Review
Biochemistry & Molecular Biology
Niloofar Piri, Henry J. Kaplan
Summary: AMD is a progressive degenerative disease that severely affects central vision in people over age 50, impacting their ability to read, write, drive, and recognize faces. The disease is complex and multifactorial, involving age, genetics, and environmental factors. The role of complement system in the development of AMD is reviewed. Understanding the pathophysiology of AMD and its risk factors is crucial for drug discovery.
Article
Biochemistry & Molecular Biology
Shruti Chandra, Manjot K. Grewal, Sarega Gurudas, Rajan Sondh, Alan Bird, Glen Jeffery, Victor Chong, Sobha Sivaprasad
Summary: The qAF8 levels in patients with non-neovascular AMD were found to be significantly lower compared to age-matched controls, indicating a early and sustained loss of function of the retinal pigment epithelium in AMD.
Review
Ophthalmology
Federico Fantaguzzi, Beatrice Tombolini, Andrea Servillo, Ilaria Zucchiatti, Riccardo Sacconi, Francesco Bandello, Giuseppe Querques
Summary: Photobiomodulation (PBM) shows potential in treating intermediate age-related macular degeneration (AMD) by improving visual acuity and contrast sensitivity, and reducing AMD lesions. However, the effectiveness of PBM in AMD remains uncertain due to the limitations of available studies.
OPHTHALMOLOGY AND THERAPY
(2023)
Review
Ophthalmology
Manuel Paez-Escamilla, Mahima Jhingan, Denise S. Gallagher, Sumit Randhir Singh, Samantha Fraser-Bell, Jay Chhablani
Summary: AMD is a leading cause of blindness globally, with challenging diagnosis and potential confusion with other diseases. This study summarizes the characteristics of various conditions that mimic AMD, along with a brief update on the classic features of AMD.
SURVEY OF OPHTHALMOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marc Biarnes, Xavier Garrell-Salat, Alba Gomez-Benlloch, Merce Guarro, Gabriel Londono, Elena Lopez, Sergi Ruiz, Meritxell Vazquez, Laura Sararols
Summary: Geographic atrophy (GA) secondary to age-related macular degeneration is a common cause of blindness worldwide. We critically appraised the methodological aspects of phase 3 clinical trials in GA and discussed the similarities and differences among the trials. Understanding key methodological aspects of clinical trials is important for readers to interpret the results, and authors should adhere to clinical trial reporting guidelines.
Article
Ophthalmology
Kai Lyn Goh, Fred K. Chen, Chandrakumar Balaratnasingam, Carla J. Abbott, Lauren A. B. Hodgson, Robyn H. Guymer, Zhichao Wu
Summary: In a cohort of patients with intermediate age-related macular degeneration (AMD), the presence of cuticular drusen was not associated with an increased risk of developing late AMD over a three-year period or with a difference in the rate of visual sensitivity decline.
Article
Medicine, General & Internal
Jonathan B. Lin, Omar A. Halawa, Joan W. Miller, Demetrios G. Vavvas
Summary: Age-related macular degeneration (AMD) is a leading cause of blindness in older adults, with a strong genetic risk factor being a complement factor H (CFH) gene polymorphism. Complement inhibition has emerged as a therapeutic strategy for slowing geographic atrophy (GA) in AMD, but randomized clinical trials have produced mixed results, leading to further research and questions about its potential as a therapy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Anton M. Kolomeyer, Eli Smith, Ebenezer Daniel, Gui-Shuang Ying, Wei Pan, Max Pistilli, Juan Grunwald, Maureen G. Maguire, Benjamin J. Kim
Summary: The extent of sclera/choroidal blood vessel B-PPA was associated with the incidence and size of geographic atrophy (GA) in eyes treated with anti-vascular endothelial growth factor agents. Patients without beta-peripapillary atrophy (B-PPA) had a higher number of GA-associated risk alleles of ARMS2 and HTRA1.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Prem N. Patel, Parth A. Patel, Matthew R. Land, Ibrahim Bakerkhatib-Taha, Harris Ahmed, Veeral Sheth
Summary: Age-related macular degeneration (AMD) is a common cause of vision loss in elderly individuals. The pathophysiology of dry AMD is associated with key proteins in the complement cascade, providing potential therapeutic targets. Early intervention may prevent disease progression.
