciplinary Sciences
Ming-Hung Chang, Kuo-Hwa Chiang, Jiunn-Min Shieh, Kuo-Chen Cheng, Chung-Han Ho
Summary: Miliary lung metastasis is not a dominant indicator for outcome evaluation in patients with non-small cell lung cancer harboring EGFR mutation under TKI prescription. Other strong prognostic indicators include performance status, liver metastasis, EGFR type, and generation of TKI.
SCIENTIFIC REPORTS
(2022)
Review
Pharmacology & Pharmacy
Bertrand Sheng-Yang Lian, Haur Yueh Lee
Summary: Prompt admissions to optimal care facilities, coordinated specialized care during the acute phase, as well as long-term follow-up to manage chronic sequelae are essential in the management of patients with epidermal necrolysis. Patients should be managed in specialized/reference centers experienced with the disease.
EXPERT OPINION ON DRUG SAFETY
(2022)
Article
Nanoscience & Nanotechnology
Meng Fan, Han Wang, Shikhar Misra, Bruce Zhang, Zhimin Qi, Xing Sun, Jijie Huang, Haiyan Wang
ACS APPLIED MATERIALS & INTERFACES
(2018)
Article
Physics, Applied
Bruce Zhang, Meng Fan, Leigang Li, Jie Jian, Jijie Huang, Han Wang, Matias Kalaswad, Haiyan Wang
APPLIED PHYSICS LETTERS
(2018)
Article
Chemistry, Physical
Seungho Cho, Chao Yun, Yoon Seo Kim, Han Wang, Jie Jian, Wenrui Zhang, Jijie Huang, Xuejing Wang, Haiyan Wang, Judith L. MacManus-Driscoll
Article
Chemistry, Multidisciplinary
Xing Sun, Jijie Huang, Jie Jian, Meng Fan, Han Wang, Qiang Li, Judith L. Mac Manus-Driscoll, Ping Lu, Xinghang Zhang, Haiyan Wang
MATERIALS HORIZONS
(2018)
Article
Chemistry, Multidisciplinary
Jijie Huang, Xuejing Wang, Nicki L. Hogan, Shengxiang Wu, Ping Lu, Zhe Fan, Yaomin Dai, Beibei Zeng, Ryan Starko-Bowes, Jie Jian, Han Wang, Leigang Li, Rohit P. Prasankumar, Dmitry Yarotski, Matthew Sheldon, Hou-Tong Chen, Zubin Jacob, Xinghang Zhang, Haiyan Wang
Article
Nanoscience & Nanotechnology
Shikhar Misra, Leigang Li, Jie Jian, Jijie Huang, Xuejing Wang, Dmitry Zemlyanov, Ji-Wook Jang, Fabio H. Ribeiro, Haiyan Wang
ACS APPLIED MATERIALS & INTERFACES
(2018)
Article
Chemistry, Multidisciplinary
Jijie Huang, Zhimin Qi, Leigang Li, Han Wang, Sichuang Xue, Bruce Zhang, Xinghang Zhang, Haiyan Wang
Article
Nanoscience & Nanotechnology
Jijie Huang, Han Wang, Xing Sun, Xinghang Zhang, Haiyan Wang
ACS APPLIED MATERIALS & INTERFACES
(2018)
Article
Physics, Applied
Bibek Gautam, Mary Ann Sebastian, Shihong Chen, Shikhar Misra, Jijie Huang, F. Javier Baca, Rose Emergo, Timothy Haugan, Zhongwen Xing, Haiyan Wang, Judy Z. Wu
APPLIED PHYSICS LETTERS
(2018)
Article
Materials Science, Multidisciplinary
Xuejing Wang, Jie Jian, Zhiguang Zhou, Cuncai Fan, Yaomin Dai, Leigang Li, Jijie Huang, Jianing Sun, Andrea Donohue, Peter Bermel, Xinghang Zhang, Hou-Tong Chen, Haiyan Wang
ADVANCED OPTICAL MATERIALS
(2019)
Article
Materials Science, Multidisciplinary
Han Wang, Fauzia Khatkhatay, Jie Jian, Jijie Huang, Meng Fan, Haiyan Wang
MATERIALS RESEARCH BULLETIN
(2019)
Article
Engineering, Electrical & Electronic
Jijie Huang, Han Wang, Hua Wang, Bruce Zhang, Xiaofeng Qian, Haiyan Wang
IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY
(2019)
Article
Engineering, Electrical & Electronic
Judy Wu, Bibek Gautam, Mary Ann Sebastian, Victor Ogunjimi, Shikhar Misra, Jijie Huang, Javier Baca, Joseph Prestigiacomo, Timothy Haugan, Haiyan Wang, Mike Osofsky
IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY
(2019)
Article
Engineering, Electrical & Electronic
Mary Ann Sebastian, Charles Ebbing, Di Zhang, Jie Jian, Jijie Huang, Yifan Zhang, Haiyan Wang, Victor Ogunjimi, Mohan Panth, Bibek Gautam, Judy Wu, Timothy Haugan
Summary: An important research goal in the applications of high temperature superconductor YBCO thin films is to increase both the critical current density and the isotropic nature of the film. This research explores the effect of Ca-doped YBCO space layers on the interface between BZO nanorods and YBCO in multilayer composite films under suitable conditions. The interplay of adding BaZrO3 to YBCO, varying pulsed laser deposition conditions for multilayer film growth, and employing calcium-doped YBCO space layers, and the resulting impact on film microstructures and superconducting properties, will be presented.
IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
ZhenJiang Lei, JiJie Huang, Zhao Li, Lei Wang, JiSheng Cui, Zhi Tang
2017 2ND INTERNATIONAL CONFERENCE ON COMMUNICATION, IMAGE AND SIGNAL PROCESSING (CCISP 2017)
(2018)