Review
Medicine, General & Internal
Amy C. Cohn, Zhichao Wu, Andrew I. Jobling, Erica L. Fletcher, Robyn H. Guymer
Summary: This article summarizes the potential of lasers in slowing the progression of AMD and key findings from clinical trials, while also highlighting the importance of advances in multimodal imaging and functional testing, as well as ongoing investigation of key pathological mechanisms in further exploring the utility of nanosecond and other subthreshold short pulse lasers in AMD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Jonathan B. Lin, Stylianos Serghiou, Joan W. Miller, Demetrios G. Vavvas
Summary: Complement dysregulation is observed in early/intermediate nonexudative AMD, but not in patients with geographic atrophy. These findings provide insights into the mechanism of AMD and inform future clinical trials.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
John T. Demirs, Junzheng Yang, Maura A. Crowley, Michael Twarog, Omar Delgado, Yubin Qiu, Stephen Poor, Dennis S. Rice, Thaddeus P. Dryja, Karen Anderson, Sha-Mei Liao
Summary: The dysregulation of the alternative complement pathway is a major pathogenic mechanism in age-related macular degeneration. Complement mRNA and protein expression levels were found to be significantly higher in macular retinal pigment epithelium/choroid tissue than in the neural retina, regardless of AMD grade status. The study suggests that the RPE/choroid is the primary site for complement inhibition to treat geographic atrophy or earlier stages of the disease.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Ana Rita Fernandes, Aleksandra Zielinska, Elena Sanchez-Lopez, Tiago dos Santos, Maria Luisa Garcia, Amelia M. Silva, Jacek Karczewski, Eliana B. Souto
Summary: This review discusses the latest developments in treatment options for age-related macular degeneration (AMD), including pharmacologic therapies and laser treatments for exudative AMD. However, there are still no successful treatments for nonexudative AMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Ophthalmology
Enrico Borrelli, Francesco Bandello, Eric H. Souied, Costanza Barresi, Alexandra Miere, Lea Querques, Riccardo Sacconi, Giuseppe Querques
Summary: New imaging technologies have provided a remarkable opportunity to bridge the gap between histology and clinical findings in neovascular AMD, enhancing our understanding of the disease.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Cheryl N. Fonteh, Alan G. Palestine, Brandie D. Wagner, Jennifer L. Patnaik, Marc T. Mathias, Niranjan Manoharan, Naresh Mandava, Rebecca Baldermann, Talisa De Carlo, Anne M. Lynch
Summary: A study found lower levels of RANTES in patients with GA AMD compared to controls. However, there was no statistical difference between male and female GA patients when moderated by sex.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2023)
Review
Ophthalmology
Nidhi Relhan, Thomas A. Albini, Avinash Pathengay, Ajay E. Kuriyan, Darlene Miller, Harry W. Flynn
BRITISH JOURNAL OF OPHTHALMOLOGY
(2016)
Article
Ophthalmology
Steven Gayer, Howard D. Palte, Thomas A. Albini, Harry W. Flynn, Ricardo Martinez-Ruiz, Nelson Salas, Andrew J. Mcclellan, Nidhi Relhan, Jean-Marie Parel
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2016)
Article
Ophthalmology
Milan Shah, Nidhi Relhan, Ajay E. Kuriyan, Janet L. Davis, Thomas A. Albini, Avinash Pathengay, Darlene Miller, Harry W. Flynn
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2016)
Article
Ophthalmology
D. Wilkin Parke, David R. P. Almeida, Thomas A. Albini, Camila V. Ventura, Audina M. Berrocal, Robert A. Mittra
Article
Ophthalmology
Marcela Marsiglia, Roberto Gallego-Pinazo, Eduardo Cunha de Souza, Marion R. Munk, Suquin Yu, Sarah Mrejen, Emmett T. Cunningham, Brandon J. Lujan, Naomi R. Goldberg, Thomas A. Albini, Alain Gaudric, Catherine Francais, Richard B. Rosen, K. Bailey Freund, Lee M. Jampol, Lawrence A. Yannuzzi
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2016)
Article
Ophthalmology
Francesco Pichi, Sunil K. Srvivastava, Saradha Chexal, Andrea Lembo, Luiz H. Lima, Piergiorgio Neri, Andrea Saitta, Jay Chhablani, Thomas A. Albini, Paolo Nucci, K. Bailey Freund, Hyewon Chung, Careen Y. Lowder, David Sarraf
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2016)
Editorial Material
Ophthalmology
Camila V. Ventura, Thomas A. Albini, Audina M. Berrocal
JAMA OPHTHALMOLOGY
(2016)
Article
Ophthalmology
Samuel P. Burke, Howard F. Fine, Thomas A. Albini
OPHTHALMIC SURGERY LASERS & IMAGING RETINA
(2016)
Editorial Material
Ophthalmology
Thomas A. Albini, Carmen Puliafito
OPHTHALMIC SURGERY LASERS & IMAGING RETINA
(2016)
Article
Ophthalmology
Carlos A. Medina, Michelle R. Butler, Avnish A. Deobhakta, Michael R. Banitt, Thomas A. Albini, William E. Smiddy, Audina M. Berrocal, Steven J. Gedde, Harry W. Flynn
OPHTHALMIC SURGERY LASERS & IMAGING RETINA
(2016)
Article
Medicine, General & Internal
Ajay E. Kuriyan, Thomas A. Albini, Justin H. Townsend, Marianeli Rodriguez, Hemang K. Pandya, Robert E. Leonard, M. Brandon Parrott, Philip J. Rosenfeld, Harry W. Flynn, Jeffrey L. Goldberg
NEW ENGLAND JOURNAL OF MEDICINE
(2017)
Review
Ophthalmology
Francesco Pichi, David Sarraf, Sruthi Arepalli, Careen Y. Lowder, Emmett T. Cunningham, Piergiorgio Neri, Thomas A. Albini, Vishali Gupta, Kimberly Baynes, Sunil K. Srivastava
PROGRESS IN RETINAL AND EYE RESEARCH
(2017)
Article
Ophthalmology
Allen C. Ho, Thomas A. Albini, David M. Brown, David S. Boyer, Carl D. Regillo, Jeffrey S. Heier
JAMA OPHTHALMOLOGY
(2017)
Letter
Ophthalmology
Steven Gayer, Howard D. Palte, Thomas A. Albini, Harry W. Flynn, Ricardo Martinez-Ruiz, Nelson Salas, Andrew J. Mcclellan, Nidhi Relhan, Jean-Marie Parel
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2017)
Article
Ophthalmology
Nicolas A. Yannuzzi, Nancy Si, Nidhi Relhan, Ajay E. Kuriyan, Thomas A. Albini, Audina M. Berrocal, Janet L. Davis, William E. Smiddy, Justin Townsend, Darlene Miller, Harry W. Flynn
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2017)
